Linda J Kenney

Linda J Kenney

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Linda J Kenney

Linda J Kenney

Publications by authors named "Linda J Kenney"

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EnvZ/OmpR Two-Component Signaling: An Archetype System That Can Function Noncanonically.

EcoSal Plus 2020 Jan;9(1)

Department of Biological Sciences, National University of Singapore, Singapore.

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http://dx.doi.org/10.1128/ecosalplus.ESP-0001-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192543PMC
January 2020

Switching Lifestyles Is an Adaptive Strategy of Bacterial Pathogens.

Front Cell Infect Microbiol 2019 11;9:421. Epub 2019 Dec 11.

Mechanobiology Institute, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.3389/fcimb.2019.00421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917575PMC
December 2019

biofilms program innate immunity for persistence in .

Proc Natl Acad Sci U S A 2019 06 3;116(25):12462-12467. Epub 2019 Jun 3.

Mechanobiology Institute, T-Lab, National University of Singapore, Singapore 117411;

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http://dx.doi.org/10.1073/pnas.1822018116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589656PMC
June 2019

Engineering an Osmosensor by Pivotal Histidine Positioning within Disordered Helices.

Structure 2019 02 29;27(2):302-314.e4. Epub 2018 Nov 29.

Department of Biological Sciences, National University of Singapore, 14 Science Drive 4, Singapore 117543, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.str.2018.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377431PMC
February 2019

The role of acid stress in Salmonella pathogenesis.

Authors:
Linda J Kenney

Curr Opin Microbiol 2019 02 5;47:45-51. Epub 2018 Dec 5.

Mechanobiology Institute, National University of Singapore, Singapore; Department of Biochemistry, National University of Singapore, Singapore; Department of Microbiology & Immunology, University of Illinois-Chicago, United States; Department of Bioengineering, University of Illinois-Chicago, United States; Jesse Brown Veterans Administration Medical Center, Chicago, IL, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mib.2018.11.006DOI Listing
February 2019

Editorial overview: Host-pathogen interactions: bacteria.

Curr Opin Microbiol 2019 02;47:iii-v

Mechanobiology Institute, NUS Singapore, Department of Microbiology and Immunology, University of Illinois-Chicago and Jesse Brown VAMC, Chicago, IL, United States.

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http://dx.doi.org/10.1016/j.mib.2019.05.003DOI Listing
February 2019

A single molecule analysis of H-NS uncouples DNA binding affinity from DNA specificity.

Nucleic Acids Res 2018 11;46(19):10216-10224

Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.

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http://dx.doi.org/10.1093/nar/gky826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212787PMC
November 2018

A New Role of OmpR in Acid and Osmotic Stress in and .

Front Microbiol 2018 22;9:2656. Epub 2018 Nov 22.

Mechanobiology Institute, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.3389/fmicb.2018.02656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262077PMC
November 2018

The Pearling Transition Provides Evidence of Force-Driven Endosomal Tubulation during Infection.

mBio 2018 06 19;9(3). Epub 2018 Jun 19.

Mechanobiology Institute, National University of Singapore, Singapore, Singapore

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http://dx.doi.org/10.1128/mBio.01083-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016247PMC
June 2018

Sequential Super-Resolution Imaging of Bacterial Regulatory Proteins: The Nucleoid and the Cell Membrane in Single, Fixed E. coli Cells.

Methods Mol Biol 2017 ;1624:269-289

Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438, Frankfurt, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7098-8_20DOI Listing
April 2018

Identification of Biofilm Inhibitors by Screening Combinatorial Libraries of Metal Oxide Thin Films.

ACS Appl Mater Interfaces 2018 Apr 5;10(15):12510-12517. Epub 2018 Apr 5.

NUS Nanoscience & Nanotechnology Institute-NanoCore , 5A Engineering Drive 1 , 117411 , Singapore.

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http://dx.doi.org/10.1021/acsami.8b02246DOI Listing
April 2018

Charged residues in the H-NS linker drive DNA binding and gene silencing in single cells.

Proc Natl Acad Sci U S A 2017 11 6;114(47):12560-12565. Epub 2017 Nov 6.

Mechanobiology Institute, National University of Singapore, Singapore 117411;

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http://dx.doi.org/10.1073/pnas.1716721114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703333PMC
November 2017

Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells.

Nat Commun 2017 11 14;8(1):1587. Epub 2017 Nov 14.

Mechanobiology Institute, National University of Singapore, T-Lab, 5A Engineering Drive 1, Singapore, 117411, Singapore.

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http://dx.doi.org/10.1038/s41467-017-02030-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686162PMC
November 2017

Engineering a Novel Porin OmpGF Via Strand Replacement from Computational Analysis of Sequence Motif.

Biochim Biophys Acta Biomembr 2017 Jul 21;1859(7):1180-1189. Epub 2017 Mar 21.

Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60612, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2017.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434230PMC
July 2017

Lipid-Mediated Regulation of Embedded Receptor Kinases via Parallel Allosteric Relays.

Biophys J 2017 Feb;112(4):643-654

Department of Biological Sciences, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.12.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340122PMC
February 2017

To ∼P or Not to ∼P? Non-canonical activation by two-component response regulators.

Mol Microbiol 2017 01 11;103(2):203-213. Epub 2016 Oct 11.

Mechanobiology Institute, 5A Engineering Drive 1, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1111/mmi.13532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218973PMC
January 2017

Erratum to: Sequential Super-Resolution Imaging of Bacterial Regulatory Proteins, the Nucleoid and the Cell Membrane in Single, Fixed E. coli Cells.

Methods Mol Biol 2017 ;1624:E1

Institute of Physical and Theoretical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438, Frankfurt, Germany.

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http://dx.doi.org/10.1007/978-1-4939-7098-8_25DOI Listing
January 2017

Single cell super-resolution imaging of E. coli OmpR during environmental stress.

Integr Biol (Camb) 2015 Oct 9;7(10):1297-308. Epub 2015 Jul 9.

Mechanobiology Institute, T-Lab, 5A Engineering Drive 1, National University of Singapore, Singapore 117411.

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http://dx.doi.org/10.1039/c5ib00077gDOI Listing
October 2015

H-NS Regulates Gene Expression and Compacts the Nucleoid: Insights from Single-Molecule Experiments.

Biophys J 2015 Oct;109(7):1321-9

Mechanobiology Institute, National University of Singapore, Singapore; Department of Biological Sciences, National University of Singapore, Singapore; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601063PMC
October 2015

Cytoplasmic sensing by the inner membrane histidine kinase EnvZ.

Prog Biophys Mol Biol 2015 Sep 1;118(3):119-29. Epub 2015 May 1.

Mechanobiology Institute, National University of Singapore, Singapore; Jesse Brown Veterans Affairs Medical Center, Chicago, USA; University of Illinois-Chicago, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080436PMC
http://dx.doi.org/10.1016/j.pbiomolbio.2015.04.005DOI Listing
September 2015

A FRET-based DNA biosensor tracks OmpR-dependent acidification of Salmonella during macrophage infection.

PLoS Biol 2015 Apr 14;13(4):e1002116. Epub 2015 Apr 14.

Mechanobiology Institute, National University of Singapore, Singapore; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, United States of America; Department of Microbiology and Immunology, University of Illinois-Chicago, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1002116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397060PMC
April 2015

Rapid, high-throughput tracking of bacterial motility in 3D via phase-contrast holographic video microscopy.

Biophys J 2015 Mar;108(5):1248-56

Mechanobiology Institute, National University of Singapore, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore; Department of Mechanical Engineering, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2015.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375448PMC
March 2015

Single-molecule studies on the mechanical interplay between DNA supercoiling and H-NS DNA architectural properties.

Nucleic Acids Res 2014 Jul 2;42(13):8369-78. Epub 2014 Jul 2.

Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore Centre for Bioimaging Sciences, National University of Singapore, Singapore Mechanobiology Institute, Singapore Department of Physics, National University of Singapore, Singapore

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http://dx.doi.org/10.1093/nar/gku566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117784PMC
July 2014

Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing.

Sci Rep 2012 13;2:509. Epub 2012 Jul 13.

NUS Graduate school For Integrative Sciences and Engineering, Singapore 119077.

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http://dx.doi.org/10.1038/srep00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3396134PMC
March 2013

The inner membrane histidine kinase EnvZ senses osmolality via helix-coil transitions in the cytoplasm.

EMBO J 2012 May 27;31(11):2648-59. Epub 2012 Apr 27.

Department of Biological Sciences, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1038/emboj.2012.99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365433PMC
May 2012

Gene silencing H-NS paralogue StpA forms a rigid protein filament along DNA that blocks DNA accessibility.

Nucleic Acids Res 2012 Apr 19;40(8):3316-28. Epub 2011 Dec 19.

NUS Graduate school for Integrative Sciences and Engineering, National University of Singapore, 28 Medical Drive, Singapore, 119077, Singapore.

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http://dx.doi.org/10.1093/nar/gkr1247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333869PMC
April 2012

Salmonella enterica response regulator SsrB relieves H-NS silencing by displacing H-NS bound in polymerization mode and directly activates transcription.

J Biol Chem 2011 Jan 8;286(3):1895-902. Epub 2010 Nov 8.

Department of Microbiology and Immunology, University of Illinois, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1074/jbc.M110.164962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023485PMC
January 2011

How important is the phosphatase activity of sensor kinases?

Authors:
Linda J Kenney

Curr Opin Microbiol 2010 Apr 10;13(2):168-76. Epub 2010 Mar 10.

Department of Microbiology & Immunology, University of Illinois at Chicago, 835 S. Wolcott St. M/C 790, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.mib.2010.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853374PMC
April 2010

A divalent switch drives H-NS/DNA-binding conformations between stiffening and bridging modes.

Genes Dev 2010 Feb;24(4):339-44

Department of Physics, National University of Singapore, Singapore 117542.

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http://dx.doi.org/10.1101/gad.1883510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816733PMC
February 2010

MzrA: a novel modulator of the EnvZ/OmpR two-component regulon.

Mol Microbiol 2009 Jun 8;72(6):1408-22. Epub 2009 May 8.

School of Life Sciences, Arizona State University, Tempe, AZ 85287-4501, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2009.06728.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727453PMC
June 2009

Threonine phosphorylation prevents promoter DNA binding of the Group B Streptococcus response regulator CovR.

Mol Microbiol 2009 Mar 23;71(6):1477-95. Epub 2009 Jan 23.

Department of Pediatric Infectious Diseases, University of Washington School of Medicine and Seattle Children's Hospital Research Institute, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2009.06616.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133594PMC
March 2009

Pathogenic adaptation of intracellular bacteria by rewiring a cis-regulatory input function.

Proc Natl Acad Sci U S A 2009 Mar 20;106(10):3982-7. Epub 2009 Feb 20.

The Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1073/pnas.0811669106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645909PMC
March 2009

Application of fluorescence resonance energy transfer to examine EnvZ/OmpR interactions.

Methods Enzymol 2007 ;422:352-60

Department of Microbiology and Immunology, University of Immunology, University of Illinois-Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1016/S0076-6879(06)22017-2DOI Listing
May 2008

Amino acids important for DNA recognition by the response regulator OmpR.

J Biol Chem 2008 Mar 14;283(13):8664-77. Epub 2008 Jan 14.

Department of Microbiology and Immunology, University of Illinois, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1074/jbc.M705550200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2417188PMC
March 2008

The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS.

Mol Microbiol 2007 Jul;65(2):477-93

University of Illinois at Chicago, Department of Microbiology and Immunology, 835 S. Wolcott Ave M/C 790, Chicago, IL 60612, USA.

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http://doi.wiley.com/10.1111/j.1365-2958.2007.05800.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2958.2007.05800.xDOI Listing
July 2007

ChxR is a transcriptional activator in Chlamydia.

Proc Natl Acad Sci U S A 2006 Jan 9;103(3):750-5. Epub 2006 Jan 9.

Program in Infectious Diseases, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.

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http://dx.doi.org/10.1073/pnas.0509690103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1325966PMC
January 2006

The response regulator OmpR oligomerizes via beta-sheets to form head-to-head dimers.

J Mol Biol 2005 Jul;350(5):843-56

Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1569, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.05.057DOI Listing
July 2005

The response regulator SsrB activates transcription and binds to a region overlapping OmpR binding sites at Salmonella pathogenicity island 2.

Mol Microbiol 2004 Nov;54(3):823-35

Department of Microbiology and Immunology, University of Illinois at Chicago, 835 S. Wolcott Avenue, M/C 790, Chicago, IL 60612, USA.

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http://doi.wiley.com/10.1111/j.1365-2958.2004.04317.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2958.2004.04317.xDOI Listing
November 2004

PhoP can activate its target genes in a PhoQ-independent manner.

J Bacteriol 2004 Apr;186(8):2476-80

Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Instituto de Biología Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, 2000 Rosario, Argentina.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC412160PMC
http://dx.doi.org/10.1128/jb.186.8.2476-2480.2004DOI Listing
April 2004

Dual regulation by phospho-OmpR of ssrA/B gene expression in Salmonella pathogenicity island 2.

Mol Microbiol 2003 May;48(4):1131-43

Department of Molecular Microbiology and Immunology, L-220, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA.

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http://dx.doi.org/10.1046/j.1365-2958.2003.03502.xDOI Listing
May 2003

Function, diversity, and evolution of signal transduction in prokaryotes.

Dev Cell 2003 Apr;4(4):459-65

Section of Molecular Genetics and Microbiology, Institute of Cellular and Molecular Biology, University of Texas, Austin, Austin, TX 78712, USA.

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http://dx.doi.org/10.1016/s1534-5807(03)00096-0DOI Listing
April 2003

Interdomain linkers of homologous response regulators determine their mechanism of action.

J Bacteriol 2003 Jan;185(1):317-24

Department of Molecular Microbiology & Immunology L220, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC141822PMC
http://dx.doi.org/10.1128/jb.185.1.317-324.2003DOI Listing
January 2003

The linker region plays an important role in the interdomain communication of the response regulator OmpR.

J Biol Chem 2002 Sep 20;277(36):32714-21. Epub 2002 Jun 20.

Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA.

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http://dx.doi.org/10.1074/jbc.M204122200DOI Listing
September 2002

Structure/function relationships in OmpR and other winged-helix transcription factors.

Authors:
Linda J Kenney

Curr Opin Microbiol 2002 Apr;5(2):135-41

Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 3181 South West Sam Jackson Park Road, Portland, Oregon 97201, USA.

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http://dx.doi.org/10.1016/s1369-5274(02)00310-7DOI Listing
April 2002

Phosphorylation alters the interaction of the response regulator OmpR with its sensor kinase EnvZ.

J Biol Chem 2002 Mar 17;277(13):11143-8. Epub 2002 Jan 17.

Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97201-3098, USA.

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http://dx.doi.org/10.1074/jbc.M111128200DOI Listing
March 2002

A phosphorylation site mutant of OmpR reveals different binding conformations at ompF and ompC.

J Mol Biol 2002 Jan;315(4):497-511

Department of Molecular Microbiology and Immunology L-220, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA.

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http://dx.doi.org/10.1006/jmbi.2001.5222DOI Listing
January 2002