Publications by authors named "Linda Snetselaar"

100Publications

Association between maternal pre-pregnancy body mass index and risk of preterm birth in more than 1 million Asian American mothers.

J Diabetes 2020 Oct 19. Epub 2020 Oct 19.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.

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http://dx.doi.org/10.1111/1753-0407.13124DOI Listing
October 2020

Association of Anemia with Neurodevelopmental Disorders in A Nationally Representative Sample of US Children.

J Pediatr 2020 Oct 6. Epub 2020 Oct 6.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2020.09.039DOI Listing
October 2020

Food Insecurity Is Associated With Cardiovascular and All-Cause Mortality Among Adults in the United States.

J Am Heart Assoc 2020 Oct 25;9(19):e014629. Epub 2020 Sep 25.

Department of Epidemiology College of Public Health University of Iowa Iowa City Iowa.

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http://dx.doi.org/10.1161/JAHA.119.014629DOI Listing
October 2020

Maternal cigarette smoking before and during pregnancy and the risk of preterm birth: A dose-response analysis of 25 million mother-infant pairs.

PLoS Med 2020 08 18;17(8):e1003158. Epub 2020 Aug 18.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1003158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446793PMC
August 2020

Do health behaviors mediate associations between personality traits and diabetes incidence?

Ann Epidemiol 2020 Aug 14. Epub 2020 Aug 14.

Department of Environmental and Occupational Health, School of Public Health, Indiana University Bloomington.

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http://dx.doi.org/10.1016/j.annepidem.2020.08.007DOI Listing
August 2020

Associations of Coffee and Tea Consumption With Survival to Age 90 Years Among Older Women.

J Am Geriatr Soc 2020 Apr 24. Epub 2020 Apr 24.

Department of Family Medicine and Public Health, University of California, San Diego, School of Medicine, La Jolla, California, USA.

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http://dx.doi.org/10.1111/jgs.16467DOI Listing
April 2020

Reversed phase UPLC/APCI-MS determination of Vitamin K and menaquinone-4 in human plasma: Application to a clinical study.

J Pharm Biomed Anal 2020 May 4;183:113147. Epub 2020 Feb 4.

Clinical Pharmacology Laboratory, Department of Pharmacy Practice and Science, University of Nebraska Medical Center, Omaha, NE, 68198, United States; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2020.113147DOI Listing
May 2020

Association of Electronic Cigarette Regulations With Electronic Cigarette Use Among Adults in the United States.

JAMA Netw Open 2020 01 3;3(1):e1920255. Epub 2020 Jan 3.

Department of Epidemiology, University of Iowa College of Public Health, Iowa City.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.20255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042861PMC
January 2020

Alcohol consumption and serum metabolite concentrations in young women.

Cancer Causes Control 2020 Feb 11;31(2):113-126. Epub 2019 Dec 11.

Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s10552-019-01256-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008965PMC
February 2020

Prediagnostic plasma polyunsaturated fatty acids and the risk of amyotrophic lateral sclerosis.

Neurology 2020 02 3;94(8):e811-e819. Epub 2019 Dec 3.

From the Departments of Nutrition (É.J.O., K.B., J.D.F., A.A.) and Epidemiology (J.E.M., A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; School of Public Health (É.J.O.), College of Medicine, University College Cork, Ireland; Epidemiology Program (L.N.K., L.L.M.), University of Hawaii Cancer Center, Honolulu; Behavioral and Epidemiology Research Group (M.L.M., V.L.S.), American Cancer Society, Atlanta, GA; Family Medicine and Public Health (A.H.S.), School of Medicine, University of California San Diego; Department of Epidemiology (L.S.), College of Public Health, University of Iowa, Iowa City; and Department of Medicine (J.E.M.) and Channing Division of Network Medicine (J.E.M., A.A.), Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000008676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136057PMC
February 2020

Editor's Response.

Authors:
Linda Snetselaar

J Acad Nutr Diet 2019 11;119(11):1798-1799

Journal of the Academy of Nutrition and Dietetics, The University of Iowa, College of Public Health, Iowa City, IA.

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http://dx.doi.org/10.1016/j.jand.2019.07.015DOI Listing
November 2019

Association between soft drink consumption and osteoporotic fractures among postmenopausal women: the Women's Health Initiative.

Menopause 2019 11;26(11):1234-1241

Women's Health Center of Excellence, Family Medicine and Public Health, University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1097/GME.0000000000001389DOI Listing
November 2019

Electronic Cigarette Use Among Young, Middle-aged, and Older Adults in the United States in 2017 and 2018.

JAMA Intern Med 2020 02;180(2):313-314

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City.

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http://dx.doi.org/10.1001/jamainternmed.2019.4957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802265PMC
February 2020

The Association between Prebiotic Fiber Supplement Use and Colorectal Cancer Risk and Mortality in the Women's Health Initiative.

Cancer Epidemiol Biomarkers Prev 2019 11 27;28(11):1884-1890. Epub 2019 Aug 27.

Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona.

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http://dx.doi.org/10.1158/1055-9965.EPI-19-0326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825571PMC
November 2019

Association between maternal pre-pregnancy obesity and preterm birth according to maternal age and race or ethnicity: a population-based study.

Lancet Diabetes Endocrinol 2019 09 5;7(9):707-714. Epub 2019 Aug 5.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA; Obesity Research and Education Initiative, University of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(19)30193-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759835PMC
September 2019

Citrus Consumption and Risk of Cutaneous Malignant Melanoma in the Women's Health Initiative.

Nutr Cancer 2020 23;72(4):568-575. Epub 2019 Jul 23.

Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

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http://dx.doi.org/10.1080/01635581.2019.1644353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980945PMC
July 2019

Inverse Association Between Serum Vitamin B12 Concentration and Obesity Among Adults in the United States.

Front Endocrinol (Lausanne) 2019 27;10:414. Epub 2019 Jun 27.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, United States.

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http://dx.doi.org/10.3389/fendo.2019.00414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610317PMC
June 2019

Association of Skipping Breakfast With Cardiovascular and All-Cause Mortality.

J Am Coll Cardiol 2019 04;73(16):2025-2032

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa; Obesity Research and Education Initiative, University of Iowa, Iowa City, Iowa; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2019.01.065DOI Listing
April 2019

Nutrient Composition Comparison between the Low Saturated Fat Swank Diet for Multiple Sclerosis and Healthy U.S.-Style Eating Pattern.

Nutrients 2019 Mar 13;11(3). Epub 2019 Mar 13.

Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/nu11030616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470969PMC
March 2019

Association between plasma concentrations of elaidic acid, a major trans fatty acid, and depression in a nationally representative sample of U.S. adults.

J Affect Disord 2019 Apr 11;249:301-306. Epub 2019 Feb 11.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA; Obesity Research and Education Initiative, University of Iowa, Iowa City, IA 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183199
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http://dx.doi.org/10.1016/j.jad.2019.02.032DOI Listing
April 2019

Review of Two Popular Eating Plans within the Multiple Sclerosis Community: Low Saturated Fat and Modified Paleolithic.

Nutrients 2019 Feb 7;11(2). Epub 2019 Feb 7.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/nu11020352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412750PMC
February 2019

Association of Food Allergy and Other Allergic Conditions With Autism Spectrum Disorder in Children.

JAMA Netw Open 2018 06 1;1(2):e180279. Epub 2018 Jun 1.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324407PMC
June 2018

Lymphedema following breast cancer: The importance of surgical methods and obesity.

Front Womens Health 2018 Jun 31;3(2). Epub 2018 May 31.

Department of Surgery, College of Medicine, University of Iowa, Iowa City, IA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293280PMC
http://dx.doi.org/10.15761/FWH.1000144DOI Listing
June 2018

Inverse Association between Organic Food Purchase and Diabetes Mellitus in US Adults.

Nutrients 2018 Dec 3;10(12). Epub 2018 Dec 3.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.3390/nu10121877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316834PMC
December 2018

Prevalence of diagnosed type 1 and type 2 diabetes among US adults in 2016 and 2017: population based study.

BMJ 2018 Sep 4;362:k1497. Epub 2018 Sep 4.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122253PMC
http://dx.doi.org/10.1136/bmj.k1497DOI Listing
September 2018

Anatomy of the Mediterranean Diet and Mortality Among Older Women with Frailty.

J Nutr Gerontol Geriatr 2018 Jul-Dec;37(3-4):269-281. Epub 2018 Aug 17.

f Public Health Sciences , Fred Hutchinson Cancer Research Center , Seattle , Washington , USA.

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https://www.tandfonline.com/doi/full/10.1080/21551197.2018.1
Publisher Site
http://dx.doi.org/10.1080/21551197.2018.1496217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378120PMC
October 2019

Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women.

Cancer Causes Control 2018 07 25;29(7):631-642. Epub 2018 May 25.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall 102E, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1007/s10552-018-1040-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365352PMC
July 2018

Changes in Electronic Cigarette Use Among Adults in the United States, 2014-2016.

JAMA 2018 May;319(19):2039-2041

Department of Epidemiology, University of Iowa College of Public Health, Iowa City.

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http://dx.doi.org/10.1001/jama.2018.4658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583238PMC
May 2018

Perceived Barriers to Adherence to Hemodialysis Dietary Recommendations.

Clin Nurs Res 2019 11 6;28(8):1009-1029. Epub 2018 May 6.

The University of Utah, Salt Lake City, USA.

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http://dx.doi.org/10.1177/1054773818773364DOI Listing
November 2019

The Combined Association of Modifiable Risk Factors with Breast Cancer Risk in the Women's Health Initiative.

Cancer Prev Res (Phila) 2018 06 26;11(6):317-326. Epub 2018 Feb 26.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York.

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http://dx.doi.org/10.1158/1940-6207.CAPR-17-0347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6866659PMC
June 2018

Association between plasma trans-fatty acid concentrations and diabetes in a nationally representative sample of US adults.

J Diabetes 2018 Aug 24;10(8):653-664. Epub 2018 Mar 24.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA.

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http://dx.doi.org/10.1111/1753-0407.12652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093805PMC
August 2018

Factors Inhibiting Physical Activity as Treatment for Diabetic Chuukese in Chuuk and Hawai'i.

Hawaii J Med Public Health 2017 09;76(9):247-252

University of Arkansas for Medical Sciences Northwest, Fayetteville, AR (NA).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592379PMC
September 2017

History of Gestational Diabetes Mellitus in Relation to Cardiovascular Disease and Cardiovascular Risk Factors in US Women.

Front Endocrinol (Lausanne) 2017 26;8:144. Epub 2017 Jun 26.

Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, United States.

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http://dx.doi.org/10.3389/fendo.2017.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483836PMC
June 2017

What Motivates Young Adults to Talk About Physical Activity on Social Network Sites?

J Med Internet Res 2017 06 22;19(6):e226. Epub 2017 Jun 22.

University of Missouri, Columbia, MO, United States.

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http://dx.doi.org/10.2196/jmir.7017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500781PMC
June 2017

The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study.

Alzheimers Dement 2017 Nov 19;13(11):1187-1196. Epub 2017 May 19.

Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Psychiatry, Wake Forest School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1016/j.jalz.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909961PMC
November 2017

Relationship Between Marital Transitions, Health Behaviors, and Health Indicators of Postmenopausal Women: Results from the Women's Health Initiative.

J Womens Health (Larchmt) 2017 04 10;26(4):313-320. Epub 2017 Jan 10.

2 Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona , Tucson, Arizona.

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http://dx.doi.org/10.1089/jwh.2016.5925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397241PMC
April 2017

Randomized control trial evaluation of a modified Paleolithic dietary intervention in the treatment of relapsing-remitting multiple sclerosis: a pilot study.

Degener Neurol Neuromuscul Dis 2017 4;7:1-18. Epub 2017 Jan 4.

Motor Control Laboratories, Department of Health and Human Physiology, College of Liberal Arts and Sciences, The University of Iowa,

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https://www.dovepress.com/randomized-control-trial-evaluatio
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http://dx.doi.org/10.2147/DNND.S116949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053098PMC
January 2017

Prediagnostic Plasma 25-Hydroxyvitamin D and Pancreatic Cancer Survival.

J Clin Oncol 2016 08 20;34(24):2899-905. Epub 2016 Jun 20.

Chen Yuan, Zhi Rong Qian, Ana Babic, Vicente Morales-Oyarvide, Douglas A. Rubinson, Kimmie Ng, Shuji Ogino, Charles S. Fuchs, and Brian M. Wolpin, Dana-Farber Cancer Institute and Harvard Medical School; Peter Kraft, Edward L. Giovannucci, Shuji Ogino, Meir J. Stampfer, Howard D. Sesso, Julie E. Buring, and JoAnn E. Manson, Harvard School of Public Health; Ying Bao, Edward L. Giovannucci, Shuji Ogino, Meir J. Stampfer, John Michael Gaziano, Howard D. Sesso, JoAnn E. Manson, and Charles S. Fuchs, Brigham and Women's Hospital and Harvard Medical School; John Michael Gaziano, Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA; Barbara B. Cochrane, University of Washington School of Nursing, Seattle, WA; Rowan T. Chlebowski, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, CA; and Linda G. Snetselaar, University of Iowa College of Public Health, Iowa City, IA.

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http://dx.doi.org/10.1200/JCO.2015.66.3005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012662PMC
August 2016

Early Life Body Fatness, Serum Anti-Müllerian Hormone, and Breast Density in Young Adult Women.

Cancer Epidemiol Biomarkers Prev 2016 07 9;25(7):1151-7. Epub 2016 May 9.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930720PMC
July 2016

Dietary Fat Intake During Adolescence and Breast Density Among Young Women.

Cancer Epidemiol Biomarkers Prev 2016 06 19;25(6):918-26. Epub 2016 May 19.

University of Maryland School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-1146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891243PMC
June 2016

Association between body composition and hip fractures in older women with physical frailty.

Geriatr Gerontol Int 2017 Jun 10;17(6):898-904. Epub 2016 May 10.

Faculty of Health Sciences and Social Welfare, University of Haifa, Israel.

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http://dx.doi.org/10.1111/ggi.12798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104679PMC
June 2017

Sources of bias in peoples' social-comparative estimates of food consumption.

J Exp Psychol Appl 2016 06 7;22(2):173-83. Epub 2016 Apr 7.

Division of Cancer Control and Population Sciences, National Cancer Institute.

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http://dx.doi.org/10.1037/xap0000081DOI Listing
June 2016

A Participatory Integrated Health Promotion and Protection Worksite Intervention: A Cluster Randomized Controlled Trial.

Top Clin Nutr 2016 Mar;31(1):36-46

Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City (Dr Snetselaar, Mr Ahrens, and Ms Smith and Hollinger); and Department of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, Georgia (Dr Hockenberry). Department of Health Management & Policy and the Center for Outcomes Research, College for Public Health & Social Justice, Saint Louis University, St. Louis, Missouri (Dr Johnston).

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http://dx.doi.org/10.1097/tin.0000000000000056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304740PMC
March 2016

Circulating Adipokines and Inflammatory Markers and Postmenopausal Breast Cancer Risk.

J Natl Cancer Inst 2015 Sep 16;107(9). Epub 2015 Jul 16.

Imperial College, London, UK (MJG); Albert Einstein College of Medicine, Bronx, NY (TW, XX, SWS, HDS, TER, RCK, DW, GYFH); University of Vermont, Burlington, VT (MC); Brigham and Women's Hospital, Harvard Medical School, Boston, MA (JEM); Fred Hutchinson Cancer Research Center, Seattle, WA (AM); University of Texas Southwestern Medical School, Dallas, TX (PES); University of California Los Angeles, Torrence, CA (RTC); University of Iowa, Iowa City, IA (LS).

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http://dx.doi.org/10.1093/jnci/djv169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651104PMC
September 2015

Body fatness during childhood and adolescence and breast density in young women: a prospective analysis.

Breast Cancer Res 2015 Jul 16;17:95. Epub 2015 Jul 16.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1186/s13058-015-0601-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502611PMC
July 2015

Hypertension, Dietary Sodium, and Cognitive Decline: Results From the Women's Health Initiative Memory Study.

Am J Hypertens 2016 Feb 1;29(2):202-16. Epub 2015 Jul 1.

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA;

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http://dx.doi.org/10.1093/ajh/hpv081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723668PMC
February 2016

Effects of Social Support About Physical Activity on Social Networking Sites: Applying the Theory of Planned Behavior.

Health Commun 2015 18;30(12):1277-85. Epub 2015 Jun 18.

f School of Humanities , University of Strathclyde.

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http://dx.doi.org/10.1080/10410236.2014.940669DOI Listing
January 2017

Adolescent endogenous sex hormones and breast density in early adulthood.

Breast Cancer Res 2015 Jun 4;17:77. Epub 2015 Jun 4.

Department of Epidemiology and Public Health, University of Maryland School of Medicine, Howard Hall 102E, Baltimore, MD, 21201, USA.

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http://dx.doi.org/10.1186/s13058-015-0581-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468804PMC
June 2015

Diet drink consumption and the risk of cardiovascular events: a report from the Women's Health Initiative.

J Gen Intern Med 2015 Apr 17;30(4):462-8. Epub 2014 Dec 17.

Division of Cardiovascular Medicine, University of Iowa Hospitals & Clinics, 200 Hawkins Dr., Int. Med. E316-1 GH, Iowa City, IA, 52242, USA,

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http://dx.doi.org/10.1007/s11606-014-3098-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371001PMC
April 2015