Publications by authors named "Lindsay M LaFave"

11Publications

Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin.

Authors:
Sai Ma Bing Zhang Lindsay M LaFave Andrew S Earl Zachary Chiang Yan Hu Jiarui Ding Alison Brack Vinay K Kartha Tristan Tay Travis Law Caleb Lareau Ya-Chieh Hsu Aviv Regev Jason D Buenrostro

Cell 2020 Nov 23;183(4):1103-1116.e20. Epub 2020 Oct 23.

Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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November 2020

Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.

Authors:
Lindsay M LaFave Vinay K Kartha Sai Ma Kevin Meli Isabella Del Priore Caleb Lareau Santiago Naranjo Peter M K Westcott Fabiana M Duarte Venkat Sankar Zachary Chiang Alison Brack Travis Law Haley Hauck Annalisa Okimoto Aviv Regev Jason D Buenrostro Tyler Jacks

Cancer Cell 2020 Aug 23;38(2):212-228.e13. Epub 2020 Jul 23.

David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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August 2020

Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status".

Authors:
Lindsay M LaFave Wendy Béguelin Richard Koche Matt Teater Barbara Spitzer Alan Chramiec Efthymia Papalexi Matthew D Keller Todd Hricik Katerina Konstantinoff Jean-Baptiste Micol Benjamin Durham Sarah K Knutson John E Campbell Gil Blum Xinxu Shi Emma H Doud Andrei V Krivtsov Young Rock Chung Inna Khodos Elisa de Stanchina Ouathek Ouerfelli Prasad S Adusumilli Paul M Thomas Neil L Kelleher Minkui Luo Heike Keilhack Omar Abdel-Wahab Ari Melnick Scott A Armstrong Ross L Levine

Nat Med 2016 06;22(6):578-9

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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June 2016

Targeting a regulator of protein homeostasis in myeloproliferative neoplasms.

Authors:
Lindsay M LaFave Ross L Levine

Nat Med 2016 Jan;22(1):20-1

Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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January 2016

Loss of BAP1 function leads to EZH2-dependent transformation.

Authors:
Lindsay M LaFave Wendy Béguelin Richard Koche Matt Teater Barbara Spitzer Alan Chramiec Efthymia Papalexi Matthew D Keller Todd Hricik Katerina Konstantinoff Jean-Baptiste Micol Benjamin Durham Sarah K Knutson John E Campbell Gil Blum Xinxu Shi Emma H Doud Andrei V Krivtsov Young Rock Chung Inna Khodos Elisa de Stanchina Ouathek Ouerfelli Prasad S Adusumilli Paul M Thomas Neil L Kelleher Minkui Luo Heike Keilhack Omar Abdel-Wahab Ari Melnick Scott A Armstrong Ross L Levine

Nat Med 2015 Nov 5;21(11):1344-9. Epub 2015 Oct 5.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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November 2015

Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis.

Authors:
Sara C Meyer Matthew D Keller Brittany A Woods Lindsay M LaFave Lennart Bastian Maria Kleppe Neha Bhagwat Sachie Marubayashi Ross L Levine

Blood 2014 Oct 12;124(14):2280-4. Epub 2014 Aug 12.

Human Oncology and Pathogenesis Program, Gerstner Sloan Kettering School of Biomedical Sciences, and Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

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October 2014

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo.

Authors:
Omar Abdel-Wahab Jie Gao Mazhar Adli Anwesha Dey Thomas Trimarchi Young Rock Chung Cem Kuscu Todd Hricik Delphine Ndiaye-Lobry Lindsay M Lafave Richard Koche Alan H Shih Olga A Guryanova Eunhee Kim Sheng Li Suveg Pandey Joseph Y Shin Leon Telis Jinfeng Liu Parva K Bhatt Sebastien Monette Xinyang Zhao Christopher E Mason Christopher Y Park Bradley E Bernstein Iannis Aifantis Ross L Levine

J Exp Med 2013 Nov 11;210(12):2641-59. Epub 2013 Nov 11.

Human Oncology and Pathogenesis Program, 2 Leukemia Service, 3 Gerstner Sloan-Kettering Graduate School of Biomedical Sciences, and 4 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.

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November 2013

Mining the epigenetic landscape in ALL.

Authors:
Lindsay M Lafave Ross L Levine

Nat Genet 2013 Nov;45(11):1269-70

1] Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. [2] Gerstner Sloan-Kettering Graduate School, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

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November 2013

JAK2 the future: therapeutic strategies for JAK-dependent malignancies.

Authors:
Lindsay M LaFave Ross L Levine

Trends Pharmacol Sci 2012 Nov 17;33(11):574-82. Epub 2012 Sep 17.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.

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November 2012

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.

Authors:
Omar Abdel-Wahab Mazhar Adli Lindsay M LaFave Jie Gao Todd Hricik Alan H Shih Suveg Pandey Jay P Patel Young Rock Chung Richard Koche Fabiana Perna Xinyang Zhao Jordan E Taylor Christopher Y Park Martin Carroll Ari Melnick Stephen D Nimer Jacob D Jaffe Iannis Aifantis Bradley E Bernstein Ross L Levine

Cancer Cell 2012 Aug;22(2):180-93

Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

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August 2012

Loss of the tumor suppressor BAP1 causes myeloid transformation.

Authors:
Anwesha Dey Dhaya Seshasayee Rajkumar Noubade Dorothy M French Jinfeng Liu Mira S Chaurushiya Donald S Kirkpatrick Victoria C Pham Jennie R Lill Corey E Bakalarski Jiansheng Wu Lilian Phu Paula Katavolos Lindsay M LaFave Omar Abdel-Wahab Zora Modrusan Somasekar Seshagiri Ken Dong Zhonghua Lin Mercedesz Balazs Rowena Suriben Kim Newton Sarah Hymowitz Guillermo Garcia-Manero Flavius Martin Ross L Levine Vishva M Dixit

Science 2012 Sep 9;337(6101):1541-6. Epub 2012 Aug 9.

Department of Physiological Chemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

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September 2012