Linzhao Cheng

Linzhao Cheng

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Linzhao Cheng

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The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model.

Fluids Barriers CNS 2019 Jul 15;16(1):20. Epub 2019 Jul 15.

Institute for Nanobiotechnology, Johns Hopkins University, 100 Croft Hall, 3400 North Charles Street, Baltimore, MD, 21218, USA.

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http://dx.doi.org/10.1186/s12987-019-0139-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628493PMC
July 2019

Highly Purified Human Extracellular Vesicles Produced by Stem Cells Alleviate Aging Cellular Phenotypes of Senescent Human Cells.

Stem Cells 2019 Jun 12;37(6):779-790. Epub 2019 Mar 12.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/stem.2996DOI Listing
June 2019

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior.

Biomaterials 2019 Jan 25;190-191:24-37. Epub 2018 Oct 25.

Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, United States; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289621PMC
January 2019

Conditional gene knockout and reconstitution in human iPSCs with an inducible Cas9 system.

Stem Cell Res 2018 05 10;29:6-14. Epub 2018 Mar 10.

Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2018.03.003DOI Listing
May 2018

Human is a key target of RUNX1 in megakaryocytic differentiation.

Blood 2018 01 3;131(2):191-201. Epub 2017 Nov 3.

Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1182/blood-2017-04-780379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757696PMC
January 2018

Generation of human iPSCs from an essential thrombocythemia patient carrying a V501L mutation in the MPL gene.

Stem Cell Res 2017 01 11;18:57-59. Epub 2016 Dec 11.

Division of Hematology, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.scr.2016.12.012DOI Listing
January 2017

Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells.

Stem Cell Res 2016 09 12;17(2):296-305. Epub 2016 Aug 12.

Department of Radiation Oncology and Molecular Radiation Sciences, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.08.006DOI Listing
September 2016

Integration-free erythroblast-derived human induced pluripotent stem cells (iPSCs) from an individual with Ataxia-Telangiectasia (A-T).

Stem Cell Res 2016 09 5;17(2):205-207. Epub 2016 Aug 5.

Department of Radiation Oncology and Molecular Radiation Sciences, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2016.08.003DOI Listing
September 2016

A Method for Genome Editing in Human Pluripotent Stem Cells.

Cold Spring Harb Protoc 2016 Apr 1;2016(4):pdb.prot090217. Epub 2016 Apr 1.

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Predoctoral Training Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

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http://dx.doi.org/10.1101/pdb.prot090217DOI Listing
April 2016

Genome Editing in Human Pluripotent Stem Cells.

Cold Spring Harb Protoc 2016 Apr 1;2016(4):pdb.top086819. Epub 2016 Apr 1.

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Predoctoral Training Program in Human Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

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http://dx.doi.org/10.1101/pdb.top086819DOI Listing
April 2016

Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.

PLoS One 2015 30;10(1):e0116933. Epub 2015 Jan 30.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Biochemistry and Molecular Biology, Unversity of Maryland School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116933PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311989PMC
October 2015

Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration-approved pharmacological reagents.

Stem Cells Transl Med 2015 Apr 23;4(4):309-19. Epub 2015 Feb 23.

Division of Hematology, Department of Medicine, Institute for Cell Engineering, Department of Chemical and Biomolecular Engineering, and Divisions of General Internal Medicine and Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

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http://dx.doi.org/10.5966/sctm.2014-0183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367506PMC
April 2015

A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach.

Stem Cells Transl Med 2015 Apr 5;4(4):320-32. Epub 2015 Mar 5.

Division of Hematology, Department of Medicine, and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Department of Stem Cells and Regenerative Medicine, Peking Union Medical College, Tianjin, People's Republic of China; Department of Transfusion, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA; Key Laboratory of Pediatric Hematology/Oncology of Ministry of Health, Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China

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http://dx.doi.org/10.5966/sctm.2014-0214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367508PMC
April 2015

Efficient and allele-specific genome editing of disease loci in human iPSCs.

Mol Ther 2015 Mar 24;23(3):570-7. Epub 2014 Nov 24.

1] Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA [2] Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/mt.2014.226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351458PMC
March 2015

Synaptic dysregulation in a human iPS cell model of mental disorders.

Nature 2014 Nov 17;515(7527):414-8. Epub 2014 Aug 17.

1] Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [2] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [3] Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA [4] The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/nature13716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501856PMC
November 2014

Targeted correction of RUNX1 mutation in FPD patient-specific induced pluripotent stem cells rescues megakaryopoietic defects.

Blood 2014 Sep;124(12):1926-30

Oncogenesis and Development Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD

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http://dx.doi.org/10.1182/blood-2014-01-550525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168347PMC
September 2014

Whole-genome sequencing identifies genetic variances in culture-expanded human mesenchymal stem cells.

Stem Cell Reports 2014 Aug 26;3(2):227-33. Epub 2014 Jun 26.

Laboratory of Genome Variations and Precision Bio-Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2014.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176531PMC
August 2014

Efficient and scalable expansion of human pluripotent stem cells under clinically compliant settings: a view in 2013.

Ann Biomed Eng 2014 Jul 17;42(7):1357-72. Epub 2013 Oct 17.

Department of Chemical and Biomolecular Engineering and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD, 21218, USA.

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http://dx.doi.org/10.1007/s10439-013-0921-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436032PMC
July 2014

Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs.

Cell Stem Cell 2014 Jul;15(1):12-3

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338993PMC
July 2014

Human induced pluripotent stem cell-derived mesenchymal stem cell seeding on calcium phosphate scaffold for bone regeneration.

Tissue Eng Part A 2014 Apr 7;20(7-8):1295-305. Epub 2014 Jan 7.

1 Biomaterials and Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School , Baltimore, Maryland.

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http://dx.doi.org/10.1089/ten.TEA.2013.0211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993076PMC
April 2014

Early frameshift mutation in PIGA identified in a large XLID family without neonatal lethality.

Hum Mutat 2014 Mar 13;35(3):350-5. Epub 2014 Jan 13.

Human Genome Laboratory, VIB Center for the Biology of Disease, Leuven, Belgium; Human Genome Laboratory, Department of Human Genetics, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/humu.22498DOI Listing
March 2014

Concise review: stem cell-based approaches to red blood cell production for transfusion.

Stem Cells Transl Med 2014 Mar 20;3(3):346-55. Epub 2013 Dec 20.

Division of Hematology, Department of Medicine, and Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.5966/sctm.2013-0054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3952923PMC
March 2014

Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis.

Stem Cells 2014 Feb;32(2):349-63

State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1002/stem.1447DOI Listing
February 2014

Expanded activity of dimer nucleases by combining ZFN and TALEN for genome editing.

Sci Rep 2013 ;3:2376

Stem Cell Program, Institute for Cell Engineering, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1038/srep02376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736171PMC
February 2014

Extensive ex vivo expansion of functional human erythroid precursors established from umbilical cord blood cells by defined factors.

Mol Ther 2014 Feb 3;22(2):451-463. Epub 2013 Sep 3.

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:

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http://dx.doi.org/10.1038/mt.2013.201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916033PMC
February 2014

Differential sensitivity to JAK inhibitory drugs by isogenic human erythroblasts and hematopoietic progenitors generated from patient-specific induced pluripotent stem cells.

Stem Cells 2014 Jan;32(1):269-78

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/stem.1545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096297PMC
January 2014

A panel of CpG methylation sites distinguishes human embryonic stem cells and induced pluripotent stem cells.

Stem Cell Reports 2014 Jan 26;2(1):36-43. Epub 2013 Dec 26.

Department of Human Genetics, Broad Stem Cell Research Center, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles Young Drive, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.stemcr.2013.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916755PMC
January 2014

Scalable expansion of human induced pluripotent stem cells in the defined xeno-free E8 medium under adherent and suspension culture conditions.

Stem Cell Res 2013 Nov 9;11(3):1103-16. Epub 2013 Aug 9.

Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA; Stem Cell Program, Institute of Cell Engineering, The Johns Hopkins University School of Medicine, Edward D. Miller Research Building, Room 747, 733 N. Broadway, Baltimore, MD 21205, USA; Institute for NanoBioTechnology, The Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1016/j.scr.2013.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628790PMC
November 2013

Generation of glycosylphosphatidylinositol anchor protein-deficient blood cells from human induced pluripotent stem cells.

Stem Cells Transl Med 2013 Nov 10;2(11):819-29. Epub 2013 Oct 10.

Division of Hematology, Department of Medicine, School of Medicine, and.

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http://dx.doi.org/10.5966/sctm.2013-0069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808197PMC
November 2013

And then there were none: no need for pluripotency factors to induce reprogramming.

Cell Stem Cell 2013 Sep;13(3):261-2

Stem Cell Program in the Institute for Cell Engineering and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.stem.2013.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659384PMC
September 2013

Generation and homing of iPSC-derived hematopoietic cells in vivo.

Mol Ther 2013 Jul;21(7):1292-3

Division of Hematology, Department of Medicine and Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/mt.2013.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702102PMC
July 2013

Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix.

Proc Natl Acad Sci U S A 2013 Jul 15;110(31):12601-6. Epub 2013 Jul 15.

Department of Chemical and Biomolecular Engineering, Johns Hopkins Physical Sciences-Oncology Center and Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1073/pnas.1306562110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732921PMC
July 2013

Induced pluripotent stem cell-derived mesenchymal stem cell seeding on biofunctionalized calcium phosphate cements.

Bone Res 2013;4:371-384

Biomaterials & Tissue Engineering Division, Department of Endodontics, Prosthodontics and Operative Dentistry, University of Maryland Dental School, Baltimore, MD 21201, USA ; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA ; University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA ; Department of Mechanical Engineering, University of Maryland, Baltimore County, MD 21250, USA.

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http://dx.doi.org/10.4248/BR201304008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023512PMC
January 2013

Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression.

Nat Protoc 2012 Nov 18;7(11):2013-21. Epub 2012 Oct 18.

Stem Cell Program, Institute for Cell Engineering, Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nprot.2012.121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756815PMC
November 2012

The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells.

PLoS One 2012 4;7(5):e36689. Epub 2012 May 4.

Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036689PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344930PMC
September 2012

Promise and challenges of human iPSC-based hematologic disease modeling and treatment.

Int J Hematol 2012 Jun 23;95(6):601-9. Epub 2012 May 23.

Division of Hematology in Department of Medicine, Johns Hopkins University School of Medicine, 720 Rutland Ave., Ross Research Building, Room 1032, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1007/s12185-012-1095-9DOI Listing
June 2012

The phenotype of a germline mutation in PIGA: the gene somatically mutated in paroxysmal nocturnal hemoglobinuria.

Am J Hum Genet 2012 Feb 2;90(2):295-300. Epub 2012 Feb 2.

Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1016/j.ajhg.2011.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276655PMC
February 2012

Concise review: Human cell engineering: cellular reprogramming and genome editing.

Stem Cells 2012 Jan;30(1):75-81

Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/stem.735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696036PMC
January 2012

Zinc fingers hit off target.

Nat Med 2011 Oct 11;17(10):1192-3. Epub 2011 Oct 11.

Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/nm1011-1192DOI Listing
October 2011

Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells.

Blood 2011 Aug 31;118(7):1801-5. Epub 2011 May 31.

Stem Cell Biology Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1182/blood-2011-03-340620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158714PMC
August 2011

Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting.

Blood 2011 May 16;117(21):5561-72. Epub 2011 Mar 16.

Division of Hematology, Department of Medicine, and Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1182/blood-2010-12-328161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110021PMC
May 2011

Molecular imaging and stem cell research.

Mol Imaging 2011 Apr;10(2):111-22

Sidney Kimmel Comprehensive Cancer Center, JohnsHopkins University School of Medicine, Baltimore, MD 21231, USA.

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April 2011

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures.

Cell Res 2011 Mar 18;21(3):518-29. Epub 2011 Jan 18.

Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/cr.2011.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193421PMC
March 2011

Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions.

Stem Cells 2010 Oct;28(10):1893-904

Laboratory for Stem Cells & Aging, Buck Institute for Age Research, Novato, California 94945, USA.

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http://dx.doi.org/10.1002/stem.499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996088PMC
October 2010

Potential of human induced pluripotent stem cells derived from blood and other postnatal cell types.

Regen Med 2010 Jul;5(4):521-30

Division of Hematology & Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Room 747, 733 N. Broadway, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.2217/rme.10.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028827PMC
July 2010

An improved method for generating and identifying human induced pluripotent stem cells.

Methods Mol Biol 2010 ;636:191-205

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-1-60761-691-7_12DOI Listing
June 2010

Multiple, interconvertible states of human pluripotent stem cells.

Cell Stem Cell 2010 Jun;6(6):497-9

Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S193459091000224
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http://dx.doi.org/10.1016/j.stem.2010.05.014DOI Listing
June 2010

Double knockouts in human embryonic stem cells.

Cell Res 2010 Mar;20(3):250-2

Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1038/cr.2010.29DOI Listing
March 2010

The dazzle in germ cell differentiation.

J Mol Cell Biol 2010 Feb 11;2(1):26-9. Epub 2009 Dec 11.

Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1093/jmcb/mjp041DOI Listing
February 2010

Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders.

Blood 2009 Dec 1;114(27):5473-80. Epub 2009 Oct 1.

Stem Cell Program, Institute for Cell Engineering, and Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-04-21
Publisher Site
http://dx.doi.org/10.1182/blood-2009-04-217406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798863PMC
December 2009

Better positioned in stem cells.

Authors:
Linzhao Cheng

Blood 2009 Aug;114(7):1285-6

Johns Hopkins University, USA.

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http://dx.doi.org/10.1182/blood-2009-05-221754DOI Listing
August 2009

Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models.

Cell Res 2009 Mar;19(3):370-9

Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1038/cr.2008.329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109972PMC
March 2009

In vivo functional efficacy of tumor-specific T cells expanded using HLA-Ig based artificial antigen presenting cells (aAPC).

Cancer Immunol Immunother 2009 Feb 18;58(2):209-20. Epub 2008 Jun 18.

Department of Pathology, Johns Hopkins School of Medicine, Ross 664G, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1007/s00262-008-0542-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680120PMC
February 2009

In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells.

Proc Natl Acad Sci U S A 2008 Dec 18;105(52):20641-6. Epub 2008 Dec 18.

Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

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http://dx.doi.org/10.1073/pnas.0809680106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634917PMC
December 2008

Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells.

J Biol Chem 2008 Sep 2;283(36):24991-5002. Epub 2008 Jul 2.

Laboratory of Molecular Cell Biology, Key Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, the Cell Bank/Stem Cell Bank, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M803893200
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http://dx.doi.org/10.1074/jbc.M803893200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529127PMC
September 2008

Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts.

Stem Cells 2008 Aug 29;26(8):1998-2005. Epub 2008 May 29.

Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Room 747, 733 North Broadway, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1634/stemcells.2008-0346DOI Listing
August 2008

Lentiviral gene transduction of mouse and human stem cells.

Methods Mol Biol 2008 ;430:243-53

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1007/978-1-59745-182-6_17DOI Listing
April 2008

How reproducible is bioluminescent imaging of tumor cell growth? Single time point versus the dynamic measurement approach.

Mol Imaging 2007 Sep-Oct;6(5):315-22

Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

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February 2008

More new lines of human parthenogenetic embryonic stem cells.

Authors:
Linzhao Cheng

Cell Res 2008 Feb;18(2):215-7

Stem Cell Program, Johns Hopkins Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1038/cr.2008.19DOI Listing
February 2008

Stem cells shine in Shanghai.

Cell Stem Cell 2008 Jan;2(1):34-7

Stem Cell Program, Johns Hopkins Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.stem.2007.12.010DOI Listing
January 2008

Antitumor activity of the histone deacetylase inhibitor MS-275 in prostate cancer models.

Prostate 2007 Aug;67(11):1182-93

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/pros.20611DOI Listing
August 2007

FLT3/ITD expression increases expansion, survival and entry into cell cycle of human haematopoietic stem/progenitor cells.

Br J Haematol 2007 Apr;137(1):64-75

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2007.06525.xDOI Listing
April 2007

Inducible and reversible transgene expression in human stem cells after efficient and stable gene transfer.

Stem Cells 2007 Mar 7;25(3):779-89. Epub 2006 Dec 7.

Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Room 747, 733 North Broadway, Baltimore, MD 21205, USA.

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http://doi.wiley.com/10.1634/stemcells.2006-0128
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March 2007

Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions.

Cell Res 2007 Jan 9;17(1):62-72. Epub 2007 Jan 9.

Institute for Cell Engineering, Department of Gynecology & Obstetrics, the Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1038/sj.cr.7310138DOI Listing
January 2007

PC3, but not DU145, human prostate cancer cells retain the coregulators required for tumor suppressor ability of androgen receptor.

Prostate 2006 Sep;66(12):1329-38

Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA.

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http://doi.wiley.com/10.1002/pros.20483
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September 2006

Culture of human embryonic stem cells on human and mouse feeder cells.

Methods Mol Biol 2006 ;331:91-104

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1385/1-59745-046-4:91DOI Listing
August 2006

HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding.

Stem Cells 2006 Apr 2;24(4):876-88. Epub 2006 Mar 2.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Bunting-Blaustein Cancer Research Building, Room 2M44, 1650 Orleans Street, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1634/stemcells.2005-0598DOI Listing
April 2006

Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells.

Stem Cells 2005 Nov-Dec;23(10):1489-501. Epub 2005 Jul 7.

The Institute for Cell Engineering, Department of Gynecology & Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://doi.wiley.com/10.1634/stemcells.2005-0034
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March 2006

Electrophysiological properties of pluripotent human and mouse embryonic stem cells.

Stem Cells 2005 Nov-Dec;23(10):1526-34. Epub 2005 Aug 9.

Department of Medicine, University of Hong Kong, Hong Kong, China.

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http://dx.doi.org/10.1634/stemcells.2004-0299DOI Listing
March 2006

Radiofrequency-enhanced vascular gene transduction and expression for intravascular MR imaging-guided therapy: feasibility study in pigs.

Radiology 2005 Sep 22;236(3):939-44. Epub 2005 Jul 22.

Department of Radiology, Johns Hopkins University School of Medicine, Traylor Bldg, Room 330, 720 Rutland Ave, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1148/radiol.2363041021DOI Listing
September 2005

Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation.

Blood 2005 Jul 10;106(1):304-10. Epub 2005 Mar 10.

Department of Laboratory Medicine, National Taiwan University Hospital,

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http://dx.doi.org/10.1182/blood-2005-01-0241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895131PMC
July 2005

Detection of dual-gene expression in arteries using an optical imaging method.

J Biomed Opt 2004 Nov-Dec;9(6):1223-9

Johns Hopkins University, Department of Biomedical Engineering, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1117/1.1803842DOI Listing
March 2005

Functional antigen-presenting leucocytes derived from human embryonic stem cells in vitro.

Lancet 2004 Jul 10-16;364(9429):163-71

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/S0140-6736(04)16629-4DOI Listing
July 2004