Linda Sugar

Linda Sugar

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Linda Sugar

Linda Sugar

Publications by authors named "Linda Sugar"

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Value of Increasing Biopsy Cores per Target with Cognitive MRI-targeted Transrectal US Prostate Biopsy.

Radiology 2019 Apr 29;291(1):83-89. Epub 2019 Jan 29.

From the Department of Medical Imaging (M.Z., L.M., M.A.H.), Division of Anatomic Pathology (L.S., M.D.), and Department of Surgery (L.K.), Sunnybrook Health Sciences Centre, Toronto, Canada; Sunnybrook Research Institute, Toronto, Canada (L.M., F.K., S.M.B., L.K.); Ontario Institute for Cancer Research, Toronto, Canada (M.A.H.); Department of Medical Imaging, Mount Sinai Hospital, University of Toronto, 600 University Ave, 5th Floor, Toronto, ON, Canada M5G 1X5 (M.A.H.); and Lunenfeld Tanenbaum Research Institute, Toronto, Canada (M.A.H.).

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http://pubs.rsna.org/doi/10.1148/radiol.2019180712
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http://dx.doi.org/10.1148/radiol.2019180712DOI Listing
April 2019

Staphylococcus-Associated Glomerulonephritis Mimicking Henoch-Schönlein Purpura and Cryoglobulinemic Vasculitis in a Patient With an Epidural Abscess: A Case Report and Brief Review of the Literature.

Can J Kidney Health Dis 2018 31;5:2054358118776325. Epub 2018 May 31.

Division of Nephrology, Institute of Health Policy, Management and Evaluation, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/2054358118776325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985547PMC
May 2018

MicroRNA-652 induces NED in LNCaP and EMT in PC3 prostate cancer cells.

Oncotarget 2018 Apr 10;9(27):19159-19176. Epub 2018 Apr 10.

Platform Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.

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http://dx.doi.org/10.18632/oncotarget.24937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922385PMC
April 2018

Next-generation prostate cancer risk calculator for primary care physicians.

Can Urol Assoc J 2018 Feb 1;12(2):E64-E70. Epub 2017 Dec 1.

Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, United States.

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http://dx.doi.org/10.5489/cuaj.4696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937391PMC
February 2018

A Pilot Study to Evaluate the Role of Magnetic Resonance Imaging for Prostate Cancer Screening in the General Population.

J Urol 2016 08 13;196(2):361-6. Epub 2016 Feb 13.

Department of Medical Imaging, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1016/j.juro.2016.01.114DOI Listing
August 2016

MiR-301a regulates E-cadherin expression and is predictive of prostate cancer recurrence.

Prostate 2016 07 15;76(10):869-84. Epub 2016 Mar 15.

Department of Anatomic Pathology, Platform Biological Sciences, Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pros.23177DOI Listing
July 2016

MiR-182 Is Associated with Growth, Migration and Invasion in Prostate Cancer via Suppression of FOXO1.

J Cancer 2015 25;6(12):1295-305. Epub 2015 Oct 25.

2. Department of Pathobiology and Laboratory Medicine, University of Toronto ; 3. Department of Pathology, Sunnybrook Health Sciences Centre. Toronto, Ontario, Canada ; 4. Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.7150/jca.13176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643086PMC
December 2015

Identification and Validation of a Five MicroRNA Signature Predictive of Prostate Cancer Recurrence and Metastasis: A Cohort Study.

J Cancer 2015 15;6(11):1160-71. Epub 2015 Sep 15.

2. Department of Anatomic Pathology, Platform Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Ave., Toronto, ON, M4N3M5, Canada.

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http://dx.doi.org/10.7150/jca.13397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615353PMC
October 2015

Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model.

Prostate 2015 Sep 5;75(12):1300-11. Epub 2015 Jun 5.

Department of Surgery (Urology), Sunnybrook Health Sciences Center, Toronto, Ontario.

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http://dx.doi.org/10.1002/pros.23013DOI Listing
September 2015

A combination of desmopressin and docetaxel inhibit cell proliferation and invasion mediated by urokinase-type plasminogen activator (uPA) in human prostate cancer cells.

Biochem Biophys Res Commun 2015 Aug 13;464(3):848-54. Epub 2015 Jul 13.

Division of Urology, Sunnybrook Health Sciences Center, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.07.050DOI Listing
August 2015

Capsaicin: a novel radio-sensitizing agent for prostate cancer.

Prostate 2015 Feb 13;75(2):113-25. Epub 2014 Oct 13.

Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pros.22896DOI Listing
February 2015

Quantitative ultrasound spectroscopic imaging for characterization of disease extent in prostate cancer patients.

Transl Oncol 2015 Feb;8(1):25-34

Physical Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada M4N 3M5; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada M4N 3M5; Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M4N 3M5; Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M4N 3M5. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2014.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350638PMC
February 2015

A prospective comparison of MRI-US fused targeted biopsy versus systematic ultrasound-guided biopsy for detecting clinically significant prostate cancer in patients on active surveillance.

J Magn Reson Imaging 2015 Jan 21;41(1):220-5. Epub 2014 Jul 21.

Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/jmri.24710DOI Listing
January 2015

Global transcriptome analysis of formalin-fixed prostate cancer specimens identifies biomarkers of disease recurrence.

Cancer Res 2014 Jun 8;74(12):3228-37. Epub 2014 Apr 8.

Authors' Affiliations: Departments of Biomedical Informatics, Biostatistics and Bioinformatics, Pathology and Laboratory Medicine, Urology, Hematology and Medical Oncology, Human Genetics, and Surgery; Winship Cancer Institute, Emory University, Atlanta; Atlanta VA Medical Center, Decatur, Georgia; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Laboratory Medicine and Pathobiology, University of Toronto; and Department of Anatomic Pathology, Sunnybrook Health Sciences Centre, Toronto, OntarioAuthors' Affiliations: Departments of Biomedical Informatics, Biostatistics and Bioinformatics, Pathology and Laboratory Medicine, Urology, Hematology and Medical Oncology, Human Genetics, and Surgery; Winship Cancer Institute, Emory University, Atlanta; Atlanta VA Medical Center, Decatur, Georgia; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Laboratory Medicine and Pathobiology, University of Toronto; and Department of Anatomic Pathology, Sunnybrook Health Sciences Centre, Toronto, OntarioAuthors' Affiliations: Departments of Biomedical Informatics, Biostatistics and Bioinformatics, Pathology and Laboratory Medicine, Urology, Hematology and Medical Oncology, Human Genetics, and Surgery; Winship Cancer Institute, Emory University, Atlanta; Atlanta VA Medical Center, Decatur, Georgia; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Laboratory Medicine and Pathobiology, University of Toronto; and Department of Anatomic Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario

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http://cancerres.aacrjournals.org/content/74/12/3228.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-2699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058362PMC
June 2014

Exercise does not counteract the effects of a "westernized" diet on prostate cancer xenografts.

Prostate 2013 Aug 30;73(11):1223-32. Epub 2013 Apr 30.

Division of Urology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/pros.22673DOI Listing
August 2013

Utility of serum tumor markers during surveillance for stage I seminoma.

Cancer 2012 Nov 19;118(21):5245-50. Epub 2012 Apr 19.

Department of Radiation Oncology, Sunnybrook Odette Cancer Center, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.27539DOI Listing
November 2012

MR imaging-controlled transurethral ultrasound therapy for conformal treatment of prostate tissue: initial feasibility in humans.

Radiology 2012 Oct 28;265(1):303-13. Epub 2012 Aug 28.

Imaging Research, Sunnybrook Research Institute, 2075 Bayview Ave, Room C713, Toronto, ON, Canada M4N 3M5.

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http://dx.doi.org/10.1148/radiol.12112263DOI Listing
October 2012

Whole-transcriptome analysis reveals established and novel associations with TMPRSS2:ERG fusion in prostate cancer.

Anticancer Res 2012 Sep;32(9):3629-41

Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada.

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September 2012

The clinical utility of miR-21 as a diagnostic and prognostic marker for renal cell carcinoma.

J Mol Diagn 2012 Jul 9;14(4):385-92. Epub 2012 May 9.

Department of Laboratory Medicine, and the Keenan Research Center in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.jmoldx.2012.02.003DOI Listing
July 2012

Prostate cancer pathology audits: is central pathology review still warranted?

Can J Urol 2012 Jun;19(3):6256-60

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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June 2012

MicroRNA detection in prostate tumors by quantitative real-time PCR (qPCR).

J Vis Exp 2012 May 16(63):e3874. Epub 2012 May 16.

Department of Laboratory Medicine & Pathobiology, University of Toronto.

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http://dx.doi.org/10.3791/3874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466958PMC
May 2012

Is thrombotic microangiopathy a paraneoplastic phenomenon? Case report and review of the literature.

NDT Plus 2011 Oct 27;4(5):292-4. Epub 2011 Jul 27.

Division of Nephrology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1093/ndtplus/sfr085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421736PMC
October 2011

Feasibility and safety of silicone rubber contrast-enhanced microcomputed tomography in evaluating the angioarchitecture of prostatectomy specimens.

Transl Oncol 2011 Jun 1;4(3):173-7. Epub 2011 Jun 1.

Department of Medical Imaging, Toronto General Hospital, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104697PMC
http://dx.doi.org/10.1593/tlo.10304DOI Listing
June 2011

miR-221 Is down-regulated in TMPRSS2:ERG fusion-positive prostate cancer.

Anticancer Res 2011 Feb;31(2):403-10

Department of Laboratory Medicine and Pathobiology, University of Toronto, and Sunnybrook Research Institute, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281770PMC
February 2011

MRI-guided transurethral ultrasound therapy of the prostate gland using real-time thermal mapping: initial studies.

Urology 2010 Dec 14;76(6):1506-11. Epub 2010 Aug 14.

Department of Urology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.urology.2010.04.046DOI Listing
December 2010

Xanthogranulomatous cystitis associated with inflammatory bowel disease.

Can Urol Assoc J 2010 Aug;4(4):E91-3

Clinical Assistant Professor, Section of Urology, The University of Chicago, Chicago, IL;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911984PMC
http://dx.doi.org/10.5489/cuaj.887DOI Listing
August 2010

Protective effect of metformin in CD1 mice placed on a high carbohydrate-high fat diet.

Biochem Biophys Res Commun 2010 Jul 2;397(3):537-42. Epub 2010 Jun 2.

Division of Urology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbrc.2010.05.152DOI Listing
July 2010

Dysregulation of kallikrein-related peptidases in renal cell carcinoma: potential targets of miRNAs.

Biol Chem 2010 Apr;391(4):411-23

Department of Laboratory Medicine and the Keenan Research Center in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1515/BC.2010.041DOI Listing
April 2010

Analysis of the spatial and temporal accuracy of heating in the prostate gland using transurethral ultrasound therapy and active MR temperature feedback.

Phys Med Biol 2009 May 8;54(9):2615-33. Epub 2009 Apr 8.

Imaging Research, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.

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http://dx.doi.org/10.1088/0031-9155/54/9/002DOI Listing
May 2009

A combination of micronutrients is beneficial in reducing the incidence of prostate cancer and increasing survival in the Lady transgenic model.

Cancer Prev Res (Phila) 2009 May 28;2(5):473-83. Epub 2009 Apr 28.

Division of Urology, S-118B, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1940-6207.CAPR-08-0124DOI Listing
May 2009

Utility of incorporating genetic variants for the early detection of prostate cancer.

Clin Cancer Res 2009 Mar 17;15(5):1787-93. Epub 2009 Feb 17.

Division of Urology, Sunnybrook Research Institute, Department of Radiation Oncology, Sunnybrook Health Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1593DOI Listing
March 2009

Systemic Erdheim-Chester disease.

Virchows Arch 2008 Feb 10;452(2):221-7. Epub 2008 Jan 10.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s00428-007-0538-9DOI Listing
February 2008

Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts.

J Natl Cancer Inst 2007 Dec 27;99(23):1793-800. Epub 2007 Nov 27.

Division of Urology, S-118B, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Toronto, ON M4N3M5, Canada.

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djm231DOI Listing
December 2007

Prostate tissue analysis immediately following magnetic resonance imaging guided transurethral ultrasound thermal therapy.

J Urol 2007 Sep 20;178(3 Pt 1):1080-5. Epub 2007 Jul 20.

Research and Anatomic Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://linkinghub.elsevier.com/retrieve/pii/S002253470701136
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http://dx.doi.org/10.1016/j.juro.2007.05.011DOI Listing
September 2007

Assessing individual risk for prostate cancer.

J Clin Oncol 2007 Aug;25(24):3582-8

Division of Urology, Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2007.10.6450DOI Listing
August 2007

Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression.

Cancer Biol Ther 2007 Jan;6(1):40-5

Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.4161/cbt.6.1.3489DOI Listing
January 2007

Variants of the hK2 protein gene (KLK2) are associated with serum hK2 levels and predict the presence of prostate cancer at biopsy.

Clin Cancer Res 2006 Nov;12(21):6452-8

Division of Urology; Department of Pathology, Sunnybrook Health Sciences Centre, University Health Network, Mount Sinai Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1485DOI Listing
November 2006

Making sense of prostate specific antigen: improving its predictive value in patients undergoing prostate biopsy.

J Urol 2006 Feb;175(2):489-94

Division of Urology, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/S0022-5347(05)00159-XDOI Listing
February 2006

Inflammation and prostate cancer.

Authors:
Linda M Sugar

Can J Urol 2006 Feb;13 Suppl 1:46-7

Department of Pathology, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada.

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February 2006

The use of genetic markers to determine risk for prostate cancer at prostate biopsy.

Clin Cancer Res 2005 Dec;11(23):8391-7

Division of Urology and Department of Pathology, Sunnybrook and Women's College Health Sciences Centre, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-1226DOI Listing
December 2005

Variation in patterns of practice in diagnosing screen-detected prostate cancer.

BJU Int 2004 Dec;94(9):1239-44

Division of Urology, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1111/j.1464-410X.2004.05150.xDOI Listing
December 2004

Antioxidants block prostate cancer in lady transgenic mice.

Cancer Res 2004 Aug;64(16):5891-6

Division of Urology, Sunnybrook and Women's College Health Sciences Centre, Princess Margaret Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0690DOI Listing
August 2004

Clinical significance of biopsy-derived primary Gleason score among radical prostatectomy candidates with Gleason 7 tumors.

Urology 2002 Apr;59(4):551-4

Department of Surgery (Urology), Toronto Sunnybrook Regional Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/s0090-4295(01)01650-8DOI Listing
April 2002