Publications by authors named "Lin-Hua Zhang"

23Publications

CRISPR/Cas9 Editing: Sparking Discussion on Safety in Light of the Need for New Therapeutics.

Hum Gene Ther 2020 Aug 24;31(15-16):794-807. Epub 2020 Jul 24.

Faculty of Pharmaceutical Sciences; University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1089/hum.2020.111DOI Listing
August 2020

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.

Arterioscler Thromb Vasc Biol 2017 11 7;37(11):2147-2155. Epub 2017 Sep 7.

From the Translational Laboratory in Genetic Medicine, A*STAR Institute, and Yong Loo Lin School of Medicine, National University of Singapore (L.T.-M., D.C., E.C.C., L.J.T., D.H.W., G.K.Y., M.R.H., R.R.S.); Departments of Vascular Medicine and Experimental Vascular Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands (J.C.v.C., A.W.M.S., G.M.D.-T., G.K.H.); Faculty of Health Sciences, Simon Fraser University, Canada (I.T.); Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (F.T., P.N., M.R.W.); Centre for Molecular Medicine and Therapeutics and Child and Family Research Institute, University of British Columbia, Canada (L.-H.Z., M.K., M.R.H.); Department of Pediatrics, University Medical Center Groningen, University of Groningen, The Netherlands (L.G.D., U.J.F.T.); Xenon Pharmaceuticals, Burnaby, Canada (I.T., C.R.); Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore (C.H.T., V.A.); Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Austria (F.D., J.B.); Beaulieu-Saucier Université de Montréal Pharmacogenomics Centre, Canada (A.B., M.-P.D.); Montréal Heart Institute Research Centre, Canada (A.B., M.-P.D.); and Université de Montréal, Canada (A.B., M.-P.D.).

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http://dx.doi.org/10.1161/ATVBAHA.117.309574DOI Listing
November 2017

Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction.

Mol Genet Metab 2017 04 6;120(4):337-341. Epub 2017 Feb 6.

Department of Pediatrics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada; Department of Pediatrics, Emma Children's Hospital, Academic Medical Centre, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ymgme.2017.02.003DOI Listing
April 2017

Exome Sequencing and the Management of Neurometabolic Disorders.

N Engl J Med 2016 Jun 25;374(23):2246-55. Epub 2016 May 25.

From the Centre for Molecular Medicine and Therapeutics (M.T.-G., C. Shyr, X.C.Y., L.-H.Z., J.J.Y.L., B.I.D., I.G., W.W.W., C.D.K.), the Departments of Medical Genetics (M.T.-G., C. Shyr, C.J.R., X.C.Y., J.J.Y.L., L.A., J.M.F., S.L., M.M., M.I.V.A., A.M.L., W.W.W.), Pediatrics (C.J.R., G.A.H., R.S., L.-H.Z., A.P.B., B.I.D., M.B.C., M.D., T.D., J.D., A. Michoulas, D.M., J.R., K.R.S., K.S., S.E.T., John Wu, S.S.-I., C.D.K.), and Pathology and Laboratory Medicine (B.R., P.E., H.V., G.S.), the Child and Family Research Institute (M.T.-G., C. Shyr, C.J.R., G.A.H., X.C.Y., A.P.B., J.J.Y.L., B.I.D., L.A., M.B.C., M.D., J.D., J.M.F., I.G., S.L., M.M., D.M., J.R., K.R.S., K.S., S.E.T., M.I.V.A., John Wu, P.E., A.M.L., H.V., S.S.-I., G.S., W.W.W., C.D.K.), and the Division of Endocrinology, Adult Metabolic Diseases Clinic (A. Mattman, S. Sirrs), University of British Columbia, and the Divisions of Biochemical Diseases (G.A.H., R.S., B.S., S.S.-I., C.D.K.), Pediatric Neurology (M.B.C., M.D., A. Michoulas, K.S.), Pediatric Nephrology (J.D.), Pediatric Endocrinology (D.M.), and Immunology (S.E.T.) and the Division of Hematology, Oncology and Transplantation, Michael Cuccione Childhood Cancer Research Program (J.R., K.R.S., John Wu), BC Children's Hospital, Vancouver, the Department of Pathology and Laboratory Medicine, Hospital for Sick Children, University of Toronto, Toronto (J.C.), the Department of Biological and Computing Sciences, University of Alberta (R.M., D.W.), and the National Institute for Nanotechnology (D.W.), Edmonton, AB, and the Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC (M. Abdelsayed, P.R.) - all in Canada; the Division of Genetics, Department of Pediatrics, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia (M. Alfadhel); the Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich (M.R.B., P.B.), and the Departmen

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http://dx.doi.org/10.1056/NEJMoa1515792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983272PMC
June 2016

Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood.

Am J Hum Genet 2014 Mar 13;94(3):453-61. Epub 2014 Feb 13.

Division of Biochemical Diseases, BC Children's Hospital, University of British Columbia, Vancouver, BC V6H 3V4, Canada; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC V6H 3V4, Canada; Treatable Intellectual Disability Endeavour in British Columbia, BC Children's Hospital, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1016/j.ajhg.2014.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951944PMC
March 2014

Regulation of ABCA1 protein expression and function in hepatic and pancreatic islet cells by miR-145.

Arterioscler Thromb Vasc Biol 2013 Dec 17;33(12):2724-32. Epub 2013 Oct 17.

From the Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1161/ATVBAHA.113.302004DOI Listing
December 2013

miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.

Diabetes 2012 Mar 7;61(3):653-8. Epub 2012 Feb 7.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db11-09
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http://dx.doi.org/10.2337/db11-0944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282802PMC
March 2012

Anti-DNA antibody modified coronary stent for plasmid gene delivery: results obtained from a porcine coronary stent model.

J Gene Med 2011 Jan 17;13(1):37-45. Epub 2010 Dec 17.

Tianjin Key Laboratory of Biomaterials, Institute of Biomedical Engineering, Peking Union Medical College & Chinese Academy of Medical Sciences, Tianjin, China.

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http://doi.wiley.com/10.1002/jgm.1529
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http://dx.doi.org/10.1002/jgm.1529DOI Listing
January 2011

Pioglitazone increases apolipoprotein A-I production by directly enhancing PPRE-dependent transcription in HepG2 cells.

J Lipid Res 2010 Aug 6;51(8):2211-22. Epub 2010 Apr 6.

Atherosclerosis Research Center, Veterans Affairs Healthcare System, Long Beach, CA 90822, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M004481
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http://dx.doi.org/10.1194/jlr.M004481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903821PMC
August 2010

Niacin inhibits surface expression of ATP synthase beta chain in HepG2 cells: implications for raising HDL.

J Lipid Res 2008 Jun 3;49(6):1195-201. Epub 2008 Mar 3.

Atherosclerosis Research Center, Veterans Administration Healthcare System, Long Beach, CA, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M700426-JLR200
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http://dx.doi.org/10.1194/jlr.M700426-JLR200DOI Listing
June 2008

[Animal study of intravascular gene therapy based on polyurethane implantable devices].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006 Oct;28(5):682-5

Tianjin Biomedical Material Key Laboratory, Institute of Biomedical Engineering, CAMS and PUMC, Tianjin 300192, China.

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October 2006

[Application of monoclonal antibody immobilized polyurethane film for site-specific gene therapy].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006 Jun;28(3):350-4

Tianjin Key Laboratory of Biomaterial Research, Laboratory of Drug Controlled Release, Institute of Biomedical Engineering, CAMS and PUMC, Tianjin 300192, China.

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June 2006

Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux.

J Biol Chem 2002 Nov 23;277(44):41835-42. Epub 2002 Aug 23.

Center for Molecular Medicine and Therapeutics, Department of Medical Genetics and Children's and Women's Hospital, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1074/jbc.M204923200DOI Listing
November 2002