Publications by authors named "Lin Feng"

1,899 Publications

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Data driven time-varying SEIR-LSTM/GRU algorithms to track the spread of COVID-19.

Math Biosci Eng 2022 Jun;19(9):8935-8962

Department of Mathematical Sciences, Middle Tennessee State University, Murfreesboro, TN 37132, USA.

COVID-19 is an infectious disease caused by a newly discovered coronavirus, which has become a worldwide pandemic greatly impacting our daily life and work. A large number of mathematical models, including the susceptible-exposed-infected-removed (SEIR) model and deep learning methods, such as long-short-term-memory (LSTM) and gated recurrent units (GRU)-based methods, have been employed for the analysis and prediction of the COVID-19 outbreak. This paper describes a SEIR-LSTM/GRU algorithm with time-varying parameters that can predict the number of active cases and removed cases in the US. Time-varying reproductive numbers that can illustrate the progress of the epidemic are also produced via this process. The investigation is based on the active cases and total cases data for the USA, as collected from the website "Worldometer". The root mean square error, mean absolute percentage error and r score were utilized to assess the model's accuracy.
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http://dx.doi.org/10.3934/mbe.2022415DOI Listing
June 2022

Clinical advantages and neuroprotective effects of monitor guided fang's capillary fascia preservation right RLN dissection technique.

Front Endocrinol (Lausanne) 2022 22;13:918741. Epub 2022 Jul 22.

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objective: To investigate the feasibility and advantages of Fang's capillary fascia preservation right recurrent laryngeal nerve (RLN) dissection technique (F-R-RLN dissection) with preservation of the capillary network and fascia between the RLN and common carotid artery for greater neuroprotective efficiency compared with traditional techniques.

Methods: We retrospectively analyzed 102 patients with papillary thyroid carcinoma undergoing right level VI lymph node dissection in our department from March 2021 to January 2022. Sixty patients underwent F-R-RLN dissection (the experimental group) and 42 patients underwent standard dissection (the control group). The intraoperative electrical signal amplitude ratios of the RLN, the number of dissected lymph nodes, and the preservation rates of the parathyroid glands were recorded and compared between the two groups.

Results: The electrical signal amplitude ratio of the lower neck part point of the RLN to the upper laryngeal inlet point in the experimental group was significantly lower than the ratio in the control group ( = 0.006, Z-score = -2.726). One patient suffered transient RLN paralysis in both groups, but this resolved within 1 month after operation. There were no significant differences between the two groups in terms of the number of level VIa or level VIb lymph nodes dissected, nor in the rate of preservation of the parathyroid glands.

Conclusions: F-R-RLN dissection is a thorough dissection technique that is effective at preventing an electrical signal amplitude decrease in the RLN, and at preventing RLN paralysis by preserving its blood supply.
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http://dx.doi.org/10.3389/fendo.2022.918741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353769PMC
August 2022

In vitro magnetosome remineralization for silver-magnetite hybrid magnetosome biosynthesis and used for healing of the infected wound.

J Nanobiotechnology 2022 Aug 6;20(1):364. Epub 2022 Aug 6.

School of Mechanical Engineering and Automation, Beihang University, Beijing, 100083, China.

Background: Magnetosomes (BMPs) are organelles of magnetotactic bacteria (MTB) that are responsible for mineralizing iron to form magnetite. In addition, BMP is an ideal biomaterial that is widely used in bio- and nano-technological applications, such as drug delivery, tumor detection and therapy, and immunodetection. The use of BMPs to create multifunctional nanocomposites would further expand the range of their applications.

Results: In this study, we firstly demonstrate that the extracted BMP can remineralize in vitro when it is exposed to AgNO solution, the silver ions (Ag) were transported into the BMP biomembrane (MM) and mineralized into a silver crystal on one crystal plane of FeO. Resulting in the rapid synthesis of an Ag-FeO hybrid BMP (BMP-Ag). The synergy between the biomembrane, FeO crystal and unmineralized iron enabled the remineralization of BMPs at an Ag concentration ≥ 1.0 mg mL. The BMP-Ag displayed good biocompatibility and antibacterial activity. At a concentration of 2.0 mg/mL, the BMP-Ag and biomembrane removed Ag-FeO NPs inhibited the growth of gram-negative and gram-positive bacteria. Thus using BMP-Ag as a wound dressing can effectively enhance the contraction of infected wounds.

Conclusions: This study represents the first successful attempt to remineralize organelles ex vivo, realizing the biosynthesis of hybrid BMP and providing an important advancement in the synthesis technology of multifunctional biological nanocomposites.
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http://dx.doi.org/10.1186/s12951-022-01532-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356440PMC
August 2022

Enhancing deep mineralization of refractory benzotriazole via carbon nanotubes-intercalated cobalt copper bimetallic oxide nanosheets activated peroxymonosulfate process: Mechanism, degradation pathway and toxicity.

J Colloid Interface Sci 2022 Jul 28;628(Pt A):448-462. Epub 2022 Jul 28.

State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China.

Peroxymonosulfate-based advanced oxidation processes (PMS-AOPs) are effective methods for the degradation of highly toxic and refractory nitrogen-containing heteroatomic pollutants such as benzotriazole (BTA). The construction of catalytic materials with multiple active centers is the key to generating abundant reactive oxygen species (ROS) and achieving high mineralization efficiency in PMS-AOPs. Herein, carbon nanotubes-intercalated cobalt copper bimetallic oxide nanosheets catalyst ([email protected]) was obtained by pyrolysis of two-dimensional (2D) MOF precursor. The degradation rate constant of BTA in [email protected]/PMS system was 4 times higher than that of metal oxide nanosheets catalyst without CNTs, while exhibiting high cycling stability and mineralization efficiency. Serial characterizations demonstrated that CoCu nanosheets was formed by CNTs-induced the directional assembly of metal oxide nanoparticles, which had high graphitization and abundant oxygen vacancies and could greatly facilitated the adsorption and electron transfer between the catalyst, PMS and BTA. Moreover, the doping of Cu species significantly improved PMS utilization and accelerated the Co(III)/Co(II) redox cycle. Both radicals (SO4• and •OH) and non-radicals (O) played a role in [email protected]/PMS system and the contributions of ROS were 72.2%, 11.1% and 16.7%, respectively. Meanwhile, the concentration of key ROS (SO) production increased from 4.76 μM to 8.56 μM compared with cobalt oxide nanosheets (CoNS). Three degradation pathways of BTA were proposed: benzene ring opening, benzene ring hydroxylation and triazole ring dimerization. Finally, the toxicity changes during the degradation process were measured and the toxicity of eleven intermediates was evaluated. This study may provide new insights into the degradation of persistent organic pollutants.
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http://dx.doi.org/10.1016/j.jcis.2022.07.162DOI Listing
July 2022

Contrasting the physical and chemical characteristics of dissolved organic matter between glacier and glacial runoff from a mountain glacier on the Tibetan Plateau.

Sci Total Environ 2022 Aug 1:157784. Epub 2022 Aug 1.

State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China. Electronic address:

Accelerated melting of mountain glaciers due to global warming has a significant impact on downstream biogeochemical evolution because a large amount of labile dissolved organic matter (DOM) is released. However, the DOM evolution processes from glacier to downstream are not well understood. To investigate these processes, samples from the glacial surface and terminating runoff of a mountain glacier on the Tibetan Plateau were collected simultaneously throughout the melting season. The samples were analyzed to determine the dissolved organic carbon (DOC) contents and chemical compositions by means of a combination of fluorescence excitation-emission matrix coupled with parallel factor analysis (EEM-PARAFAC) and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). The results indicate that the DOC concentrations were higher in the snow samples than in the glacial runoff samples, although a significantly higher concentration of inorganic ions was found in the glacial runoff samples, suggesting the dominant source of DOM in the glacial runoff was the glacier. The EEM-PARAFAC revealed four fluorescent components in both the snow and glacial runoff samples. However, significantly different ratios between the four components of these two categories of samples suggested chemical, physical and/or biological evolution of DOM during transport. Molecular chemical composition analyses by FT-ICR MS revealed that the DOM composition varied dramatically between the glacier and the glacial runoff. More than 50 % of the molecules were transformed from aliphatic and peptide-like compounds in the snow samples into highly unsaturated and phenolic-like compounds in the glacial runoff samples. The potential chemical transformation of DOM was likely related to biological and/or photolytic evolution during transport. Our results suggest that chemical evolution of glacial DOM could occur during the downstream transport, which is expected to be useful for further research exploring the fate of DOM and carbon cycling from the cryospheric environment and evaluating the biogeochemical effects.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157784DOI Listing
August 2022

Association Between Dialysis Facility Ownership and Access to the Waiting List and Transplant in Pediatric Patients With End-stage Kidney Disease in the US.

JAMA 2022 08;328(5):451-459

Department of Epidemiology and Biostatistics, University of California, San Francisco.

Importance: Care of adults at profit vs nonprofit dialysis facilities has been associated with lower access to transplant. Whether profit status is associated with transplant access for pediatric patients with end-stage kidney disease is unknown.

Objective: To determine whether profit status of dialysis facilities is associated with placement on the kidney transplant waiting list or receipt of kidney transplant among pediatric patients receiving maintenance dialysis.

Design, Setting, And Participants: This retrospective cohort study reviewed the US Renal Data System records of 13 333 patients younger than 18 years who started dialysis from 2000 through 2018 in US dialysis facilities (followed up through June 30, 2019).

Exposures: Time-updated profit status of dialysis facilities.

Main Outcomes And Measures: Cox models, adjusted for clinical and demographic factors, were used to examine time to wait-listing and receipt of kidney transplant by profit status of dialysis facilities.

Results: A total of 13 333 pediatric patients who started receiving maintenance dialysis were included in the analysis (median age, 12 years [IQR, 3-15 years]; 6054 females [45%]; 3321 non-Hispanic Black patients [25%]; 3695 Hispanic patients [28%]). During a median follow-up of 0.87 years (IQR, 0.39-1.85 years), the incidence of wait-listing was lower at profit facilities than at nonprofit facilities, 36.2 vs 49.8 per 100 person-years, respectively (absolute risk difference, -13.6 (95% CI, -15.4 to -11.8 per 100 person-years; adjusted hazard ratio [HR] for wait-listing at profit vs nonprofit facilities, 0.79; 95% CI, 0.75-0.83). During a median follow-up of 1.52 years (IQR, 0.75-2.87 years), the incidence of kidney transplant (living or deceased donor) was also lower at profit facilities than at nonprofit facilities, 21.5 vs 31.3 per 100 person-years, respectively; absolute risk difference, -9.8 (95% CI, -10.9 to -8.6 per 100 person-years) adjusted HR for kidney transplant at profit vs nonprofit facilities, 0.71 (95% CI, 0.67-0.74).

Conclusions And Relevance: Among a cohort of pediatric patients receiving dialysis in the US from 2000 through 2018, profit facility status was associated with longer time to wait-listing and longer time to kidney transplant.
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http://dx.doi.org/10.1001/jama.2022.11231DOI Listing
August 2022

Developments in smoking cessation interventions for patients with chronic obstructive pulmonary disease in the past 5 years: a scoping review.

Expert Rev Respir Med 2022 Aug 2. Epub 2022 Aug 2.

Department of Research on Tobacco Dependence Therapies, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Introduction: Smoking cessation is the most effective strategy for slowing the progression of chronic obstructive pulmonary disease (COPD). However, COPD patients find it difficult to quit smoking with standard cessation interventions.

Areas Covered: A scoping review of smoking cessation for COPD patients was conducted by searching the MEDLINE, Embase, and Cochrane Library databases for all studies published between 1 January 2016 and 22 September 2021. Four themes were set up and 47 studies were included eventually. The majority of the included studies (61.7%, 29/47) investigated efficacy and effectiveness, including new strategies for extended treatment and mobile health (mHealth) delivery approach. Studies examining accessibility and utilization (31.9%, 15/47), safety (10.6%, 5/47), and health economics (6.4%, 3/47) were also reviewed. The quality of the included randomized controlled trials was also evaluated.

Expert Opinion: Pharmacotherapy combined with behavioral interventions delivered via mHealth may be a promising strategy to help COPD smokers quit. However, the overall quality of the current studies is poor, making it challenging for clinicians to make informed decisions. Future high-quality studies are needed to provide conclusive evidence on the optimal pharmacotherapies and the most cost-effective comprehensive smoking cessation interventions, particularly those integrated into disease management for smokers with COPD.
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http://dx.doi.org/10.1080/17476348.2022.2108797DOI Listing
August 2022

The Influence of 0.5% Tropicamide on Anterior Segment Parameters With CASIA2 in Emmetropic, Myopic, and Hyperopic Eyes.

Front Physiol 2022 12;13:957097. Epub 2022 Jul 12.

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.

To evaluate the effects of 0.5% tropicamide on anterior segment parameters with the CASIA2 imaging device in emmetropic, myopic, and hyperopic eyes. In this prospective study, a total of 125 subjects (34 emmetropic subjects, 57 myopic subjects, and 34 hyperopic subjects) at the Shanghai Eye and ENT Hospital of Fudan University were recruited from June 2021 to September 2021. The 0.5% tropicamide solution was used once every 5 min a total of 5 times for cycloplegia. The anterior segment parameters were recorded by CASIA2 before and after cycloplegia. Changes in anterior segment parameters were compared among the three refractive groups. Crystalline lens rise (CLR) and crystalline lens thickness (CLT) significantly decreased in all three refractive groups after cycloplegia (all < 0.01). The anterior radius of lens (ARL) and anterior chamber depth (ACD) significantly increased in all three refractive groups after cycloplegia (all < 0.01). Posterior radius of lens (PRL) significantly increased in hyperopic eyes after cycloplegia ( < 0.01) while it remained unchanged in emmetropic eyes and myopic eyes. Central corneal thickness (CCT), anterior chamber width (ACW), lens decentration (LD), and lens tilt (LT) remained unchanged after cycloplegia in all three refractive groups (all > 0.05). Changes in CLR, CLT, ARL, PRL, and ACD in hyperopic eyes were greater than those in emmetropic eyes and myopic eyes (all < 0.05). Apart from various changes in anterior segment parameters after application by 0.5% tropicamide in all three refractive groups, significant changes in CLR, CLT, ARL, PRL, and ACD in hyperopic eyes should be noted for proper clinical interpretation.
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http://dx.doi.org/10.3389/fphys.2022.957097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315225PMC
July 2022

An emerging role of vitamin D in amino acid absorption in different intestinal segments of on-growing grass carp ().

Anim Nutr 2022 Sep 28;10:305-318. Epub 2022 May 28.

Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.

Vitamin D (VD), an essential nutrient for animals, has been demonstrated to stimulate the uptake of certain amino acids. However, the role of VD in the intestine, the primary site for digestion and absorption of nutrients, remains poorly characterized. Here, the grass carp () was studied to assess the influence of different doses of VD (15.2, 364.3, 782.5, 1,167.9, 1,573.8, and 1,980.1 IU/kg) on growth performance, intestinal morphology, digestive absorption, amino acid transport, and potential signaling molecule levels in a feeding experiment. As a result, dietary VD improved growth performance, intestinal structure, and digestive and brush border enzyme activities. Additionally, most intestinal free amino acids and their transporters were upregulated after VD intake, except for Ala, Lys, Asp, Leu, solute carrier () , , and mRNA in different segments, Leu and 4 mRNA in the proximal intestine, and mRNA in the mid and distal intestine. In the crucial target of rapamycin (TOR) signal pathway of amino acid transport, the gene and protein expression of TOR, S6 kinase 1, and activating transcription factor 4 were elevated, whereas 4E-binding protein 1 was decreased, further suggesting an advanced amino acid absorption capacity in the fish due to VD supplementation. Based on percentage weight gain, feed efficiency, and trypsin activity, the VD requirements of on-growing grass carp were estimated to be 968.33, 1,005.00, and 1,166.67 IU/kg, respectively. Our findings provide novel recommendations for VD supplementation to promote digestion and absorption capacities of fish, contributing to the overall productivity of aquaculture.
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http://dx.doi.org/10.1016/j.aninu.2022.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9293741PMC
September 2022

Cholesterol Biosynthesis Modulates CSFV Replication.

Viruses 2022 06 30;14(7). Epub 2022 Jun 30.

College of Animal Sciences, Jilin University, Changchun 130062, China.

Classical swine fever (CSF) caused by the classical swine fever virus (CSFV) has resulted in severe losses to the pig industry worldwide. It has been proposed that lipid synthesis is essential for viral replication, and lipids are involved in viral protein maturation and envelope production. However, the specific crosstalk between CSFV and host cell lipid metabolism is still unknown. In this study, we found that CSFV infection increased intracellular cholesterol levels in PK-15 cells. Further analysis demonstrated that CSFV infection upregulated PCSK9 expression to block the uptake of exogenous cholesterol by LDLR and enhanced the cholesterol biosynthesis pathway, which disrupted the type I IFN response in PK-15 cells. Our findings provide new insight into the mechanisms underpinning the pathogenesis of CSFV and hint at methods for controlling the disease.
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http://dx.doi.org/10.3390/v14071450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9316236PMC
June 2022

Water Quality Measurement and Modelling Based on Deep Learning Techniques: Case Study for the Parameter of Secchi Disk.

Sensors (Basel) 2022 Jul 20;22(14). Epub 2022 Jul 20.

Zhejiang Institute of Hydraulics and Estuary, Hangzhou 310020, China.

The Secchi disk is often used to monitor the transparency of water. However, the results of personal measurement are easily affected by subjective experience and objective environment, and it is time-consuming. With the rapid development of computer technology, using image processing technology is more objective and accurate than personal observation. A transparency measurement algorithm is proposed by combining deep learning, image processing technology, and Secchi disk measurement. The white part of the Secchi disk is cropped by image processing. The classification network based on resnet18 is applied to classify the segmentation results and determine the critical position of the Secchi disk. Then, the semantic segmentation network Deeplabv3+ is used to segment the corresponding water gauge at this position, and subsequently segment the characters on the water gauge. The segmentation results are classified by the classification network based on resnet18. Finally, the transparency value is calculated according to the segmentation and classification results. The results from this algorithm are more accurate and objective than that of personal observation. The experiments show the effectiveness of this algorithm.
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http://dx.doi.org/10.3390/s22145399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324665PMC
July 2022

A Novel ERK2 Degrader Z734 Induces Apoptosis of MCF-7 Cells via the HERC3/p53 Signaling Pathway.

Molecules 2022 Jul 6;27(14). Epub 2022 Jul 6.

School of Life Sciences, Chongqing University, Chongqing 401331, China.

Breast cancer is one of the leading causes of death worldwide, and synthetic chemicals targeting specific proteins or various molecular pathways for tumor suppression, such as ERK inhibitors and degraders, have been intensively investigated. The targets of ERK participate in the regulation of critical cellular mechanisms and underpin the progression of anticancer therapy. In this study, we identified a novel small molecule, which we named Z734, as a new mitogen-activated protein kinase 1 (ERK2) degrader and demonstrated that Z734 inhibits cell growth by inducing p53-mediated apoptotic pathways in human breast cancer cells. Treatment with Z734 resulted in the inhibition of cancer cell proliferation, colony formation and migration invasion, as well as cancer cell death via apoptosis. In addition, the Co-IP and GST pulldown assays indicated that the HECT and RLD domains containing E3 ubiquitin protein ligase 3 (HERC3) could directly interact with ERK2 through the HECT domain, promoting ERK2 ubiquitination. We also observed a strong link between HERC3 and p53 for the modulation of apoptosis. HERC3 can increase the protein and phosphorylation levels of p53, which further promotes apoptotic activity. In a xenograft mouse model, the effect was obtained in a treatment group that combined Z734 with lapatinib compared with that of the single-treatment groups. In summary, our results indicated that Z734 actively controls the development of breast cancer through apoptosis, and HERC3 may mediate ERK2 and p53 signaling, which offers new potential targets for clinical therapy.
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http://dx.doi.org/10.3390/molecules27144337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319741PMC
July 2022

Impacts of Mercury Exposure Levels and Sources on the Demethylation of Methylmercury Through Human Gut Microbiota.

Bull Environ Contam Toxicol 2022 Jul 25. Epub 2022 Jul 25.

School of Public Health, Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, China.

This study aims to investigate methylmercury (MeHg) demethylation processes in human gut. Here, we determined the compositions and MeHg demethylation rates of gut microbiota in residents from different Hg exposure levels (Wanshan (WS) town and Yangtou (YT) town) and different Hg exposure sources (Zhuchang (ZC) town and YT town) regions. MeHg and inorganic Hg exposure levels in residents of WS town were significantly higher than those of YT and ZC town. Desulfovibrio and Methanogens, which related to Hg methylation/demethylation, showed significantly higher abundance in WS and ZC, comparing with YT. In vitro experiments demonstrated that human intestinal microbiota could degrade MeHg directly. Besides, gut microbiota in WS and ZC exhibited significantly higher demethylation rates than YT, suggesting Desulfovibrio and Methanogens may play important roles in intestinal MeHg demethylation. This study highlights Hg exposure levels and sources may affect demethylation efficiency of gut microbiota, which provides new insights for MeHg demethylation processes in human body.
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http://dx.doi.org/10.1007/s00128-022-03569-5DOI Listing
July 2022

is a Novel Prognostic Biomarker and Correlated With an Immunosuppressive Tumor Microenvironment in Pan-Cancer.

Front Cell Dev Biol 2022 8;10:930933. Epub 2022 Jul 8.

Department of Urology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen, China.

Adaptor-related protein complex 3, sigma one subunit (AP3S1) is one of the encoding subunits of the adaptor complex AP-3. However, its role in various tumor types and relationship with the tumor immune microenvironment (TIME) remains unclear. AP3S1 expression was analyzed using datasets from The Cancer Genome Atlas, Genotype-Tissue Expression, UALCAN, and HPA databases. Then, we performed a systematic analysis of the genetic alterations, clinical features, and prognostic value of AP3S1 in pan-cancer. Gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA) were used to identify the signaling pathways associated with AP3S1. The correlation between immune cell infiltration and AP3S1 expression was analyzed using immune cell infiltration data from the ImmuCellAI, TIMER2, and a previous study. Finally, we analyzed the association of AP3S1 with tumor mutational burden (TMB), microsatellite instability (MSI), and immune-related genes. We found AP3S1 overexpression in most tumors and a significant association with low survival rates. GSEA and GSVA results show that AP3S1 is involved in tumor progression and associated with immune pathways in different tumor types. We also found that AP3S1 expression was positively correlated with the level of infiltration of immunosuppressive cells (tumor-associated macrophages, cancer-associated fibroblasts, Tregs) and negatively correlated with immune killer cells, including NK cells and CD8 T cells, in pan-cancer. The expression of AP3S1 could affect TMB and MSI in various cancers. In addition, AP3S1 was positively correlated with most immunosuppressive genes, including PD-1, PD-L1, CTLA4, LAG3 and TIGIT in most cancer types. Our study reveals that AP3S1 is a potential pan-cancer oncogene and plays an essential role in tumorigenesis and cancer immunity. Elevated expression of AP3S1 indicates an immunosuppressive microenvironment and can be used as a potential prognostic biomarker and a target for immunotherapy.
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http://dx.doi.org/10.3389/fcell.2022.930933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9304770PMC
July 2022

Investigation on the chemical recovery and stability of a newly developed method for Cs measurement in marine biota Scomber Japonicus.

Authors:
Jianhua He Feng Lin

Appl Radiat Isot 2022 Jul 19;188:110381. Epub 2022 Jul 19.

Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, 361005, China.

Seven sets of experiments based on a newly developed Mincing-Digesting method for Cs measuring in marine biota Scomber Japonicus were conducted to investigate the method's stability and chemical recovery. The results show the chemical recovery of radiocesium for aqueous parts is 68.77 ± 11.2%, which is relatively stable with R = 0.97, means this value could be used when measuring the Scomber Japonicus or other marine biota belonging to the same category and having similar muscular tissue and cellular structure. Meanwhile, the Minimum Detectable Activity (MDA) of the method is 0.013Bq/kg which is comparable with that of the conventional method, means that the method could be further developed as a reliable and efficient way to measure other radionuclides in other marine biotas in the future if more experiments were conducted.
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http://dx.doi.org/10.1016/j.apradiso.2022.110381DOI Listing
July 2022

Optical diffuser constructed by assembly of cellulose ether and polymer complex particles.

Carbohydr Polym 2022 Oct 2;294:119804. Epub 2022 Jul 2.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Center for Advanced Low-Dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. Electronic address:

Using sustainable cellulose and its derivatives to prepare optical diffuser is an economic and green approach. Herein, we report a novel optical diffuser constructed by interfacial assembly of cellulose ether (CE) and polymer complex particles (PCP) on flexible and transparent poly(ethylene terephthalate) (PET) substrate. Owning to the rich hydroxyl groups of CEs, the complex thin film can be further crosslinked by thermal treatment which greatly improves the optical diffusion performance and durability. Without crosslinking, haze (H) of the cellulose complex film is about 81 %, and the film will dissolve in high pH value solution. While after the proper crosslinking, H of the film increases to 95 %, and the film can resist the erosion of high pH solution. Moreover, CE/PCP complex film shows improved anti-bending capacity compared with commercially available optical diffuser for liquid crystal display.
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http://dx.doi.org/10.1016/j.carbpol.2022.119804DOI Listing
October 2022

Berberine Ameliorates Insulin Resistance by Inhibiting IKK/NF-κB, JNK, and IRS-1/AKT Signaling Pathway in Liver of Gestational Diabetes Mellitus Rats.

Metab Syndr Relat Disord 2022 Jul 21. Epub 2022 Jul 21.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Berberine is derived from rhizoma coptidis, a well-known Traditional Chinese herbal Medicine that has been found to be effective in the treatment of type 2 diabetes mellitus in recent years. The aim of the present study was to investigate the effects of berberine on a gestational diabetes mellitus (GDM) rat model and the related mechanisms. GDM was induced in Sprague-Dawley rats using a high-fat diet before and during pregnancy. Berberine (100 mg/kg/day) was administered from the 7th to 20th day of pregnancy. Insulin resistance (IR), glucose tolerance, and maternal, fetal, and placental weight were determined. Liver histopathological analysis, as well as analysis of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), inhibitor kappa B kinaseβ (IKKβ), nuclear factor kappa-B (NF-κB), c-Jun N-terminal kinase (JNK), insulin receptor substrate-1 (IRS-1), and protein kinase B (AKT), was performed at the end of pregnancy. Treatment of GDM rats with berberine markedly decreased IR, the number of dead and absorptive fetuses, maternal body weight gain, and fetal and placental weight compared with GDM without berberine. Furthermore, berberine decreased CRP and TNF-α levels, IKKβ expression, NF-κB P65 nuclear translocation, and changed the phosphorylation of JNK, IRS-1, and AKT in the liver of GDM rats. Berberine improved IR and maternal-fetal outcomes of GDM rats, possibly through modulation of IKK/NF-κB, JNK, and IRS-1/AKT signaling pathways in the liver. Therefore, berberine may be a potential GDM treatment.
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http://dx.doi.org/10.1089/met.2022.0017DOI Listing
July 2022

Effects of Cuisine-Based Chinese Heart-Healthy Diet in Lowering Blood Pressure Among Adults in China: Multicenter, Single-Blind, Randomized, Parallel Controlled Feeding Trial.

Circulation 2022 Jul 11;146(4):303-315. Epub 2022 Jul 11.

Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China (Y. Wang, L.F., P.G., X.C., Y. Zhu, H.L., G.X., Y. Wu).

Background: More than one-fifth of the world's population consumes Chinese cuisines regularly, but no evidence-based healthy diets fitting the Chinese food culture are available for implementation.

Methods: A multicenter, patient- and outcome assessor-blind, randomized feeding trial was conducted among 265 participants with 130 to 159 mm Hg baseline systolic blood pressure (SBP) for 4 major Chinese cuisines (Shangdong, Huaiyang, Cantonese, Szechuan). After a 7-day run-in period on a control diet matching the usual local diets, participants were randomized to continue with the control diet or the cuisine-based Chinese heart-healthy diet for another 28 days. The primary outcome was SBP, and secondary outcomes included diastolic blood pressure and food preference score. Linear regression models were used to estimate the intervention effects and adjustments for the center. The incremental cost per 1 mm Hg reduction in SBP was also calculated.

Results: A total of 265 participants were randomized (135 on the Chinese heart-healthy diet and 130 on the control diet), with 52% women, mean age of 56.5±9.8 years, and mean SBP and diastolic blood pressure of 139.4±8.3 and 88.1±8.0 mm Hg, respectively, at baseline. The change in SBP and diastolic blood pressure from baseline to the end of the study in the control group was -5.0 (95% CI, -6.5 to -3.5) mm Hg and -2.8 (95% CI, -3.7 to -1.9) mm Hg, respectively. The net difference of change between the 2 groups in SBP and diastolic blood pressure were -10.0 (95% CI, -12.1 to -7.9) mm Hg and -3.8 (95% CI, -5.0 to -2.5) mm Hg, respectively. The effect size did not differ among cuisines ( for interaction=0.173). The mean food preference score was 9.5 (with 10 the best preferred) at baseline, and the net change during intervention was 0.1 (95% CI, -0.1 to 0.2; =0.558). The incremental cost-effectiveness ratio per 1 mm Hg SBP reduction was CNY 0.4 (USD 0.06) per day. No difference in the number of adverse events was found between the 2 groups (=0.259), and none of the adverse events was associated with the intervention.

Conclusions: The Chinese heart-healthy diet is effective, palatable, and cost-effective in reducing blood pressure in Chinese adults with high blood pressure, with a clinically significant effect applicable across major Chinese cuisine cultures.

Registration: URL: https://www.

Clinicaltrials: gov; Unique identifier: NCT03882645.
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http://dx.doi.org/10.1161/CIRCULATIONAHA.122.059045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311470PMC
July 2022

Chemomechanics of Rechargeable Batteries: Status, Theories, and Perspectives.

Chem Rev 2022 Aug 15;122(15):13043-13107. Epub 2022 Jul 15.

School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.

Chemomechanics is an old subject, yet its importance has been revived in rechargeable batteries where the mechanical energy and damage associated with redox reactions can significantly affect both the thermodynamics and rates of key electrochemical processes. Thanks to the push for clean energy and advances in characterization capabilities, significant research efforts in the last two decades have brought about a leap forward in understanding the intricate chemomechanical interactions regulating battery performance. Going forward, it is necessary to consolidate scattered ideas in the literature into a structured framework for future efforts across multidisciplinary fields. This review sets out to distill and structure what the authors consider to be significant recent developments on the study of chemomechanics of rechargeable batteries in a concise and accessible format to the audiences of different backgrounds in electrochemistry, materials, and mechanics. Importantly, we review the significance of chemomechanics in the context of battery performance, as well as its mechanistic understanding by combining electrochemical, materials, and mechanical perspectives. We discuss the coupling between the elements of electrochemistry and mechanics, key experimental and modeling tools from the small to large scales, and design considerations. Lastly, we provide our perspective on ongoing challenges and opportunities ranging from quantifying mechanical degradation in batteries to manufacturing battery materials and developing cyclic protocols to improve the mechanical resilience.
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http://dx.doi.org/10.1021/acs.chemrev.2c00002DOI Listing
August 2022

The aero body righting of frog Rana rugulosus via hindleg swings.

J Exp Zool A Ecol Integr Physiol 2022 Jul 11. Epub 2022 Jul 11.

School of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen, Shenzhen, People's Republic of China.

Frogs can keep an excellent aerial balance for landing and achieve consecutive jumps reliably. A safe landing requires an accurate body righting in the air. However, there is no systematic study on how the frogs adjust the aerial postures and body attitudes after jumping. The stretched long hindlegs swung quickly in the aerial phase, which revealed a clear relationship with the body attitudes. This study aimed to verify the function of frogs' hindlegs on aero body righting in the air. We captured the motions of both hindlegs and found the hindlegs adopted two movement modes, the bilateral parallel, and separated swings. The hindleg-induced torques by the two movements were negatively correlated with the body's angular accelerations on pitch and roll, respectively. Moreover, an analytical model was derived based on the conservation of angular momentum and verified by the dynamic simulations. Thus, we confirmed that the hindlegs are the dominant mechanism in aerial pitch and roll controls. We anticipate our achievements to inspire the design of air-righting tools.
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http://dx.doi.org/10.1002/jez.2642DOI Listing
July 2022

Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights.

Molecules 2022 Jun 29;27(13). Epub 2022 Jun 29.

Department of Neurosurgery, The First Hospital of Jilin University, Changchun 130021, China.

Ischemic stroke (IS) is a leading cause of death and disability worldwide. Currently, the main therapeutic strategy involves the use of intravenous thrombolysis to restore cerebral blood flow to prevent the transition of the penumbra to the infarct core. However, due to various limitations and complications, including the narrow time window in which this approach is effective, less than 10% of patients benefit from such therapy. Thus, there is an urgent need for alternative therapeutic strategies, with neuroprotection against the ischemic cascade response after IS being one of the most promising options. In the past few decades, polyphenolic compounds have shown great potential in animal models of IS because of their high biocompatibility and ability to target multiple ischemic cascade signaling pathways, although low bioavailability is an issue that limits the applications of several polyphenols. Here, we review the pathophysiological changes following cerebral ischemia and summarize the research progress regarding the applications of polyphenolic compounds in the treatment of IS over the past 5 years. Furthermore, we discuss several potential strategies for improving the bioavailability of polyphenolic compounds as well as some essential issues that remain to be addressed for the translation of the related therapies to the clinic.
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http://dx.doi.org/10.3390/molecules27134181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268254PMC
June 2022

Characterization of Roasting Time on Sensory Quality, Color, Taste, and Nonvolatile Compounds of Yuan An Yellow Tea.

Molecules 2022 Jun 27;27(13). Epub 2022 Jun 27.

Institute of Fruit and Tea, Hubei Academy of Agricultural Sciences, Wuhan 430068, China.

Roasting is crucial for producing Yuan An yellow tea (YAYT) as it substantially affects sensory quality. However, the effect of roasting time on YAYT flavor quality is not clear. To investigate the effect of roasting time on the sensory qualities, chemical components, odor profiles, and metabolic profile of YAYTs produced with 13 min roasting, 16 min roasting, 19 min roasting, 22 min roasting, and 25 min roasting were determined. The YAYTs roasted for 22 min got higher sensory scores and better chemical qualities, such as the content of gallocatechin (GC), gallocatechin gallate (GCG), free amino acids, solutable sugar, meanwhile the lightness decreased, the hue of tea brew color (b) increased, which meant the tea brew got darker and yellower. YAYTs roasted for 22 min also increased the contents of key odorants, such as benzaldehyde, nonanal, β-cyclocitral, linalool, nerol, α-cedrol, β-ionone, limonene, 2-methylfuran, indole, and longiborneol. Moreover, non-targeted metabolomics identified up to 14 differentially expressed metabolites through pair-wise comparisons, such as flavonoids, phenolic acids, sucrose, and critical metabolites, which were the main components corresponding to YAYT roasted for 22 min. In summary, the current results provide scientific guidance for the production of high quality YAYT.
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http://dx.doi.org/10.3390/molecules27134119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268202PMC
June 2022

Activity limitation and participation restriction in Osteoarthritis and Rheumatoid arthritis: findings based on the National Health and Nutritional Examination Survey.

BMC Musculoskelet Disord 2022 Jul 6;23(1):647. Epub 2022 Jul 6.

Department of Rehabilitation Medicine, Sir Run Run Hospital, Nanjing Medical University, Nanjing, People's Republic of China.

Background: Osteoarthritis (OA) and Rheumatoid arthritis (RA) are the most common joint diseases leading to chronic pain and disability. Given the chronicity and disabling nature of OA and RA, they are likely to influence full participation of individuals in the society. An activity limitation occurs when a person has difficulty executing an activity; a participation restriction is experienced when a person has difficulty participating in a real-life situation. The aim of this study was to examine the associations between OA and RA and the domains of activity limitation and participation restriction.

Methods: A cross-sectional study design comprised 3604 adults from the 2009 to 2018 National Health and Nutrition Examination Survey (NHANES). All participants aged ≥ 20 years with complete data were included. Activity limitation and participation restriction were assessed by reported difficulty in performing 14 tasks selected from Physical Functioning Questionnaire. Data on OA and RA were obtained from Medical Conditions Questionnaire. Weighted logistic regression model was used to examine the associations between OA and RA and the selected tasks.

Results: Over 36% of participants had limitations. Both OA (OR = 2.11) and RA (OR = 2.36) were positively associated with activity limitation and participation restriction (p < 0.001). Poor or fair health was associated with difficulty in physical functioning, with highest odds observed in leisure activities (OR = 2.05), followed by difficulty in attending social events (OR = 1.99), walking for a quarter mile (OR = 1.97), preparing meals (OR = 1.93) and walking up ten steps (OR = 1.92).

Conclusion: Adults with OA and RA had nearly similar odds of having activity limitations and participation restrictions. Difficulty in executing most activities of daily living (ADLs) has significant association with poor or fair health. Holistic interdisciplinary care to individuals with OA or RA focusing on ADLs and environmental factors may improve health status.
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http://dx.doi.org/10.1186/s12891-022-05607-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258218PMC
July 2022

Breeding for disease resistance in soybean: a global perspective.

Theor Appl Genet 2022 Jul 5. Epub 2022 Jul 5.

Division of Plant Sciences and National Center for Soybean Biotechnology, University of Missouri-Columbia, Columbia, MO, 65211, USA.

Key Message: This review provides a comprehensive atlas of QTLs, genes, and alleles conferring resistance to 28 important diseases in all major soybean production regions in the world. Breeding disease-resistant soybean [Glycine max (L.) Merr.] varieties is a common goal for soybean breeding programs to ensure the sustainability and growth of soybean production worldwide. However, due to global climate change, soybean breeders are facing strong challenges to defeat diseases. Marker-assisted selection and genomic selection have been demonstrated to be successful methods in quickly integrating vertical resistance or horizontal resistance into improved soybean varieties, where vertical resistance refers to R genes and major effect QTLs, and horizontal resistance is a combination of major and minor effect genes or QTLs. This review summarized more than 800 resistant loci/alleles and their tightly linked markers for 28 soybean diseases worldwide, caused by nematodes, oomycetes, fungi, bacteria, and viruses. The major breakthroughs in the discovery of disease resistance gene atlas of soybean were also emphasized which include: (1) identification and characterization of vertical resistance genes reside rhg1 and Rhg4 for soybean cyst nematode, and exploration of the underlying regulation mechanisms through copy number variation and (2) map-based cloning and characterization of Rps11 conferring resistance to 80% isolates of Phytophthora sojae across the USA. In this review, we also highlight the validated QTLs in overlapping genomic regions from at least two studies and applied a consistent naming nomenclature for these QTLs. Our review provides a comprehensive summary of important resistant genes/QTLs and can be used as a toolbox for soybean improvement. Finally, the summarized genetic knowledge sheds light on future directions of accelerated soybean breeding and translational genomics studies.
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http://dx.doi.org/10.1007/s00122-022-04101-3DOI Listing
July 2022

Co-axial Projective Imaging for Augmented Reality Telementoring in Skin Cancer Surgery.

Ann Biomed Eng 2022 Jul 5. Epub 2022 Jul 5.

Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, 230026, Anhui, China.

Telemedicine has the potential to overcome the unequal distribution of medical resources worldwide. In this study, we report the second-generation co-axial projective imaging (CPI-2) system featured with orthotopic image projection for augmented reality surgical telementoring. The CPI-2 system can acquire surgical scene images from the local site, transmit them wirelessly to the remote site, and project the virtual annotations drawn by a remote expert with great accuracy to the surgical field. The performance characteristics of the CPI-2 system are quantitatively verified in benchtop experiments. The ex vivo study that compares the CPI-2 system and a monitor-based telementoring system shows that the CPI-2 system can reduce the focus shift and avoid subjective mapping of the instructions from a monitor to the real-world scene, thereby saving operation time and achieving precise teleguidance. The clinical feasibility of the CPI-2 system is validated in teleguided skin cancer surgery. Our ex vivo and in vivo experiment results imply the improved performance of surgical telementoring, and the clinical utility of deploying the CPI-2 system for surgical interventions in resource-limited settings. The CPI-2 system has the potential to reduce healthcare disparities in remote areas with limited resources.
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http://dx.doi.org/10.1007/s10439-022-03000-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255459PMC
July 2022

Rigid registration algorithm based on the minimization of the total variation of the difference map.

J Synchrotron Radiat 2022 Jul 20;29(Pt 4):1085-1094. Epub 2022 Jun 20.

Department of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA.

Image registration is broadly used in various scenarios in which similar scenes in different images are to be aligned. However, image registration becomes challenging when the contrasts and backgrounds in the images are vastly different. This work proposes using the total variation of the difference map between two images (TVDM) as a dissimilarity metric in rigid registration. A method based on TVDM minimization is implemented for image rigid registration. The method is tested with both synthesized and real experimental data that have various noise and background conditions. The performance of the proposed method is compared with the results of other rigid registration methods. It is demonstrated that the proposed method is highly accurate and robust and outperforms other methods in all of the tests. The new algorithm provides a robust option for image registrations that are critical to many nano-scale X-ray imaging and microscopy applications.
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http://dx.doi.org/10.1107/S1600577522005598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255568PMC
July 2022

Collagen gel contraction assays: From modelling wound healing to quantifying cellular interactions with three-dimensional extracellular matrices.

Eur J Cell Biol 2022 Jun-Aug;101(3):151253. Epub 2022 Jun 27.

Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing 100871, China; Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China. Electronic address:

Cells respond to and actively remodel the extracellular matrix (ECM). The dynamic and bidirectional interaction between cells and ECM, especially their mechanical interactions, has been found to play an essential role in triggering a series of complex biochemical and biomechanical signal pathways and in regulating cellular functions and behaviours. The collagen gel contraction assay (CGCA) is a widely used method to investigate cell-ECM interactions in 3D environments and provides a mechanically associated readout reflecting 3D cellular contractility. In this review, we summarize various versions of CGCA, with an emphasis on recent high-throughput and low-consumption CGCA techniques. More importantly, we focus on the technique of force monitoring during the contraction of collagen gel, which provides a quantitative characterization of the overall forces generated by all the resident cells in the collagen hydrogel. Accordingly, we present recent biological applications of the CGCA, which have expanded from the initial wound healing model to other studies concerning cell-ECM interactions, including fibrosis, cancer, tissue repair and the preparation of biomimetic microtissues.
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http://dx.doi.org/10.1016/j.ejcb.2022.151253DOI Listing
August 2022

Intestinal Microbes in Patients With Schizophrenia Undergoing Short-Term Treatment: Core Species Identification Based on Co-Occurrence Networks and Regression Analysis.

Front Microbiol 2022 17;13:909729. Epub 2022 Jun 17.

Medical Laboratory, The Fourth People's Hospital of Ya'an, Ya'an, China.

Schizophrenia, a common mental disorder, has a tremendous impact on the health and economy of people worldwide. Evidence suggests that the microbial-gut-brain axis is an important pathway for the interaction between the gut microbiome and the development of schizophrenia. What is not clear is how changes in the gut microbiota composition and structure during antipsychotic treatment improve the symptoms of schizophrenia. In this study, 25 patients with schizophrenia were recruited. Their fecal samples were collected before and after hospital treatment for 14-19 days. The composition and structure of the intestinal microbiota were evaluated by 16S rRNA sequencing analysis, and the results showed significant differences in fecal microbiota before and after treatment. (relative abundances of 82.60 and 86.64%) and (relative abundances of 14.17 and 13.57%) were the first dominant species at the phylum and genus levels, respectively. The random forest algorithm and co-occurrence network analysis demonstrated that intestinal flora (especially the core species ASV57) could be used as biomarkers to distinguish different clinical states and match treatment regimens accordingly. In addition, after fecal microbiota transplantation, antibiotic-treated recipient mice showed multiple behavioral improvements. These included decreased psychomotor hyperactivity, increased social interaction, and memory. In conclusion, this study suggests that differences in the composition and structure of gut microbiota after treatment are associated with the development and severity of schizophrenia. Results may provide a potential target for the treatment of this disorder.
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http://dx.doi.org/10.3389/fmicb.2022.909729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9247572PMC
June 2022

Terahertz anisotropy in fascia and lean meat tissues.

Biomed Opt Express 2022 May 4;13(5):2605-2615. Epub 2022 Apr 4.

School of Electronic and Information Engineering, Beihang University, 37 Xueyuan Road, Beijing 100191, China.

Terahertz (THz) spectroscopy provides multifaceted capabilities for observing low-energy responses of macromolecules, cells and tissues, understanding THz biophysical effects, and expecting to realize the application of THz technology in biomedicine. However, its high-frequency characteristics of limited penetration depth and strong absorption of water in the body comparable to microwaves are impeding the proliferation of THz spectroscopy. Here we show that THz spectroscopy makes possible the observation of THz anisotropy phenomena for the first time in fascia and lean tissue. Through optical microscopy, we infer that the microscopic mechanism of THz anisotropy comes from the periodic stripe structure of the biological tissue. The above related experimental findings may be expected to promote the application of THz technology in biomedicine.
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http://dx.doi.org/10.1364/BOE.454338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9203107PMC
May 2022
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