Publications by authors named "Lionel B Ivashkiv"

100Publications

The hypoxia-lactate axis tempers inflammation.

Nat Rev Immunol 2020 02;20(2):85-86

Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.

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http://dx.doi.org/10.1038/s41577-019-0259-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021227PMC
February 2020

Interferon target-gene expression and epigenomic signatures in health and disease.

Nat Immunol 2019 12 19;20(12):1574-1583. Epub 2019 Nov 19.

Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.

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http://dx.doi.org/10.1038/s41590-019-0466-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024546PMC
December 2019

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation.

Nat Commun 2019 07 25;10(1):3320. Epub 2019 Jul 25.

Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 10021, USA.

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http://dx.doi.org/10.1038/s41467-019-11147-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658531PMC
July 2019

The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.

Immunity 2019 08 11;51(2):241-257.e9. Epub 2019 Jul 11.

Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Research Institute and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709581PMC
August 2019

'-Omics' shed light on B cells in lupus.

Nat Immunol 2019 08;20(8):946-948

Research Institute and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.

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http://dx.doi.org/10.1038/s41590-019-0446-6DOI Listing
August 2019

TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis.

Ann Rheum Dis 2019 09 16;78(9):1205-1214. Epub 2019 May 16.

David Z Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA

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http://dx.doi.org/10.1136/annrheumdis-2018-214783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692909PMC
September 2019

Insights into rheumatic diseases from next-generation sequencing.

Nat Rev Rheumatol 2019 06;15(6):327-339

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, USA.

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http://dx.doi.org/10.1038/s41584-019-0217-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673602PMC
June 2019

IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy.

Nat Rev Immunol 2018 09;18(9):545-558

Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, USA.

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http://www.nature.com/articles/s41577-018-0029-z
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http://dx.doi.org/10.1038/s41577-018-0029-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340644PMC
September 2018

Regulation of age-associated B cells by IRF5 in systemic autoimmunity.

Nat Immunol 2018 04 26;19(4):407-419. Epub 2018 Feb 26.

Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, USA.

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http://dx.doi.org/10.1038/s41590-018-0056-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095139PMC
April 2018

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.

Nat Commun 2018 02 13;9(1):658. Epub 2018 Feb 13.

Arthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special Surgery, New York, NY, 10021, USA.

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http://www.nature.com/articles/s41467-018-03081-7
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http://dx.doi.org/10.1038/s41467-018-03081-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811492PMC
February 2018

Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation.

Nat Immunol 2017 Oct 21;18(10):1104-1116. Epub 2017 Aug 21.

Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York, USA.

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http://dx.doi.org/10.1038/ni.3818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605457PMC
October 2017

Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.

Immunity 2017 08;47(2):235-250.e4

Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA; Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2017.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568089PMC
August 2017

Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes.

PLoS One 2017 14;12(7):e0179762. Epub 2017 Jul 14.

Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179762PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510804PMC
September 2017

Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption.

J Immunol 2017 05 17;198(9):3436-3447. Epub 2017 Mar 17.

Arthritis and Tissue Degeneration Program and The David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021;

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http://dx.doi.org/10.4049/jimmunol.1601716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425156PMC
May 2017

IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages.

Cell Rep 2016 09;16(12):3121-3129

Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021, USA; Department of Medicine, Weill Cornell Medical College and Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079287PMC
http://dx.doi.org/10.1016/j.celrep.2016.08.051DOI Listing
September 2016

Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.

Sci Rep 2016 08 25;6:31959. Epub 2016 Aug 25.

Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1038/srep31959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4997257PMC
August 2016

Epigenetic Regulation of Myeloid Cells.

Microbiol Spectr 2016 06;4(3)

Arthritis and Tissue Degeneration Program and David Z. Rosensweig Genomics Center, Hospital for Special Surgery, New York, NY 10021.

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http://dx.doi.org/10.1128/microbiolspec.MCHD-0010-2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5268423PMC
June 2016

RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis.

J Immunol 2016 06 9;196(12):4977-86. Epub 2016 May 9.

Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021; Department of Medicine, Weill Cornell Medical College, New York, NY 10065

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http://dx.doi.org/10.4049/jimmunol.1502044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893988PMC
June 2016

Cutting Edge: EZH2 Promotes Osteoclastogenesis by Epigenetic Silencing of the Negative Regulator IRF8.

J Immunol 2016 06 29;196(11):4452-4456. Epub 2016 Apr 29.

Arthritis and Tissue Degeneration Program David Z. Rosensweig Genomics Research Center Hospital for Special Surgery.

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http://dx.doi.org/10.4049/jimmunol.1501466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875854PMC
June 2016

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes.

Protein Cell 2016 Mar 13;7(3):201-9. Epub 2016 Feb 13.

School of Medicine and Institute for Immunology, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s13238-016-0248-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791428PMC
March 2016

TNF biology, pathogenic mechanisms and emerging therapeutic strategies.

Nat Rev Rheumatol 2016 Jan 10;12(1):49-62. Epub 2015 Dec 10.

Arthritis &Tissue Degeneration Program and David Z. Rosensweig Center for Genomics Research, Hospital for Special Surgery, 535 E 70th Street, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nrrheum.2015.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809675PMC
January 2016

Intravenous Immunoglobulin (IVIG) Attenuates TNF-Induced Pathologic Bone Resorption and Suppresses Osteoclastogenesis by Inducing A20 Expression.

J Cell Physiol 2016 Feb;231(2):449-458

Arthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomic Research, Hospital for Special Surgery, New York, NY 10021 USA.

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http://dx.doi.org/10.1002/jcp.25091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779648PMC
February 2016

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.

Nat Immunol 2015 Aug 29;16(8):838-849. Epub 2015 Jun 29.

Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021.

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http://dx.doi.org/10.1038/ni.3205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509841PMC
August 2015

Use of RNA sequencing to evaluate rheumatic disease patients.

Arthritis Res Ther 2015 Jul 1;17:167. Epub 2015 Jul 1.

Arthritis and Tissue Degeneration Program and the David Z Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 10021, USA.

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http://dx.doi.org/10.1186/s13075-015-0677-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488125PMC
July 2015

Metabolic-epigenetic coupling in osteoclast differentiation.

Nat Med 2015 Mar;21(3):212-3

Arthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomics Research, Hospital for Special Surgery, New York, New York, USA; and in the Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.3815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795459PMC
March 2015

Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation.

Nat Commun 2014 Nov 13;5:5418. Epub 2014 Nov 13.

1] Arthritis and Tissue Degeneration Program and David C. Rosensweig Center for Genomics Research, Hospital for Special Surgery, New York, New York 10021, USA [2] Department of Medicine, Weill Cornell Medical College, New York, New York 10021, USA [3] Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ncomms6418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249944PMC
November 2014

BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes.

Eur J Immunol 2015 Jan 1;45(1):287-297. Epub 2014 Dec 1.

Arthritis and Tissue Degeneration Program and David Z. Rosensweig Center for Genomics Research, Hospital for Special Surgery, New York, New York, USA.

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http://dx.doi.org/10.1002/eji.201444862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293348PMC
January 2015

Modulation of TNF-induced macrophage polarization by synovial fibroblasts.

J Immunol 2014 Sep 23;193(5):2373-83. Epub 2014 Jul 23.

Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY 10021; Department of Medicine, Weill Cornell Medical College, New York, NY 10021; and Weill Cornell Graduate School of Medical Sciences, New York, NY 10021.

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http://dx.doi.org/10.4049/jimmunol.1400486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135020PMC
September 2014

Regulation of type I interferon responses.

Nat Rev Immunol 2014 Jan;14(1):36-49

Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nri3581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084561PMC
January 2014

Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.

Immunity 2013 Sep 5;39(3):454-69. Epub 2013 Sep 5.

Arthritis and Tissue Degeneration Program and Genomics Center, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.immuni.2013.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857147PMC
September 2013

PTPN22 in autoimmunity: different cell and different way.

Immunity 2013 Jul;39(1):91-3

Arthritis and Tissue Degeneration Program and Genomics Center, Hospital for Special Surgery, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.immuni.2013.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785409PMC
July 2013

Kinase inhibitors: a new tool for the treatment of rheumatoid arthritis.

Clin Immunol 2013 Jul 17;148(1):66-78. Epub 2013 Apr 17.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.clim.2013.04.007DOI Listing
July 2013

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.

J Clin Invest 2013 Feb 25;123(2):928-32. Epub 2013 Jan 25.

Arthritis and Tissue Degeneration Program, Autoimmunity and Inflammation Program, Hospital for Special Surgery, Weill Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1172/JCI66168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561822PMC
February 2013

Epigenetic regulation of macrophage polarization and function.

Trends Immunol 2013 May 4;34(5):216-23. Epub 2012 Dec 4.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.it.2012.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647003PMC
May 2013

Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors.

Arthritis Rheum 2012 Dec;64(12):3856-66

Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1002/art.37691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510320PMC
December 2012

ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes.

J Immunol 2012 Apr 24;188(7):3447-57. Epub 2012 Feb 24.

Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.1102211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311708PMC
April 2012

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.

J Exp Med 2012 Feb 16;209(2):319-34. Epub 2012 Jan 16.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10065, USA.

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http://jem.rupress.org/content/209/2/319.full.pdf
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http://www.jem.org/cgi/doi/10.1084/jem.20111566
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http://dx.doi.org/10.1084/jem.20111566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280875PMC
February 2012

Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8.

Ann N Y Acad Sci 2011 Nov;1237:88-94

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06217.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263822PMC
November 2011

Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states.

Eur J Immunol 2011 Sep;41(9):2477-81

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10010, USA.

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http://dx.doi.org/10.1002/eji.201141783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264328PMC
September 2011

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors.

Arthritis Res Ther 2011 Jul 28;13(4):234. Epub 2011 Jul 28.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1186/ar3379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239342PMC
July 2011

Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages.

Nat Immunol 2011 May 22;12(7):607-15. Epub 2011 May 22.

Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, New York, USA.

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http://dx.doi.org/10.1038/ni.2043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258532PMC
May 2011

How ITAMs inhibit signaling.

Sci Signal 2011 Apr 19;4(169):pe20. Epub 2011 Apr 19.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, 535 East 70th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1126/scisignal.2001917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261782PMC
April 2011

Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway.

Immunology 2011 Apr 24;132(4):567-77. Epub 2011 Jan 24.

Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1111/j.1365-2567.2010.03402.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075510PMC
April 2011

TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages.

Proc Natl Acad Sci U S A 2011 Jan 10;108(4):1573-8. Epub 2011 Jan 10.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.1010030108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029683PMC
January 2011

IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling.

Proc Natl Acad Sci U S A 2010 Nov 25;107(45):19438-43. Epub 2010 Oct 25.

Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.1007816107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2984206PMC
November 2010

Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27.

J Immunol 2010 Dec 22;185(11):7047-56. Epub 2010 Oct 22.

Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.1001290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3019240PMC
December 2010

Systemic lupus erythematosus monocytes are less responsive to interleukin-10 in the presence of immune complexes.

Arthritis Rheum 2011 Jan;63(1):212-8

Hospital for Special Surgery and Weill Cornell Medical College, New York, New York 10021, USA.

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http://dx.doi.org/10.1002/art.30083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014998PMC
January 2011

Downregulation of Friend leukemia virus integration 1 as a feedback mechanism that restrains lipopolysaccharide induction of matrix metalloproteases and interleukin-10 in human macrophages.

J Interferon Cytokine Res 2010 Dec 29;30(12):893-900. Epub 2010 Sep 29.

Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York, New York, USA.

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http://dx.doi.org/10.1089/jir.2010.0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004135PMC
December 2010

Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.

J Immunol 2010 Nov 24;185(9):5023-31. Epub 2010 Sep 24.

Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, Hospital for Special Surgery, New York, NY 10021, USA.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1001544
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http://dx.doi.org/10.4049/jimmunol.1001544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010732PMC
November 2010

STAT activation during viral infection in vivo: where's the interferon?

Cell Host Microbe 2010 Aug;8(2):132-5

Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.chom.2010.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016222PMC
August 2010

The type I interferon signaling pathway is a target for glucocorticoid inhibition.

Mol Cell Biol 2010 Oct 2;30(19):4564-74. Epub 2010 Aug 2.

Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, 1300 York Avenue, New York, New York 10021, USA.

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http://dx.doi.org/10.1128/MCB.00146-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950533PMC
October 2010

Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages.

J Immunol 2010 May 16;184(10):5545-52. Epub 2010 Apr 16.

Graduate Program in Cell Biology and Genetics, Weill Cornell Graduate School of Medical Sciences, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.0901293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016855PMC
May 2010

Overview of the biology of type I interferons.

Arthritis Res Ther 2010 14;12 Suppl 1:S1. Epub 2010 Apr 14.

Arthritis and Tissue Degeneration Program and Department of Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1186/ar2881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991774PMC
November 2012

Type I interferon: a new player in TNF signaling.

Curr Dir Autoimmun 2010 18;11:94-104. Epub 2010 Feb 18.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1159/000289199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827816PMC
May 2010

Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages.

Proc Natl Acad Sci U S A 2010 Feb 26;107(7):3012-7. Epub 2010 Jan 26.

Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0914902107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840310PMC
February 2010

Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors.

J Immunol 2009 Dec 4;183(11):7223-33. Epub 2009 Nov 4.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.0900072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783334PMC
December 2009

Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases.

Immunity 2009 Oct;31(4):539-50

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.immuni.2009.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774226PMC
October 2009

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages.

Hum Immunol 2009 Apr 7;70(4):211-7. Epub 2009 Feb 7.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York, USA.

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http://dx.doi.org/10.1016/j.humimm.2009.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811352PMC
April 2009

Cross-regulation of signaling by ITAM-associated receptors.

Nat Immunol 2009 Apr 19;10(4):340-7. Epub 2009 Mar 19.

Hospital for Special Surgery, Weill Cornell Graduate School of Medical Sciences, New York, New York, USA.

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http://dx.doi.org/10.1038/ni.1706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753670PMC
April 2009

Roles of semaphorins in the immune and hematopoietic system.

Rheumatol Int 2009 May 13;29(7):727-34. Epub 2009 Jan 13.

Division of Rheumatology, College of Medicine, Korea University, 126-1, Anam-Dong 5-Ga, Sungbuk-Ku, Seoul, 136-705, South Korea.

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http://dx.doi.org/10.1007/s00296-009-0852-4DOI Listing
May 2009

Targeting cytokines in inflammatory diseases: focus on interleukin-1-mediated autoinflammation.

F1000 Biol Rep 2009 Sep 8;1:70. Epub 2009 Sep 8.

Arthritis and Tissue Degeneration Program and Department of Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.3410/B1-70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948254PMC
September 2009

Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1.

J Immunol 2008 Oct;181(7):5089-97

Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, New York University School of Medicine, New York, NY 10016, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610354PMC
http://dx.doi.org/10.4049/jimmunol.181.7.5089DOI Listing
October 2008

A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways.

Nat Rev Immunol 2008 10;8(10):816-22

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, 535 East 70th Street, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/nri2396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581615PMC
October 2008

Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2.

J Leukoc Biol 2008 Nov 4;84(5):1353-60. Epub 2008 Aug 4.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York, USA.

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http://dx.doi.org/10.1189/jlb.0107040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567899PMC
November 2008

IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.

J Immunol 2008 Jun;180(12):8057-65

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742170PMC
http://dx.doi.org/10.4049/jimmunol.180.12.8057DOI Listing
June 2008

IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38.

J Immunol 2008 May;180(9):6325-33

Arthritis and Tissue Degeneration Program, Department of Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.180.9.6325DOI Listing
May 2008

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes.

Nat Immunol 2008 Apr 16;9(4):378-87. Epub 2008 Mar 16.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ni1576DOI Listing
April 2008

Insoluble immune complexes are most effective at triggering IL-10 production in human monocytes and synergize with TLR ligands and C5a.

Clin Immunol 2008 Apr 16;127(1):56-65. Epub 2008 Jan 16.

Hospital for Special Surgery, Weill Medical College, Cornell University, 535 East 70th Street, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.clim.2007.11.014DOI Listing
April 2008

'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.

Nat Immunol 2008 Feb 16;9(2):186-93. Epub 2007 Dec 16.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA.

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http://dx.doi.org/10.1038/ni1548DOI Listing
February 2008

Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis.

J Orthop Res 2008 Jan;26(1):106-16

Osteolysis Research Laboratory, Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA.

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http://dx.doi.org/10.1002/jor.20486DOI Listing
January 2008

Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation.

J Leukoc Biol 2007 Aug 14;82(2):237-43. Epub 2007 May 14.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA.

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http://dx.doi.org/10.1189/jlb.1206763DOI Listing
August 2007

A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells.

J Biol Chem 2007 Jun 17;282(26):18676-85. Epub 2007 Apr 17.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M610232200
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http://dx.doi.org/10.1074/jbc.M610232200DOI Listing
June 2007

Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.

Hum Immunol 2007 Mar 8;68(3):156-64. Epub 2007 Jan 8.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York 10021, USA.

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http://dx.doi.org/10.1016/j.humimm.2006.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736914PMC
March 2007

Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs.

J Immunol 2007 Feb;178(4):2204-11

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.4049/jimmunol.178.4.2204DOI Listing
February 2007

FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.

Immunity 2007 Jan;26(1):67-78

Graduate Program in Immunology and Microbial Pathogenesis, Weill Medical College and Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S107476130600566
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http://dx.doi.org/10.1016/j.immuni.2006.11.010DOI Listing
January 2007

Dysregulation of interleukin-10-dependent gene expression in rheumatoid arthritis synovial macrophages.

Arthritis Rheum 2006 Sep;54(9):2711-21

Hospital for Special Surgery, New York, New York 10021, USA.

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http://dx.doi.org/10.1002/art.22055DOI Listing
September 2006

Involvement of complement receptor 3 (CR3) and scavenger receptor in macrophage responses to wear debris.

J Orthop Res 2006 Nov;24(11):2036-44

Osteolysis Research Laboratory, Hospital for Special Surgery, 535 East 70th Street, New York, New York 10021, USA.

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http://dx.doi.org/10.1002/jor.20275DOI Listing
November 2006

Twist mediates suppression of inflammation by type I IFNs and Axl.

J Exp Med 2006 Aug 10;203(8):1891-901. Epub 2006 Jul 10.

Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20051725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118370PMC
August 2006