Publications by authors named "Linda C Hsieh-Wilson"

66Publications

Sulfated glycans engage the Ang-Tie pathway to regulate vascular development.

Nat Chem Biol 2020 Oct 5. Epub 2020 Oct 5.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.

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October 2020

Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding Proteins.

J Am Chem Soc 2020 08 3;142(32):13672-13676. Epub 2020 Aug 3.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.

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August 2020

O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis.

Proc Natl Acad Sci U S A 2019 04 2;116(16):7857-7866. Epub 2019 Apr 2.

Ministry of Education Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences, Zhejiang University, 310058 Hangzhou, China;

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April 2019

An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.

ACS Chem Biol 2019 01 8;14(1):4-10. Epub 2019 Jan 8.

MOE Laboratory of Biosystems Homeostasis & Protection, College of Life Sciences , Zhejiang University , Hangzhou 310058 , China.

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January 2019

Optimization of Chemoenzymatic Mass Tagging by Strain-Promoted Cycloaddition (SPAAC) for the Determination of O-GlcNAc Stoichiometry by Western Blotting.

Biochemistry 2018 10 24;57(40):5769-5774. Epub 2018 Sep 24.

Division of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.

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October 2018

A Molecular Window into the Brain: Special Issue on Molecules and the Brain.

Biochemistry 2018 07;57(27):3989-3990

Division of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.

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July 2018

Deciphering the Functions of O-GlcNAc Glycosylation in the Brain: The Role of Site-Specific Quantitative O-GlcNAcomics.

Biochemistry 2018 07 2;57(27):4010-4018. Epub 2018 Jul 2.

Department of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.

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July 2018

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau α-synuclein and β-amyloid aggregates.

J Biol Chem 2018 07 11;293(27):10826-10840. Epub 2018 May 11.

From the Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center, Dallas, Texas 75390,

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July 2018

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs).

Sci Rep 2018 04 23;8(1):6382. Epub 2018 Apr 23.

Neuroscience Research Institute, Department of Molecular Cellular Developmental Biology, University of California, Santa Barbara, CA, 93106, USA.

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April 2018

Methods for the Detection, Study, and Dynamic Profiling of O-GlcNAc Glycosylation.

Methods Enzymol 2018 7;598:101-135. Epub 2017 Aug 7.

California Institute of Technology, Pasadena, CA, United States. Electronic address:

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January 2019

Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth.

Proc Natl Acad Sci U S A 2017 12 11;114(52):13697-13702. Epub 2017 Dec 11.

Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA 91125;

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December 2017

Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation.

ACS Chem Biol 2017 12 29;12(12):3126-3133. Epub 2017 Nov 29.

Division of Chemistry and Chemical Engineering, California Institute of Technology , 1200 East California Boulevard, Pasadena, California 91125, United States.

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December 2017

Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.

Proc Natl Acad Sci U S A 2016 12 12;113(52):15120-15125. Epub 2016 Dec 12.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125;

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December 2016

Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag.

Mol Biosyst 2016 05;12(6):1756-9

Department of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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May 2016

Glycan Engineering for Cell and Developmental Biology.

Cell Chem Biol 2016 Jan;23(1):108-121

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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January 2016

Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans.

Exp Neurol 2015 Dec 24;274(Pt B):115-25. Epub 2015 Aug 24.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125, USA. Electronic address:

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December 2015

Long-lived engineering of glycans to direct stem cell fate.

Angew Chem Int Ed Engl 2015 Jan 4;54(5):1466-70. Epub 2014 Dec 4.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125 (USA).

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January 2015

Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E.

PLoS Pathog 2014 Dec 4;10(12):e1004495. Epub 2014 Dec 4.

Division of Cell Biology, La Jolla Institute for Allergy and Imunology (LIAI), La Jolla, California, United States of America.

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December 2014

Photoactivatable glycopolymers for the proteome-wide identification of fucose-α(1-2)-galactose binding proteins.

J Am Chem Soc 2014 Jul 25;136(27):9528-31. Epub 2014 Jun 25.

Division of Chemistry and Chemical Engineering, California Institute of Technology and Howard Hughes Medical Institute , 1200 East California Boulevard, Pasadena, California 91125, United States.

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July 2014

Directing neuronal signaling through cell-surface glycan engineering.

J Am Chem Soc 2014 May 30;136(19):6794-7. Epub 2014 Apr 30.

Division of Chemistry and Chemical Engineering, California Institute of Technology and Howard Hughes Medical Institute , 1200 East California Boulevard, Pasadena, California 91125, United States.

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May 2014

Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags.

Curr Protoc Chem Biol 2013 ;5(4):281-302

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California.

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March 2015

Chemistry. Improving biologic drugs via total chemical synthesis.

Science 2013 Dec;342(6164):1332-3

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA.

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December 2013

Synthetic probes of glycosaminoglycan function.

Curr Opin Chem Biol 2013 Dec 20;17(6):1014-22. Epub 2013 Oct 20.

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA.

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December 2013

Tailored glycopolymers as anticoagulant heparin mimetics.

Angew Chem Int Ed Engl 2013 Nov 9;52(45):11796-9. Epub 2013 Oct 9.

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, 1200 E. California Blvd, Pasadena, CA 91125 (USA).

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November 2013

Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation.

Sci Signal 2013 Aug 27;6(290):ra75. Epub 2013 Aug 27.

Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.

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August 2013

Tunable heparan sulfate mimetics for modulating chemokine activity.

J Am Chem Soc 2013 Jul 23;135(30):10898-901. Epub 2013 Jul 23.

Division of Chemistry and Chemical Engineering, California Institute of Technology and Howard Hughes Medical Institute, 1200 East California Boulevard, Pasadena, California 91125, USA.

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July 2013

Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.

Science 2012 Aug;337(6097):975-80

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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August 2012

A sulfated carbohydrate epitope inhibits axon regeneration after injury.

Proc Natl Acad Sci U S A 2012 Mar 12;109(13):4768-73. Epub 2012 Mar 12.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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March 2012

Chemoenzymatic probes for detecting and imaging fucose-α(1-2)-galactose glycan biomarkers.

J Am Chem Soc 2012 Mar 29;134(10):4489-92. Epub 2012 Feb 29.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, United States.

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March 2012

Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation.

Nat Chem Biol 2012 Jan 22;8(3):253-61. Epub 2012 Jan 22.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.

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January 2012

Microarray method for the rapid detection of glycosaminoglycan-protein interactions.

Methods Mol Biol 2012 ;808:321-36

Division of Chemistry and Chemical Engineering, California Institute of Technology and the Howard Hughes Medical Institute, Pasadena, CA, USA.

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March 2012

Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches.

Proc Natl Acad Sci U S A 2011 Jun 31;108(24):9747-52. Epub 2011 May 31.

Division of Chemistry and Chemical Engineering, California Institute of Technology and Howard Hughes Medical Institute, 1200 East California Boulevard, Pasadena, CA 91125, USA.

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June 2011

End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans.

Chem Sci 2010 Sep;1(3):322-325

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California, 91125, USA. ; ; Tel: +1 626 395 6101.

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September 2010

Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags.

Nat Chem Biol 2010 Sep 25;6(9):645-51. Epub 2010 Jul 25.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, USA.

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September 2010

Identification of the plasticity-relevant fucose-alpha(1-2)-galactose proteome from the mouse olfactory bulb.

Biochemistry 2009 Aug;48(30):7261-70

Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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August 2009

Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes.

Diabetes 2009 Feb 4;58(2):309-17. Epub 2008 Nov 4.

Department of Biological Chemistry, School of Medicine, The Johns Hopkins University, Baltimore, Maryland, USA.

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February 2009

Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.

J Am Chem Soc 2008 Sep 7;130(35):11576-7. Epub 2008 Aug 7.

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

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September 2008

The chemical neurobiology of carbohydrates.

Chem Rev 2008 May 2;108(5):1708-31. Epub 2008 May 2.

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

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May 2008

Neuroactive chondroitin sulfate glycomimetics.

J Am Chem Soc 2008 Mar 15;130(10):2959-61. Epub 2008 Feb 15.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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March 2008

Chemical approaches to understanding O-GlcNAc glycosylation in the brain.

Nat Chem Biol 2008 Feb;4(2):97-106

Division of Chemistry and Chemical Engineering, and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

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February 2008

Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics.

Nat Chem Biol 2007 Jun 13;3(6):339-48. Epub 2007 May 13.

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

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June 2007

Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method.

Bioconjug Chem 2007 May-Jun;18(3):806-14. Epub 2007 Mar 20.

Structural Glycobiology Section, CCR-Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702, USA.

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August 2007

Profiling the sulfation specificities of glycosaminoglycan interactions with growth factors and chemotactic proteins using microarrays.

Chem Biol 2007 Feb;14(2):195-208

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA.

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February 2007

Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.

Nat Chem Biol 2006 Sep 30;2(9):467-73. Epub 2006 Jul 30.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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September 2006

Discovery of a TNF-alpha antagonist using chondroitin sulfate microarrays.

J Am Chem Soc 2006 Jun;128(24):7740-1

Division of Chemistry and Chemical Engineering and Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

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June 2006

Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.

Proc Natl Acad Sci U S A 2006 Jan 22;103(1):21-6. Epub 2005 Dec 22.

Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

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January 2006

Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways.

J Neurochem 2005 Dec 21;95(6):1642-52. Epub 2005 Nov 21.

Department of Physiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka, Japan.

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December 2005

Chemical approaches to deciphering the glycosaminoglycan code.

Curr Opin Chem Biol 2005 Dec 18;9(6):609-19. Epub 2005 Oct 18.

Howard Hughes Medical Institute, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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December 2005

A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth.

J Am Chem Soc 2005 Feb;127(5):1340-1

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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February 2005

Tailor-made glycoproteins.

Trends Biotechnol 2004 Oct;22(10):489-91

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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October 2004

Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain.

Proc Natl Acad Sci U S A 2004 Sep 30;101(36):13132-7. Epub 2004 Aug 30.

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

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September 2004

Parallel identification of O-GlcNAc-modified proteins from cell lysates.

J Am Chem Soc 2004 Sep;126(34):10500-1

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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September 2004

A chondroitin sulfate small molecule that stimulates neuronal growth.

J Am Chem Soc 2004 Jun;126(25):7736-7

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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June 2004

A 'molecular switchboard'--covalent modifications to proteins and their impact on transcription.

Org Biomol Chem 2004 Jan 2;2(1):1-7. Epub 2003 Dec 2.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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January 2004

Use of cerny epoxides for the accelerated synthesis of glycosaminoglycans.

Org Lett 2003 Oct;5(22):4179-82

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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October 2003

Dynamic glycosylation of the transcription factor CREB: a potential role in gene regulation.

J Am Chem Soc 2003 Jun;125(22):6612-3

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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June 2003

Phosphorylation of spinophilin modulates its interaction with actin filaments.

J Biol Chem 2003 Jan 1;278(2):1186-94. Epub 2002 Nov 1.

Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA.

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January 2003

The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines.

Neuromolecular Med 2002 ;2(1):61-9

Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA.

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February 2003