Lillian L Siu

Lillian L Siu

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Lillian L Siu

Publications by authors named "Lillian L Siu"

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Referrals to a Phase I Clinic and Trial Enrollment in the Molecular Screening Era.

Oncologist 2019 Jul 4;24(7):e518-e525. Epub 2019 Mar 4.

Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656436PMC
July 2019

Utilization of tumor genomics in clinical practice: an international survey among ASCO members.

Future Oncol 2019 Jul 26;15(21):2463-2470. Epub 2019 Jun 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.2217/fon-2019-0010DOI Listing
July 2019

Designing circulating tumor DNA-based interventional clinical trials in oncology.

Genome Med 2019 04 19;11(1):22. Epub 2019 Apr 19.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

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https://genomemedicine.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s13073-019-0634-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474042PMC
April 2019

Somatic Tumor Variant Filtration Strategies to Optimize Tumor-Only Molecular Profiling Using Targeted Next-Generation Sequencing Panels.

J Mol Diagn 2019 Mar 19;21(2):261-273. Epub 2018 Dec 19.

Advanced Molecular Diagnostics Laboratory, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Clinical Laboratory Genetics, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2018.09.008DOI Listing
March 2019

Current Treatment Landscape of Nasopharyngeal Carcinoma and Potential Trials Evaluating the Value of Immunotherapy.

J Natl Cancer Inst 2019 03 26. Epub 2019 Mar 26.

Clinical Investigative Branch, Cancer Therapy Evaluation Program, National Institute of Health, Bethesda, MD.

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http://dx.doi.org/10.1093/jnci/djz044DOI Listing
March 2019

Phase Ib Trial With Birabresib, a Small-Molecule Inhibitor of Bromodomain and Extraterminal Proteins, in Patients With Selected Advanced Solid Tumors.

J Clin Oncol 2018 10 7;36(30):3007-3014. Epub 2018 May 7.

Jeremy Lewin and Lillian L. Siu, Princess Margaret Cancer Center, Toronto, Ontario, Canada; Jean-Charles Soria and Christophe Massard, Institut Gustave Roussy and University Paris-Sud, Villejuif; Jean-Pierre Delord, Institut Claudius Regaud Oncopole, Toulouse; Mohamed Bekradda, Oncology Therapeutic Development, Clichy; Keyvan Rezai, Hôpital René Huguenin, Saint-Cloud, France; Anastasios Stathis, Oncology Institute of Southern Switzerland, Bellinzona; Solange Peters, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; Ahmad Awada and Philippe G. Aftimos, Université Libre de Bruxelles, Brussels, Belgium; and Zhen Zeng, Azher Hussain, and Susan Perez, Merck & Co, Kenilworth, NJ.

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http://dx.doi.org/10.1200/JCO.2018.78.2292DOI Listing
October 2018

Pretreatment neurocognitive function and self-reported symptoms in patients with newly diagnosed head and neck cancer compared with noncancer cohort.

Head Neck 2018 09 17;40(9):2029-2042. Epub 2018 Apr 17.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Canada.

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http://dx.doi.org/10.1002/hed.25198DOI Listing
September 2018

Concurrent-Adjuvant Chemoradiation Therapy for Stage III-IVB Nasopharyngeal Carcinoma-Exploration for Achieving Optimal 10-Year Therapeutic Ratio.

Int J Radiat Oncol Biol Phys 2018 08 2;101(5):1078-1086. Epub 2018 May 2.

Departments of Clinical Oncology, The University of Hong Kong and the University of Hong Kong-Shenzhen Hospital, Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.04.069DOI Listing
August 2018

Precision Medicine in Head and Neck Cancer: Myth or Reality?

Clin Med Insights Oncol 2018 4;12:1179554918779581. Epub 2018 Jun 4.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1177/1179554918779581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989049PMC
June 2018

Rational design and identification of immuno-oncology drug combinations.

Eur J Cancer 2018 05 7;95:38-51. Epub 2018 Apr 7.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, 610 University Ave, Toronto, Ontario, M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.02.027DOI Listing
May 2018

Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience.

Clin Colorectal Cancer 2018 03 23;17(1):73-79. Epub 2017 Oct 23.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2017.10.010DOI Listing
March 2018

Head and Neck Cancer Survivorship Care Guideline: American Society of Clinical Oncology Clinical Practice Guideline Endorsement Summary.

J Oncol Pract 2018 03 19;14(3):167-171. Epub 2017 Dec 19.

Brigham and Women's Hospital and Harvard Medical School, Boston, MA; American Society of Clinical Oncology, Alexandria, VA; and Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/JOP.2017.029041DOI Listing
March 2018

Giant Prolactinoma Presenting As a Base of Skull Tumor With Nasopharyngeal Extension: A Potential Diagnostic Pitfall in Neuroendocrine Lesions of the Base of Skull.

Head Neck Pathol 2017 Dec 14;11(4):537-540. Epub 2017 Feb 14.

Department of Pathology, University Health Network, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada.

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http://dx.doi.org/10.1007/s12105-017-0782-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677065PMC
December 2017

Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma: American Society of Clinical Oncology Endorsement of the American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline.

J Clin Oncol 2017 Dec 24;35(36):4078-4090. Epub 2017 Oct 24.

Harry Quon and Arlene Forastiere, Johns Hopkins University School of Medicine, Baltimore, MD; Neha Vapiwala, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Erin B. Kennedy, American Society of Clinical Oncology, Alexandria, VA; David J. Adelstein, Taussig Cancer Institute, Cleveland, OH; Holly Boykin, Head and Neck Cancer Alliance, Charleston, SC; Joseph A. Califano, University of California San Diego Medical Center, San Diego; F. Chris Holsinger, Stanford University Medical Center, Palo Alto, CA; Brian Nussenbaum, Washington University School of Medicine, St. Louis, MO; David I. Rosenthal, The University of Texas MD Anderson Cancer Center, Houston TX; and Lillian L. Siu and John N. Waldron, Princess Margaret Cancer Centre, Toronto, Canada.

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http://dx.doi.org/10.1200/JCO.2017.73.8633DOI Listing
December 2017

The Cisplatin Total Dose and Concomitant Radiation in Locoregionally Advanced Head and Neck Cancer: Any Recent Evidence for Dose Efficacy?

Curr Treat Options Oncol 2017 07;18(7):39

Division of Medical Oncology and Hematology, Drug Development Program, Princess Margaret Cancer Centre, University Health Network, University of Toronto, 700 University Avenue, Toronto, ON, CA M5G 1Z5, Canada.

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http://dx.doi.org/10.1007/s11864-017-0482-0DOI Listing
July 2017

Head and Neck Cancer Survivorship Care Guideline: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Cancer Society Guideline.

J Clin Oncol 2017 May 27;35(14):1606-1621. Epub 2017 Feb 27.

Larissa Nekhlyudov, Brigham & Women's Hospital, Harvard Medical School, Boston; Thomas Q. Garvey, Harvard Vanguard Medical Associates, Billerica, MA; Christina Lacchetti, American Society of Clinical Oncology, Alexandria VA; Nancy B. Davis, Aurora Cancer Care, Green Bay, WI; David P. Goldstein and Lillian L. Siu, Princess Margaret Cancer Centre, Toronto, Canada; J. Chris Nunnink and Jose I. Ruades Ninfea, University of Vermont, Burlington, VT; Andrew L. Salner, Hartford Hospital, Hartford, CT; and Talya Salz, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.71.8478DOI Listing
May 2017

Determinants of the recommended phase 2 dose of molecular targeted agents.

Cancer 2017 Apr 9;123(8):1409-1415. Epub 2017 Feb 9.

Princess Margaret Cancer Centre, Drug Development Program, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.30579DOI Listing
April 2017

Cancer Clinical Trials: The Rear-View Mirror and the Crystal Ball.

Cell 2017 02;168(4):575-578

Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 1Z5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.027DOI Listing
February 2017

Approaches to modernize the combination drug development paradigm.

Genome Med 2016 10 28;8(1):115. Epub 2016 Oct 28.

Drug Development Program, Division of Medical Oncology & Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, M5G 2M9, Canada.

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http://dx.doi.org/10.1186/s13073-016-0369-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084460PMC
October 2016

Testing ERBB2 p.L755S kinase domain mutation as a druggable target in a patient with advanced colorectal cancer.

Cold Spring Harb Mol Case Stud 2016 Sep;2(5):a001016

Drug Development Program, Division of Medical Oncology and Hematology; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5S 1A8, Canada;; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1101/mcs.a001016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002925PMC
September 2016

A comparison of weekly versus 3-weekly cisplatin during adjuvant radiotherapy for high-risk head and neck cancer.

Oral Oncol 2016 08;59:43-49

Division of Medical Oncology and Hematology, University of Toronto, Princess Margaret Cancer Center, 610 University Ave, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1016/j.oraloncology.2016.05.016DOI Listing
August 2016

Genomically personalized therapy in head and neck cancer.

Cancers Head Neck 2016 9;1. Epub 2016 Jun 9.

Drug Development Program, Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, Suite 5-718, Toronto, ON M5G 2M9 Canada.

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http://dx.doi.org/10.1186/s41199-016-0004-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457141PMC
June 2016

PD-L1 Testing in Cancer: Challenges in Companion Diagnostic Development.

JAMA Oncol 2016 Jan;2(1):15-6

Princess Margaret Cancer Centre, Drug Development Program Toronto, Ontario, Canada.

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http://dx.doi.org/10.1001/jamaoncol.2015.4685DOI Listing
January 2016

Selecting the best drugs for phase I clinical development and beyond.

Am Soc Clin Oncol Educ Book 2013 :469-73

From the Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1200/EdBook_AM.2013.33.469DOI Listing
December 2015

Development of Fibroblast Growth Factor Receptor Inhibitors: Kissing Frogs to Find a Prince?

J Clin Oncol 2015 Oct 31;33(30):3372-4. Epub 2015 Aug 31.

Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1200/JCO.2015.62.7380DOI Listing
October 2015

Next-Generation Sequencing to Guide Clinical Trials.

Clin Cancer Res 2015 Oct;21(20):4536-44

Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610034PMC
October 2015

Pharmacokinetic assessment of dacomitinib (pan-HER tyrosine kinase inhibitor) in patients with locally advanced head and neck squamous cell carcinoma (LA SCCHN) following administration through a gastrostomy feeding tube (GT).

Invest New Drugs 2015 Aug 5;33(4):895-900. Epub 2015 May 5.

Department of Medical Oncology, Bras Family Drug Development Program, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON, Canada, M5G 2M9.

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http://dx.doi.org/10.1007/s10637-015-0245-3DOI Listing
August 2015

Chemoradiotherapy regimens for locoregionally advanced nasopharyngeal carcinoma: A Bayesian network meta-analysis.

Eur J Cancer 2015 Aug 1;51(12):1570-9. Epub 2015 Jun 1.

Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada; Division of Medical Oncology, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2015.04.027DOI Listing
August 2015

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.

Authors:
Ayalew Tefferi Hagop Kantarjian S Vincent Rajkumar Lawrence H Baker Jan L Abkowitz John W Adamson Ranjana Hira Advani James Allison Karen H Antman Robert C Bast John M Bennett Edward J Benz Nancy Berliner Joseph Bertino Ravi Bhatia Smita Bhatia Deepa Bhojwani Charles D Blanke Clara D Bloomfield Linda Bosserman Hal E Broxmeyer John C Byrd Fernando Cabanillas George Peter Canellos Bruce A Chabner Asher Chanan-Khan Bruce Cheson Bayard Clarkson Susan L Cohn Gerardo Colon-Otero Jorge Cortes Steven Coutre Massimo Cristofanilli Walter J Curran George Q Daley Daniel J DeAngelo H Joachim Deeg Lawrence H Einhorn Harry P Erba Francisco J Esteva Elihu Estey Isaiah J Fidler James Foran Stephen Forman Emil Freireich Charles Fuchs James N George Morie A Gertz Sergio Giralt Harvey Golomb Peter Greenberg Jordan Gutterman Robert I Handin Samuel Hellman Paulo Marcelo Hoff Ronald Hoffman Waun Ki Hong Mary Horowitz Gabriel N Hortobagyi Clifford Hudis Jean Pierre Issa Bruce Evan Johnson Philip W Kantoff Kenneth Kaushansky David Khayat Fadlo R Khuri Thomas J Kipps Margaret Kripke Robert A Kyle Richard A Larson Theodore S Lawrence Ross Levine Michael P Link Scott M Lippman Sagar Lonial Gary H Lyman Maurie Markman John Mendelsohn Neal J Meropol Yoav Messinger Therese M Mulvey Susan O'Brien Roman Perez-Soler Raphael Pollock Josef Prchal Oliver Press Jerald Radich Kanti Rai Saul A Rosenberg Jacob M Rowe Hope Rugo Carolyn D Runowicz Brenda M Sandmaier Alan Saven Andrew I Schafer Charles Schiffer Mikkael A Sekeres Richard T Silver Lillian L Siu David P Steensma F Marc Stewart Wendy Stock Richard Stone Rainer Storb Louise C Strong Martin S Tallman Michael Thompson Naoto T Ueno Richard A Van Etten Julie M Vose Peter H Wiernik Eric P Winer Anas Younes Andrew D Zelenetz Charles A LeMaistre

Mayo Clin Proc 2015 Aug 23;90(8):996-1000. Epub 2015 Jul 23.

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http://dx.doi.org/10.1016/j.mayocp.2015.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365030PMC
August 2015

A cost-effectiveness analysis of human papillomavirus vaccination of boys for the prevention of oropharyngeal cancer.

Cancer 2015 Jun 13;121(11):1785-92. Epub 2015 Apr 13.

Pharmacoeconomics Research Unit, Cancer Care Ontario, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.29111DOI Listing
June 2015

Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials.

Oncologist 2015 Jun 11;20(6):653-9. Epub 2015 May 11.

Drug Development Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Division of Hematology and Oncology Toxicology, Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA; Department of Medical Oncology, Institut Curie, Paris and Saint-Cloud, France; INSERM U900, Institut Curie, Paris, France; Translational Sciences, MedImmune LLC, Gaithersburg, Maryland, USA.

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http://dx.doi.org/10.1634/theoncologist.2015-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571794PMC
June 2015

Early phase clinical trials to identify optimal dosing and safety.

Mol Oncol 2015 May 14;9(5):997-1007. Epub 2014 Aug 14.

Princess Margaret Cancer Centre, University Health Network, Division of Medical Oncology and Hematology, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.molonc.2014.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329110PMC
May 2015

Cancer genomics: the challenge of drug accessibility.

Curr Opin Oncol 2015 May;27(3):250-7

Bras Drug Development Program, Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/CCO.0000000000000185DOI Listing
May 2015

Pre-clinical characterization of Dacomitinib (PF-00299804), an irreversible pan-ErbB inhibitor, combined with ionizing radiation for head and neck squamous cell carcinoma.

PLoS One 2014 22;9(5):e98557. Epub 2014 May 22.

Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre and University of Toronto, Toronto, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098557PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031184PMC
January 2015

Could the human papillomavirus vaccination be cost-effective in males for the prevention of oropharyngeal cancer?

Expert Rev Pharmacoecon Outcomes Res 2014 Dec 6;14(6):763-5. Epub 2014 Aug 6.

Centre for Excellence in Economic Analysis Research, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada.

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http://dx.doi.org/10.1586/14737167.2014.946012DOI Listing
December 2014

A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin.

Invest New Drugs 2014 Dec 12;32(6):1269-77. Epub 2014 Sep 12.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, 610 University Avenue, M5G 2 M9, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s10637-014-0159-5DOI Listing
December 2014

Genomic testing in cancer: patient knowledge, attitudes, and expectations.

Cancer 2014 Oct 24;120(19):3066-73. Epub 2014 Jun 24.

Division of Medical Oncology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.28807DOI Listing
October 2014

Defining dose-limiting toxicity for phase 1 trials of molecularly targeted agents: results of a DLT-TARGETT international survey.

Eur J Cancer 2014 Aug 10;50(12):2050-6. Epub 2014 Jun 10.

Gustave Roussy Cancer Campus, DITEP (Département d'Innovations Thérapeutiques et Essais Précoces), Villejuif, France; Université Paris-Sud XI, Orsay, France.

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http://dx.doi.org/10.1016/j.ejca.2014.04.030DOI Listing
August 2014

Phase 1 trial design: is 3 + 3 the best?

Cancer Control 2014 Jul;21(3):200-8

Drug Development Program, Princess Margaret Cancer Centre, Toronto, Ontario, Canada M5G 2M9.

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http://dx.doi.org/10.1177/107327481402100304DOI Listing
July 2014

Tilting the balance of dose modification for oral anticancer drugs?

J Clin Oncol 2014 May 7;32(15):1537-9. Epub 2014 Apr 7.

Princess Margaret Cancer Centre, University Health Network; University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.1200/JCO.2014.55.2372DOI Listing
May 2014

Promising SINEs for embargoing nuclear-cytoplasmic export as an anticancer strategy.

Cancer Discov 2014 May 17;4(5):527-37. Epub 2014 Apr 17.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1158/2159-8290.CD-13-1005DOI Listing
May 2014

Evolution of clinical trial design in early drug development: systematic review of expansion cohort use in single-agent phase I cancer trials.

J Clin Oncol 2013 Nov 14;31(33):4260-7. Epub 2013 Oct 14.

Arif Manji, Irene Brana, Eitan Amir, Ian F. Tannock, Philippe L. Bedard, Amit Oza, Lillian L. Siu, and Albiruni R. Abdul Razak, Princess Margaret Cancer Centre, University Health Network; George Tomlinson, University of Toronto; and Arif Manji, Hospital for Sick Children, Toronto, and Southlake Regional Health Centre, Newmarket, Ontario, Canada.

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http://dx.doi.org/10.1200/JCO.2012.47.4957DOI Listing
November 2013

A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors.

Invest New Drugs 2013 Oct 17;31(5):1182-91. Epub 2013 Jul 17.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, 610 University Avenue, 5-125, M5G 2M9, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s10637-013-0001-5
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http://dx.doi.org/10.1007/s10637-013-0001-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771370PMC
October 2013

Tumour heterogeneity in the clinic.

Nature 2013 Sep;501(7467):355-64

Princess Margaret Cancer Centre, University Health Network, Division of Medical Oncology and Hematology, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/nature12627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5224525PMC
September 2013

Accounting for tumor heterogeneity in the development of predictive biomarkers.

Authors:
Lillian L Siu

Clin Adv Hematol Oncol 2013 May;11(5):312-3

University of Toronto, Toronto, Ontario, Canada.

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May 2013