Publications by authors named "Lingzi Xu"

6 Publications

  • Page 1 of 1

Health-related risky behaviors in Chinese adolescents with autism: a cross-sectional study.

Child Adolesc Psychiatry Ment Health 2021 Jul 30;15(1):39. Epub 2021 Jul 30.

Peking University Institute of Mental Health, Peking University Sixth Hospital, Key Laboratory of Mental Health, National Health Commission (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), No. 51 Huayuan North Road, Haidian District, Beijing, 100191, China.

Background: Health-related risky behaviors (HRB) generally refer to behaviors that have a negative influence on health and quality of life. HRB in adolescents with autism have not been well understood so far. We aim to explore health-related risky behaviors and their risk factors with autistic adolescents.

Methods: In this study, 150 adolescents with autism and 150 neurotypical adolescents were enrolled. Participants in both groups completed the Adolescent Health-Related Risky Behavior Inventory (AHRBI). Autism Spectrum Screening Questionnaire (ASSQ), Wechsler Intelligence Scale, Theory of Mind (ToM) Test, Zung Self-rating Anxiety Scale (SAS), Zung Self-rating Depression Scale (SDS), and Self-Esteem Scale (SES) were also assessed in the autism group to explore risk factors.

Results: The results showed that the total score of AHRBI and scores of "aggression and violence (AV)", "suicide or self-injury (SS)", "health-compromising behavior (HCB)", and "unprotected sex (US)" subscales in the autism group were significantly higher than those in the control group (Z value = - 4.58 ~ - 2.26, all P < 0.05). Anxiety, depression, low self-esteem, low IQ score, low ToM test score, increasing age, and communication disorder were found as risk factors for health-related risky behaviors in autistic adolescents.

Conclusions: Adolescents with autism have more health-related risky behaviors than neurotypical adolescents. We should pay attention to the emotional state, self-esteem, cognitive function, and verbal communication levels of autistic adolescent with health-related risky behaviors.
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http://dx.doi.org/10.1186/s13034-021-00390-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8325271PMC
July 2021

Surface-enhanced Raman scattering of flexible cotton fiber-Ag for rapid adsorption and detection of malachite green in fish.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Dec 13;263:120174. Epub 2021 Jul 13.

School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun, Liaoning 113001, PR China. Electronic address:

The residual of malachite green (MG) in fish is one of the major food safety concerns for consumers. It is important to develop simple and instant analytical methods to identify MG residues in fish. We fabricated flexible cotton surface-enhanced Raman scattering substrate, which offers good flexibility, uniformity and excellent adsorption capability. The UV-vis DRS spectra, transmission electron microscopy and scanning electron elemental mapping images shown that the Ag NPs were closely packed on the surface of cotton fiber. The adsorption feature of cotton fiber could adsorb MG from solution and surface of fish. The Quick Easy Cheap Effective Rugged and Safe (QuEChERS) sample preparation method was used to adsorb MG in fish for SERS sensing. The limit of detection of MG in fish using this developed method was as low as 0.05 ppm. The QuEChERS-SERS analysis method exhibits the capability for multiplex detecting mixture of MG and Dimetridazole at different ratios (5 ppm, 1/400 and 1/4000) from fish. The results indicated that the cotton fiber-Ag composite was suitable employed as SERS substrate for simple and instant detecting trace contaminants in food.
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http://dx.doi.org/10.1016/j.saa.2021.120174DOI Listing
December 2021

Ultrasonic desulfurization of amphiphilic magnetic-Janus nanosheets in oil-water mixture system.

Ultrason Sonochem 2021 Aug 7;76:105662. Epub 2021 Jul 7.

Liaoning Shihua University, Fushun 113001, China.

FeO was obtained by reacting FeCl and FeCl with polyethylene glycol, and labeled onto a amphiphilic Janus nanosheet. It was confirmed by infrared spectroscopy, SEM, AFM and EDS that the FeO nanoparticles changed from hydrophilic to amphiphilic. The oxidative desulfurization performance of amphiphilic iron oxide was studied. Results showed that the Janus nanosheets labeled with FeO could significantly improve the removal rate of thiophene sulfide in simulated oil synergistically with ultrasonic waves, and the desulfurization rate could reach 100%. Further, the effect of ultrasound on the sensing ability of the oil-water interface was studied and the ultrasonic attenuation coefficient was calculated. In addition to the desulfurization mechanism of FeO, it was found that although the ultrasonic attenuation coefficient of the amphiphilic nanosheets was high, the number of hydroxyl radicals determined the desulfurization efficiency. The amphiphilic Fe ions were more favorable for the formation of hydroxyl radicals than the single hydrophilic ones.
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http://dx.doi.org/10.1016/j.ultsonch.2021.105662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281658PMC
August 2021

Fabrication of plasmonic cotton gauze-Ag composite as versatile SERS substrate for detection of pesticides residue.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Aug 31;257:119766. Epub 2021 Mar 31.

School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun, Liaoning 113001, PR China. Electronic address:

Plasmonic cotton gauze-Ag composite were fabricated through a simple, instant and cost-effective way, in which the Ag NPs were immobilized on the surface of cotton gauze through in-situ growth process. The in-situ growth of Ag NPs was started from electroless-immobilized Ag seeds on the surface of cotton fiber, which could form numerous hot spots for SERS compared with current method. The cotton gauze-Ag composite was employed as versatile substrate in surface-enhanced Raman scattering (SERS) spectroscopy. The plasmonic cotton gauze-Ag exhibited excellent uniformity, temporal stability and enhanced effect for SERS measurement. The detection limit of P-aminothiopheno (PATP) was 10 M. Furthermore, the plasmonic cotton gauze-Ag composite presented excellent flexibility and adsorption capability, which enable to adsorb and detect pesticide residue from irregular surface of cucumber directly by simple swabbing process, the detection limit could achieve 0.1 ppm. The cotton gauze-Ag composite also shown excellent selectivity is SERS sensing. The fabrication method could be simply extended to other cellulose compound, such as absorbent cotton, paper and even for natural fibers. This study proposed a new method for fabricating the cost-effective, eco-friendly and flexible SERS substrates.
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http://dx.doi.org/10.1016/j.saa.2021.119766DOI Listing
August 2021

Reliability and Validity of the Simplified Chinese Version of the Aberrant Behavior Checklist in Chinese Autism Population.

Front Psychiatry 2020 14;11:545445. Epub 2020 Oct 14.

Institute of Mental Health, Peking University Sixth Hospital, Beijing, China.

The Aberrant Behavior Checklist (ABC) is a widely used scale in autism clinical intervention research for the assessment of core symptoms and comorbid emotional and behavioral problems among people with autism. The aim of this study was to examine the psychometric properties of the Simplified Chinese version of the Aberrant Behavior Checklist (SC-ABC) using a sample of people with autism in a Chinese population. In total, we enrolled 799 patients aged 1.5-33 years old. We collected data using the SC-ABC ( = 799), Autism Behavior Checklist ( = 743), Attention Deficit Hyperactivity Disorder Rating Scale-IV (ADHD-RS-IV) ( = 433) and Achenbach Child Behavior Checklist (CBCL) ( = 319). Eighty-four patients were separately assessed with the SC-ABC by two caregivers simultaneously. Forty-four patients were assessed with the SC-ABC again by same caregiver 2 weeks after the first assessment. SC-ABC data from the whole sample were used for confirmatory factor analysis. We evaluated criterion validity using Spearman's correlation coefficient between scores of the SC-ABC and scores of the Autism Behavior Checklist, ADHD-RS-IV and CBCL separately in the whole sample and different age groups. We calculated the intragroup correlation coefficients and Spearman's correlation coefficient for interrater reliability in 84 samples and test-retest reliability in 44 samples. We conducted Cronbach's α for internal consistency. For the SC-ABC, the intragroup correlation coefficients of five subscales and the total score in interrater and test-retest reliability ranged from 0.87 to 0.92 and from 0.93 to 0.97 (all < 0.01). The Spearman's correlation coefficient of five subscales and the total score in interrater and test-retest reliability ranged from 0.78 to 0.85 and 0.86 to 0.94, respectively (all < 0.01). Cronbach's α of five subscales and the total score ranged from 0.75 to 0.96 (all < 0.01). The Spearman's correlation coefficient for criterion validity for the whole sample and different age groups ranged from 0.39 to 0.76 (all < 0.01). The model fit for the original five factor model was acceptable, with fit indices of SMR = 0.062 and RMSEA = 0.052. The SC-ABC has satisfactory psychometric properties and can be used in the assessment of core symptoms and comorbid emotional and behavioral problems in patients with autism.
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http://dx.doi.org/10.3389/fpsyt.2020.545445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591387PMC
October 2020

Predictors of outcome in early onset schizophrenia: a 10-year follow-up study.

BMC Psychiatry 2020 02 14;20(1):67. Epub 2020 Feb 14.

Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), 51 Huayuanbei Road, Haidian District, Beijing, 100191, China.

Background: Younger age at onset is generally thought to be a predictor of poor outcome in Early Onset Schizophrenia (EOS), but there is a paucity of epidemiological data supporting this belief. This study aims to describe long-term outcomes and predictors of patient functioning in EOS, with a focus on the effect of age at onset.

Methods: We consecutively enrolled 118 EOS patients who were hospitalized in 2006. Mean age at baseline was 13.3 ± 2.3 years. Sixty-five subjects were successfully interviewed. Mean length of follow up was 10.4 ± 0.3 years. Baseline data were collected from inpatient medical records, while follow up was conducted primarily through telephone interviews of patient relatives. WHODAS 2.0 was used to measure global functioning at follow up. Outcomes included education, employment, marriage status, physical health, subsequent diagnoses and treatment, and patient functioning. Univariate and multivariate regression models were used to assess predictors of outcome, while propensity scores were used to adjust for confounding in analyzing the effect of age at onset on functional outcome.

Results: Of the 65 subjects where follow-up data were available, 3 were deceased at follow up. Five (8%) discontinued treatment. Diagnostic stability was 76%. Nearly a quarter (24%) were using clozapine at follow up. In male and female patients, 61 and 55% respectively were overweight, while 29 and 32% respectively were obese. Sixteen (26%) were economically self-sufficient, while 34 (55%) were unemployed. Thirteen (21%) patients had ever been married. The median WHODAS score was 15 (IQR 2 to 35), roughly corresponding to the 78th percentile on population norms. Extroverted personality (p = 0.01), suspicious personality (p = 0.02), and high level of education (p = 0.001) predicted better functioning. Age of onset was not associated with function in either the univariate model (p = 0.24), full model (p = 0.17) or the final risk factor model (p = 0.11), nor after using propensity scores to further adjust for confounders.

Conclusion: The long-term functional outcome of EOS is more optimistic than generally believed. Age at disease onset does not predict long-term functional outcome in EOS populations.
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http://dx.doi.org/10.1186/s12888-020-2484-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023710PMC
February 2020
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