Publications by authors named "Lin Ma"

1,550 Publications

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Individual and joint associations of co-exposure to multiple plasma metals with telomere length among middle-aged and older Chinese in the Dongfeng-Tongji cohort.

Environ Res 2022 Aug 4:114031. Epub 2022 Aug 4.

Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. Electronic address:

Studies on associations of metals with leucocyte telomere length (LTL) were mainly limited to several most common toxic metals and single-metal effect, but the impact of other common metals and especially the overall joint associations and interactions of metal mixture with LTL are largely unknown. We included 15 plasma metals and LTL among 4906 participants from Dongfeng-Tongji cohort. Multivariable linear regression was used to estimate associations of individual metals with LTL. We also applied Bayesian kernel machine regression (BKMR) and quantile g-computation regression (Q-g) to evaluate the overall association and interactions, and identified the major contributors as well as the potential modifications by major characteristics. Multivariable linear regression found vanadium, copper, arsenic, aluminum and nickel were negatively associated with LTL, and a 2-fold change was related to 1.9%-5.1% shorter LTL; while manganese and zinc showed 3.7% and 4.0% longer LTL (all P < 0.05) in multiple-metal models. BKMR confirmed above metals and revealed a linearly inverse joint association between 15 metals and LTL. Q-g regression further indicated each quantile increase in mixture was associated with 5.2% shorter LTL (95% CI: -8.1%, -2.3%). Furthermore, manganese counteracted against aluminum and vanadium respectively (P<0.05). In addition, associations of vanadium, aluminum and metal mixture with LTL were more prominent in overweight participants. Our results are among the first to provide a new comprehensive view of metal mixture exposure on LTL attrition in the general population, including identifying the major components, metals interactions and the overall effects.
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http://dx.doi.org/10.1016/j.envres.2022.114031DOI Listing
August 2022

Efficacy and safety of a treatment in patients with locoregionally advanced nasopharyngeal carcinoma (LANC) involving carotid artery invasion.

Eur Arch Otorhinolaryngol 2022 Aug 2. Epub 2022 Aug 2.

College of Otolaryngology Head and Neck Surgery, National Clinical Research Center for Otolaryngologic Diseases, Key Lab of Hearing Science, Ministry of Education, Beijing Key Lab of Hearing Impairment for Prevention and Treatment, Medical School of Chinese PLA, 28 Fuxing Road, Beijing, 100853, People's Republic of China.

Purpose: Locally advanced nasopharyngeal carcinoma (LANC) often invades the parapharyngeal space and internal carotid artery. Are patients with LANC invading carotid artery are at risk of massive neck hemorrhage after radiotherapy?

Methods: This retrospective study included 130 LANC patients with carotid artery invasion admitted to our hospital between January 2012 and September 2019. All patients were treated with induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) ± epidermal growth factor receptor (EGFR) inhibitor. Univariate and multivariate analysis of risk factors were conducted for the prognosis and the occurrence of massive neck hemorrhage of LANC patients with carotid artery invasion.

Outcomes: The 5-year progression-free survival (PFS), distant metastasis-free survival (DMFS), local nodal recurrence-free survival (LNRFS), local recurrence-free survival (LRFS), nodal recurrence-free survival (NRFS) and overall survival (OS) of the 130 patients were 75.2%, 76.8%, 90.0%, 93.9%, 95.8% and 87.2%, respectively. The incidence of fatal bleeding after radiotherapy was 2.3% (3/130). The primary site of the three cases were all the pharyngeal recess, with more than 270° carotid artery invasion, suffering nasopharyngeal necrosis after radiotherapy (2 of which were diabetics and 1 received re-radiation after recurrence). Univariate analysis showed that clinical stage was negatively correlated with DMFS and PFS (P < 0.05). The induction chemotherapy TP regimen, platinum-based concurrent chemotherapy and EGFR inhibitors (Nituzumab/Cetuximab) significantly improved PFS and DMFS (P < 0.05). Patients with hemoglobin levels > 110 g/L had significantly inferior PFS, DMFS and OS than those with hemoglobin levels ≤ 110 g/L (P < 0.05). Multivariate analysis showed that the EGFR inhibitor was an independent risk factor for PFS and DMFS, while the lowest hemoglobin level was an independent risk factor for OS.

Conclusions: In LANC patients whose carotid artery invasion was < 270°, induction chemotherapy (IC) followed by helical tomotherapy (HT) and concurrent chemoradiotherapy (CCRT) with EGFR (epidermal growth factor receptor) inhibitor had mild and tolerable side effects, better PFS and DMFS, with no massive hemorrhage. In patients whose primary tumor was pharyngeal recess with carotid artery invasion ≥ 270°, poorly controlled diabetes or re-radiotherapy led to a higher risk of massive hemorrhage after radiotherapy.
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http://dx.doi.org/10.1007/s00405-022-07446-zDOI Listing
August 2022

Case Report: Trigeminocardiac Reflex in Endovascular Recanalization of Intracranial Internal Carotid Artery Occlusion.

Front Neurol 2022 13;13:902620. Epub 2022 Jul 13.

Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.

Background: The trigeminocardiac reflex (TCR) is a unique brainstem reflex that manifests as sudden negative hemodynamic changes. Although rare, TCR may develop during interventional neuroradiology procedures. Intracranial internal carotid artery occlusion (ICAO) is a cause or risk factor of ischemic stroke. Endovascular recanalization is an effective treatment for intracranial ICAO. The occurrence of TCR during the endovascular treatment of intracranial ICAO has not been reported previously.

Methods: We identified and reviewed four intracranial ICAO cases who suffered a sudden negative hemodynamic change during endovascular therapy at our hospital between March 2019 and December 2020.

Results: There were five sudden heart rate and/or blood pressure drops in the four cases; all occurred just after contrast agents were injected. Some angioarchitectural characteristics were common among the four cases. First, the intracranial internal carotid artery distal to the ophthalmic artery was occluded, leaving the ophthalmic artery as the only outflow tract. Second, there were obstructive factors proximal to the end of the guiding catheter, including a vasospasm or dilated balloon. This type of angioarchitecture with a limited outflow tract creates a "blind alley." The five negative hemodynamic events all recovered: two spontaneously and three after drug administration. Postoperatively, two of the four patients developed ocular symptoms.

Conclusions: Intracranial ICAOs may produce a distinctive angioarchitecture, such as a blind alley, that predisposes patients to TCR. Surgeons should pay special attention to the possibility of TCR during the endovascular recanalization of intracranial ICAO. Low-pressure contrast injections should be attempted, and anticholinergics should be ready for use.
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http://dx.doi.org/10.3389/fneur.2022.902620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328409PMC
July 2022

Distinctions Between Fecal and Intestinal Mucosal Microbiota in Subgroups of Irritable Bowel Syndrome.

Dig Dis Sci 2022 Jul 25. Epub 2022 Jul 25.

Department of Gastroenterology, Xi'an Jiaotong University Second Affiliated Hospital, Xi'an, 710004, China.

Background And Aims: Recent studies have shown that changes in the intestinal microbiota contribute to the pathogenesis of irritable bowel syndrome (IBS). This study aimed to investigate the characteristics of the fecal and intestinal mucosal microbiota in IBS patients, and the correlation between microbiota and clinical manifestations.

Methods: Fecal and intestinal mucosal samples were collected from 14 constipation-predominant IBS (IBS-C) patients, 20 diarrhea-predominant IBS (IBS-D) patients, and 20 healthy controls (HCs). 16S rRNA gene sequencing and fluorescence in situ hybridization were used for the analysis of samples.

Results: Community richness and diversity of the fecal microbiota in IBS patients were significantly reduced compared with the HCs. The mucosal samples in IBS patients showed decreased Bifidobacterium and increased Bacteroides caccae compared with HCs; Eubacterium and Roseburia were decreased in IBS-C patients and increased in IBS-D patients. A comparison of the fecal and mucosal microbiota in IBS patients showed significantly increased Bifidobacterium in fecal samples and a decrease in mucosal samples in IBS-C patients; Bacteroides caccae and Roseburia were significantly reduced in fecal samples and increased in mucosal samples of IBS patients. A correlation between microbiota and clinical manifestations in IBS patients showed that Bacteroides caccae and Roseburia in fecal samples and Bifidobacterium and Eubacterium in mucosal samples were associated with abdominal pain and distention.

Conclusions: Distinct differences exist between the fecal and intestinal mucosal microbiota in IBS patients, with the changes in the latter appearing more consistent with the pathophysiology of IBS. Changes in intestinal microbiota were associated with the clinical manifestations in IBS.
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http://dx.doi.org/10.1007/s10620-022-07588-4DOI Listing
July 2022

The Evaluation of the Biological Effects of Melanin by Using Silkworm as a Model Animal.

Toxins (Basel) 2022 Jun 21;14(7). Epub 2022 Jun 21.

School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China.

Melanin has been reported to have potential applications in industries such as cosmetics and food due to its anti-UV and antioxidative qualities. However, the corresponding data on its safety evaluation or biological consequences are fairly limited; such data are critical given its widespread use. The effect of different concentrations (1, 2, 3, and 4%) of melanin on growth status (larvae length and weight, cocoon weight, and morphology), the microstructure of the various tissues (fat body, silk gland, and midgut), and silk properties was studied by using the silkworm () as the model organism. The weight and length of silkworm larvae fed with melanin were lower than the control, indicating that melanin appears to have a negative effect on the growth status of silkworms; however, the histophysiology analysis indicates that the cell morphologies are not changed, the XRD and FTIR spectra indicate that the secondary and crystalline structures of silks are also well preserved, and the thermogravimetric analysis and tensile test indicate that the thermal stability and mechanical properties are well maintained and even improved to some extent. Generally, it indicates that melanin has a certain inhibitory effect on the growth of silkworm larva but causes no harm to the cell microstructures or silk properties; this demonstrates that the safety of melanin as a food addictive should be considered seriously. The increase of thermal stability and mechanical properties shows that melanin may be a good chemical modifier in textile industries.
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http://dx.doi.org/10.3390/toxins14070421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9317675PMC
June 2022

Construction of a Meta-Evidence Prototype Database of Traditional Chinese Medicine Splenogastric Diseases and Its Application in an Automatic Meta-Analysis System.

Evid Based Complement Alternat Med 2022 13;2022:6933523. Epub 2022 Jul 13.

TCM Science and Technology Information Center, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: Traditional Chinese medicine splenogastric diseases (TCMSDs) are equivalent to digestive system diseases in modern medicine. The forms of clinical evidence of TCMSDs include clinical trials, such as randomized controlled trials (RCTs) and systematic reviews (SRs). SRs mainly rely on manual operations and have the shortcomings of time consumption and low efficiency; therefore, they cannot meet the needs of rapid clinical decision-making. It is urgent to establish a new and smart form of a database to support the progress of SRs.

Methods: We searched and screened all TCMSD RCT reports, in both Chinese and English, and extracted them into meta-evidence through predesigned structural Microsoft Excel tables. All meta-evidence was imported into an online clinical meta-evidence collection and management system after data quality checking. The meta-evidence database of traditional Chinese medicine (TCM) splenogastric disease (MED-TCMSD) was then tested as a backend of an automatic meta-analysis system.

Results: A total of 405 cases of TCMSD RCTs were processed into meta-evidence. The most common diseases were stomach stuffiness disease, epigastralgia, and chronic atrophic gastritis. Banxiaxiexin decoction and its modifications were the most used interventions. More than half of the cases employed TCM in conjunction with regular therapeutics. The top reported outcomes included clinical effects, adverse events, and TCM syndromes. The MED-TCMSD worked well as a part of the automatic meta-analysis system.

Conclusions: We developed and tested a new form of clinical evidence, meta-evidence, for automatic SR and fast evidence-based decision-making. As an example of the MED, the MED-TCMSD can improve the production and updating efficiency of the evidence of TCMSDs. The methods of constructing the MED-TCMSD can be further applied to the development of MEDs of other diseases.
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http://dx.doi.org/10.1155/2022/6933523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300305PMC
July 2022

Preparation and Evaluation of a Microsponge Dermal Stratum Corneum Retention Drug Delivery System for Griseofulvin.

AAPS PharmSciTech 2022 Jul 19;23(6):199. Epub 2022 Jul 19.

School of Pharmacy, Yanbian University, Yanji, 133002, China.

Griseofulvin (GF) is used as an antifungal to treat superficial skin fungal infections such as tinea capitis and tinea pedis. Currently, GF is only available in traditional oral dosage forms and suffers from poor and highly variable bioavailability, hepatotoxicity, and long duration of treatment. Therefore, the main objective of this study was to reduce the side effects of the drug and to increase the concentration of the drug retained in the cutaneous stratum corneum (SC) and improve its efficacy through the preparation of drug-laden GF microsponge (GFMS). The emulsification-solvent-diffusion method was used to prepare GFMS, and the prescriptions were screened by a single-factor approach. The optimized formulation (GFF8) had a microsponge particle size (μm) of 28.36 ± 0.26, an encapsulation efficiency (%) of 87.53 ± 1.07, a yield (%) of 86.58 ± 0.42, and drug release (%) from 77.57 ± 3.88. The optimized microsponge formulation was then loaded into a Carbopol 934 gel matrix and skin retention differences between the microsponge gel formulation and normal gels were examined by performing skin retention and fluorescence microscopy tests. Finally, the hepatoprotective and cutaneous stratum corneum retention abilities of microsponge gel formulations compared to oral GF formulations were assessed by hepatotoxicity, pharmacokinetics, and tissue distribution studies. This provides a new perspective on GF dermal stratum corneum retention administration.
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http://dx.doi.org/10.1208/s12249-022-02362-1DOI Listing
July 2022

[Assessment of soil fertility in Artemisia argyi planting areas in Qichun county based on minimum data set].

Zhongguo Zhong Yao Za Zhi 2022 Jul;47(14):3738-3748

Resource Center for Chinese Materia Medica, Hubei University of Chinese Medicine Wuhan 430065, China.

This study aims to explore the soil fertility in the main Artemisia argyi planting areas in Qichun county.To be specific, the soil physical and chemical properties in the main planting areas of A.argyi in Qichun county were analyzed.On this basis, 12 indexes were selected for principal component analysis(PCA) which was then combined with the norm value of each index and the correlation coefficients between the indexes to establish the minimum data set(MDS).The radar map was plotted to directly demonstrate the level of each index and the comprehensive level of the sampling sites.The comprehensive index model was used to calculate the soil fertility quality index(SFQI) of the total data set(TDS) and MDS(SFQI-TDS and SFQI-MDS, respectively), and linear regression of the two was performed.The results showed that the indexes that made up the MDS for soil fertility evaluation were pH, available potas-sium, available iron, available zinc, available manganese, available copper, and available magnesium.The radar map suggested the greatest difference in soil organic matter and smallest difference in available nitrogen among the 14 sampling sites.Moreover, the overall content of available phosphorus and available iron was high, while that of available nitrogen was the lowest.The SFQI-MDS which was yielded based on the weight of each index in MDS calculated with the norm value was more sensitive and the SFQI had stronger correlation with TDS-SFQI, which can better represent TDS-SFQI.SFQI-MDS was in the range of 0.298-0.784, with the average of 0.565 and variation coefficient of 18.38%.Caohe Town had the highest average SFQI-MDS.Clustering of SFQI-MDS value suggested that the soil fertility can be classified into 4 levels: level Ⅰ(SFQI ≥ 0.677) indicated excellent soil fertility, which accounted for 11.24%(mainly in Qingshi town, Balihu, and Zhangbang town); level Ⅱ(0.571≤SFQI≤0.680) meant good fertility, which made up 43.82%(mainly in Caohe town, Hengche town, and Pengsi town); level Ⅲ(0.466≤SFQI≤0.557) indicated average fertility, which took up 32.58%(mainly in Chidong town and Zhulin town); level Ⅳ(SFQI≤0.421) suggested poor fertility, which accounted for 12.36%(mainly in Guanyao town).It is recommended that nitrogen, potassium, magnesium, and calcium fertilizers should be increased and organic ferti-lizer should be applied for the cultivation of A.argyi in Qichun county to improve soil fertility and soil physical and chemical properties.
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http://dx.doi.org/10.19540/j.cnki.cjcmm.20220414.102DOI Listing
July 2022

Meta-Analysis of the Efficacy and Safety of Interleukin-23-Targeted Drugs in the Treatment of Moderate-to-Severe Psoriasis.

Authors:
Teng Zhu Lin Ma

Contrast Media Mol Imaging 2022 28;2022:2172980. Epub 2022 Jun 28.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

In this study, our purpose was to systematically evaluate the efficacy and safety of interleukin-23 (IL-23)-targeted drugs in the treatment of moderate-to-severe psoriasis and provide an evidence-based reference for clinical treatment. A computer search of PubMed, EMBASE, Web of Science, Cochrane Library, Chinese Journal Full Text Database, Chinese Science and Technology Journal Database, and Wanfang Database was conducted from the establishment of the database to 2021-09-30. The efficacy of IL-23-targeted drugs (trial group) was compared with placebo (control group) in the treatment of psoriasis; i.e., PASI score improvement of 75% or more (PASI 75, PASI 90, and PASI 100) and the safety of randomized controlled trials (RCTs) were collected. Meta-analysis was performed using Rev Man 5.4.3 statistical software after data extraction for clinical studies that met the inclusion criteria. A total of 9 studies were included, all included studies were large multicenter, randomized, double-blind, placebo-controlled studies, and all used correct randomization methods and were of good quality. Meta-analysis showed that the improvement rates of PASI 75, PASI 90, and PASI 100 in the test group were superior to those in the control group (OR = 70.21 (42.25, 166.66), < 0.00001), (OR = 78.41 (53.09, 115.79), < 0.00001), and (OR = 77.10 (38.61, 153.99), < 0.00001), < 0.05. However, more adverse effects occurred, and the differences were statistically significant. IL-23-targeted drugs have significantly higher response rates compared to placebo in the treatment of psoriasis, and the safety was acceptable.
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http://dx.doi.org/10.1155/2022/2172980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256449PMC
July 2022

Real-world safety of ulinastatin: a post-marketing surveillance of 11,252 patients in China.

BMC Pharmacol Toxicol 2022 07 16;23(1):51. Epub 2022 Jul 16.

Guangdong Province Pharmacological Society, No. 753 East Dongfeng Road, Guangzhou, 510080, Guangdong, China.

Background: The safety assessment of ulinastatin can guide clinical practice. The present study aimed to investigate the real-world safety of ulinastatin in China.

Methods: This multicenter study retrospectively analyzed the post-marketing surveillance data of consecutive patients treated with ulinastatin between August 2014 and June 2017 in the general wards and the intensive care units (ICU) of nine hospitals in China. Adverse drug reactions/adverse drug events (ADRs/ADEs) were collected and evaluated in a post-marketing database.

Results: A total of 11,252 consecutive patients were included in the study: 7009 ICU patients and 4243 general ward patients. Eleven patients with ADRs/ADEs were observed, including nine ICU patients and two general ward patients. The clinical manifestations were liver dysfunction (n = 5 ICU cases, n = 1 general case), thrombocytopenia (n = 2 ICU cases, n = 1 general case), leukopenia (n = 1 ICU case), and rash (n = 1 ICU case). During the study period, the drug ADR/ADE rate of ulinastatin injection was 0.98‰ (11/11,252 × 1000‰). Among the 11,252 valid patients, only 327 received ulinastatin in accordance with the drug specifications. After excluding unreasonable drug use, the calculated ADR rate was 3.06‰ (1/327 × 1000‰) (95% confidence interval: 0.0‰-17.1‰). In ICU and general ward patients, the use of other drugs combined with ulinastatin was associated with the occurrence of ADRs/ADEs (100% with ADRs/ADEs vs. 0% in controls, P < 0.001).

Conclusions: The incidence of ADRs/ADEs of ulinastatin is < 5‰. The ADRs/ADEs involved limited organs, mainly the skin, gastrointestinal tract, and blood. In most cases, the ADRs/ADEs gradually alleviated or recovered after drug withdrawal. The inappropriate/off-label use of ulinastatin should be the focus of surveillance.
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http://dx.doi.org/10.1186/s40360-022-00585-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288682PMC
July 2022

Automatic segmentation of hyperreflective dots via focal priors and visual saliency.

Med Phys 2022 Jul 15. Epub 2022 Jul 15.

Department of Radiology, Peking University Third Hospital, Beijing, China.

Purpose: Hyperreflective dots (HRDs) can be observed in spectral domain optical coherence tomography (SD-OCT), which can provide a sensitive marker in the treatment decision process. Quantitative analyses of HRDs are the key to make appropriate decisions on observation, treatment, and retreatment. The purpose of this study is to automatically and accurately segment HRDs in SD-OCT B-scans with diabetic retinopathy (DR).

Methods: The authors propose an automatic segmentation algorithm of HRDs via focal priors and visual saliency. The algorithm is divided into three stages: segmentation of retinal layers, calculation of the multiscale local contrast saliency map, and adaptive threshold segmentation. First, a method based on improved graph search is used to segment retinal layers to obtain the region of interest (ROI) and the reflectivity estimation of the retinal pigment epithelium (RPE) layer; then, the multiscale local contrast saliency map is obtained by using a local contrast measure, which measures the dissimilarity between the current pixels and corresponding neighborhoods; finally, an adaptive threshold is applied to segment HRDs.

Results: Experimental results on 20 SD-OCT B-scans demonstrate that our method is effective for HRDs segmentation. The average dice similarity coefficient (DSC) and detection accuracy are 71.12% and 85.07%, respectively.

Conclusions: The proposed method can accurately segment HRDs in SD-OCT B-scans with DR and outperforms current state-of-the-art methods. Our method can provide reliable HRDs segmentation to assist ophthalmologists in clinical diagnosis, treatment, disease monitoring, and progression.
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http://dx.doi.org/10.1002/mp.15848DOI Listing
July 2022

Three new species of Apseudomorpha (Crustacea, Tanaidacea) from Jiaozhou Bay, the Yellow Sea, and the South China Sea off coasts of China.

Zookeys 2022 15;1096:119-160. Epub 2022 Apr 15.

Department of Marine Organism Taxonomy and Phylogeny, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China Institute of Oceanology, Chinese Academy of Sciences Qingdao China.

Three new species of the crustacean order Tanaidacea are described from the coasts of China. (family Apseudidae), from the South China Sea, can be distinguished from the most similar species, , by the features of the maxilliped endite, cheliped dactylus, pereopod 1 carpus and propodus, and pleopods basal article. (family Kalliapseudidae), from Jiaozhou Bay and the Yellow Sea, can be differentiated from the most similar species, , by the features of the antennule article 1, pereopods 1 and 6 propodi, and uropod basal article. (family Parapseudidae), from Jiaozhou Bay, can be clearly separated from its congeners by its rostrum, antennule article 1, and pereopod 4 dactylus. A morphological key and comparison table of genus from the South China Sea, as well as all known species of the genera and are provided.
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http://dx.doi.org/10.3897/zookeys.1096.79382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033751PMC
April 2022

Flower-like [email protected] with core-shell nanostructure as electrode material for supercapacitors with high rate and capacitance.

J Colloid Interface Sci 2022 Jul 6;626:951-962. Epub 2022 Jul 6.

Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, China.

To enhance the specific capacitance as well as maintain satisfactory rate performance of nickel hydroxide and nickel sulfide, in this work, the ultra-fine nickel-tin nanoparticles with high conductivity are selected to synthesize [email protected](OH) and [email protected] nanoflowers. Alloy as the core material improves the electrical conductivity of the composite, and the nanosheets prepared by electrochemical corrosion effectively avoid aggregation as well as increase the active sites of the electrode material. By adjusting the corrosion time, the [email protected](OH) with better morphology displays a high specific capacitance (1277.37C g at 1 A g) and good rate performance (1028C g at 20 A g). After sulfurization, the optimal [email protected] perfectly retains the morphological characterizations of the precursor and exhibits ultra-high specific capacitance (1619.02C g at 1 A g) as well as outstanding rate performance (1312C g at 20 A g). The samples before and after vulcanization both have the excellent electrochemical properties, which is attributed to the rational design and construction of the alloy-based core-shell nanostructures. Besides, the all-solid-state hybrid supercapacitor (HSC) is assembled by [email protected] as the positive electrode and activated carbon as the negative electrode, displaying outstanding energy density of 70.54 Wh kg at 808.67 W kg and excellent cycling stability (93.21 % after 10,000 cycles). This work provides a novel ingenuity for synthesizing high-performance supercapacitor electrodes.
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http://dx.doi.org/10.1016/j.jcis.2022.07.016DOI Listing
July 2022

Platelet protease activated receptor 4 (PAR 4) receptor genotype is associated with an increased risk of preterm birth.

J Thromb Haemost 2022 Jul 11. Epub 2022 Jul 11.

Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Background: Platelet protease activated receptor-4 (PAR4) Thr120 is a common genetic variant associated with increased platelet activity. Increased platelet activity is implicated in the pathogenesis of preeclampsia and preterm birth.

Objective: Compare the rate of preeclampsia and preterm birth in pregnant individuals homozygous for PAR4 Thr120 variant vs not.

Study Design: This is a prospective cohort study of patients who delivered November 2020-July 2021. Maternal blood collected on admission for PAR4 genotyping. The primary outcome was the rate of preeclampsia/gestational hypertension in those with Thr/Thr genotype compared with Ala/Thr or Ala/Ala. Secondary outcomes included rates of preterm birth and placental pathology.

Results: Three hundred and twenty singletons were included and 52 (16.3%) were PAR4 Thr/Thr. Those PAR4 Thr/Thr were more likely to be Black (67.3% vs 29.5%, p < .001), younger (28 ± 6 vs 31 ± 6, p = .004), and have higher body mass index (35.2 ± 6.8 vs 33.1 ± 7.4, p = .047). There was no difference in preeclampsia/gestational hypertension (19.2% vs 22.8%, p = .705). Those Thr/Thr had a significantly higher rate of preterm birth (15.4% vs 3.7%, adjusted odds ratio [aOR] 4.04 [1.47-11.10], p = .007), indicated preterm birth because of fetal growth restriction or preeclampsia (5.8% vs 0.4%, aOR 10.03 [1.48-67.87], p = .02), spontaneous preterm birth (7.7% vs 2.2%, aOR 4.81 [1.27-18.27], p = .02), and placental intervillous thrombosis (18.5% vs 7.9%, aOR 4.12 [1.14-14.92], p = .03).

Conclusion: Platelet receptor PAR4 Thr120 is a common variant associated with an increased risk of placental vascular pathology and preterm birth in homozygous individuals. Although a cohort study cannot establish causation, this strong association warrants further exploration.
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http://dx.doi.org/10.1111/jth.15814DOI Listing
July 2022

Shear Wave Elastography in the Diagnosis of Peripheral Neuropathy in Patients With Chronic Kidney Disease Stage 5.

Front Endocrinol (Lausanne) 2022 23;13:899822. Epub 2022 Jun 23.

Department of Nephrology, Affiliated Hospital of Weifang Medical University, Weifang, China.

Objective: To observe the feasibility of shear wave elastography (SWE) in the diagnosis of peripheral neuropathy in patients undergoing hemodialysis [chronic kidney disease stage 5 dialysis (CKD5D)].

Methods: Forty patients with CKD5D were divided into a uremic peripheral neuropathy (UPN) group (n = 25) and a non-UPN group (n = 15) according to the results of a neuro-electrophysiological examination. Sixteen healthy control subjects were also enrolled in this study. Two-dimensional ultrasound examination was conducted, and SWE was then performed to measure Young's modulus of the tibial nerve. The left and right diameters (D1), anterior and posterior diameters (D2), perimeter (C), cross-sectional area (CSA), and Young's modulus (E) were measured three times at the same non-entrapment site. The average values were recorded and calculated. The following evaluation indices were also analyzed: sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and area under the receiver operating characteristic curve (AUC).

Results: D1, D2, C, and CSA were not significantly different among the three groups (P > 0.05). However, the difference in the E value among the three groups was statistically significant (P < 0.05). The AUC was 0.889 based on the E value. Using a tibial nerve E value of 48.35 kPa as the cutoff value, the sensitivity, specificity, PPV, and NPV were 86.0%, 84.0%, 81.1%, and 88.1%, respectively.

Conclusions: SWE is useful for the diagnosis of peripheral neuropathy in patients with CKD5D. Young's modulus of 48.35 kPa for the tibial nerve is the optimal cutoff value and has the best diagnostic efficiency for peripheral neuropathy in CKD5D patients.
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http://dx.doi.org/10.3389/fendo.2022.899822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259929PMC
June 2022

Ambient ozone pollution and prevalence of chronic kidney disease: A nationwide study based on the China National survey of chronic kidney disease.

Chemosphere 2022 Jul 5;306:135603. Epub 2022 Jul 5.

Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, 100034, China; Advanced Institute of Information Technology, Peking University, Hangzhou, 311215, China; National Institute of Health Data Science at Peking University, Beijing, 100191, China. Electronic address:

The health hazards of ambient ozone (O) pollution are receiving increasing attention worldwide. However, the evidence on the association between O and risks of chronic kidney disease (CKD) remains insufficient and inconsistent, particularly in developing countries where there is an absence of macroscopic investigations at a large population scale. Based on data from a representative nationwide cross-sectional CKD survey in 13 Chinese provinces and a high resolution O air pollution inversion dataset, generalized linear models were used to evaluate the associations of O concentration with prevalence of CKD. The results of this study suggested that long-term O exposure was positively associated with the risk of CKD. A 10 μg/m increment in O concentration was associated with an increased odds of CKD prevalence [OR = 1.11 (95% CI: 1.03, 1.21)] among all the 47,086 participants. Stronger associations were found in urban regions, younger adults <65 years, and people with higher socio-economic status (income and education level). A 10 μg/m increment in O concentration was associated with a higher increased odds of CKD prevalence in urban regions [OR = 1.31 (95% CI: 1.16, 1.47)] compared to rural regions [OR = 0.95 (95% CI: 0.84, 1.08), P for subgroup difference<0.001]. A stronger association of O concentration with CKD prevalence was found among younger people aged <65 years [OR = 1.21 (95% CI: 1.10, 1.33)] compared to those aged ≥65 years [OR = 0.92 (95% CI: 0.79, 1.07), P for subgroup difference = 0.003]. Our study demonstrated that long-term O exposure may increase risk of CKD in the general Chinese population, and the findings stressed the importance of persistent efforts in air pollution prevention and control.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135603DOI Listing
July 2022

Characteristics and Prognosis of Antibody Non-responders With Coronavirus Disease 2019.

Front Med (Lausanne) 2022 20;9:813820. Epub 2022 Jun 20.

Department of Pulmonary and Critical Care Medicine, The Eighth Medical Centre, Chinese People's Liberation Army General Hospital, Beijing, China.

Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been spreading globally. Information regarding the characteristics and prognosis of antibody non-responders to COVID-19 is limited.

Methods: In this retrospective, single-center study, we included all patients with confirmed COVID-19 using real-time reverse transcriptase-polymerase chain reaction (RT-PCR) admitted to the Fire God Mountain hospital from February 3, 2020, to April 14, 2020. A total of 1,921 patients were divided into the antibody-negative ( = 94) and antibody-positive ( = 1,827) groups, and 1:1 propensity score matching was used to match the two groups.

Results: In the antibody-negative group, 40 patients (42.6%) were men, and 49 (52.1%) were older than 65 years. Cough was the most common symptom in the antibody negative group. White blood cell counts, neutrophils, C-reactive protein, procalcitonin, interleukin-6, lactate dehydrogenase, creatine kinase, creatine kinase isoenzyme, urea nitrogen, and creatinine were significantly higher in the antibody-negative patients than in the antibody-positive group ( < 0.005). The number of days of nucleic acid-negative conversion in the antibody-negative group was shorter than that in the antibody-positive group ( < 0.001). The hospitalization time of the antibody-negative patients was shorter than that of the antibody-positive patients ( < 0.001).

Conclusion: Some COVID-19 patients without specific antibodies had mild symptoms; however, the inflammatory reaction caused by innate clinical immunity was more intense than those associated with antibodies. Non-specific immune responses played an essential role in virus clearance. There was no direct correlation between excessive inflammatory response and adverse outcomes in patients. The risk of reinfection and vaccination strategies for antibody-negative patients need to be further explored.
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http://dx.doi.org/10.3389/fmed.2022.813820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251059PMC
June 2022

Enhancing Li Transport in NMC811||Graphite Lithium-Ion Batteries at Low temperatures by Using Low-Polarity-Solvent Electrolytes.

Angew Chem Int Ed Engl 2022 Jul 5:e202205967. Epub 2022 Jul 5.

Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD 20742, USA.

LiNi Co Mn O (x+y+z=1)||graphite lithium-ion battery (LIB) chemistry promises practical applications. However, its low-temperature (≤ -20 °C) performance is poor because the increased resistance encountered by Li transport in and across the bulk electrolytes and the electrolyte/electrode interphases induces capacity loss and battery failures. Though tremendous efforts have been made, there is still no effective way to reduce the charge transfer resistance (R ) which dominates low-temperature LIBs performance. Herein, we propose a strategy of using low-polarity-solvent electrolytes which have weak interactions between the solvents and the Li to reduce R , achieving facile Li transport at sub-zero temperatures. The exemplary electrolyte enables LiNi Mn Co O ||graphite cells to deliver a capacity of ≈113 mAh g (98 % full-cell capacity) at 25 °C and to remain 82 % of their room-temperature capacity at -20 °C without lithium plating at 1/3C. They also retain 84 % of their capacity at -30 °C and 78 % of their capacity at -40 °C and show stable cycling at 50 °C.
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http://dx.doi.org/10.1002/anie.202205967DOI Listing
July 2022

The Acute Toxicities and Efficacy of Concurrent Chemotherapy With Docetaxel Plus Cisplatin, or Docetaxel, or Cisplatin and Helical Tomotherapy in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma: A Randomized Single-Center Phase II Trial.

Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221109974

Department of Radiation Oncology, 104607First Medical Center of Chinese PLA General Hospital, Beijing, China.

The objective of this trial is to evaluate and compare the acute toxicity in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) treated with docetaxel plus cisplatin, or docetaxel, or cisplatin concurrently with helical tomotherapy during concurrent chemoradiotherapy (CCRT). In a prospective, single-center, open-label, randomized phase II study, after 2 cycles of induction chemotherapy with docetaxel plus cisplatin regimen, 125 patients with LA-NPC (stage III and IVA, UICC eighth) diagnosed pathologically from June 2017 to November 2019 were randomized into CCRT with docetaxel plus cisplatin group (25 patients), CCRT with docetaxel group (50 patients), and CCRT with cisplatin group (50 patients). The incidence of grade 3 or 4 acute toxicities and clinical efficacy were analyzed among the 3 groups. Safety evaluation was completed in all the 125 patients, during the CCRT period, 66.4% of patients completed 3 cycles of chemotherapy, 24.0% completed 2 cycles of chemotherapy, and 9.6% completed 1 cycle of chemotherapy according to the research plan. The incidence of grade 3 or 4 acute toxicity in CCRT with docetaxel plus cisplatin (DP), docetaxel (D), and cisplatin (P) groups was 88.0%, 72.0%, and 56.0%, respectively. The incidence of grade 3 or 4 acute toxicities in the DP group was significantly higher than that in the D and P groups ( = .015), no significant difference was detected between the D and P groups ( = .096). The most common toxicities were mucositis (40.0%), leukopenia (29.6%), neutropenia (26.4%), and pharyngo-esophagitis (12.0%); compared to D and P groups, DP group did not significantly improved the 3-year overall survival (96.0% vs 87.0% and 87.6%), progression-free survival (92.0% vs 79.7% and,76.9%), locoregional failure-free survival (96.0% vs 91.8% and 92.7%), and distant failure-free survival (100% vs 90.0% and 89.0%), there were no significant difference in survival data among the 3 groups (all > .05). Higher survival benefits did not achieve from intensified CCRT with DP, CCRT with P or D obtained similar short-term survival outcomes with similar acceptable toxicities in LA-NPC patients.
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http://dx.doi.org/10.1177/15330338221109974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251964PMC
July 2022

CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation.

Cell Res 2022 Aug 29;32(8):744-760. Epub 2022 Jun 29.

RNA Biomedical Institute, Sun Yat-Sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China.

Chromatin is spatially organized into three-dimensional structures at different levels including A/B compartments, topologically associating domains and loops. The canonical CTCF-mediated loop extrusion model can explain the formation of loops. However, the organization mechanisms underlying long-range chromatin interactions such as interactions between A-A compartments are still poorly understood. Here we show that different from the canonical loop extrusion model, RYBP-mediated phase separation of CTCF organizes inter-A compartment interactions. Based on this model, we designed and verified an induced CTCF phase separation system in embryonic stem cells (ESCs), which facilitated inter-A compartment interactions, improved self-renewal of ESCs and inhibited their differentiation toward neural progenitor cells. These findings support a novel and non-canonical role of CTCF in organizing long-range chromatin interactions via phase separation.
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http://dx.doi.org/10.1038/s41422-022-00676-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343660PMC
August 2022

Subchronic toxicity of magnesium oxide nanoparticles to silkworm.

RSC Adv 2022 Jun 10;12(27):17276-17284. Epub 2022 Jun 10.

Institute of Life Science, Jiangsu University Zhenjiang Jiangsu 212013 P. R. China

Despite many research efforts devoted to the study of the effects of magnesium oxide nanoparticles (MgO NPs) on cells or animals in recent years, data related to the potential long-term effects of this nanomaterial are still scarce. The aim of this study is to explore the subchronic effects of MgO NPs on silkworm, a complete metamorphosis insect with four development stages (egg, larva, pupa, month). With this end in view, silkworm larvae were exposed to MgO NPs at different mass concentrations (1%, 2%, 3% and 4%) throughout their fifth instar larva. Their development, survival rate, cell morphology, gene expressions, and especially silk properties were compared with a control. The results demonstrate that MgO NPs have no significant negative impact on the growth or tissues. The cocooning rate and silk quality also display normal results. However, a total of 806 genes are differentially expressed in the silk gland (a vital organ for producing silk). GO (Gene Ontology) results show that the expression of many genes related to transporter activity are significantly changed, revealing that active transport is the main mechanism for the penetration of MgO NPs, which also proves that MgO NPs are adsorbed by cells. KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis demonstrates that the longevity regulating pathway-worm, peroxisome and MAPK signaling pathway are closely involved in the biological effects of MgO NPs. Overall, subchronic exposure to MgO NPs induced no apparent negative impact on silkworm growth or silks but changed the expressions of some genes.
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http://dx.doi.org/10.1039/d2ra01161aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186304PMC
June 2022

Influence of empathy and professional values on ethical decision-making of emergency nurses: A cross sectional study.

Int Emerg Nurs 2022 Jul 21;63:101186. Epub 2022 Jun 21.

School of Nursing, Sun Yat-sen University, Guangzhou, China. Electronic address:

Introduction: Emergency nurses are likely to experience serious ethical dilemmas and conflicts because of the dangerous and unpredictable care situations. Nursing ethical decision-making ability is therefore a core competence. Empathy and professional values may be the important variables that influence ethical decision-making. However, for emergency nurses, there is a lack of empirical evidence to support presently. This study aimed to explore the influence of empathy and professional values on nursing ethical decision-making of emergency nurses.

Methods: A convenience sample of 236 emergency nurses from 10 general hospitals in China were surveyed. Their ethical decision-making ability, empathy and professional values were measured using the Judgment About Nursing Decision scale, Jefferson Scale of Empathy-Health Professionals, and Nursing Professional Values Scale-Revised, respectively. Additionally, their sociodemographic data were collected. Univariate analysis, Pearson analysis, and multiple linear regression were performed.

Results: The mean ethical decision-making score of emergency nurses was 295.06 ± 26.49, which was medium level. Their average ethical choice score was higher than that of ethical action (P < 0.001). The multiple linear regression results showed that professional values (Standardized coefficients (β) = 0.295, 95% confidence interval (CI): 0.618-1.618), empathy (β = 0.210, 95% CI: 0.620-1.613), job title (β = 0.253, 95% CI: 0.357-2.800) and number of forms of in-service training on ethical decision-making (β = 0.243, 95% CI: 0.254-3.942) were the independent factors significantly influencing the ethical decision-making ability. The multivariate linear regression model had an F statistic of 32.153 (P < 0.001) and an R = 0.588.

Conclusions: Strengthening nurses' empathy and professional values can help nurses make ethical decisions. More clinical experience and in-service training on ethical decision-making can help emergency nurses better handle ethical dilemmas and conflicts.
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http://dx.doi.org/10.1016/j.ienj.2022.101186DOI Listing
July 2022

New insight into human health risk from polycyclic aromatic hydrocarbons on surfaces of buildings and facilities for industrial legacy regeneration.

J Hazard Mater 2022 08 16;436:129158. Epub 2022 May 16.

Environmental Sustainable Development Technology Center, 100102 Beijing, China.

Although many industrial heritage sites have been repurposed into attractive landscapes, the contamination and health risks from polycyclic aromatic hydrocarbons (PAHs) on industrial legacy surfaces remain unexplored. We collected 441wiping surface samples from 95 buildings and facilities at Beijing coking plant in China and found that the concentrations of 16 US EPA priority PAHs (∑PAHs) ranged from ND-982.16 and ND-4262.20 mg/m on the surfaces of buildings and facilities, respectively. The main source of PAHs was the coking process, and spatial distribution of PAHs was consistent with ∑PAHs in the soil. The carcinogenic risks of BaP, DBA, BbF, BaA, Ind of the facilities remained as industrial heritage relics, and those of Bap, DBA and BbF in the buildings with commercial uses exceeded the acceptable level (10). The hazard quotient of 9 PAHs was below the acceptable level (1.0). The remedial goals for BaP and DBA (0.11 mg/m) and BbF, BaA and Ind (1.14 mg/m) at the facility heritage relics were derived. Similarly, the RGs for the buildings with commercial uses of BaP, DBA and BbF were 0.16, 0.16, and 1.64 mg/m, respectively. Overall, we determined that carcinogenic PAHs on the surfaces of industrial legacy should be regulated for regeneration.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129158DOI Listing
August 2022

Polyelectrolyte aerogels with regeneration capacity for efficient removal of particulate matters.

J Colloid Interface Sci 2022 Nov 15;625:446-456. Epub 2022 Jun 15.

Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan 250100, PR China. Electronic address:

Hypothesis: With the rapid development of economy and global industrialization, the problem of air pollution has become a worldwide topic. The efficient filtration of airborne particulate matters (PMs) is critical for human health and environmental sustainability.

Experiments: Herein, self-supporting bio-based polyelectrolyte aerogels were prepared and acted as the advanced filters for efficient removal of PMs. The natural choline cation (Ch) or the organic cation, 1-butyl-3-methylimidazolium (Bmim), are introduced into alginate (Alg) to form the polyelectrolytes of ChAlg or BmimAlg due to the electrostatic interaction. By the directional freeze-drying in liquid N, hierarchically porous aerogels with mechanical robustness, flexibility and thermo-stability were prepared. This specific structure may permit the polluted air to pass adequately through the aerogel channels, which are conducive to intercept various PMs with different diameters.

Findings: As an example, the removal efficiency of ChAlg aerogels for PM, PM and PM are respectively up to (99.24 ± 0.03)%, (99.22 ± 0.02)%, and (93.41 ± 0.22)% within 15 h durability test. One outstanding character lies in ensuring high removal efficiency, while achieving a good balance with the low pressure drop (10 Pa), which is driven by synergistic effect of passive trapping and electrostatic capture. Moreover, the polyelectrolyte aerogels exhibit excellent antimicrobial activity and regenerated capacity. These properties endow the aerogels of polyelectrolyte ChAlg or BmimAlg with remarkable potential as new advanced filters for masks and other personal protective equipment.
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http://dx.doi.org/10.1016/j.jcis.2022.06.046DOI Listing
November 2022

Clinical Study on the Use of Acupuncture for the Treatment of Female Sexual Dysfunction: A Pilot Study.

Sex Med 2022 Aug 20;10(4):100541. Epub 2022 Jun 20.

Maternal and Child Health Care Hospital of Zaozhuang, Zaozhuang, Shandong, China.

Introduction: Female sexual dysfunction (FSD) seriously affects the quality of life of women. However, most women do not have access to effective treatment.

Aim: This study aimed to determine the feasibility and effectiveness of the use of acupuncture in FSD treatment based on existing clear acupuncture protocol and experience-supported face-to-face therapy.

Methods: A retrospective analysis was performed on 24 patients with FSD who received acupuncture from October 2018 to February 2022. The Chinese version of the female sexual function index , subjective sensation, sexual desire, sexual arousal, vaginal lubrication, orgasm, sexual satisfaction, and dyspareunia scores were compared before and after the treatment in all 24 patients.

Main Outcome Measure: A specific female sexual function index questionnaire was used to assess changes in female sexual function before and after the acupuncture treatment.

Results: In this study, the overall treatment improvement rate of FSD was 100%. The Chinese version of the female sexual function index total score, sexual desire score, sexual arousal score, vaginal lubrication score, orgasm score, sexual satisfaction score, and dyspareunia score during intercourse were significantly different before and after the treatment (P < .05). Consequently, participants reported high levels of satisfaction with acupuncture. This study indicates that acupuncture could be a new and effective technique for treating FSD. The main advantages of this study are its design and efficacy in treating FSD. To the best of our knowledge, this is the first study to evaluate the efficacy of acupuncture in the treatment of FSD using the female sexual function index scale from 6 dimensions. The second advantage is that the method used (ie, the nonpharmacological method) is simple, readily available, highly safe with few side effects, and relatively inexpensive with high patient satisfaction. However, limitations include small sample size and lack of further detailed grouping, pre and post control study of patients, blank control group, and pre and post control study of sex hormones.

Conclusion: Acupuncture can effectively treat FSD from all dimensions with high safety, good satisfaction, and definite curative effect, and thus, it is worthy of promotion and application. Zhang JT, Ma L, Gong X, et al. Clinical Study on the Use of Acupuncture for the Treatment of Female Sexual Dysfunction: A Pilot Study. Sex Med 2022;10:100541.
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http://dx.doi.org/10.1016/j.esxm.2022.100541DOI Listing
August 2022

Development of Cationic Cellulose-Modified Bentonite-Alginate Nanocomposite Gels for Sustained Release of Alachlor.

ACS Omega 2022 Jun 31;7(23):20032-20043. Epub 2022 May 31.

School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, P. R. China.

The nanocomposite gel prepared from nanoclay and natural polysaccharides showed a good sustained-release property. Herein, a cationic cellulose-modified bentonite-alginate nanocomposite gel was prepared and used to enhance the sustained release of alachlor. The underlying effect and mechanism of the structure of modified bentonite-alginate nanocomposite gels on the release behavior of alachlor were explored by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The results showed that the release of alachlor from the nanocomposite gels was dominated by Fickian diffusion and closely related to the adsorption capacity and permeability of the matrix. The cationic cellulose intercalated into the interlayer space of bentonite through an ion exchange reaction, which significantly enhanced the hydrophobicity of bentonite and its interaction with alachlor. The stacking aggregation of bentonite nanoplatelets and permeability of the gel network were decreased through the electrostatic interaction between cationic cellulose and alginate molecular chains, thus remarkably enhancing the sustained-release property of the nanocomposite gel. The release kinetics revealed that the release rate of alachlor from the nanocomposite gel first decreased and then increased as the content of bentonite and modified bentonite gradually increased. Also, the best sustained-release property of the nanocomposite gel was obtained at bentonite and modified bentonite additions of about 10%, under which the release time of 50% alachlor ( ) from bentonite-alginate and modified bentonite-alginate nanocomposite gels was 4.4 and 5.6 times longer than the release time from pure alginate gels, respectively.
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http://dx.doi.org/10.1021/acsomega.2c01805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202269PMC
June 2022

Hippocampal Proteomic Analysis in Male Mice Following Aggressive Behavior Induced by Long-Term Administration of Perampanel.

ACS Omega 2022 Jun 1;7(23):19388-19400. Epub 2022 Jun 1.

Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, Ningxia, PR China.

Antiepileptic drugs have been shown to be associated with inducing or exacerbating adverse psychotropic reaction, including aggressive behavior. Perampanel, the first pharmacological compound approved by the FDA in 2012, is an effective antiepileptic drug for intractable epilepsy but induces severe aggression. So far, the underlying molecular mechanisms of aggression induced by perampanel remain incompletely understood. In the present study, a model of aggressive behavior based on the clinical use of perampanel was established and resident-intruder test and open field test were performed. Changes in hippocampal protein profiles were detected by tandem mass tag (TMT) proteomics. The behavioral results indicated that long-term use of perampanel increased the aggressive behavior of C57BL/6J mice. Proteomic analysis revealed that 93 proteins were significantly altered in the hippocampus of the perampanel-treated group (corrected < 0.05), which were divided into multiple functional groups, mainly related to synaptic function, synaptogenesis, postsynaptic density protein, neurite outgrowth, AMPA-type glutamate receptor immobilization, and others. Bioinformatic analysis showed that differentially expressed proteins were involved in synaptic plasticity and the Ras signaling pathway. Furthermore, validation results by western blot demonstrated that glutamate receptor 1 (GluA1) and phosphorylation of mitogen-activated protein kinase (ERK1/2) were notably up-regulated, and synaptophysin () and postsynaptic density 95 (PSD95) were down-regulated in perampanel-treated mice. Therefore, our results provide valuable insight into the molecular mechanisms of aggressive behavior induced by perampanel, as well as potential options for safety treatment of perampanel in the future.
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http://dx.doi.org/10.1021/acsomega.2c01008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202264PMC
June 2022

Dynamical reciprocity in interacting games: Numerical results and mechanism analysis.

Phys Rev E 2022 May;105(5-1):054302

School of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, People's Republic of China.

We study the evolution of two mutually interacting pairwise games on different topologies. On two-dimensional square lattices, we reveal that the game-game interaction can promote the cooperation prevalence in all cases, and the cooperation-defection phase transitions even become absent and fairly high cooperation is expected when the interaction becomes very strong. A mean-field theory is developed that points out dynamical routes arising therein. Detailed analysis shows indeed that there are rich categories of interactions in either the individual or bulk scenario: invasion, neutral, and catalyzed types; their combination puts cooperators at a persistent advantage position, which boosts the cooperation. The robustness of the revealed reciprocity is strengthened by the studies of model variants, including the public goods game, asymmetrical or time-varying interactions, games of different types, games with timescale separation, different updating rules, etc. The structural complexities of the underlying population, such as Newman-Watts small world networks, Erdős-Rényi random networks, and Barabási-Albert networks, also do not alter the working of the dynamical reciprocity. In particular, as the number of games engaged increases, the cooperation level continuously improves in general. However, our analysis shows that the dynamical reciprocity works only in structured populations, otherwise the game-game interaction has no any impact on the cooperation at all. In brief, our work uncovers a cooperation mechanism in the structured populations, which indicates the great potential for human cooperation since concurrent issues are so often seen in the real world.
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http://dx.doi.org/10.1103/PhysRevE.105.054302DOI Listing
May 2022

A facile metal-free one-flask synthesis of multi-substituted furans a BF·EtO mediated formal [4 + 1] reaction of 3-chloro-3-phenyldiazirines and α,β-alkenyl ketones.

RSC Adv 2022 May 18;12(24):15190-15195. Epub 2022 May 18.

School of Chemistry and Chemical Engineering, Guangxi University Nanning Guangxi 530004 China

A facile, efficient and metal free one-flask approach to diversely substituted furans from easily accessible 3-chloro-3-phenyldiazirines and α,β-alkenyl ketones is reported. This protocol integrates three steps of cyclopropanation, Cloke-Wilson rearrangement and elimination of HCl in one-flask to give products in moderate to good yields. It provides a metal and oxidant free approach to multi-substituted furans with the advantages of easy operation, mild reaction conditions and a broad scope of substrates.
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http://dx.doi.org/10.1039/d2ra01472fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9115646PMC
May 2022

Oesophageal reconstruction with a reversed gastric conduit for a complex oesophageal cancer patient: a case report.

Authors:
Yanbo Yang Lin Ma

BMC Surg 2022 Jun 11;22(1):225. Epub 2022 Jun 11.

Department of Thoracic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Sichuan, 610041, Chengdu, People's Republic of China.

Background: The gastric conduit is the best replacement organ for oesophageal reconstruction, but a reversed gastric conduit (RGC) is rare. Oesophageal reconstruction for oesophageal cancer patients with a previous history of complicated gastrointestinal surgery is rather difficult. Here, we report a case in which oesophageal reconstruction was successfully managed using RGC based solely on the left gastroepiploic artery supply.

Case Presentation: A 69-year-old man with oesophageal cancer had a history of endoscopic intestinal polypectomy and pylorus-preserving pancreaticoduodenectomy (PPPD). The right gastroepiploic artery and right gastric artery had been completely severed. The only supply artery that could be used for the gastric conduit was just the left gastroepiploic artery. Because of the complex history of abdominal surgery, we had no choice but to use the RGC to complete the oesophageal reconstruction, in which the gastric conduit was passed reversely through the hiatus to the oesophageal bed and layered end-to-side manual intrathoracic anastomosis with the esophagus. The patient had transient feeding problems with postoperative delayed thoracic stomach emptying but no anastomotic stenosis or thoracic stomach fistula. He was satisfied with his life and had no long-term complications. There was no significant effect on gut physiological function, and RGC could work normally.

Conclusions: Oesophageal reconstruction with RGC is a feasible procedure for complex oesophageal carcinoma that can simplify complicated surgical procedures, has less influence on gut function, is less invasive, and is safe.
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http://dx.doi.org/10.1186/s12893-022-01630-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188175PMC
June 2022
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