Linda Resar

Linda Resar

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Linda Resar

Linda Resar

Publications by authors named "Linda Resar"

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74Publications

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Approaches to Bloodless Surgery for Oncology Patients.

Hematol Oncol Clin North Am 2019 Oct 31;33(5):857-871. Epub 2019 Jul 31.

Department of Medicine (Hematology), Oncology & Institute for Cellular Engineering, The Johns Hopkins Medical Institutions, Center for Bloodless Medicine and Surgery, Ross Building Room 1015, 1800 Orleans Street, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1016/j.hoc.2019.05.009DOI Listing
October 2019

Equity and diversity in academic medicine: a perspective from the JCI editors.

J Clin Invest 2019 Oct;129(10):3974-3977

Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1172/JCI130902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763240PMC
October 2019

Greater anemia tolerance among hospitalized females compared to males.

Transfusion 2019 Aug 7;59(8):2551-2558. Epub 2019 May 7.

Johns Hopkins Health System Blood Management Program, Department of Anesthesiology/Critical Care Medicine, Faculty, Armstrong Institute for Patient Safety and Quality, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://dx.doi.org/10.1111/trf.15338DOI Listing
August 2019

Genetic Engineering of Primary Mouse Intestinal Organoids Using Magnetic Nanoparticle Transduction Viral Vectors for Frozen Sectioning.

J Vis Exp 2019 May 10(147). Epub 2019 May 10.

Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine; Department of Oncology, Johns Hopkins University School of Medicine; Department of Pathology, Johns Hopkins University School of Medicine; Institute for Cell Engineering, Johns Hopkins University School of Medicine;

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https://www.jove.com/video/57040/genetic-engineering-primary
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http://dx.doi.org/10.3791/57040DOI Listing
May 2019

Preoperative treatment of anemia and outcomes in surgical Jehovah's Witness patients.

Am J Hematol 2019 02 18;94(2):E55-E58. Epub 2018 Dec 18.

Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/ajh.25359DOI Listing
February 2019

PBOV1 as a potential biomarker for more advanced prostate cancer based on protein and digital histomorphometric analysis.

Prostate 2018 05 9;78(7):547-559. Epub 2018 Mar 9.

Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://doi.wiley.com/10.1002/pros.23499
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http://dx.doi.org/10.1002/pros.23499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882516PMC
May 2018

Lessons from the Crypt: HMGA1-Amping up Wnt for Stem Cells and Tumor Progression.

Cancer Res 2018 04 4;78(8):1890-1897. Epub 2018 Apr 4.

Department of Medicine, Division of Hematology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435269PMC
April 2018

Transcriptomic analysis in pediatric spinal ependymoma reveals distinct molecular signatures.

Oncotarget 2017 Dec 14;8(70):115570-115581. Epub 2017 Dec 14.

Children's Brain Tumour Research Centre, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.18632/oncotarget.23311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777794PMC
December 2017

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche.

Nat Commun 2017 04 28;8:15008. Epub 2017 Apr 28.

Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Room 1025, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/ncomms15008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414379PMC
April 2017

Hmga1 deficiency: "SAC-King" the SAC genes to incite chromosomal instability.

Cell Cycle 2017 01 15;16(1):17-18. Epub 2016 Dec 15.

a Department of Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA.

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http://dx.doi.org/10.1080/15384101.2016.1214034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270530PMC
January 2017

Fecal Metabolome in Hmga1 Transgenic Mice with Polyposis: Evidence for Potential Screen for Early Detection of Precursor Lesions in Colorectal Cancer.

J Proteome Res 2016 12 4;15(12):4176-4187. Epub 2016 Nov 4.

Department of Chemistry, ‡School of Molecular Biosciences, and §Institute of Biological Chemistry, Washington State University , Pullman, Washington 99164, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00035DOI Listing
December 2016

Bloodless medicine: current strategies and emerging treatment paradigms.

Transfusion 2016 Oct 29;56(10):2637-2647. Epub 2016 Jul 29.

Department of Anesthesiology/Critical Care Medicine, and the, Baltimore, Maryland.

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http://dx.doi.org/10.1111/trf.13736DOI Listing
October 2016

Patent foramen ovale in adults with sickle cell disease and stroke.

Am J Hematol 2016 09 20;91(9):E358-60. Epub 2016 Jul 20.

Hematology Division, the Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/ajh.24440DOI Listing
September 2016

Symptomatic Avascular Necrosis: An Understudied Risk Factor for Acute Care Utilization by Patients with SCD.

South Med J 2016 09;109(9):519-24

From the School of Medicine, University of Maryland, Baltimore, the School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York, and the Departments of Medicine, Psychiatry and Behavioral Sciences, Oncology, and Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, Maryland, and the Division of Hematology, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.14423/SMJ.0000000000000512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014389PMC
September 2016

IBRUTinib: BRUTe force against bortezomib-resistant myeloma cells.

Cell Cycle 2015 ;14(9):1349-50

a Department of Medicine ; The Johns Hopkins University School of Medicine , Baltimore , MD USA.

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http://dx.doi.org/10.1080/15384101.2015.1022058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614695PMC
April 2016

Ultramassive transfusion: give blood, save a life.

Transfusion 2016 Mar;56(3):546-8

Department of Medicine (Hematology), Oncology & Institute for Cellular Engineering, The Johns Hopkins Medical Institutions, Baltimore, MD.

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http://doi.wiley.com/10.1111/trf.13403
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http://dx.doi.org/10.1111/trf.13403DOI Listing
March 2016

Hemoglobin thresholds for transfusion in pediatric patients at a large academic health center.

Transfusion 2015 Dec 29;55(12):2890-7. Epub 2015 Sep 29.

Department of Pediatrics, the Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://dx.doi.org/10.1111/trf.13296DOI Listing
December 2015

The Efficacy and Utility of Acute Normovolemic Hemodilution.

Anesth Analg 2015 Dec;121(6):1412-4

From the *Department of Anesthesiology/Critical Care Medicine and †Department of Medicine (Hematology), Oncology, and the Institute for Cellular Engineering, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://dx.doi.org/10.1213/ANE.0000000000000935DOI Listing
December 2015

Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.

PLoS One 2015 30;10(1):e0116933. Epub 2015 Jan 30.

Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Biochemistry and Molecular Biology, Unversity of Maryland School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0116933PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311989PMC
October 2015

Through a Gender Lens: A View of Gender and Leadership Positions in a Department of Medicine.

J Womens Health (Larchmt) 2015 Oct 22;24(10):837-42. Epub 2015 Jul 22.

4 Division of Hematology, Departments of Medicine, Oncology, and Institute for Cellular Engineering, Johns Hopkins University School of Medicine , Baltimore, Maryland.

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http://dx.doi.org/10.1089/jwh.2014.5054DOI Listing
October 2015

How I treat priapism.

Blood 2015 Jun 25;125(23):3551-8. Epub 2015 Mar 25.

The James Buchanan Brady Urological Institute and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD;

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http://dx.doi.org/10.1182/blood-2014-09-551887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458797PMC
June 2015

Characterizing metabolic changes in human colorectal cancer.

Anal Bioanal Chem 2015 Jun 6;407(16):4581-95. Epub 2015 May 6.

Department of Chemistry, Washington State University, Pullman, WA, 99164, USA.

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http://dx.doi.org/10.1007/s00216-015-8662-xDOI Listing
June 2015

HMGA1 drives metabolic reprogramming of intestinal epithelium during hyperproliferation, polyposis, and colorectal carcinogenesis.

J Proteome Res 2015 Mar 23;14(3):1420-31. Epub 2015 Feb 23.

Department of Chemistry, Washington State University , 100 Dairy Road, Pullman, Washington 99164, United States.

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http://dx.doi.org/10.1021/pr501084sDOI Listing
March 2015

Bloodless medicine: what to do when you can't transfuse.

Hematology Am Soc Hematol Educ Program 2014 Dec 18;2014(1):553-8. Epub 2014 Nov 18.

Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD.

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http://dx.doi.org/10.1182/asheducation-2014.1.553DOI Listing
December 2014

Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.

Transfusion 2014 Oct 18;54(10 Pt 2):2668-77. Epub 2014 Jun 18.

Department of Anesthesiology/Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://dx.doi.org/10.1111/trf.12752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234090PMC
October 2014

Hydroxyurea therapy for priapism prevention and erectile function recovery in sickle cell disease: a case report and review of the literature.

Int Urol Nephrol 2014 Sep 14;46(9):1733-1736. Epub 2014 May 14.

Urology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1007/s11255-014-0737-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335636PMC
September 2014

Detection of paroxysmal nocturnal hemoglobinuria clones to exclude inherited bone marrow failure syndromes.

Eur J Haematol 2014 Jun 18;92(6):467-70. Epub 2014 Mar 18.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/ejh.12299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161035PMC
June 2014

The high mobility group A1 molecular switch: turning on cancer - can we turn it off?

Expert Opin Ther Targets 2014 May 31;18(5):541-53. Epub 2014 Mar 31.

The Johns Hopkins University School of Medicine, Hematology Division , Ross Research Building, Room 1015, 720 Rutland Avenue, Baltimore MD 21205 , USA.

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http://dx.doi.org/10.1517/14728222.2014.900045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404637PMC
May 2014

More common than you think: common variable immune deficiency.

Case Rep Hematol 2013 5;2013:153767. Epub 2013 Dec 5.

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; The Institute for Cellular Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; The Johns Hopkins University School of Medicine, Ross Research Building, Room 1025, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1155/2013/153767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870096PMC
January 2014

Hitting the bull's eye: targeting HMGA1 in cancer stem cells.

Expert Rev Anticancer Ther 2014 Jan;14(1):23-30

Department of Medicine, Pathobiology Graduate Program, Hematology Division, Oncology, the Institute for Cellular Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1586/14737140.2013.859988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333104PMC
January 2014

A novel method of data analysis for utilization of red blood cell transfusion.

Transfusion 2013 Dec 29;53(12):3052-9. Epub 2013 Apr 29.

Department of Anesthesiology/Critical Care Medicine, Department of Medicine (Hematology), Oncology & Pediatrics, The Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Pathology (Transfusion Medicine), The Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Pathology (Transfusion Medicine), Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1111/trf.12227DOI Listing
December 2013

HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells.

PLoS One 2013 2;8(5):e63419. Epub 2013 May 2.

Hematology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063419PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642138PMC
December 2013

Inactivation of the Cdkn2a locus cooperates with HMGA1 to drive T-cell leukemogenesis.

Leuk Lymphoma 2013 Aug 1;54(8):1762-8. Epub 2013 Feb 1.

Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA,

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http://dx.doi.org/10.3109/10428194.2013.764422DOI Listing
August 2013

Patent foramen ovale in patients with sickle cell disease and stroke: case presentations and review of the literature.

Case Rep Hematol 2013 16;2013:516705. Epub 2013 Jul 16.

Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1155/2013/516705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730376PMC
August 2013

Metabolomics of colorectal cancer: past and current analytical platforms.

Anal Bioanal Chem 2013 Jun 14;405(15):5013-30. Epub 2013 Mar 14.

Department of Chemistry, Washington State University, Pullman, WA 99164, USA.

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http://dx.doi.org/10.1007/s00216-013-6777-5DOI Listing
June 2013

HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells.

PLoS One 2012 20;7(1):e30034. Epub 2012 Jan 20.

Hematology Division, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030034PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262796PMC
June 2012

High mobility group A1 and cancer: potential biomarker and therapeutic target.

Histol Histopathol 2012 05;27(5):567-79

Hematology Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.14670/HH-27.567DOI Listing
May 2012

AKNA: another AT-hook transcription factor "hooking-up" with inflammation.

Cell Res 2011 Nov 14;21(11):1528-30. Epub 2011 Jun 14.

Division of Hematology, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1038/cr.2011.96DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365640PMC
November 2011

HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis.

BMC Genomics 2011 Nov 4;12:549. Epub 2011 Nov 4.

Department of Medicine, Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1186/1471-2164-12-549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245506PMC
November 2011

Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia.

Leuk Lymphoma 2011 Oct 5;52(10):1999-2006. Epub 2011 Jul 5.

Division of Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.3109/10428194.2011.591012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214625PMC
October 2011

"Let"-ing go with clonal expansion?

Blood 2011 Jun;117(22):5788-90

Johns Hopkins University School of Medicine.

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http://dx.doi.org/10.1182/blood-2011-04-346668DOI Listing
June 2011

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures.

Cell Res 2011 Mar 18;21(3):518-29. Epub 2011 Jan 18.

Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/cr.2011.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193421PMC
March 2011

Ghosal hematodiaphyseal dysplasia: a rare cause of a myelophthisic anemia.

Pediatr Blood Cancer 2010 Dec;55(6):1187-90

The Johns Hopkins University School of Medicine, Division of Hematology, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/pbc.22662DOI Listing
December 2010

Low dose, oral epsilon aminocaproic acid for renal papillary necrosis and massive hemorrhage in hemoglobin SC disease.

Pediatr Blood Cancer 2010 Jan;54(1):148-50

Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1002/pbc.22295DOI Listing
January 2010

The high mobility group A1 gene: transforming inflammatory signals into cancer?

Authors:
Linda M S Resar

Cancer Res 2010 Jan 12;70(2):436-9. Epub 2010 Jan 12.

The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2109., USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-1212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807996PMC
January 2010

Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia.

Pediatr Blood Cancer 2008 Feb;50(2):357-9

Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/pbc.21104DOI Listing
February 2008

Treatment of hepatitis-associated aplastic anemia with high-dose cyclophosphamide.

Pediatr Blood Cancer 2007 Dec;49(7):947-51

Department of Pediatric Oncology, Johns Hopkins Hospital, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/pbc.21143DOI Listing
December 2007

High mobility group protein HMGI(Y) enhances tumor cell growth, invasion, and matrix metalloproteinase-2 expression in prostate cancer cells.

Prostate 2004 Jul;60(2):160-7

Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/pros.20049DOI Listing
July 2004

Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation.

Oncogene 2004 May;23(25):4466-76

Gene Regulation Section, Laboratory of Cancer Prevention, NCI at Frederick, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1038/sj.onc.1207581DOI Listing
May 2004

HMG-I/Y is a c-Jun/activator protein-1 target gene and is necessary for c-Jun-induced anchorage-independent growth in Rat1a cells.

Mol Cancer Res 2004 May;2(5):305-14

Cell and Cancer Biology Branch, National Cancer Institute, Rockville, MD, USA.

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May 2004

Concentrations of B vitamins and homocysteine in children with sickle cell anemia.

South Med J 2004 Feb;97(2):149-55

Department of Medicine and Pediatrics, the Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University School of Medicine and Medical Institutions, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1097/01.SMJ.0000051740.56511.93DOI Listing
February 2004

Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapy.

J Pediatr Hematol Oncol 2002 Dec;24(9):737-41

Department of Pediatrics, Johns Hopkins University School of Medicine, Ross Research Building, Room 1125, 720 Rutland Avenue, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1097/00043426-200212000-00011DOI Listing
December 2002

HMG-I/Y in human breast cancer cell lines.

Breast Cancer Res Treat 2002 Feb;71(3):181-91

Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1023/a:1014444114804DOI Listing
February 2002