Linnea M Baudhuin

Linnea M Baudhuin

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Linnea M Baudhuin

Linnea M Baudhuin

Publications by authors named "Linnea M Baudhuin"

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Variability in gene-based knowledge impacts variant classification: an analysis of FBN1 missense variants in ClinVar.

Eur J Hum Genet 2019 Oct 21;27(10):1550-1560. Epub 2019 Jun 21.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1038/s41431-019-0440-3DOI Listing
October 2019

Privacy in Direct-to-Consumer Genetic Testing.

Clin Chem 2019 May 28;65(5):612-617. Epub 2019 Feb 28.

Associate Professor of Philosophy, Purdue University Fort Wayne (IPFW), Fort Wayne, IN.

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http://dx.doi.org/10.1373/clinchem.2018.298935DOI Listing
May 2019

Plasma Ceramides.

Arterioscler Thromb Vasc Biol 2018 08;38(8):1933-1939

From the Department of Laboratory Medicine and Pathology (J.W.M., L.J.D., L.M.B., A.S.J.).

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http://dx.doi.org/10.1161/ATVBAHA.118.311199DOI Listing
August 2018

Genetic variation in statin intolerance and a possible protective role for UGT1A1.

Pharmacogenomics 2018 Jan 6;19(2):83-94. Epub 2017 Dec 6.

Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.2217/pgs-2017-0146DOI Listing
January 2018

Technical Advances for the Clinical Genomic Evaluation of Sudden Cardiac Death: Verification of Next-Generation Sequencing Panels for Hereditary Cardiovascular Conditions Using Formalin-Fixed Paraffin-Embedded Tissues and Dried Blood Spots.

Circ Cardiovasc Genet 2017 Dec;10(6)

From the Department of Laboratory Medicine and Pathology (L.M.B., C.L., L.J.T., R.A., M.L.K., K.E.K., P.T.L., J.J.M.), Department of Cardiovascular Diseases (M.J.A., J.J.M.), Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), and Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (M.J.A.), Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1161/CIRCGENETICS.117.001844DOI Listing
December 2017

Clinical UGT1A1 Genetic Analysis in Pediatric Patients: Experience of a Reference Laboratory.

Mol Diagn Ther 2017 06;21(3):327-335

Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1007/s40291-017-0265-0DOI Listing
June 2017

Miniaturized Nanopore DNA Sequencing: Accelerating the Path to Precision Medicine.

Clin Chem 2017 03 11;63(3):632-634. Epub 2017 Jan 11.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

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http://www.clinchem.org/lookup/doi/10.1373/clinchem.2016.261
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http://dx.doi.org/10.1373/clinchem.2016.261420DOI Listing
March 2017

Classifying Germline Sequence Variants in the Era of Next-Generation Sequencing.

Clin Chem 2016 06 9;62(6):799-806. Epub 2016 Feb 9.

Director, Molecular Genetics Laboratory, Department of Pathology and Laboratory Medicine, Children's Mercy, Kansas City, MO.

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http://dx.doi.org/10.1373/clinchem.2015.247874DOI Listing
June 2016

"Big Data" in Laboratory Medicine.

Clin Chem 2015 Dec 20;61(12):1433-40. Epub 2015 Oct 20.

Director, Central Lab and Chief, Clinical Chemistry Laboratory Service, Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital and Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1373/clinchem.2015.248591DOI Listing
December 2015

Confirming Variants in Next-Generation Sequencing Panel Testing by Sanger Sequencing.

J Mol Diagn 2015 Jul 8;17(4):456-61. Epub 2015 May 8.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2015.03.004DOI Listing
July 2015

Decreased frequency of FBN1 missense variants in Ghent criteria-positive Marfan syndrome and characterization of novel FBN1 variants.

J Hum Genet 2015 May 5;60(5):241-52. Epub 2015 Feb 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1038/jhg.2015.10DOI Listing
May 2015

Increased frequency of FBN1 truncating and splicing variants in Marfan syndrome patients with aortic events.

Genet Med 2015 Mar 7;17(3):177-87. Epub 2014 Aug 7.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1038/gim.2014.91DOI Listing
March 2015

Genetic and biochemical analyses in dyslipidemic patients undergoing LDL apheresis.

J Clin Apher 2014 Oct 13;29(5):256-65. Epub 2014 Jan 13.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1002/jca.21317DOI Listing
October 2014

The FDA and 23andMe: violating the First Amendment or protecting the rights of consumers?

Clin Chem 2014 Jun 1;60(6):835-7. Epub 2014 May 1.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2014.223321
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http://dx.doi.org/10.1373/clinchem.2014.223321DOI Listing
June 2014

UGT1A1 genetic analysis as a diagnostic aid for individuals with unconjugated hyperbilirubinemia.

J Pediatr 2013 Jun 4;162(6):1146-52, 1152.e1-2. Epub 2013 Jan 4.

Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.jpeds.2012.11.042DOI Listing
June 2013

Quality guidelines for next-generation sequencing.

Clin Chem 2013 May;59(5):858-9

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May 2013

A new era of genetic testing and its impact on research and clinical care.

Clin Chem 2012 Jun;58(6):1070-1

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June 2012

How novel molecular diagnostic technologies and biomarkers are revolutionizing genetic testing and patient care.

Expert Rev Mol Diagn 2012 Jan;12(1):25-37

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1586/erm.11.85DOI Listing
January 2012

Determining the optimal approach for government-regulated genetic testing.

Clin Chem 2011 Jan 27;57(1):7-8. Epub 2010 Sep 27.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

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http://www.clinchem.org/cgi/doi/10.1373/clinchem.2010.156687
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http://dx.doi.org/10.1373/clinchem.2010.156687DOI Listing
January 2011

Genetic markers for coronary artery disease.

Clin Lab Sci 2009 ;22(4):226-32

Mayo Clinic, Jacksonville, FL, USA.

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February 2010

Warfarin pharmacogenetics: ready for clinical utility?

Clin Lab Sci 2009 ;22(3):151-5

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.

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December 2009

Genetics of coronary artery disease: focus on genome-wide association studies.

Am J Transl Res 2009 Mar 5;1(3):221-34. Epub 2009 Mar 5.

Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, MN.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776326PMC
March 2009

Pharmacogenetics in hemostasis: friend or foe?

Semin Thromb Hemost 2009 Feb 23;35(1):42-9. Epub 2009 Mar 23.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1055/s-0029-1214147DOI Listing
February 2009

LDLR promoter variant and exon 14 mutation on the same chromosome are associated with an unusually severe FH phenotype and treatment resistance.

Eur J Hum Genet 2009 Jan 23;17(1):85-90. Epub 2008 Jul 23.

Department of Laboratory Medicine and Pathology, Cardiovascular Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1038/ejhg.2008.138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2985960PMC
January 2009

Comparison of three methods for genotyping the UGT1A1 (TA)n repeat polymorphism.

Clin Biochem 2007 Jun 23;40(9-10):710-7. Epub 2007 Mar 23.

Mayo Clinic and Foundation, Department of Laboratory Medicine and Pathology, Hilton 730, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.clinbiochem.2007.03.007DOI Listing
June 2007

MYH Y165C and G382D mutations in hepatocellular carcinoma and cholangiocarcinoma patients.

J Cancer Res Clin Oncol 2006 Mar 15;132(3):159-62. Epub 2005 Nov 15.

Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, 200 First Street SW, 920 Hilton Building, Rochester, MN 55905, USA.

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http://link.springer.com/10.1007/s00432-005-0056-6
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http://dx.doi.org/10.1007/s00432-005-0056-6DOI Listing
March 2006

Use of microsatellite instability and immunohistochemistry testing for the identification of individuals at risk for Lynch syndrome.

Fam Cancer 2005 ;4(3):255-65

Department of Laboratory Medicine and Pathology, Mayo Clinic and Foundation, 200 First St. SW, 920 Hilton Building, Rochester, MN 55905, USA.

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http://link.springer.com/10.1007/s10689-004-1447-6
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http://dx.doi.org/10.1007/s10689-004-1447-6DOI Listing
December 2005

Characterization of hMLH1 and hMSH2 gene dosage alterations in Lynch syndrome patients.

Gastroenterology 2005 Sep;129(3):846-54

Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1053/j.gastro.2005.06.026DOI Listing
September 2005

Analysis of hMLH1 and hMSH2 gene dosage alterations in hereditary nonpolyposis colorectal cancer patients by novel methods.

J Mol Diagn 2005 May;7(2):226-35

Department of Laboratory Medicine and Pathology, Division of Laboratory Genetics, Mayo Clinic, 200 First St. SW, 920 Hilton Bldg., Rochester, MN 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867519PMC
http://dx.doi.org/10.1016/S1525-1578(10)60549-1DOI Listing
May 2005

S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).

FASEB J 2004 Feb 4;18(2):341-3. Epub 2003 Dec 4.

Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

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http://dx.doi.org/10.1096/fj.03-0302fjeDOI Listing
February 2004

Unfolding the pathophysiological role of bioactive lysophospholipids.

Curr Drug Targets Immune Endocr Metabol Disord 2003 Mar;3(1):23-32

Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, OH 44195, USA.

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March 2003

Role of ether-linked lysophosphatidic acids in ovarian cancer cells.

J Lipid Res 2002 Mar;43(3):463-76

Department of Cancer Biology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

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March 2002