Publications by authors named "Lingdong Chen"

7 Publications

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Highly antifouling, biocompatible and tough double network hydrogel based on carboxybetaine-type zwitterionic polymer and alginate.

Carbohydr Polym 2021 Apr 10;257:117627. Epub 2021 Jan 10.

College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, PR China. Electronic address:

Because of resistance to bio-macromolecular adhesion, antifouling hydrogels have attracted great attention in biomedical field. But traditional antifouling hydrogels made by hydrophilic polymers are always poor of mechanical properties. Herein, a new hybrid ionic-covalent cross-linked double network (DN) hydrogel was prepared by a simple one-pot method based on sodium alginate and the zwitterionic material carboxybetaine acrylamide (CBAA). The DN hydrogel has good mechanical properties, including high elastic modulus (0.28 MPa), high tensile strength (0.69 MPa), as well as good self-recovery capability. More importantly, the DN hydrogel is highly resistance to the adsorption of non-specific protein, cells, bacteria and algae, exhibiting an outstanding antifouling property. The in vitro and in vivo experiments prove that the DN hydrogel is highly biocompatible. This study provides a new strategy for the preparation of antifouling DN hydrogels with good mechanical properties for different needs, such as tissue scaffolds, wound dressings, implantable devices, and other fields.
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http://dx.doi.org/10.1016/j.carbpol.2021.117627DOI Listing
April 2021

Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor.

Mater Sci Eng C Mater Biol Appl 2020 Dec 24;117:111298. Epub 2020 Jul 24.

College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China. Electronic address:

A purely physically crosslinked double network (DN) hydrogel, poly(sulfobetaine-co-acrylic acid)/chitosan-citrate (P(SBMA-co-AAc)/CS-Cit) DN hydrogel, was prepared based on electrostatic interaction and hydrogen bonding between the polymer chains. The hydrogel is highly stretchable, transparent, anti-fatigue, self-adhesive and has good self-healing properties with a self-healing efficiency as high as 95.4%. Furthermore, the resistance of the P(SBMA-co-AAc)/CS-Cit DN hydrogel is sensitive to a wide strain window and the relative resistance shows stable and reliable change during deformation. Herein, the hydrogel was demonstrated as a strain sensor to detect human motions, such as joint bending and swallowing. More excitingly, before ionic crosslinking, the P(SBMA-co-AAc)/CS-Cit composite hydrogel is injectable, thus the P(SBMA-co-AAc)/CS-Cit DN hydrogel sensor can be made into various complex shapes by injecting the P(SBMA-co-AAc)/CS-Cit composite hydrogel into citrate solution, including multilayer structures, exhibiting a great potential for applications as 3D printing strain sensors.
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http://dx.doi.org/10.1016/j.msec.2020.111298DOI Listing
December 2020

Ultra-high strength poly(N-(2-hydroxyethyl)acrylamide)/chitosan hydrogel with "repelling and killing" bacteria property.

Carbohydr Polym 2019 Dec 8;225:115160. Epub 2019 Aug 8.

College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, PR China. Electronic address:

Hydrogels with good mechanical properties are promising for various applications. In this work, a simple yet effective method for preparing a novel double-network hydrogel was reported. First, nonfouling polymer, poly(N-(2-hydroxyethyl)acrylamide) (PHEAA), was crosslinked through covalent bonds. Antibacterial polysaccharide, chitosan (CS), was then crosslinked by chelation between the N-glucosamine units on the CS and citrate or sulfate ions. The poly(N-(2-hydroxyethyl)acrylamide)/chitosan double-network hydrogels (PHEAA/CS DN hydrogels) exhibited high tensile strength (3.8 MPa), strong elastic modulus (0.6 MPa). And the dynamic ionic crosslinking in CS network provided the DN gels with fast self-recovery ability as well as excellent fatigue resistance. Furthermore, the mechanical properties of the DN gels were enhanced after stretching and relaxing because of the molecular orientation and reconstruction of chitosan network. More importantly, the hydrogels have excellent antifouling and antibacterial properties, which is called "repelling and killing", making them competitive candidates for applications in the biomedical field.
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http://dx.doi.org/10.1016/j.carbpol.2019.115160DOI Listing
December 2019

Antibacterial and Antifouling Hybrid Ionic-Covalent Hydrogels with Tunable Mechanical Properties.

ACS Appl Mater Interfaces 2019 Sep 23;11(35):31594-31604. Epub 2019 Aug 23.

College of Materials Science and Engineering , Zhejiang University of Technology , Hangzhou , Zhejiang 310014 , P. R. China.

Because of their self-recovery ability and fatigue resistance, double-network (DN) hydrogels with hybrid ionical-covalent cross-linking have received wide attention. In this work, by a simple "one-pot" method, a novel kind of hybrid ionic-covalent chitosan/poly(sulfobetaine methacrylate) (CS/PSBMA) DN hydrogels was prepared. The hydrogels showed high tensile strength (2.0 MPa), strong elastic modulus (0.5 MPa), fast self-recovery ability as well as excellent fatigue resistance, high mechanical strength, and toughness retention rate after soaking in water for 24 h. Additionally, the mechanical properties of the DN gels were enhanced after stretch and relaxation because of the rearrangement of the CS network. More excitingly, because of the antifouling feature of PSBMA and the inherent antibacterial property of CS, the hybrid DN hydrogels demonstrated a "repel and kill" effect on microorganisms. The CS/PSBMA DN hydrogels may find potential applications in biomedical fields, such as artificial connective tissues, implantable devices, and wound dressing.
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http://dx.doi.org/10.1021/acsami.9b08870DOI Listing
September 2019

Dual-Sensitive Graphene Oxide Loaded with Proapoptotic Peptides and Anticancer Drugs for Cancer Synergetic Therapy.

Langmuir 2019 05 23;35(18):6120-6128. Epub 2019 Apr 23.

College of Materials Science & Engineering , Zhejiang University of Technology , Hangzhou , Zhejiang 310014 , China.

A dual-sensitive drug delivery system (DDS) based on graphene oxide (GO) which is simultaneously loaded with proapoptotic peptides and anticancer drugs was rationally designed and fabricated for cancer synergetic therapy. Specifically, a kind of cell apoptosis peptide (KLAKLAK) (KLA) was anchored on the surface of GO via a disulfide bond to obtain GO-SS-KLA. Then, the aromatic anticancer drug doxorubicin (DOX) was loaded on GO through π-π conjugation and hydrogen bonding interactions. Finally, bovine serum albumin (BSA) was used to coat the GO carrier to obtain a biological medium-stable GO-based DDS, [email protected]/BSA. The results show that KLA and DOX can be released responding to the reductive and pH stimulus inside the cells, respectively, and achieve a synergetic therapy for cancer. Moreover, the results of stability studies show that [email protected]/BSA could be stably dispersed in water for more than 8 days and in 10% fetal bovine serum for at least 6 days. The constructed [email protected]/BSA exhibits great potential as a drug carrier for co-delivery of various therapeutic agents.
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http://dx.doi.org/10.1021/acs.langmuir.9b00611DOI Listing
May 2019

A dual-sensitive mesoporous silica nanoparticle based drug carrier for cancer synergetic therapy.

Colloids Surf B Biointerfaces 2019 Mar 28;175:65-72. Epub 2018 Nov 28.

College of Materials Science & Engineering, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

A multifunctional envelope-type mesoporous silica nanoparticle (MSN) was delicately designed for subcellular co-delivery of drug and therapeutic peptide to tumor cells. Firstly, a kind of cell apoptosis peptide (KLAKLAK) (KLA) was anchored on surface of MSN via disulfide bond to obtain MSN-SS-KLA. Subsequently, anticancer drug doxorubicin hydrochloride (DOX) was loaded into the pores of MSN-SS-KLA. Then, the drug loaded MSN-SS-KLA ([email protected]) was further coated with bovine serum albumin (BSA) to obtain a biological media stable MSN based drug delivery system (DDS), [email protected]/BSA, for cancer synergetic therapy. The results show that stability of the [email protected]/BSA is much better than that of [email protected] and it could keep well dispersed in serum for more than 24 h. After accumulating at tumor site by EPR effect, the [email protected]/BSA could be effectively phagocytosed by HeLa cells and release apoptotic peptide KLA as well as DOX simultaneously responding to reductive stimulus inside the cells. In vitro cell experiment results show that the [email protected]/BSA complex exhibits much better inhibition on HeLa cells compared with pure DOX, indicating that co-delivery of KLA and DOX is expected to achieve synergetic therapy of cancer.
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http://dx.doi.org/10.1016/j.colsurfb.2018.11.071DOI Listing
March 2019

[Development and application of drug poisoning treatment software].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2014 Jun;26(6):438-9

Department of Emergency, the Second Affiliated Hospital of Nantong University, Nantong 226000, Jiangsu, China.

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http://dx.doi.org/10.3760/cma. j. issn.2095-4352. 2014. 06.015DOI Listing
June 2014