Publications by authors named "Lin Tian"

605 Publications

Local photothermal and photoelectric effect synergistically boost hollow CeO/CoS heterostructure electrocatalytic oxygen evolution reaction.

J Colloid Interface Sci 2022 Jul 22;628(Pt A):663-672. Epub 2022 Jul 22.

School of Materials and Chemical Engineering, Xuzhou University of Technology, Xuzhou 221018, China; University and College Key Lab of Natural Product Chemistry and Application in Xinjiang, School of Chemistry and Environmental Science, Yili Normal University, Yining 835000, China. Electronic address:

Solar-assisted electrocatalytic oxygen evolution reaction (OER) plays a key role in energy conversion and storage technology. Herein, we provide the novel design and synthesis of an advanced category of CeO/CoS heterostructures, which combines the local photothermal effect (LPTE) action of CeO and the photoelectric effect CoS to boost OER. Interestingly, the hollow framework, rich heterointerface, coupled local photothermal effect and photoelectric effect equip CeO/CoS with remarkably excellent electrocatalytic OER performance. As a result, the optimized CeO/CoS-6 only needs an overpotential of 283 mV to reach 10 mA cm as well as a smaller Tafel slop of 33.2 mV dec, outperforming the RuO catalyst (323 mA @ 10 mA cm). Upon combination of experimental data and mechanistic study, it is revealed that the enhanced OER performance is primarily ascribed to the photo-induced local thermal. partly resulting from photoelectric effect, where the photogenerated electron flow from CeO to CoS can photogenerated holes in CeO to boost water oxidation. This work is extremely expected to offer a novel avenue for the rational design and fabrication of outstanding OER electrocatalysts upon LPTE.
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http://dx.doi.org/10.1016/j.jcis.2022.07.125DOI Listing
July 2022

Altered Gut Microbiota in Patients With Peutz-Jeghers Syndrome.

Front Microbiol 2022 13;13:881508. Epub 2022 Jul 13.

Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China.

Background: Peutz-Jeghers syndrome (PJS) is a rare genetic disorder characterized by the development of pigmented spots and gastrointestinal polyps and increased susceptibility to cancers. It remains unknown whether gut microbiota dysbiosis is linked to PJS.

Aim: This study aimed to assess the structure and composition of the gut microbiota, including both bacteria and fungi, in patients with PJS and investigate the relationship between gut microbiota dysbiosis and PJS pathogenesis.

Methods: The bacterial and fungal composition of the fecal microbiota was analyzed in 23 patients with PJS (cases), 17 first-degree asymptomatic relatives (ARs), and 24 healthy controls (HCs) using 16S (MiSeq) and ITS2 (pyrosequencing) sequencing for bacteria and fungi, respectively. Differential analyses of the intestinal flora were performed from the phylum to species level.

Results: Alpha-diversity distributions of bacteria and fungi indicated that the abundance of both taxa differed between PJS cases and controls. However, while the diversity and composition of fecal bacteria in PJS cases were significantly different from those in ARs and HCs, fungal flora was more stable. High-throughput sequencing confirmed the special characteristics and biodiversity of the fecal bacterial and fungal microflora in patients with PJS. They had lower bacterial biodiversity than controls, with a higher frequency of the Proteobacteria phylum, Enterobacteriaceae family, and genus, and a lower frequency of the Firmicutes phylum and the Lachnospiraceae and Ruminococcaceae families. Of fungi, was significantly higher in PJS cases than in controls.

Conclusion: The findings reported here confirm gut microbiota dysbiosis in patients with PJS. This is the first report on the bacterial and fungal microbiota profile of subjects with PJS, which may be meaningful to provide a structural basis for further research on intestinal microecology in PJS.
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http://dx.doi.org/10.3389/fmicb.2022.881508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326469PMC
July 2022

Factors associated with depression in residents in the post-epidemic era.

QJM 2022 Jul 28. Epub 2022 Jul 28.

The affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, Jiangsu, 214151, China.

Objective: To explore the factors associated with depression in residents in the post-epidemic era of COVID-19.

Methods: A multi-stage stratified random sampling method was used to conduct a questionnaire survey among community residents through self-designed questionnaires and self-rating depression scale (SDS). Multivariate logistic regression analysis was performed on the influencing factors of depressive symptoms.

Results: A total of 1993 residues completed the survey of depression status. The incidence of depressive symptoms was 27.04%. The multivariate logistic regression analysis showed that female (OR 6.239, 95% CI: 2.743-10.698), BMI>24 (OR 2.684, 95% CI: 1.059-3.759), and drinking (OR 1.730, 95% CI: 1.480-3.153) were the risk factors for developing depressive symptoms. Married (OR 0.417, 95% CI: 0.240-0.652), monthly income (3001∼5000 yuan, OR 0.624, 95% CI: 0.280-0.756; >5000 yuan, OR 0.348, 95% CI: 0.117-0.625), ordinary residents (OR 0.722, 95% CI: 0.248-0.924) and urban residents (OR 0.655, 95% CI: 0.394-0.829) were the protective factors of depressive symptoms.

Conclusions: Under the post-epidemic era of COVID-19, depressive symptoms among community residents have been decreased, but still need to pay more attention. Gender, BMI, drinking, marriage, monthly income, nature of personnel, and residential area are associated with the incidence of depressive symptoms.
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http://dx.doi.org/10.1093/qjmed/hcac181DOI Listing
July 2022

Analysis of the Artistic Effect of Garden Plant Landscaping in Urban Greening.

Authors:
Lin Tian

Comput Intell Neurosci 2022 15;2022:2430067. Epub 2022 Jul 15.

College of Humanities and Arts, Chongqing University of Science and Technology, Chongqing 401331, China.

At present, China is at an essential stage in the progress of social civilisation. At the same time, China's current economic level is developing rapidly and the level of urbanisation is also increasing. However, the uncontrolled development of urban space and excessive consumption of land resources have led to many urban ecological and environmental problems. As a result, there is an urgent need to improve the urban habitat. Plant landscaping is an important part of the urban environment. In addition, plant landscaping is also a crucial part of the visual arts and plays a key role in the shaping of urban spaces. In the context of the urban construction boom, people are increasingly demanding quality in the urban environment. Spatial scale, as a vital factor influencing the visual effect of planting, is gradually becoming a focus of landscape design. Urban greening based on plant landscape can not only improve the urban ecological environment and enhance people's quality of life but also resolve the contradiction between the demand for urban green space and the continuous reduction of urban greening land. Therefore, plant landscaping is recognised as a key step towards global sustainable development. However, according to current research and application practice, the development of urban greenery is limited and hindered by the value of plant landscaping and its applications. In addition, no comprehensive theoretical system has yet been established at the plant scale. In other words, there are still problems of scale in plant landscaping, such as unreasonable density, disproportion, and unclear hierarchy. Therefore, this paper begins with the definition of plant spatial scale in the city and analyses plant spatial types and scale characteristics from multiple perspectives, so as to establish an overall knowledge of plant landscaping. After that, through a study of the current situation of plant landscaping in cities, a quantitative analysis of the visual scale of plant space in urban squares is carried out to address the issues of plant scale design in this research. The focus of the analysis is on the scale of plants in relation to related elements. Furthermore, this study explores the influence of visual aesthetic scale and psychological scale on planting based on the functional scale of plant elements. Finally, the above quantitative analyses are applied to derive some relative data criteria and to summarise the design strategies for the spatial scale of planting in the city. The findings of this study can provide some guiding suggestions and references for the future construction of urban greenery, thus promoting the orderly development of plant landscaping in cities.
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http://dx.doi.org/10.1155/2022/2430067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9307354PMC
July 2022

Distribution, behavior, and risk assessment of chlorinated paraffins in paddy plants throughout whole growth cycle.

Environ Int 2022 Jul 15;167:107404. Epub 2022 Jul 15.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China. Electronic address:

Paddy plants provide staple food for 3 billion people worldwide. This study explores the environmental fate and behavior of a high-volume production emerging contaminants chlorinated paraffins (CPs) in the paddy ecosystem. Very-short-, short-, medium-, and long-chain CPs (vSCCPs, SCCPs, MCCPs, and LCCPs, respectively) were analyzed in specific tissue of paddy plants at four main growth stages and soils from the Yangtze River Delta, China throughout a full rice growing season. The total CP concentrations in the paddy roots, stalks, leaves, panicles, hulls, rice, and soils ranged from 181 to 1.74 × 10, 21.7-383, 19.6-585, 108-332, 245-470, 59.6-130, and 99.6-400 ng/g dry weight, respectively. The distribution profile indicated the translocation of SCCPs and MCCPs from soils to paddy tissue, highlighting their elevated bioaccumulative potential. The evolution of CP level/mass/pattern during the whole growth cycle suggested atmospheric CPs deposition on leaves and hulls, as well as stalk-rice transfer. CSOIL plant uptake model well predicted the level, distribution pattern, and bioconcentration factors (BCFs) of SCCPs and MCCPs in paddy shoot and recognized the soil-air-shoot pathway as the major contributor. Moreover, risk evaluation indicated that MCCPs intake and subsequent risks dominated the total exposure to CPs via rice ingestion. This is the first report on the occurrence, fate and risk assessment of all CPs classes in paddy ecosystems, and the results underline the potential health effects caused by the in-use MCCPs via rice ingestion.
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http://dx.doi.org/10.1016/j.envint.2022.107404DOI Listing
July 2022

Evaluating the neuropeptide-social cognition link in ageing: the mediating role of basic cognitive skills.

Philos Trans R Soc Lond B Biol Sci 2022 Aug 11;377(1858):20210048. Epub 2022 Jul 11.

Department of Psychology, College of Public Health and Health, University of Florida, Gainesville, FL, USA.

The roles of oxytocin (OT) and arginine-vasopressin (AVP) as crucial modulators of social cognition and related behaviours have been extensively addressed in the literature. The involvement of these neuropeptides in social cognition in ageing, however, and a potential mediating effect of basic cognitive capacities on this link, are not well understood. To fill these research gaps, this study assessed associations of plasma OT and AVP levels with dynamic emotion identification accuracy in generally healthy older men (aged 55-95 years) and probed the underlying roles of crystallized and fluid cognition in these associations. Higher plasma OT levels were associated with lower accuracy in dynamic emotion identification, with this negative relationship fully mediated by cognition. For plasma AVP levels, in contrast, there was no association with dynamic emotion identification accuracy. Integrated within existing theoretical accounts, results from this study advance understanding of the neuropeptide-social cognition link in ageing and support basic cognitive capacities as mediators in this association. This article is part of the theme issue 'Interplays between oxytocin and other neuromodulators in shaping complex social behaviours'.
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http://dx.doi.org/10.1098/rstb.2021.0048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9274329PMC
August 2022

Effects of Different Types of Early Restrictive Fluid Resuscitation on Immune Function and Multiorgan Damage on Hemorrhagic Shock Rat Model in a Hypothermic Environment.

Comput Math Methods Med 2022 6;2022:4982047. Epub 2022 Jul 6.

Department of Anesthesia, General Hospital of Northern Theater Command, Shenyang, China.

Objective: This study was aimed at investigating the effects of different types of fluid restriction fluid resuscitation on the immune dysfunction and organ injury of hemorrhagic shock rats under a hypothermic environment.

Methods: SD rats were divided into sham operation group (SHAM), hemorrhagic shock model group (HS), crystal liquid limited resuscitation group (CRLLR), colloidal liquid limited resuscitation group (COLLR), and nonlimited resuscitation group (NLR); rats in each group were placed in a low-temperature environment of 0-5°C for 30 min, and then, a hemorrhagic shock rat model was prepared. Sodium lactate Ringer's restricted resuscitation solution, hydroxyethyl starch restricted resuscitation solution, and hydroxyethyl starch were used for resuscitation, and hemodynamic examination was performed. The mortality rate, inflammatory factors, oxidative stress factors, and immune function were detected by ELISA. The dysfunction and injury of the intestinal, lung, liver, and kidney were examined by histological methods.

Results: Hemorrhagic shock resulted in decreased immune function and activation of inflammation. Unrestricted fluid infusion further activated the inflammatory response. The crystalloid-restricted fluid infusion performed effectively to regulate inflammatory response, promote antioxidative activity, and reduce the immunosuppressive reaction. Rehydration could regulate the coagulation. The hydroxyethyl starch reduced the expression of platelet glycoproteins Ib and IIb/IIIa and blocked the binding of fibrinogen to activated platelets, thereby inhibiting intrinsic coagulation and platelet adhesion and aggregation. Rats in the CRLLR group showed to relieve the injury of the lung, liver, kidney, and intestine from hemorrhagic shock in low-temperature environment.

Conclusion: The early application of restrictive crystalloid resuscitation in hemorrhagic shock rats in hypothermic environment showed the best therapy results. Early LR-restrictive fluid replacement promotes the balance of inflammatory response and the recovery of immunosuppressive state, resists oxidative stress, stabilizes the balance of coagulation and fibrinolysis, improves coagulation function, and relieves organ injury.
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http://dx.doi.org/10.1155/2022/4982047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9279086PMC
July 2022

Targeting p53-MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trials.

J Hematol Oncol 2022 07 13;15(1):91. Epub 2022 Jul 13.

The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi Tongren International Rehabilitation Hospital, Wuxi, 214151, Jiangsu, China.

p53, encoded by the tumor suppressor gene TP53, is one of the most important tumor suppressor factors in vivo and can be negatively regulated by MDM2 through p53-MDM2 negative feedback loop. Abnormal p53 can be observed in almost all tumors, mainly including p53 mutation and functional inactivation. Blocking MDM2 to restore p53 function is a hotspot in the development of anticancer candidates. Till now, nine MDM2 inhibitors with different structural types have entered clinical trials. However, no MDM2 inhibitor has been approved for clinical application. This review focused on the discovery, structural modification, preclinical and clinical research of the above compounds from the perspective of medicinal chemistry. Based on this, the possible defects in MDM2 inhibitors in clinical development were analyzed to suggest that the multitarget strategy or targeted degradation strategy based on MDM2 has the potential to reduce the dose-dependent hematological toxicity of MDM2 inhibitors and improve their anti-tumor activity, providing certain guidance for the development of agents targeting the p53-MDM2 interaction.
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http://dx.doi.org/10.1186/s13045-022-01314-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277894PMC
July 2022

Age-Related Differences in Amygdala Activation Associated With Face Trustworthiness but No Evidence of Oxytocin Modulation.

Front Psychol 2022 23;13:838642. Epub 2022 Jun 23.

Department of Psychology, University of Florida, Gainesville, FL, United States.

The amygdala has been shown to be responsive to face trustworthiness. While older adults typically give higher face trustworthiness ratings than young adults, a direct link between amygdala response and age-related differences in face trustworthiness evaluation has not yet been confirmed. Additionally, there is a possible modulatory role of the neuropeptide oxytocin in face trustworthiness evaluation, but the results are mixed and effects unexplored in aging. To address these research gaps, young, and older adults were randomly assigned to oxytocin or placebo self-administration a nasal spray before rating faces on trustworthiness while undergoing functional magnetic resonance imaging. There was no overall age-group difference in face trustworthiness ratings, but older compared to young participants gave higher trustworthiness ratings to ambivalently untrustworthy-looking faces. In both age groups, lower face trustworthiness ratings were associated with higher left amygdala activity. A comparable negative linear association was observed in right amygdala but only among young participants. Also, in the right amygdala, lower and higher, compared to moderate, face trustworthiness ratings were associated with greater right amygdala activity (i.e., positive quadratic (U-shaped) association) for both age groups. Neither the behavioral nor the brain effects were modulated by a single dose of intranasal oxytocin administration, however. These results suggest dampened response to faces with lower trustworthiness among older compared to young adults, supporting the notion of reduced sensitivity to cues of untrustworthiness in aging. The findings also extend evidence of an age-related positivity effect to the evaluation of face trustworthiness.
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http://dx.doi.org/10.3389/fpsyg.2022.838642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262048PMC
June 2022

Coal Structure Characteristics in the Northern Qinshui Basin and Their Discrimination Method Based on the Particle Size of Drilling Cuttings.

ACS Omega 2022 Jul 16;7(26):22956-22968. Epub 2022 Jun 16.

Institute of Resources and Environment, Henan Polytechnic University, Jiaozuo 454000, PR China.

Coal structure, including primary coal, cataclastic coal, granulated coal, and mylonitized coal, is one of the key factors controlling coal and gas outburst, and it also determines the efficiency of coalbed methane (CBM) extraction. Therefore, it is significant to identify the characteristics of coal structures and to predict them in advance. In this work, the spatial distribution, mechanical properties, and microscopic morphology of the four coal structures from the No. 3 coal seam of the Xinyuan Mine in the northern part of the Qinshui Basin were investigated through the in situ observation in the roadway, the hardness coefficient () test, and the scanning electron microscope analysis. Moreover, the drilling cuttings from the gas pressure releasing holes were sampled and sieved, and then, the correspondence between different coal structures and the particle size of the cuttings was analyzed quantitatively based on the Rosin-Rammler model. The result shows that the spatial distribution of the coal structure has strong heterogeneity in the vertical and lateral directions. The value decreases successively with the increase in coal structure deformation, which indicate that can directly characterize the coal structure. Furthermore, the relations between and drilling cutting average particle size ( ), crushability indicator (), crushing degree index (λ), and the median diameter ( ) were established. Specifically, the coal deformation degree is positively correlated with the mass fraction of large particles in the cuttings under the same drilling parameters. Overall, as increases, and decrease, and and λ increase. However, parameters , , and λ of granulated coal are inconsistent with other coal structures, and mylonitized coal is inconsistent with other coal structures in , as a result of the coal structure broken characteristics itself and the difference in the stress state between the coal and the drill bit during the rock breaking process. Ultimately, the coal structures determined by the surface CBM well logging curve and the cuttings particle size method were compared, and they have a high degree of coincidence in the distinction between primary coal and tectonic coal.
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http://dx.doi.org/10.1021/acsomega.2c03017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260932PMC
July 2022

Time trends and associated factors of global burden due to drug use disorders in 204 countries and territories, 1990-2019.

Drug Alcohol Depend 2022 Jun 20;238:109542. Epub 2022 Jun 20.

Department of Pharmacy, Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. Electronic address:

Background: Drug use disorders (DUDs) have been a public health crisis which strongly impacted community health and socio-economic development. However, there are few studies based on the latest global data to show changes in the disease burden due to DUDs, specifically investigating associations between the country-level socio-economic factors and the burden of DUDs.

Methods: Data of DUDs were extracted from the Global Burden of Disease Study 2019 database to explore the trends of the disease burden due to DUDs from 1990 to 2019. Univariate linear regression and stepwise multiple linear regression analysis were performed to analyze the correlations between burden due to DUDs and country-level socio-economic factors.

Results: Globally, the number of disability-adjusted life-years (DALYs) caused by DUDs approximately increased by 2.6% yearly from 1990 to 2019, though the age-standardized DALY rate has not changed significantly in the past 30 years. The age-standardized DALY rate of opioid use disorders showed an upward trend during the past 30 years and was highest among 5 types of DUDs in 2019. Inequality-adjusted human development index (β = 15.9, 95% confidence interval [CI]: 12.9-18.9, P < 0.001) was identified as the key risk factor associated with square-root transformed age-standardized DALY rate of DUDs.

Conclusions: Global burden due to DUDs has increased significantly over the past 30 years. More effective targeted public health policies should be formulated to manage the public health challenge of DUDs, especially in developed countries and territories.
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http://dx.doi.org/10.1016/j.drugalcdep.2022.109542DOI Listing
June 2022

Amisulpride steady-state plasma concentration and adverse reactions in patients with schizophrenia: a study based on therapeutic drug monitoring data.

Int Clin Psychopharmacol 2022 Jun 27. Epub 2022 Jun 27.

The Affiliated Wuxi Mental Health Center of JiangNan University, Wuxi Tongren Rehabilitation Hospital, Wuxi, Jiangsu, China.

The aim of the study was to evaluate the reference range of amisulpride for Chinese patients with schizophrenia and to assess its possible influencing factors based on therapeutic drug monitoring information. The relative adverse reactions of patients induced by amisulpride were also systematically investigated. A total of 425 patients with schizophrenia were assessed, including Positive and Negative Syndrome Scales, Treatment Emergent Symptom Scale, blood routine examination, hepatorenal function, lipids, hormones, as well as myocardial enzymes at baseline, and following treatment with amisulpride for 8 weeks. The steady-state plasma concentration of amisulpride was assayed using two-dimensional liquid chromatography. At the same dose, the amisulpride plasma concentration of patients combined with clozapine was higher than that without clozapine. The therapeutic reference range of amisulpride can be defined as 230.3-527.1 ng/ml for Chinese patients with schizophrenia. The potential side effects appear to be associated with significantly increased levels of LDH, CK, creatine kinase isoenzyme (CK-MB), TC and decreased level of E2, relative to the amisulpride plasma concentration. These findings could provide individualized medication and reduce the adverse effects of amisulpride for Chinese patients with schizophrenia.
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http://dx.doi.org/10.1097/YIC.0000000000000420DOI Listing
June 2022

Deposition records of persistent organic pollutants and black carbon in dated sediment cores from China marginal seas: Implications for terrestrial sources and transport processes.

Mar Pollut Bull 2022 Aug 29;181:113874. Epub 2022 Jun 29.

Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Institute of Atmospheric Sciences, Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China.

Black carbon (BC) and persistent organic pollutants (POPs) were analyzed from three sediment cores collected offshore in the East China Marginal Seas. The results showed steadily increasing or stable BC concentrations and fluxes. By contrast, time trends of POPs fluxes were consistent with historical records of commercial production and use in China. Although the POP inventories decreased significantly with increase in offshore distance, the relatively consistent trends for individual POPs in different sea areas confirmed that the main sources are derived from mainland China and that atmospheric input was an important contribution. POPs inventories decreased by 59-91 % during transport from the Yellow Sea to the remote East China Sea and deposition to the sediment. This suggests that the source signal for POPs may be preserved under stable depositional environments, even though only a fraction of those pollutants are buried in open sea sediments.
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http://dx.doi.org/10.1016/j.marpolbul.2022.113874DOI Listing
August 2022

Properties of Basalt Fiber Core Rods and Their Application in Composite Cross Arms of a Power Distribution Network.

Polymers (Basel) 2022 Jun 16;14(12). Epub 2022 Jun 16.

Key Laboratory of Physical and Chemical Analysis for Electric Power of Hainan Province, Hairuihou Street No. 23, Haikou 570100, China.

As basalt fiber has better mechanical properties and stability than glass fiber, cross arms made of continuous basalt-fiber-reinforced epoxy matrix composites are capable of meeting the mechanical requirements in the event of typhoons and broken lines in coastal areas, mountainous areas and other special areas. In this paper, continuous basalt-fiber-reinforced epoxy matrix composites were used to fabricate the core rods and composite cross arms. The results verified that basalt fiber composite cross arms can meet the strict requirements of transmission lines in terms of quality and reliability. In addition to high electrical insulation performance, the flexural modulus and the flexural strength of basalt fiber core rods are 1.8 and 1.06 times those of glass fiber core rods, respectively. Basalt fiber core rods were found to be much better load-bearing components compared to glass fiber core rods. However, the leakage current and the result of scanning electron microscopy (SEM) analysis reveal that the interface bonding strength between basalt fibers and the matrix resin is weak. A 3D reconstruction of micro-CT indicates that the volume of pores inside basalt fiber core rods accounts for 0.0048% of the total volume, which is greater than the 0.0042% of glass fiber rods. Therefore, improving the interface bond between basalt fibers and the resin can further improve the properties of basalt fiber core rods.
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http://dx.doi.org/10.3390/polym14122443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227450PMC
June 2022

Association between DNA methylation variability and self-reported exposure to heavy metals.

Sci Rep 2022 Jun 22;12(1):10582. Epub 2022 Jun 22.

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.

Individuals encounter varying environmental exposures throughout their lifetimes. Some exposures such as smoking are readily observed and have high personal recall; others are more indirect or sporadic and might only be inferred from long occupational histories or lifestyles. We evaluated the utility of using lifetime-long self-reported exposures for identifying differential methylation in an amyotrophic lateral sclerosis cases-control cohort of 855 individuals. Individuals submitted paper-based surveys on exposure and occupational histories as well as whole blood samples. Genome-wide DNA methylation levels were quantified using the Illumina Infinium Human Methylation450 array. We analyzed 15 environmental exposures using the OSCA software linear and MOA models, where we regressed exposures individually by methylation adjusted for batch effects and disease status as well as predicted scores for age, sex, cell count, and smoking status. We also regressed on the first principal components on clustered environmental exposures to detect DNA methylation changes associated with a more generalised definition of environmental exposure. Five DNA methylation probes across three environmental exposures (cadmium, mercury and metalwork) were significantly associated using the MOA models and seven through the linear models, with one additionally across a principal component representing chemical exposures. Methylome-wide significance for four of these markers was driven by extreme hyper/hypo-methylation in small numbers of individuals. The results indicate the potential for using self-reported exposure histories in detecting DNA methylation changes in response to the environment, but also highlight the confounded nature of environmental exposure in cohort studies.
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http://dx.doi.org/10.1038/s41598-022-13892-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217962PMC
June 2022

Ligand-binding specificities of four odorant-binding proteins in Conogethes punctiferalis.

Arch Insect Biochem Physiol 2022 Jun 22:e21947. Epub 2022 Jun 22.

College of Bioscience and Resource Environment/Key Laboratory of Urban Agriculture (North China), Ministry of Agriculture and Rural Affairs of the People's Republic of China, Beijing University of Agriculture, Beijing, China.

Odorant-binding proteins (OBPs) play essential roles in lepidopteran insects' perception of host volatiles by binding and transporting hydrophobic ligands. The yellow peach moth (YPM), Conogethes punctiferalis (Guenée), is a serious agricultural pest, with broad host range and cryptic feeding habits. However, few studies about YPM perceiving pheromones and host plant odorants have been reported. In this study, four OBP genes (CpunOBP8, CpunOBP9, CpunABP, and CpunGOBP2) were cloned from the antennae of YPM. The recombinant proteins were expressed and purified by prokaryotic expression system, with their binding affinities to 26 ligands being tested. Four CpunOBPs all had six conserved cysteine residues, which were typical structural characteristics of classical OBPs. The fluorescence competitive binding assay indicated that CpunOBP8 and CpunABP could not only exhibit high binding affinities to female sex pheromones, but also to host plant odorants. For example, CpunOBP8 bound strongly with cis-10-hexadecenal, hexadecanal, and so forth, whereas CpunABP bound with cis-10-hexadecenal, camphene, and 3-carene. Comparatively, CpunOBP9 and CpunGOBP2 could only bind with host plant odorants, with CpunOBP9 binding strongly to 3-methyl-1-butanol, hexyl acetate, and so forth, while CpunGOBP2 displaying the widest binding spectra and correlating with 3-carene, pentyl acetate, and so forth. The results indicated that on the one hand, each of the four CpunOBPs had its specific binding spectra when binding and transporting olfactory ligands; on the other hand, the same ligand might be bound to more than one CpunOBPs, which would provide information for the potential application of semiochemicals in controlling YPM.
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http://dx.doi.org/10.1002/arch.21947DOI Listing
June 2022

The Machine Learning Model for Distinguishing Pathological Subtypes of Non-Small Cell Lung Cancer.

Front Oncol 2022 26;12:875761. Epub 2022 May 26.

Department of Nuclear Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Purpose: Machine learning models were developed and validated to identify lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) using clinical factors, laboratory metrics, and 2-deoxy-2[F]fluoro-D-glucose ([F]F-FDG) positron emission tomography (PET)/computed tomography (CT) radiomic features.

Methods: One hundred and twenty non-small cell lung cancer (NSCLC) patients (62 LUAD and 58 LUSC) were analyzed retrospectively and randomized into a training group (n = 85) and validation group (n = 35). A total of 99 feature parameters-four clinical factors, four laboratory indicators, and 91 [F]F-FDG PET/CT radiomic features-were used for data analysis and model construction. The Boruta algorithm was used to screen the features. The retained minimum optimal feature subset was input into ten machine learning to construct a classifier for distinguishing between LUAD and LUSC. Univariate and multivariate analyses were used to identify the independent risk factors of the NSCLC subtype and constructed the Clinical model. Finally, the area under the receiver operating characteristic curve (AUC) values, sensitivity, specificity, and accuracy (ACC) was used to validate the machine learning model with the best performance effect and Clinical model in the validation group, and the DeLong test was used to compare the model performance.

Results: Boruta algorithm selected the optimal subset consisting of 13 features, including two clinical features, two laboratory indicators, and nine PEF/CT radiomic features. The Random Forest (RF) model and Support Vector Machine (SVM) model in the training group showed the best performance. Gender (P=0.018) and smoking status (P=0.011) construct the Clinical model. In the validation group, the SVM model (AUC: 0.876, ACC: 0.800) and RF model (AUC: 0.863, ACC: 0.800) performed well, while Clinical model (AUC:0.712, ACC: 0.686) performed moderately. There was no significant difference between the RF and Clinical models, but the SVM model was significantly better than the Clinical model.

Conclusions: The proposed SVM and RF models successfully identified LUAD and LUSC. The results indicate that the proposed model is an accurate and noninvasive predictive tool that can assist clinical decision-making, especially for patients who cannot have biopsies or where a biopsy fails.
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http://dx.doi.org/10.3389/fonc.2022.875761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9177952PMC
May 2022

Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors.

Commun Biol 2022 Jun 10;5(1):578. Epub 2022 Jun 10.

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Dopamine supports locomotor control and higher brain functions such as motivation and learning. Consistently, dopaminergic dysfunction is involved in a spectrum of neurological and neuropsychiatric diseases. Detailed data on dopamine dynamics is needed to understand how dopamine signals translate into cellular and behavioral responses, and to uncover pathological disturbances in dopamine-related diseases. Genetically encoded fluorescent dopamine sensors have recently enabled unprecedented monitoring of dopamine dynamics in vivo. However, these sensors' utility for in vitro and ex vivo assays remains unexplored. Here, we present a blueprint for making dopamine sniffer cells for multimodal dopamine detection. We generated sniffer cell lines with inducible expression of seven different dopamine sensors and perform a head-to-head comparison of sensor properties to guide users in sensor selection. In proof-of-principle experiments, we apply the sniffer cells to record endogenous dopamine release from cultured neurons and striatal slices, and for determining tissue dopamine content. Furthermore, we use the sniffer cells to measure dopamine uptake and release via the dopamine transporter as a radiotracer free, high-throughput alternative to electrochemical- and radiotracer-based assays. Importantly, the sniffer cell framework can readily be applied to the growing list of genetically encoded fluorescent neurotransmitter sensors.
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http://dx.doi.org/10.1038/s42003-022-03488-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187629PMC
June 2022

Interspecies comparison of heat and mass transfer characteristics in monkey and human nasal cavities.

Comput Biol Med 2022 Aug 31;147:105676. Epub 2022 May 31.

Mechanical & Automotive Engineering, School of Engineering, RMIT University, VIC, Australia. Electronic address:

Air conditioning in the nasal airways plays an important role in regulating ambient atmospheric temperature and humidity conditions of the inhaled air. Inevitably, it may alter the behaviour and fate of inhaled ambient aerosols within the human respiratory airways due to hygroscopic growth and droplet evaporation, which is a phenomena of variations in particle sizes due to physical and chemical reactions on particle surfaces in different temperature and humidity fields. Although laboratory animals have been widely used to predict health effects of human exposure to ambient substances, the nasal temperature and humidity responses in animal surrogates and human nasal cavities are still less-investigated. This paper provides a comparative study between two monkey and two human nasal subjects under the same ambient temperature and humidity conditions, where nasal models were reconstructed from CT images and the heat and mass transfer process incorporating with the intricate nose anatomy were modelled by the computational fluid dynamics (CFD) approach. Present model comparison revealed that the monkey nasal models can reach equilibrium temperature and moisture state for inhaled ambient air in a much shorter distance compared to the human models. This indicate that heat transfer in the monkey models is more effective compared to the human models due to having a higher complexity coefficient and a smaller hydraulic radius. Hence, in order to achieve comparable or similar inhalation exposure patterns in animal surrogates, corresponding adjustments such as changing the size of released particles, or the inhalation flow rates, to achieve comparable particle Stokes number are needed. The outcomes of this study would provide informative insights for future inhalation toxicology studies related to hygroscopic materials and targeted drug delivery through nasal airways.
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http://dx.doi.org/10.1016/j.compbiomed.2022.105676DOI Listing
August 2022

Pitx2 suppression at meiotic stages associates with seasonal inhibition of testis development in Rattus norvegicus caraco.

Integr Zool 2022 May 31. Epub 2022 May 31.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Key Laboratory of Weed and Rodent Biology and Management, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.

The bicoid-related transcription factor 2 (Pitx2) plays a crucial role in the development of many organs and tissues by affecting the mitotic cell cycle. Postnatal testis development is related to mitosis and meiosis in multiple cell types, but the role of Pitx2 gene in seasonal inhibition of testicular development remains unknown in rodents. We analyzed PITX2 protein and Pitx2 mRNA expression features using both laboratory and wild male Rattus norvegicus caraco. In postnatal testicle of laboratory colony, we found that PITX2 was expressed in Leydig cells, pachytene spermatocytes, round spermatids, and elongating spermatids rather than spermatogonia and leptotene/zygotene spermatocytes. Pitx2b expression significantly increased along with the occurrence of pachytene spermatocytes and round spermatids, while decreased along with the processes of elongated spermatids. In wild male rats with similar testes weight, a significantly suppressed Pitx2b expression occurred with an active meiotic stage in the inhibited testes in autumn and winter, compared with the normally developing testes in spring and summer. These results indicate that Pitx2b expression suppression plays a crucial role in the seasonal inhibition of testis development.
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http://dx.doi.org/10.1111/1749-4877.12663DOI Listing
May 2022

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in groundwater: current understandings and challenges to overcome.

Environ Sci Pollut Res Int 2022 Jul 20;29(33):49513-49533. Epub 2022 May 20.

College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai, 201306, China.

Perfluoroalkyl and polyfluoroalkyl substances (PFASs) have been frequently detected in groundwater globally. With the phase-out of perfluorooctane sulfonate (PFOS) and perfluorooctanate (PFOA) due to their risk to the ecosystem and human population, various novel PFASs have been used as replacements and detected in groundwater. In order to summarize the current understanding and knowledge gaps on PFASs in groundwater, we reviewed the studies about environmental occurrence, transport, and risk of legacy and novel PFASs in groundwater published from 1999 to 2021. Our review suggests that PFOS and PFOA could still be detected in groundwater due to the long residence time and the retention in the soil-groundwater system. Firefighting training sites, industrial parks, and landfills were commonly hotspots of PFASs in groundwater. More novel PFASs have been detected via nontarget analysis using high-resolution mass spectrometry. Some novel PFASs had concentrations comparable to that of PFOS and PFOA. Both legacy and novel PFASs can pose a risk to human population who rely on contaminated groundwater as drinking water. Transport of PFASs to groundwater is influenced by various factors, i.e., the compound structure, the hydrochemical condition, and terrain. The exchange of PFASs between groundwater and surface water needs to be better characterized. Field monitoring, isotope tracing, nontarget screening, and modeling are useful approaches and should be integrated to get a comprehensive understanding of PFASs sources and behaviors in groundwater.
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http://dx.doi.org/10.1007/s11356-022-20755-4DOI Listing
July 2022

Stress Distribution and Variation Monitored by Microseismic Tracking on a Fractured Horizontal Well: A Case Study from the Qinshui Basin.

ACS Omega 2022 Apr 15;7(16):14363-14370. Epub 2022 Apr 15.

Safety Production Supervision Brigade of Jiaozuo City Urban and Rural Integration Demonstration Zone, Jiaozuo 454000, China.

stress is an important parameter regulating the production of coalbed methane (CBM), and the monitoring of rock deformation can provide a description of the state of stress. Microseismic monitoring in a multistage fractured horizontal CBM well was conducted as a case study with a completion depth of 1445.36 m. The results show that there is a good correlation among the seismicity parameters, -value, stress drop, fracture length, fracture density, and orientation. In the stress concentration region, the fracture is longer with a smaller density, where the -value is lower. On the contrary, in the stress relaxation zone, the fracture is shorter with a complex shape, where the -value is higher. Stress drop is relatively higher where fractures are concentrated, which indicate the areas with successful reservoir stimulation. The reliability of the above results was verified by the normal fault occurring between stages 7 and 8. In the area affected by the hanging wall of the normal fault (stage 6 and 7), the -value is 0.38-0.39, while in the area affected by the footwall (stage 8 and 9), the -value is 0.64-0.66. This phenomenon reflects an obvious stress concentration in the hanging wall of normal fault, which is consistent with the conventional understanding. The microseismic source parameters have great potential in evaluating reservoir stress. With further exploration of source parameters, microseismic will provide more support for CBM development.
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http://dx.doi.org/10.1021/acsomega.2c01356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089681PMC
April 2022

Quantification of long-term accumulation of inhaled ultrafine particles via human olfactory-brain pathway due to environmental emissions - a pilot study.

NanoImpact 2021 04 4;22:100322. Epub 2021 May 4.

College of Air Transportation, Shanghai University of Engineering Science, Shanghai 201620, China. Electronic address:

Olfactory pathway as a viable route for brain uptake of environmental pollutants has been hypothesized in past decade. In such a hypothesis, subclinical low-dose exposure and chronic brain accumulation of exogenous airborne agents are critical to define neurodegenerations, however the information is extremely lacking. Advances in granular measurement of air pollutants, real-time personal exposure monitoring and big data analytics have opened-up an unprecedented opportunity to enable researchers conduct longitudinal investigation and potentially link the external environment condition to risks of human developing neurodegenerative diseases in a foreseeable future. Detailed case studies are provided in this work that illustrate the quantification of human brain accumulation of ultrafine particles (UFPs) from exposure, surface deposition, and pathway penetration via the transport route of nasal olfactory in prolonged timespans. The study links the individual components along the olfactory pathway, showcases the available research capacity, and pinpoints the critical areas of research need in environmental, toxicological and epidemiological studies, significant to a joint effort to bring together an interdisciplinary solution to uncover the insight of time course and dose dependency between environmental exposure and risk of developing neurodegenerative diseases in a foreseeable future. It should be noted that current study assumes that nanoparticle penetration along the olfactory pathway is unidirectional and follows the rate observed in the rodent study. Tissue responses in determining the penetration and retention corresponding to size and composition of the inhaled nanoparticles are not considered.
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http://dx.doi.org/10.1016/j.impact.2021.100322DOI Listing
April 2021

Risk factors for the postoperative bladder neck contracture in patients with small-volume prostatic hyperplasia.

Asian J Surg 2022 May 4. Epub 2022 May 4.

Department of Urology, Urology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China; Fujian Key Laboratory of Precision Medicine for Cancer, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China. Electronic address:

Objective: This study was to explore the risk factors for postoperative bladder neck contracture (BNC) after transurethral operation of prostate in patients with small-volume prostatic obstruction.

Methods: Clinicopathologic data at our center from February 2016 to January 2020 were retrospectively collected and analyzed. Clinicopathological characteristics between patients with and without BNC were compared. Multivariate logistic regression was used to determine the risk factors for postoperative BNC.

Results: There were a total of 39 patients (8.53%) with postoperative BNC. Multivariate logistic regression analysis demonstrated that preoperative bladder neck diameter (BND), intravesical prostatic protrusion (IPP), surgical methods (transurethral resection of prostate (TURP)/anatomical endoscopic enucleation of the prostate (AEEP)), and postoperative urinary tract infection (UTI) were independent risk factors for postoperative BNC in patients with small-volume prostatic obstruction (P < 0.05). The incidence of postoperative BNC in patients undergoing AEEP was significantly decreased compared with those undergoing TURP. The optimal cut-off value of preoperative IPP was 6.10 mm while the optimal cut-off value of preoperative BND was 2.52 cm.

Conclusions: Larger preoperative bladder neck and higher preoperative IPP lead to decreased incidence of postoperative BNC in patients with small-volume prostatic obstruction. Active management of postoperative UTI could effectively prevent the occurrence of postoperative BNC. Compared with TURP, complete AEEP would contribute to reduce BNC in patients with small-volume prostatic obstruction.
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http://dx.doi.org/10.1016/j.asjsur.2022.04.076DOI Listing
May 2022

Convergent lines of evidence supporting involvement of NFKB1 in schizophrenia.

Psychiatry Res 2022 06 1;312:114588. Epub 2022 May 1.

Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China; Institute of Neuropsychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address:

Objectives: NFKB1 was associated with treatment-refractory schizophrenia (SZ) and response to antipsychotics; however, the underlying mechanisms through which NFKB1 confers its risk for SZ are largely unknown. We aimed to investigate the potential role of NFKB1 in SZ.

Methods: In the present study, we investigated the association of the risk SNP rs230529 of NFKB1 with gray matter density and with NFKB1 mRNA levels in various human brain regions. The spatiotemporal expression pattern of NFKB1 in human brains was explored. We constructed a miRNA-NFKB1-target gene regulatory network and analyzed its druggability through targeting NFKB1 for SZ treatment.

Results: NFKB1 showed the highest expression levels in the cerebellum, in which these levels were stratified by genotypes of rs230529. Interestingly, the allelic state of rs230529 was significantly associated with regional gray matter density in multiple brain regions (including the cerebellum), which also differed between patients with schizophrenia and controls. Furthermore, regulatory targets of NFKB1 were enriched among SZ susceptibility genes. A substantial proportion of NFKB1 target genes were subject to combinatorial regulation by NFKB1 and miRNAs, constituting a hybrid NFKB1-miRNA-gene regulatory network. Some components of this network showed expression changes relevant to both the disease and the treatment. Finally, we detected the dynamic changes of NFKB1-miR-155-5p-GSK3B and NFKB1-miR-155-5p/let-7a-5p-IL6 networks in course of the treatment of SZ.

Conclusion: Taken together, our findings support the involvement of NFKB1-mediated dysregulation in the development of SZ.
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http://dx.doi.org/10.1016/j.psychres.2022.114588DOI Listing
June 2022

Recent advances in fuel cell reaction electrocatalysis based on porous noble metal nanocatalysts.

Dalton Trans 2022 May 24;51(20):7763-7774. Epub 2022 May 24.

University and College Key Lab of Natural Product Chemistry and Application in Xinjiang, School of Chemistry and Environmental Science, Yili Normal University, Yining 835000, China.

As the center of fuel cells, electrocatalysts play a crucial role in determining the conversion efficiency from chemical energy to electrical energy. Therefore, the development of advanced electrocatalysts with both high activity and stability is significant but challenging. Active site, mass transport, and charge transfer are three central factors influencing the catalytic performance of electrocatalysts. Endowed with rich available surface active sites, facilitated electron transfer and mass diffusion channels, and highly active components, porous noble metal nanomaterials are widely considered as promising electrocatalysts toward fuel cell-related reactions. The past decade has witnessed great achievements in the design and fabrication of advanced porous noble metal nanocatalysts in the field of electrocatalytic fuel oxidation reaction (FOR) and oxygen reduction reaction (ORR). Herein, the recent research advances regarding porous noble metal nanocatalysts for fuel cell-related reactions are reviewed. In the discussions, the inherent structural features of porous noble metal nanostructures for electrocatalytic reactions, advanced synthetic strategies for the fabrication of porous noble metal nanostructures, and the structure-performance relationships are also provided.
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http://dx.doi.org/10.1039/d2dt00841fDOI Listing
May 2022

Aging in an "infodemic": The role of analytical reasoning, affect, and news consumption frequency on news veracity detection.

J Exp Psychol Appl 2022 May 2. Epub 2022 May 2.

Department of Psychology.

Increasing misinformation spread poses a threat to older adults but there is little research on older adults within the fake news literature. Embedded in the Changes in Integration for Social Decisions in Aging (CISDA) model, this study examined the role of (a) analytical reasoning; (b) affect; (c) news consumption frequency, and their interplay with (d) news content on news veracity detection in aging. Conducted during the early phase of the COVID-19 pandemic, the present study asked participants to view and evaluate COVID or non-COVID (i.e., everyday) news articles, followed by measures of analytical reasoning, affect, and news consumption frequency. News veracity detection was comparable between young and older adults. Additionally, fake news detection for non-COVID news was predicted by individual differences in analytic reasoning for both age groups. However, chronological age effects in fake news detection emerged within the older adult sample and interacted with the CISDA-derived components of analytical reasoning, affect, and news consumption frequency by news content. Collectively, these findings suggest that age-related vulnerabilities to deceptive news are only apparent in very old age. Our findings advance understanding of psychological mechanisms in news veracity detection in aging. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
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http://dx.doi.org/10.1037/xap0000426DOI Listing
May 2022

Neurophotonic tools for microscopic measurements and manipulation: status report.

Neurophotonics 2022 Jan 27;9(Suppl 1):013001. Epub 2022 Apr 27.

Yale School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, Connecticut, United States.

was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, ' agenda has been well aligned with this focus on neurotechnologies featuring new optical methods and tools applicable to brain studies. While the BRAIN Initiative 2.0 is pivoting towards applications of these novel tools in the quest to understand the brain, this status report reviews an extensive and diverse toolkit of novel methods to explore brain function that have emerged from the BRAIN Initiative and related large-scale efforts for measurement and manipulation of brain structure and function. Here, we focus on neurophotonic tools mostly applicable to animal studies. A companion report, scheduled to appear later this year, will cover diffuse optical imaging methods applicable to noninvasive human studies. For each domain, we outline the current state-of-the-art of the respective technologies, identify the areas where innovation is needed, and provide an outlook for the future directions.
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http://dx.doi.org/10.1117/1.NPh.9.S1.013001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9047450PMC
January 2022

Frequency-specific coactivation patterns in resting-state and their alterations in schizophrenia: An fMRI study.

Hum Brain Mapp 2022 08 27;43(12):3792-3808. Epub 2022 Apr 27.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

The resting-state human brain is a dynamic system that shows frequency-dependent characteristics. Recent studies demonstrate that coactivation pattern (CAP) analysis can identify recurring brain states with similar coactivation configurations. However, it is unclear whether and how CAPs depend on the frequency bands. The current study investigated the spatial and temporal characteristics of CAPs in the four frequency sub-bands from slow-5 (0.01-0.027 Hz), slow-4 (0.027-0.073 Hz), slow-3 (0.073-0.198 Hz), to slow-2 (0.198-0.25 Hz), in addition to the typical low-frequency range (0.01-0.08 Hz). In the healthy subjects, six CAP states were obtained at each frequency band in line with our prior study. Similar spatial patterns with the typical range were observed in slow-5, 4, and 3, but not in slow-2. While the frequency increased, all CAP states displayed shorter persistence, which caused more between-state transitions. Specifically, from slow-5 to slow-4, the coactivation not only changed significantly in distributed cortical networks, but also increased in the basal ganglia as well as the amygdala. Schizophrenia patients showed significant alteration in the persistence of CAPs of slow-5. Using leave-one-pair-out, hold-out and resampling validations, the highest classification accuracy (84%) was achieved by slow-4 among different frequency bands. In conclusion, our findings provide novel information about spatial and temporal characteristics of CAP states at different frequency bands, which contributes to a better understanding of the frequency aspect of biomarkers for schizophrenia and other disorders.
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http://dx.doi.org/10.1002/hbm.25884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9294298PMC
August 2022

Application value of overlap guiding tube (OGT) in assisting overlap esophagojejunostomy during laparoscopic total gastrectomy for gastric/gastroesophageal junction (G/GEJ) tumors.

Gastric Cancer 2022 Jul 23;25(4):827-836. Epub 2022 Apr 23.

Department of General Surgery and Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Background: The overlap guiding tube (OGT) method, which was designed by our team to assist in overlap esophagojejunostomy, could potentially provide new perspectives for esophagojejunostomy. The application of the OGT-assisted method was first explored by our team and has not yet been reported.

Methods: This cohort study analyzed the 3 month outcomes of 38 gastric/gastroesophageal junction (G/GEJ) tumor patients who underwent OGT-assisted overlap esophagojejunostomy.

Results: There were 27 males and 11 females, aged 40-82 years. All patients underwent surgery successfully. The success rate of inserting anvil fork into esophageal lumen at first attempt was 97.4%. The total operation time, esophagojejunostomy time, volume of intraoperative blood loss, and length of surgical incision were 317.6 ± 51.5 min, 20.8 ± 3.8 min, 50.0 (range 15.0-200.0) ml, and 5.0 (range 4.0-8.0) cm, respectively. No procedures were converted to other laparoscopic anastomosis techniques or open approaches. The time to postoperative initial flatus, liquid diet intake, soft diet intake, and length of postoperative hospital stay were 3.0 (range 1.0-6.0) days, 4.0 (range 2.0-9.0)days, 6.0 (range 3.0-11.0) days, and 8.5 (range 6.0-16.0) days, respectively. Overall, postoperative complications were observed in 8 (21.1%) patients. Among them, one patients developed esophagojejunal anastomotic leakage. After 3 months of follow-up, none of the patients developed anastomotic stenosis or experienced unplanned secondary surgery or perioperative death.

Conclusions: OGT-assisted overlap esophagojejunostomy for patients with G/GEJ tumors is safe and feasible, with good short-term effects. OGT method has a satisfactory success rate of inserting anvil fork into esophageal lumen at first attempt and could prevent from developing esophageal submucosa pseudocanals.
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http://dx.doi.org/10.1007/s10120-022-01296-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225966PMC
July 2022
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