Publications

Emi2 Is Essential for Mouse Spermatogenesis.
Cell Rep 2017 Jul;20(3):697-708
Institute of Molecular and Cell Biology (IMCB), A(∗)STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos #3-09, Singapore 138673, Republic of Singapore; Department of Biochemistry, National University of Singapore (NUS), Singapore 117597, Republic of Singapore. Electronic address:



Overexpression of Parkinson's Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology.
eNeuro 2017 Mar-Apr;4(2). Epub 2017 Mar 17.
Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Soloman H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana 70130; Diana Helis Henry Medical Research Foundation, New Orleans, Louisiana 70130.


Cdk2 catalytic activity is essential for meiotic cell division in vivo.
Biochem J 2016 Sep 1;473(18):2783-98. Epub 2016 Jul 1.
A*STAR (Agency for Science, Technology and Research), Institute of Molecular and Cell Biology (IMCB), 61 Biopolis Drive, Proteos#3-09, Singapore 138673 Department of Biochemistry, National University of Singapore (NUS), Singapore 117597.



Impaired Recall of Positional Memory following Chemogenetic Disruption of Place Field Stability.
Cell Rep 2016 Jul 30;16(3):793-804. Epub 2016 Jun 30.
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:



Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels.
Am J Pathol 2016 Mar 14;186(3):701-15. Epub 2016 Jan 14.
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. Electronic address:

Chronic centrosome amplification without tumorigenesis.
Proc Natl Acad Sci U S A 2015 Nov 2;112(46):E6321-30. Epub 2015 Nov 2.
San Diego Branch, Ludwig Institute for Cancer Research, La Jolla, CA 92093; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093



Folliculin-interacting proteins Fnip1 and Fnip2 play critical roles in kidney tumor suppression in cooperation with Flcn.
Proc Natl Acad Sci U S A 2015 Mar 16;112(13):E1624-31. Epub 2015 Mar 16.
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702



IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.
J Autoimmun 2014 Sep 28;53:33-45. Epub 2014 Feb 28.
Laboratory of Experimental Immunology, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute-Frederick, MD 21702, USA. Electronic address:

Normal viability of Kai1/Cd82 deficient mice.
Mol Carcinog 2014 Aug 8;53(8):610-24. Epub 2013 Feb 8.
Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University College of Human Medicine, Grand Rapids, Michigan; Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Experimental mutagenesis of huntingtin to map cleavage sites: different outcomes in cell and mouse models.
J Huntingtons Dis 2014 ;3(1):73-86
Department of Neuroscience, University of Florida, Gainesville, FL, USA SantaFe HealthCare Alzheimer's Disease Research Center, University of Florida, Gainesville, FL, USA Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA McKnight Brain Institute, University of Florida, Gainesville, FL, USA.


In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA.
J Neurosci 2014 Apr;34(17):6098-106
Departments of Cell Biology and Pathology, Biochemistry and Molecular Biology, Instituto de Neurociencias de Castilla y León (INCyL), Universidad de Salamanca, Salamanca 37007, Spain, Neural Development Group, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, and Institute of Biomedical Research of Salamanca, Salamanca 37007, Spain.

TrkA in vivo function is negatively regulated by ubiquitination.
J Neurosci 2014 Mar;34(11):4090-8
Neural Development Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702, Department of Target Discovery and Experimental Microbiology, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702, University of Maryland School of Nursing and Program in Neuroscience, Baltimore, Maryland 21201, and Department of MVIMG, Wexner Medical Center Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210.

LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.
PLoS One 2014 21;9(1):e85883. Epub 2014 Jan 21.
Division of Hematology/Oncology, Vanderbilt University Medical Center and the Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America.

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss.
Nat Neurosci 2013 Oct 25;16(10):1392-400. Epub 2013 Aug 25.
1] Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [2] Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [3] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. [4] Adrienne Helis Malvin Medical Research Foundation, New Orleans, Louisiana, USA.

Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation.
J Biol Chem 2013 Jun 19;288(23):16262-73. Epub 2013 Apr 19.
Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, NCI, National Institutes of Health, Frederick, Maryland 21702, USA.


Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.
Cell Rep 2013 May 16;3(5):1457-64. Epub 2013 May 16.
Tumor Angiogenesis Section, Mouse Cancer Genetics Program (MCGP), Center for Cancer Research (CCR), National Cancer Institute (NCI), Frederick, MD 21702, USA.







Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration.
Proc Natl Acad Sci U S A 2012 Mar 21;109(10):3826-31. Epub 2012 Feb 21.
Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (ASTAR), Republic of Singapore 138673.


Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
J Neurosci 2012 Jan;32(1):183-93
Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Hum Mol Genet 2011 Jul 22;20(14):2770-82. Epub 2011 Apr 22.
Department of Neuroscience and Santa Fe Health Alzheimer’s Disease Research Center, McKnight Brain Institute, University of Florida, 100 Newell Dr., Gainesville, FL 32610, USA.

The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons.
J Neurosci 2011 Jun;31(22):8013-24
Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, and Carolina Center for Developmental Disabilities, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

Embryonic stem cell-derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery.
Stem Cell Res 2011 May 19;6(3):195-205. Epub 2011 Jan 19.
Department of Target Discovery and Experimental Microbiology, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702-5011, USA.

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Proc Natl Acad Sci U S A 2011 Apr 18;108(14):5759-64. Epub 2011 Mar 18.
Tumor Angiogenesis Section, Mouse Cancer Genetics Program, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.
Blood 2011 Jan 15;117(4):1228-38. Epub 2010 Nov 15.
Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute/NIH, Bethesda, MD 20892, USA.

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Nat Neurosci 2011 Jan 21;14(1):54-61. Epub 2010 Nov 21.
The Lundbeck Foundation Research Center MIND, Department of Medical Biochemistry, Aarhus University, Aarhus, Denmark.

In glaucoma the upregulated truncated TrkC.T1 receptor isoform in glia causes increased TNF-alpha production, leading to retinal ganglion cell death.
Invest Ophthalmol Vis Sci 2010 Dec 23;51(12):6639-51. Epub 2010 Jun 23.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.


Monocyte chemoattractant protein-1 (MCP-1), not MCP-3, is the primary chemokine required for monocyte recruitment in mouse peritonitis induced with thioglycollate or zymosan A.
J Immunol 2009 Sep 29;183(5):3463-71. Epub 2009 Jul 29.
Laboratory of Molecular Immunoregulation, Cancer, and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA.

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