Publications by authors named "Lina Wang"

1,111 Publications

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Molecular characterization of nitrogen-containing organic compounds in the winter North China Plain.

Sci Total Environ 2022 May 23:156189. Epub 2022 May 23.

Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China. Electronic address:

The molecular characteristics of organic aerosols (OAs) in heavily polluted areas affected by coal combustion (CC) were investigated. In terms of relative abundance, the total nitrogen-containing organic compounds (NOC) accounted for about 61%-68% of all molecules detected in methanol-soluble organic carbon (MSOC) by LC - Q-TOF - MS. More than 85% of the CHON- formulas are nitro-aromatic compounds, which are generally considered to be secondary organic compounds, as evidenced by the lower degree of overlap of these substances in the atmospheric samples and CC samples. Some polycyclic aromatic compounds with 4 N and 1-2O and very low H/C and O/C ratio produced by CC are unstable and easily react to form compounds with higher degrees of saturation. Almost all of the CHON+ homologues detected in the CC samples were also found in the atmospheric samples, indicating that the large amount of CHON+ compounds produced by CC are stable during atmospheric processes. The CHN+ compounds produced by CC contain a certain amount of highly unsaturated compounds, among which 1 N-containing polycyclic aromatic hydrocarbons (1 N-PAHs) is stable in atmosphere and can serve as markers of CC.
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http://dx.doi.org/10.1016/j.scitotenv.2022.156189DOI Listing
May 2022

Research on Application of Data Mining Algorithm in Cardiac Medical Diagnosis System.

Biomed Res Int 2022 14;2022:7262010. Epub 2022 May 14.

Oral and Maxillofacial Surgery, Rizhao Stomatological Hospital, Rizhao, 276825, China.

Heart disease is a very common high-incidence disease. Due to the wide variety of pathology of heart disease, how to improve the medical diagnosis of heart disease and carry out earlier intervention and treatment is a problem that needs to be solved urgently. The paper adds the decision tree algorithm and its comparison and proposes an optimized classification algorithm Co-SVM. Based on the establishment of a heart disease diagnosis classifier based on data mining algorithms, it is aimed at exploring which of these four algorithms is more suitable for heart disease diagnosis problems and optimizing them. A brief description of the cause, influencing factors, and acquired data of heart disease can be seen from the accuracy and scientificity of the data, which further enhances the authenticity and reliability of the clinical diagnosis model of heart disease. At the same time, the ultrasound diagnosis technology of heart disease is introduced, and the important role of ultrasound diagnosis technology in the medical diagnosis of heart disease is discussed. This thesis uses the heart disease clinical data set to establish a heart disease diagnosis classifier based on the decision tree algorithm, neural network algorithm, support vector machine algorithm, and Co-SVM algorithm. Through experimental comparison and analysis, the optimal classification is selected according to the obtained results. The algorithm is Co-SVM algorithm. The experimental results show that the proposed Co-SVM algorithm has a higher accuracy rate than the other three classic algorithms, and the effectiveness of the Co-SVM algorithm is verified by the evaluation results of multiple algorithms. By applying the Co-SVM algorithm in the medical diagnosis system, it is helpful to assist doctors in making more accurate and precise diagnosis of the condition.
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http://dx.doi.org/10.1155/2022/7262010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9124123PMC
May 2022

2-Hydroxy-4-(Methylthio) Butanoic Acid Isopropyl Ester Supplementation Altered Ruminal and Cecal Bacterial Composition and Improved Growth Performance of Finishing Beef Cattle.

Front Nutr 2022 4;9:833881. Epub 2022 May 4.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

The objective of this study was to evaluate the effects of isopropyl ester of 2-hydroxy-4-(methylthio)-butyrate acid (HMBi) on ruminal and cecal fermentation, microbial composition, nutrient digestibility, plasma biochemical parameters, and growth performance in finishing beef cattle. The experiment was conducted for 120 days by a complete randomized block design. Sixty 24-month-old Angus steers (723.9 ± 11.6 kg) were randomly assigned to one of the flowing three treatments: basal diet (the concentrate: 7.6 kg/head·d, the rice straw: ) supplemented with 0 g/d MetaSmart (H), a basal diet supplemented with 15 g/d of MetaSmart (H), and a basal diet supplemented with 30 g/d of MetaSmart (H). Results showed that the average daily gain (ADG) increased linearly ( = 0.004) and the feed conversion ratio (FCR) decreased linearly ( < 0.01) with the increasing HMBi supplementation. Blood urea nitrogen (BUN) concentration significantly decreased in the H group ( < 0.05) compared with H or H. The ruminal pH value tended to increase linearly ( = 0.086) on day 56 with the increased HMBi supplementation. The concentrations of ammonia-nitrogen (NH-N), propionate, isobutyrate, butyrate, isovalerate, valerate, and total volatile fatty acid (VFA) were linearly decreased in the cecum ( < 0.05). The results of Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) showed that the abundance of most pathways with a significant difference was higher in the rumen and lower in the cecum in the H group compared to the H group, and those pathways were mainly related to the metabolism of amino acids, carbohydrates, and lipids. Correlation analysis showed that ADG was positively associated with the ratio of firmicutes/bacteroidetes both in the rumen and cecum. Additionally, the abundance of , and was positively correlated with ADG and negatively correlated with FCR and BUN in the rumen. In the cecum, ADG was positively correlated with the abundances of , and , and negatively correlated with the abundances of and . Overall, these results indicated that dietary supplementation of HMBi can improve the growth performance and the feed efficiency of finishing beef cattle by potentially changing bacterial community and fermentation patterns of rumen and cecum.
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http://dx.doi.org/10.3389/fnut.2022.833881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116427PMC
May 2022

Prevalence of depressive disorders and associated demographic characteristics in Shandong: An epidemiological investigation.

J Affect Disord 2022 May 18;311:198-204. Epub 2022 May 18.

Department of Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, United Kingdom. Electronic address:

Background: Depression is characterized by debilitating symptoms and high recurrence rates, and there are relatively few large-scale epidemiological surveys of depressive disorders conducted in Shandong since 2005. Data from the largest Epidemiological Survey of Mental Disorders conducted in 2015 in Shandong were collected to investigate the prevalence of depressive disorders and associated demographic characteristics in general adult population.

Methods: A multi-stage stratified cluster sampling method was adopted to select residents and a two-stage screening and assessment process was used to define the prevalence and characteristics of depressive disorders. Respondents were initially screened using the General Health Questionnaire followed by a structured clinical interview using the DSM-IV criteria.

Results: Among 27,489 respondents who completed the survey, 1277 respondents met the diagnostic criteria for depressive disorders. The adjusted prevalence in the last month was 4.86%, among which the prevalence of major depressive disorder, dysthymia, and unspecified depressive disorder were 2.32%, 1.78%, and 0.75%, respectively. 40.35% of depression patients had moderate or severe functional impairment and only 10.65% of patients had visited a psychiatric service. Univariate and multivariate analyses revealed that age, gender, occupation, education, marital status, and urban/rural living were associated with the prevalence.

Limitations: The key limitation is that this is a cross-sectional survey therefore cannot draw any causal relationship between risk factors and disease progression.

Conclusions: Findings from this largest epidemiological study reveal current prevalence of depressive disorders and associated demographic factors and offers opportunities for policy makers and health-care professionals to improve mental health provision in Shandong.
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http://dx.doi.org/10.1016/j.jad.2022.05.084DOI Listing
May 2022

Lithiophilic hollow Co[Co(CN)] embedded carbon nanotube film for dendrite-free lithium metal anodes.

J Colloid Interface Sci 2022 May 13;623:532-540. Epub 2022 May 13.

School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, PR China.

Lithium metal is considered to be an ideal anode material due to its ultra-high theoretical capacity and extremely low electric potential. Unfortunately, the infinite volume expansion and unregulated formation of lithium dendrites in the plating/stripping process restrict its practical utilization. Herein, we designed a hollow Co[Co(CN)] (CoCoPBA) embedded high-conductivity carbon film as a three-dimensional (3D) lithiophilic current collector ([email protected]). The interwoven carbon nanotubes with hollow nanoparticles can effectively promote electron transfer and reduce local current density, adapting to the huge volume expansion in long-term electrochemical cycling. At the same time, lithiophilic hollow CoCoPBA nanoparticles provide abundant active sites due to their large surface area, efficiently reducing nucleation overpotential and making lithium deposition easier and more uniform, both confirmed by theoretical calculation and experiment. Accordingly, compared with bare Cu electrodes, [email protected] electrodes have a flat and uniform Li deposition morphology, which is beneficial to enhance the cycle life of lithium metal anodes. And the symmetrical cell assembled by [email protected] shows stable cycling performance of more than 500 h at 2 mA cm with 1 mAh cm. Besides, the assembled lithium-sulfur full cell also has higher cycle stability and rate performance.
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http://dx.doi.org/10.1016/j.jcis.2022.05.055DOI Listing
May 2022

Novel scheme towards interfacial charge transfer between ZnInS and BiOBr for efficient photocatalytic removal of organics and chromium (VI) from water.

Chemosphere 2022 May 16;303(Pt 1):134973. Epub 2022 May 16.

Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, PR China.

Construction of Z-scheme heterostructure is an effective strategy to enhance the charge carriers' separation. However, successfully achieving this on the defect heterojunction to improve the photocatalytic activity remains challenging. This work successfully obtained sulfur vacancy in the ZnInS/BiOBr (SZIS/BOB) heterojunction composites with S-O covalent bonding using a hydrothermal method. As a result, they exhibited superior photocatalytic and stability performance. The optimized SZIS/BOB-10 exhibited excellent rhodamine B degradation (95.2%) and chromium (VI) reduction (97.8%) within 100 min under visible light. The enhanced composites with S-vacancies, S-O bond, and internal electric field induced the Z-scheme charge transfer mechanism. We had verified this mechanism based on the surface photovoltage spectra, electron spin response spectra, and density functional theory calculations. This work not only provides valuable insights into designing photocatalysts with a direct Z scheme heterostructure but also delineates a promising strategy for developing efficient photocatalysts to degrade organic pollutants.
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http://dx.doi.org/10.1016/j.chemosphere.2022.134973DOI Listing
May 2022

The Sleep Quality of the Frontline Healthcare Workers and the Improving Effect of Tai Chi.

Front Psychiatry 2022 2;13:883590. Epub 2022 May 2.

Department of Traditional Chinese Medicine, Naval Medical University, Shanghai, China.

Background: A number of studies have documented that coronavirus disease 2019 (COVID-19) brought more negative impact on the physical and psychological functioning of frontline healthcare workers. Especially, sleep quality was focused. This study aimed to investigate the sleep quality of frontline healthcare workers, risk factors for sleep quality, and the effect of Tai Chi training.

Methods: A total of 98 frontline healthcare workers were recruited, coming from the infection department, fever clinic, laboratory, and medical imaging department in a COVID-19-designated hospital in Shanghai. Of them, 50 participated in a 2-week intervention and were randomized to receive a Tai Chi training or relaxation training. Participants were assessed at baseline, 7 and 14 days after participation. Demographic information, sleep quality, and anxiety were measured by using the demographic questionnaire, Pittsburgh Sleep Quality Index (PSQI) and Beck Anxiety Inventory (BAI).

Results: 13.3% participants were above the cut-off score (>10) for the PSQI. Regression analysis showed gender, age, working years, and job category had effect on sleep quality. Compared to the control group, participants in the Tai Chi training group had lower scores on both PSQI ( < 0.05) and BAI ( < 0.01) after the 2-week intervention.

Conclusion: It was demonstrated that poor sleep quality existed in the frontline healthcare workers, which was related to gender, age, working years, and job category. Tai Chi training can dramatically improve their sleep quality and reduce anxiety symptoms.
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http://dx.doi.org/10.3389/fpsyt.2022.883590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108151PMC
May 2022

Systematic review and meta-analysis of the risk factors of surgical site infection in patients with colorectal cancer.

Transl Cancer Res 2022 Apr;11(4):857-871

Department of General Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.

Background: Surgical site infection (SSI) influenced the result of surgical treatment, which was known as the second most prevalent hospital-based infection. But, the factors of SSI are not uniform. The purpose of this study was to identify the risk factors of SSI in patients with colorectal cancer. We conducted a meta-analysis of epidemiological research to provide a scientific basis for the prevention of SSI.

Methods: The PubMed, Medline, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang databases were independently searched by 2 researchers to identify all relevant studies. Studies were selected if they met the selection criteria, which was defined according to the PICOS principles. The quality of the evidence was assessed using Egger's P value, study heterogeneity, and sample size. Studies were categorized into 3 groups as follows: low quality (Class 4), moderate quality (Class 2/3), and high quality (Class 1). The meta-analysis was performed using RevMan 5.3 software.

Results: A total of 17 studies involving 61,611 patients were included in the meta-analysis. The results identified 7 patient-related risk factors of SSI, including male gender, obesity, diabetes mellitus, American Society of Anesthesiologists (ASA) score, cigarette smoking, tumor location, and serum albumin level, and 5 treatment-related risk factors, including laparoscopic surgery, operation time, blood loss, blood transfusion, and abdominal surgical history. Age was not directly related to SSI in colorectal cancer.

Conclusions: It is possible that patients can be treated effectively by identifying these factors of SSI.
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http://dx.doi.org/10.21037/tcr-22-627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091005PMC
April 2022

Body Mass Index and the Risk of Atrial Fibrillation: A Mendelian Randomization Study.

Nutrients 2022 Apr 29;14(9). Epub 2022 Apr 29.

Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Department of Epidemiology & Biostatistics, School of Public Health, Southeast University, Nanjing 210009, China.

Although observational studies have shown positive associations between body mass index (BMI) and the risk of atrial fibrillation (AF), the causal relationship is still uncertain owing to the susceptibility to confounding and reverse causation. This study aimed to examine the potential causality of BMI on AF by conducting a two-sample Mendelian randomization (TSMR) study.

Methods: The independent genetic variants associated with BMI ( = 303) at the genome-wide significant level were derived as instrumental variables (IV) from the Genetic Investigation of Anthropometric Traits (GIANT) consortium consisting of 681,275 individuals of European ancestry. We then derived the outcome data from a GWAS meta-analysis comprised of 60,620 cases and 970,216 controls of European ancestry. The TSMR analyses were performed in five methods, namely inverse variance weighted (IVW) method, MR-Egger regression, the weighted median estimator (WME), the generalized summary data-based Mendelian randomization (GSMR), and the robust adjusted profile score (RAPS), to investigate whether BMI was causally associated with the risk of AF.

Results: We found a genetically determined 1-standard deviation (SD) increment of BMI causally increased a 42.5% risk of AF (OR = 1.425; 95% CI, 1.346 to 1.509) based on the IVW method, which was consistent with the results of MR-Egger regression, WME, GSMR, as well as RAPS. The Mendelian randomization assumptions did not seem to be violated.

Conclusion: This study provides evidence that higher BMI causally increased the risk of AF, suggesting control of BMI and obesity for prevention of AF.
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http://dx.doi.org/10.3390/nu14091878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9101688PMC
April 2022

Genome-wide transcriptome analysis reveals the regulatory network governing terpene trilactones biosynthesis in Ginkgo biloba.

Tree Physiol 2022 May 9. Epub 2022 May 9.

College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, Hubei, China.

Gingko biloba is currently the only remaining gymnosperm of the Ginkgoaceae Ginkgo genus, and its history can be traced back to the Carboniferous 200 million years ago. Terpene trilactones (TTLs) are one of the main active ingredients in G. biloba, including ginkgolides and bilobalide. They have good curative effect on cardiovascular and cerebrovascular diseases because of their special antagonistic effect of platelet-activating factors. Therefore, it is necessary to deeply mine genes related to TTLs and to analyze their transcriptional regulation mechanism, which will hold vitally important scientific and practical significance for quality improvement and regulation of G. biloba. In this study, we performed RNA-Seq on the root (R), stem (S), immature leaf (IL), mature leaf (ML), microstrobilus (M), ovulate strobilus (OS), immature fruit (IF), and mature fruit (MF) of G. biloba. The TTL regulatory network of G. biloba in different organs was revealed by different transcriptomic analysis strategies. Weighted gene co-expression network analysis (WGCNA) revealed that the five modules were closely correlated with organs. The 12 transcription factors, 5 structural genes, and 24 CYP450 were identified as candidate regulators for TTL accumulation by WGCNA and cytoscape visualization. Finally, 6 AP2/ERFs, 2 CYP450s, and bHLH were inferred to regulate the metabolism of TTLs by correlation analysis. This study is the comprehensive to authenticate transcription factors, structural genes, and CYP450 involved in TTL biosynthesis, thereby providing molecular evidence for revealing the comprehensive regulatory network involved in TTL metabolism in G. biloba.
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http://dx.doi.org/10.1093/treephys/tpac051DOI Listing
May 2022

A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice.

Nat Neurosci 2022 May 2;25(5):646-658. Epub 2022 May 2.

Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.

Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors, including feeding, but less is known about how these circuits may interact. In this study, we found that DA neurons in the mouse ventral tegmental area bidirectionally regulate the activity of 5-HT neurons in the dorsal raphe nucleus (DRN), with weaker stimulation causing DRD2-dependent inhibition and overeating, while stronger stimulation causing DRD1-dependent activation and anorexia. Furthermore, in the activity-based anorexia (ABA) paradigm, which is a mouse model mimicking some clinical features of human anorexia nervosa (AN), we observed a DRD2 to DRD1 shift of DA neurotransmission on 5-HT neurons, which causes constant activation of these neurons and contributes to AN-like behaviors. Finally, we found that systemic administration of a DRD1 antagonist can prevent anorexia and weight loss in ABA. Our results revealed regulation of feeding behavior by stimulation strength-dependent interactions between DA and 5-HT neurons, which may contribute to the pathophysiology of AN.
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http://dx.doi.org/10.1038/s41593-022-01062-0DOI Listing
May 2022

Neuron-specific enolase promotes stem cell-like characteristics of small-cell lung cancer by downregulating NBL1 and activating the BMP2/Smad/ID1 pathway.

Oncogenesis 2022 Apr 29;11(1):21. Epub 2022 Apr 29.

Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, 510180, Guangzhou, Guangdong, China.

Little is known about the biological functions of neuron-specific enolase (NSE) as a specific biomarker for small-cell lung cancer (SCLC). Herein, we elucidate the effect and mechanism of NSE on SCLC stem cell-like characteristics. Upregulated NSE expression was observed in spheroid cells. The gain-of-function and loss-of-function approaches demonstrated that modulation of NSE positively regulated cell proliferation, drug resistance, spherical clone formation, tumor growth, and stem cell-like characteristics of SCLC cells. Mechanistic studies revealed that NSE might downregulate the expression of neuroblastoma suppressor of tumorigenicity 1 (NBL1) by interacting with NBL1, thereby attenuating the competitive inhibitory effect of NBL1 on BMP2 and enhancing the interaction between BMP2 and BMPR1A; this, in turn, may activate the BMP2/Smad/ID1 pathway and promote SCLC stem cell-like characteristics. Moreover, overexpression of NBL1or knockdown of BMP2 rescued the NSE-induced stem cell-like characteristics. In clinical specimens, NSE expression was positively associated with ALDH1A1 expression and negatively correlated with NBL1 expression. High NSE and ALDH1A1 expressions and low NBL1 expression were correlated with poor prognosis in patients with SCLC. In summary, our study demonstrated that NSE promoted stem cell-like characteristics of SCLC via NBL1 and the activation of the BMP2/Smad/ID1 pathway.
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http://dx.doi.org/10.1038/s41389-022-00396-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9054797PMC
April 2022

Generation and Characterization of the Charge-Transferred Diradical Complex CaCO with an Open-Shell Singlet Ground State.

J Am Chem Soc 2022 May 28;144(18):8355-8361. Epub 2022 Apr 28.

Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse 4, D-35043 Marburg, Germany.

The CaCO complex is generated via the reaction of excited-state calcium atom with carbon dioxide in a solid neon matrix. Infrared absorption spectroscopy and quantum chemical calculations reveal that the complex has a planar four-membered ring structure with a strongly bent CO ligand side-on coordinated to the calcium center in an ηO, O manner. The complex has an open-shell singlet ground state, which can be described as the bonding interactions between a Ca (4s) cation in the doublet ground state and a doublet ground state CO anion. The analysis of the bonding situation suggests that the Ca-OC bonds have a large (75%) electrostatic character. The covalent (orbital) interactions come from the coupling of the unpaired electrons of Ca and CO giving rise to electron-sharing bonding and a stronger contribution from dative bonding (Ca)←(CO). The atomic orbitals (AOs) of Ca that are engaged in the covalent bonds are the 4s AO for the electron-sharing bonds and the 3d AOs for the dative bonds. This is further evidence for the assignment of the heavier alkaline-earth atoms as transition metals rather than main-group elements.
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http://dx.doi.org/10.1021/jacs.2c02768DOI Listing
May 2022

Catechin or quercetin guests in an intrinsically microporous polyamine (PIM-EA-TB) host: accumulation, reactivity, and release.

RSC Adv 2021 Aug 12;11(44):27432-27442. Epub 2021 Aug 12.

Department of Chemistry, University of Bath Claverton Down Bath BA2 7AY UK

Microporous polymer materials based on molecularly "stiff" structures provide intrinsic microporosity, typical micropore sizes of 0.5 nm to 1.5 nm, and the ability to bind guest species. The polyamine PIM-EA-TB contains abundant tertiary amine sites to interact hydrogen bonding to guest species in micropores. Here, quercetin and catechin are demonstrated to bind and accumulate into PIM-EA-TB. Voltammetric data suggest apparent Langmuirian binding constants for catechin of 550 (±50) × 10 M in acidic solution at pH 2 (PIM-EA-TB is protonated) and 130 (±13) × 10 M in neutral solution at pH 6 (PIM-EA-TB is not protonated). The binding capacity is typically 1 : 1 (guest : host polymer repeat unit), but higher loadings are readily achieved by host/guest co-deposition from tetrahydrofuran solution. In the rigid polymer environment, bound -quinol guest species exhibit 2-electron 2-proton redox transformation to the corresponding quinones, but only in a thin mono-layer film close to the electrode surface. Release of guest molecules occurs depending on the level of loading and on the type of guest either spontaneously or with electrochemical stimuli.
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http://dx.doi.org/10.1039/d1ra04543aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037788PMC
August 2021

The blooming of an old story on the bouquet.

Biol Reprod 2022 Apr 26. Epub 2022 Apr 26.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

As an evolutionarily conserved process, the bouquet stage during meiosis was discovered over a century ago, and active research on this important stage continues. Since the discovery of the first bouquet-related protein Taz1p in 1998, several bouquet formation-related proteins have been identified in various eukaryotes. These proteins are involved in the interaction between telomeres and the inner nuclear membrane (INM), and once these interactions are disrupted, meiotic progression is arrested, leading to infertility. Recent studies have provided significant insights into the relationships and interactions among bouquet formation-related proteins. In this review, we summarize the components involved in telomere-INM interactions and focus on their roles in bouquet formation and telomere homeostasis maintenance. In addition, we examined bouquet-related proteins in different species from an evolutionary viewpoint, highlighting the potential interactions among them.
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http://dx.doi.org/10.1093/biolre/ioac075DOI Listing
April 2022

Percutaneous coronary intervention in insulin-treated diabetic patients: A meta-analysis.

Ann Noninvasive Electrocardiol 2022 Apr 25:e12953. Epub 2022 Apr 25.

Department of General Practice, Jinshan Hospital of Fudan University, Shanghai, China.

Background: This meta-analysis of randomized controlled trials (RCTs) compared long-term adverse clinical outcomes of percutaneous coronary intervention (PCI) in insulin-treated diabetes mellitus (ITDM) and non-ITDM patients.

Methods: This is a meta-analysis study. The PubMed and Embase databases were searched for articles on long-term adverse clinical outcomes of PCI in ITDM and non-ITDM patients. The risk ratios (RR) and 95% confidence intervals (CI) were calculated.

Results: A total of 11 related RCTs involving 8853 DM patients were included. Compared with non-ITDM patients, ITDM patients had significantly higher all-cause mortality (ACM) (RR = 1.52, 95% CI: 1.25-1.85, p  = .689, I  = 0%), major adverse cardiac and cerebrovascular events (MACCE) (RR = 1.35, 95% CI: 1.18-1.55, p  = .57, I  = 0%), myocardial infarction (MI) (RR = 1.41, 95% CI: 1.16-1.72, p  = .962, I  = 0%), and stent thrombosis (ST) (RR = 1.75, 95% CI: 1.23-2.48, p  = .159, I  = 32.4%). No significant difference was found in the target lesion revascularization (TLR) and target vessel revascularization (TVR) between the ITDM and non-ITDM groups.

Conclusions: The results showed that ITDM patients had significantly higher ACM, MACCE, MI, and ST, compared with non-ITDM patients.
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http://dx.doi.org/10.1111/anec.12953DOI Listing
April 2022

Effects of g-CN Heterogenization into Intrinsically Microporous Polymers on the Photocatalytic Generation of Hydrogen Peroxide.

ACS Appl Mater Interfaces 2022 May 24;14(17):19938-19948. Epub 2022 Apr 24.

Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.

Graphitic carbon nitride (g-CN) is known to photogenerate hydrogen peroxide in the presence of hole quenchers in aqueous environments. Here, the g-CN photocatalyst is embedded into a host polymer of intrinsic microporosity (PIM-1) to provide recoverable heterogenized photocatalysts without loss of activity. Different types of g-CN (including [email protected], [email protected], and [email protected]) and different quenchers are investigated. Exploratory experiments yield data that suggest binding of the quencher either (i) directly by adsorption onto the g-CN (as shown for α-glucose) or (ii) indirectly by absorption into the microporous polymer host environment (as shown for Triton X-100) enhances the overall photochemical HO production process. The amphiphilic molecule Triton X-100 is shown to interact only weakly with g-CN but strongly with PIM-1, resulting in accumulation and enhanced HO production due to the microporous polymer host.
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http://dx.doi.org/10.1021/acsami.1c23960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9073839PMC
May 2022

Spectroscopic characterization and photochemistry of the Criegee intermediate CFC(H)OO.

J Environ Sci (China) 2022 Apr 14;114:160-169. Epub 2022 Jan 14.

Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysts and Innovative Materials, Fudan University, Shanghai 200433, China. Electronic address:

Criegee intermediates (CIs), also known as carbonyl oxide, are reactive intermediates that play an important role in the atmospheric chemistry. Investigation on the structures and reactivity of CIs is of fundamental importance in understanding the underlying mechanism of their atmospheric reactions. In sharp contrast to the intensively studied parent molecule (CHOO) and the alkyl-substituted derivatives, the knowledge about the fluorinated analogue CFC(H)OO is scarce. By carefully heating the triplet carbene CFCH in an O-doped Ar-matrix to 35 K, the elusive carbonyl oxide CFC(H)OO in syn- and anti-conformations has been generated and characterized with infrared (IR) and ultraviolet-visible (UV-vis) spectroscopy. The spectroscopic identification is supported by O-labeling experiments and quantum chemical calculations at the B3LYP/6-311++G(3df,3pd) and MP2/6-311++G(2d,2p) levels. Upon the long-wavelength irradiation (λ > 680 nm), both conformers of CFC(H)OO decompose to give trifluoroacetaldehyde CFC(H)O and simultaneously rearrange to the isomeric dioxirane, cyclic-CFCH(OO), which undergoes isomerization to the lowest-energy carboxylic acid CFC(O)OH upon UV-light excitation at 365 nm. The O-oxidation of CFCH via the intermediacy of CFC(H)OO and cyclic-CFCH(OO) might provide new insight into the mechanism for the degradation of hydro-chlorofluorocarbon CFCHCl (HCFC-123) in the atmosphere.
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http://dx.doi.org/10.1016/j.jes.2021.08.018DOI Listing
April 2022

Insights into Recent Studies on Biotransformation and Pharmacological Activities of Ginsenoside Rd.

Biomolecules 2022 03 28;12(4). Epub 2022 Mar 28.

Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, 229 Taibai North Road, Xi'an 710069, China.

It is well known that ginsenosides-major bioactive constituents of Panax ginseng-are attracting more attention due to their beneficial pharmacological activities. Ginsenoside Rd, belonging to protopanaxadiol (PPD)-type ginsenosides, exhibits diverse and powerful pharmacological activities. In recent decades, nearly 300 studies on the pharmacological activities of Rd-as a potential treatment for a variety of diseases-have been published. However, no specific, comprehensive reviews have been documented to date. The present review not only summarizes the in vitro and in vivo studies on the health benefits of Rd, including anti-cancer, anti-diabetic, anti-inflammatory, neuroprotective, cardioprotective, ischemic stroke, immunoregulation, and other pharmacological effects, it also delves into the inclusion of potential molecular mechanisms, providing an overview of future prospects for the use of Rd in the treatment of chronic metabolic diseases and neurodegenerative disorders. Although biotransformation, pharmacokinetics, and clinical studies of Rd have also been reviewed, clinical trial data of Rd are limited; the only data available are for its treatment of acute ischemic stroke. Therefore, clinical evidence of Rd should be considered in future studies.
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http://dx.doi.org/10.3390/biom12040512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9031344PMC
March 2022

Prognostic value of radial peripapillary capillary density for visual field outcomes in pituitary adenoma: A case-control study.

J Clin Neurosci 2022 Jun 18;100:113-119. Epub 2022 Apr 18.

Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, 8 Chongwenmen Nei Dajie, Dongcheng District, Beijing 100005, China; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing 100041, China. Electronic address:

Pituitary adenomas are known to cause optic chiasmal compression leading to visual field (VF) defects. Herein, we analysed the factors influencing early VF recovery following transsphenoidal surgery and explored the significance of retinal vessel density parameters in predicting prognoses. We collected data of 50 patients with pituitary adenoma and an abnormal VF prior to surgery. Patients were categorised into VF recovery (n = 25) and non-recovery (n = 25) groups within 1 week postoperatively. The VF, optic chiasm form, tumour volume, retinal thickness, and vessel density parameters were measured. The χ test was used for single-factor analyses, and odds ratios (ORs) for each factor were calculated. Logistic regression was implemented to determine interactions between radial peripapillary capillary (RPC) density and other factors. Tumour volume (≥5 cm, OR = 5.09), duration of visual symptoms (≥6 months, OR = 6.00), preoperative VF (mean deviation [MD] < -10 dB, OR = 6.77), thin retinal nerve fibre layer (OR = 9.04), ganglion cell layer complex thickness (OR = 7.67), and RPC density (whole ≤ 48%; OR = 15.58; temporal ≤ 49.3%; OR = 14.64) were found to be risk factors for postoperative VF recovery. After adjusting for these factors, RPC density was a dependent factor affecting VF recovery in patients with pituitary adenoma. RPC density seemed to be a stronger indicator than preoperative MD, tumour volume, duration of visual symptoms, or retinal thickness for predicting early VF recovery following optic chiasm decompression, thus helping surgeons determine the optimal timing of surgery and formulate effective treatment plans.
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http://dx.doi.org/10.1016/j.jocn.2022.04.012DOI Listing
June 2022

[Pathogenic genes and corresponding ciliary defects associated with primary ciliary dyskinesia].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2022 Apr;39(4):433-437

Respiratory Medicine Department, Beijing Children' s Hospital, Capital Medical University, National Clinical Research Center of Respiratory Diseases, National Center for Children' s Health, Beijing 100045, China.

Primary ciliary dyskinesia (PCD) is a recessive genetic disorder of motile cilia with substantial genetic and phenotypic heterogeneity. Clinical features of PCD vary from one patient to another, and no single test has the sensitivity and specificity to accurately diagnose PCD. Genetic testing combined with other auxiliary tests can facilitate the confirmatory diagnosis of PCD. So far more than 40 genes have been associated with PCD, but most research have focused on common genes, which hinders our understanding of other rare PCD-genes. This review has summarized the PCD-associated genes and the corresponding characteristics of dysfunctional cilia, with an aim to provide a basis for early identification of such diseases.
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http://dx.doi.org/10.3760/cma.j.cn511374-20201222-00898DOI Listing
April 2022

Effectiveness and safety of blonanserin for improving social and cognitive functions in patients with first-episode schizophrenia: a study protocol for a prospective, multicentre, single-arm clinical trial.

BMJ Open 2022 04 20;12(4):e054079. Epub 2022 Apr 20.

Department of Clinical Research, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China

Introduction: Both the pharmacological characteristics of blonanserin and its related small sample size studies suggest that blonanserin could alleviate social and cognitive dysfunctions in patients with schizophrenia. However, no large sample size studies have been performed so far. This study aimed to investigate the effectiveness and safety of blonanserin in improving social and cognitive functions in patients with first-episode schizophrenia.

Methods And Analysis: This is a prospective, multicentre, single-arm clinical trial. A total of 188 patients with first-episode schizophrenia will be enrolled and will undergo a 0-7 day washout period before blonanserin administration. Doses of blonanserin will first be set to 4 mg P.O. twice per day after meals and gradually increased to 8-16 mg/d P.O., depending on patient's age and symptoms, for 26 weeks. Maximum dose of blonanserin will not be exceeding 24 mg/day. The primary endpoint of the study is the changes of Personal and Social Performance (PSP) score in patients from baseline to week 26. Secondary endpoints include changes in MATRICS consensus cognitive battery (MCCB), Paced Auditory Serial Addition Test (PASAT), grooved pegboard test (GPT), Positive and Negative Syndrome Scale (PANSS) total score and PANSS 5-factor subscale scores. Other endpoints include changes of serum brain-derived neurotrophic factor (BDNF) at corresponding visits and MRI results. Moreover, incidence of adverse events, changes in endocrine and metabolic profiles, renal, hepatic and sexual functions and extrapyramidal symptoms will be strictly monitored and recorded.

Ethics And Dissemination: The study was approved by the ethics committee of the leading site Peking University Sixth Hospital (No. 2018-18), and all included patients are requested to provide written informed consent before enrolment. The study will be conducted according to the principles of the Declaration of Helsinki and follow the principles for clinical research.

Trial Registration Number: NCT03784222.
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http://dx.doi.org/10.1136/bmjopen-2021-054079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021809PMC
April 2022

Pinning Stabilizer Design for Probabilistic Boolean Control Networks via Condensation Digraph.

IEEE Trans Neural Netw Learn Syst 2022 Apr 19;PP. Epub 2022 Apr 19.

This article investigates the design of pinning controllers for state feedback stabilization of probabilistic Boolean control networks (PBCNs), based on the condensation digraph method. First, two effective algorithms are presented to achieve state feedback stabilization of the considered system from the perspective of condensation digraph. One is to find the desired matrix, and the other is to search for the minimum number of pinned nodes and specific pinned nodes. Then, all the mode-independent pinning controllers can be designed based on the desired matrix and pinned nodes. Several examples are delineated to illustrate the validity of the main results.
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http://dx.doi.org/10.1109/TNNLS.2022.3164909DOI Listing
April 2022

Strain Modulation for Light-Stable n-i-p Perovskite/Silicon Tandem Solar Cells.

Adv Mater 2022 Apr 18:e2201315. Epub 2022 Apr 18.

Experimental Center of Advanced Materials, School of Materials Science and Engineering, Beijing Institute of Technology, Beijing, 100081, China.

Perovskite/silicon tandem solar cells are promising to penetrate photovoltaic market. However, the wide-bandgap perovskite absorbers used in top-cell often suffer severe phase segregation under illumination, which restricts the operation lifetime of tandem solar cells. Here, a strain modulation strategy to fabricate light-stable perovskite/silicon tandem solar cells is reported. By employing adenosine triphosphate, the residual tensile strain in the wide-bandgap perovskite absorber is successfully converted to compressive strain, which mitigates light-induced ion migration and phase segregation. Based on the wide-bandgap perovskite with compressive strain, single-junction solar cells with the n-i-p layout yield a power conversion efficiency (PCE) of 20.53% with the smallest voltage deficits of 440 mV. These cells also maintain 83.60% of initial PCE after 2500 h operation at the maximum power point. Finally, these top cells are integrated with silicon bottom cells in a monolithic tandem device, which achieves a PCE of 26.95% and improved light stability at open-circuit.
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http://dx.doi.org/10.1002/adma.202201315DOI Listing
April 2022

Observation of macrophage autophagy in the healing of diabetic ulcers a lysosome-targeting polarity-specific two-photon probe.

RSC Adv 2022 Jan 27;12(6):3654-3661. Epub 2022 Jan 27.

Jiangsu Sevencontinent Green Chemical Co., Ltd. Zhangjiagang 215600 China

As a disease with high incidence, mutilation, and fatality rates, diabetic ulcers (DUs) have become a difficult and complicated disease of widely concern in recent years due to the unclear healing mechanism. The main reason for the delayed healing in DU patients is the unduly long chronic inflammation window, and the polarization state of macrophages plays a key role in this process. Since autophagy is believed to be closely related to the polarization trend of macrophages, recent studies have shown that autophagy is closely related to the healing of DU. To this end, a lysosome-targeting polarity-sensitive probe, XZTU-VIS, was developed to monitor the changes in lysosomal polarity, thereby assessing the autophagy of macrophages in mice suffering from DU. The experimental results showed that under two-photon fluorescence microscopy, the green channel fluorescence signal of XZTU-VIS decreased significantly during autophagy. In the meantime, DU models established using BV-2 cells and mice showed a process that could cause inflammation and the release of ROS, thereby inducing autophagy.
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http://dx.doi.org/10.1039/d1ra08417hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8979232PMC
January 2022

Proposed protocol for the investigation of the safety and efficacy of the COVID-19 vaccine for patients with psychosis, with pilot safety findings from a Chinese psychiatrist's self-experiment.

Am J Transl Res 2022 15;14(3):2063-2072. Epub 2022 Mar 15.

Key Laboratory of Real Time Tracing of Brain Circuit of Neurology and Psychiatry (RTBNP_Lab), Tianjin Medical University Affiliated Tianjin Fourth Center Hospital, The Fourth Central Hospital Affiliated to Nankai University, Tianjin Fourth Center Hospital Tianjin 300140, China.

We present a study protocol designed to test the safety and efficacy of the 2019 coronavirus disease (COVID-19) vaccine in patients with major psychotic disease. A secondary objective is to investigate optional vaccination methods for these patients. In a self-experiment, a Chinese psychiatrist examined the safety and efficacy of the COVID-19 vaccine under clinical use of typical antipsychotic agents and sedatives (olanzapine, duloxetine, and diazepam). For patients with extremely drug-resistant conditions, the safety of the COVID-19 vaccine under electroconvulsive therapy was also investigated. The entire study process was recorded on high-definition video. This clinical study protocol is, to our knowledge, the first of its kind. Our findings will shed new light on the protection of patients with psychotic diseases from COVID-19 infection. The protocol was registered at Chinese clinical trial registry (www.chictr.org.cn, ChiCTR2100051297).
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8991108PMC
March 2022

Circulating Vitamin D Levels and the Risk of Atrial Fibrillation: A Two-Sample Mendelian Randomization Study.

Front Nutr 2022 28;9:837207. Epub 2022 Mar 28.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, China.

Aim: We performed a two-sample Mendelian randomization (MR) analysis to evaluate the association between serum vitamin D levels and atrial fibrillation (AF) risks.

Methods: Data on the single-nucleotide polymorphisms (SNPs) related to vitamin D, 25-hydroxyvitamin D, and AF outcome were obtained from a UK Biobank study, SUNLIGHT consortium, and the latest meta-analysis of genome-wide association studies GWASs with six independent cohorts, respectively. MR analysis was performed to obtain the estimates, followed by the use of inverse variance weighted (IVW) method, weighted median method, maximum likelihood, MR-egger method, and MR-PRESSO methods.

Results: The IVW estimate showed that genetically predicted vitamin D and 25-hydroxyvitamin D levels were not causally associated with the risk of AF with two models. The association was consistent in complementary analyses.

Conclusions: Our MR finding suggested that no genetic evidence of serum vitamin D levels was significantly associated with AF risk. Further researches are necessary to explore the potential role and mechanisms of circulating serum vitamin D levels on AF.
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http://dx.doi.org/10.3389/fnut.2022.837207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8996811PMC
March 2022

Methodology of Measuring Motoric Cognitive Risk Syndrome-Focusing on Slow Gait Speed: Protocol for a Systematic Review.

Front Psychiatry 2022 23;13:858950. Epub 2022 Mar 23.

School of Medicine, Huzhou University, Huzhou, China.

Introduction: Older adults with motoric cognitive risk (MCR) syndrome are at high risk of developing dementia. Although the definition of MCR is well recognized and consensus, previous studies did not reach an agreement on diagnostic criteria and measurement methods/tools for slow gait speed, which is one of four components of MCR diagnosis. The substantial heterogeneity in the methodology of slow gait speed diagnosis for MCR limits comparability and meta-analysis of studies.

Objective: The study aims to conduct systematic and standardized integration for diagnostic criteria and methods of slow gait speed diagnosis for MCR based on previous evidence that may improve comparability between future studies.

Methods: A systematic literature review will be undertaken by searching the following electronic databases (until February 1, 2022): PUBMED, EMBASE, The Cochrane Library, Web of Science. Additional studies will be identified by checking the reference lists of included studies or relevant reviews, manually searching the internet search engine Google Scholar, and searching the authors' personal files, if necessary. Two researchers will perform data extraction independently, and discrepancies will be resolved by discussion, which will include a third researcher if requires. The paper selection will perform in duplicate. Finally, a narrative account will synthesize the findings to answer the objectives of this review.

Discussion: This is the first study on systematic and standardized integration for diagnostic criteria and measurement methods/tools for slow gait speed in diagnosing MCR. The findings of this study will be convenient for medical staff to examine the intended use and applicability of each instrument/tool for evaluating the gait speed, and provide insight into developing uniform guidelines for MCR.

Systematic Review Registration: PROSPERO registration number: CRD42021232671.
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http://dx.doi.org/10.3389/fpsyt.2022.858950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8995464PMC
March 2022

Inhibitory effects of estrogenic endocrine disrupting chemicals on fin regeneration in zebrafish are dependent on estrogen receptors.

Aquat Toxicol 2022 Jun 5;247:106156. Epub 2022 Apr 5.

College of Environment, Zhejiang University of Technology, Hangzhou 310032, PR China. Electronic address:

For fish and other aquatic organisms, disrupting their capacity for repair and regeneration will reduce their quality of life and survivorship in the wild. Studies have shown that 17α-ethinylestradiol (EE2), a synthetic estrogenic endocrine disrupting chemical (EEDC), can inhibit caudal fin regeneration in larval zebrafish following fin amputation. However, whether the inhibitory effects of EE2 are dependent on estrogen receptor (ER) remains unknown. Therefore, in this study, amputated zebrafish larvae were exposed to the ER agonist EE2 alone and in combination with the ER antagonist ICI 182,780 (ICI), and the change in regenerative capacity was determined. The inhibition of fin regeneration caused by EE2 alone (100 ng/L) was ameliorated after combination with ICI (30-300 μg/L), and these changes in regeneration-related signaling and the immune system corresponded with morphological observations, implying that the effects of EE2 on regeneration were possibly initiated by the activation of ER. Furthermore, the role of ER was confirmed with a natural ligand of ER, namely, 17β-estradiol (E2), and as expected, the effects of E2 (10, 100 and 1000 ng/L) paralleled those of EE2. In conclusion, EEDCs can disrupt the regenerative capacity in zebrafish, possibly due to the binding and activation of ERs and the consequent alteration of signaling pathways that regulate fin regeneration and immune competence. Given that EEDCs appear to be ubiquitous in the aquatic environment, the risk of these chemicals might be readdressed regarding their potential effects on tissue repair and regeneration.
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http://dx.doi.org/10.1016/j.aquatox.2022.106156DOI Listing
June 2022
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