Publications by authors named "Lili Wang"

1,993 Publications

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Self-supported molybdenum nickel oxide catalytic electrode designed via molecular cluster-mediated electroplating and electrochemical activation for an efficient and durable oxygen evolution reaction.

J Colloid Interface Sci 2022 Aug 3;628(Pt A):607-618. Epub 2022 Aug 3.

School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Henan Normal University, Henan, Xinxiang 453007, PR China. Electronic address:

Efficient and durable nonprecious catalysts for the oxygen evolution reaction (OER) are crucial for practical water electrolysis for hydrogen production. A self-supported OER catalytic electrode with sufficient exposure of the catalyst and tight anchoring onto the current collector is vital for the catalytic activity and stability, and is therefore deemed to be a preferable tactic to enhance water electrolysis performance. Herein, a polyoxometalate (POM) molecular cluster-mediated electroplating and activation tactics are proposed to design a self-supported molybdenum nickel oxide (MoNiO) catalytic electrode for the OER. The MoNiO active layer can anchor tightly onto the Ni foam current collector with sufficient surface exposure and high structural stability, therefore enabling high alkali OER catalytic efficiency (222 mV at 10 mA cm) and robust durability (only slight decay in catalytic efficiency upon 12 days of chronopotentiometry (V-t) test). Moreover, the easily processable electroplating and active protocol can serve as a general approach to prepare other OER catalytic electrodes by altering the reactants and current collectors. The current work paves a facile and universal way to design a highly active and durable molybdenum (Mo) based hybrid catalytic electrode for OER via molecular cluster-assisted electroplating and activation treatment.
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http://dx.doi.org/10.1016/j.jcis.2022.08.009DOI Listing
August 2022

Analysis of Pyrolysis Characteristics of Oily Sludge in Different Regions and Environmental Risk Assessment of Heavy Metals in Pyrolysis Residue.

ACS Omega 2022 Aug 22;7(30):26265-26274. Epub 2022 Jul 22.

Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment of the People's Republic of China, 8 Jiangwangmiao Street, Nanjing 210042, Jiangsu Province, China.

As a resource treatment method, pyrolysis realizes the recovery of oil and immobilization of heavy metals in oily sludge (OS). The results showed that the composition of OS had little effect on the trend of the whole pyrolysis process, but it had different effects on the mass loss and maximum weight loss rate at each pyrolysis stage. SEM-EDS results showed that the pyrolysis residue had a porous internal structure, which was similar to that of activated carbon. The elements S, Ca, O, Fe, Al, and Si were embedded in the carbon skeleton. After OS pyrolysis, the oil content of the solid residue was far less than 2%, which met the pollution control requirements for comprehensive utilization specified in China's oil and gas industry standard. At the same time, the ratio of exchangeable fraction decreased and the ratio of residual fraction increased after OS pyrolysis. The potential ecological hazard coefficient ( ) of Cd in OS2, OS2-500, and OS2-600 was greater than 40, which were strong and medium hazards. The values of OS2-700 and other metals were far lower than 40, which were low hazards. With the increase of pyrolysis temperature, the comprehensive ecological hazard index (RI) of heavy metals in the residue gradually decreased and the RI value of OS2-700 decreased to 28.01. Therefore, the pyrolysis residue had an internal porous structure and controllable environmental risk. It could be used as an adsorption material for heavy metals to realize the comprehensive utilization of OS.
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http://dx.doi.org/10.1021/acsomega.2c01994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352164PMC
August 2022

Does aquatic physical therapy affect the rehabilitation of breast cancer in women? A systematic review and meta-analysis of randomized controlled trials.

PLoS One 2022 3;17(8):e0272337. Epub 2022 Aug 3.

Department of Nursing, Shanxi Provincial People's Hospital, Taiyuan, Shanxi, China.

To determine and evaluate the benefits of aquatic physical therapy as a rehabilitation strategy for women with breast cancer on health outcomes. Electronic databases including PubMed, Web of Science, Embase, Cochrane Library and China National Knowledge Infrastructure (CNKI), Weipu (VIP) and Wanfang database were systematically searched until June 2021. Randomized controlled trials were included if they evaluated the effects of aquatic physical therapy in breast cancer patients. The quality of the trials included was assessed by the two independent researchers according to the Cochrane Collaboration Handbook recommendations. Outcome measures were fatigue, waist circumference and quality of life (QoL). The study was registered under PROSPERO (CRD42021157323). Totally, five studies comprising 356 participants were included in the study. Meta-analyses showed that aquatic physical therapy interventions significantly reduced the fatigue score (MD = -2.14, 95%CI: -2.82, -1.45, p<0.01) compared with usual care; In addition, we also observed that, compared with land-based exercise, aquatic physical therapy greatly improved the QoL (MD = 2.85, 95%CI: 0.62, 5.09, p = 0.01). However, aquatic physical therapy cannot improve physical index (waist circumference) compared to usual care (MD = -3.49, 95%CI: -11.56,4.58, p = 0.4). Consequently, aquatic physical therapy had a positive effect on the fatigue and QoL. The results of this meta-analysis can provide a reliable evidence for evaluating the interventional effectiveness of aquatic physical therapy.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272337PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348687PMC
August 2022

Estimating National Exposures and Potential Bladder Cancer Cases Associated with Chlorination DBPs in U.S. Drinking Water.

Environ Health Perspect 2022 Aug 1;130(8):87002. Epub 2022 Aug 1.

U.S. Environmental Protection Agency (U.S. EPA), Washington, DC, USA.

Background: Disinfection byproducts (DBPs) in public water systems (PWS) are an unintended consequence resulting from reactions between mostly chlorine-based disinfectants and organic and inorganic compounds in source waters. Epidemiology studies have shown that exposure to DBP (specifically trihalomethanes) was associated with an increased risk of bladder cancer.

Objective: Our goal was to characterize the relative differences in exposures and estimated potential bladder cancer risks for people served by different strata of PWS in the United States and to evaluate uncertainties associated with these estimates.

Methods: We stratified PWS by source water type (surface vs. groundwater) and population served (large, medium, and small) and calculated population-weighted mean trihalomethane-4 (THM4) concentrations for each stratum. For each stratum, we calculated a population attributable risk (PAR) for bladder cancer using odds ratios derived from published pooled epidemiology estimates as a function of the mean THM4 concentration and the fraction of the total U.S. population served by each stratum of systems. We then applied the stratum-specific PARs to the total annual number of new bladder cancer cases in the U.S. population to estimate bladder cancer incidence in each stratum.

Results: Our results show that approximately 8,000 of the 79,000 annual bladder cancer cases in the United States were potentially attributable to DBPs in drinking water systems. The estimated attributable cases vary based on source water type and system size. Approximately 74% of the estimated attributable cases were from surface water systems serving populations of people. We also identified several uncertainties that may affect the results from this study, primarily related to the use of THM4 as a surrogate measure for DBPs relevant to bladder cancer.

Discussion: Despite significant reductions in exposure over the past several decades, our study suggests that of the bladder cancer cases in the United States may still be attributed to exposure to DBPs found in drinking water systems. https://doi.org/10.1289/EHP9985.
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http://dx.doi.org/10.1289/EHP9985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342685PMC
August 2022

MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling.

Cancer Sci 2022 Aug 1. Epub 2022 Aug 1.

Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China.

Liver metastases still remain a major cause of colorectal cancer (CRC) patient death. MYO10 is upregulated in several tumor types, however, its significance and the underlying mechanism in CRC is not entirely clear. Here we found that MYO10 was highly expressed in CRC tumor tissues, especially in liver metastasis tissues. MYO10 knockout reduced CRC cell proliferation, invasion, and migration in vitro, and CRC metastasis in vivo. We identified RACK1 by LC-MS/MS and demonstrated that MYO10 interacts with and stabilizes RACK1. Mechanistically, MYO10 promotes CRC cell progression and metastasis via ubiquitination-mediated RACK1 degradation and integrin/Src/FAK signaling activation. Therefore, the MYO10/RACK1/integrin/Src/FAK axis may play an important role in CRC progression and metastasis.
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http://dx.doi.org/10.1111/cas.15519DOI Listing
August 2022

A Magnetically Capsule Robot for Biomedical Application.

Appl Bionics Biomech 2022 21;2022:2233417. Epub 2022 Jul 21.

Tianjin Hospital of ITCWM Nankai Hospital, Tianjin, China.

Magnetic-driven capsule robot has been widely studied due to its advantages of safety and reliability. However, when doctors carry out clinical examination, the capsule robot cannot achieve the ideal control effect due to the influence of the external magnetic field air gap. This paper is based on the kinetic energy theorem, combined with the principle of spiral mechanism in mechanical design foundation to construct a calculation method of energy utilization and to improve the control effect of capsule robot, suitable for the human gastrointestinal tract precise control of capsule robot to perform a variety of complex tasks. By calculating the energy utilization rate of the capsule robot under the control of external magnetic field, the method can improve the energy utilization rate by improving the equation parameters, so that the capsule robot can run according to the doctor's ideal performance in practical application. Based on the analysis of the magnetic driven screw capsule robot, the model of the utilization rate of the external magnetic field of the capsule robot is established, and the fluid simulation of the capsule robot is carried out by using the method of computational fluid dynamics. The simulation results and experimental results show that the control effect of capsule robot can be improved by calculating the energy utilization rate of the robot, which is of great significance to human clinical examination and treatment.
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http://dx.doi.org/10.1155/2022/2233417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334122PMC
July 2022

Retraction Note: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer.

Mol Cancer 2022 Jul 30;21(1):157. Epub 2022 Jul 30.

Department of Clinical Laboratory, The Second Hospital of Shandong University, No. 247 Beiyuan Street, Jinan, 250033, China.

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http://dx.doi.org/10.1186/s12943-022-01627-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338635PMC
July 2022

Evolution of the Electronic Structure of Ultrathin MnBiTe Films.

Nano Lett 2022 Aug 27;22(15):6320-6327. Epub 2022 Jul 27.

State Key Laboratory of Low Dimensional Quantum Physics, Department of Physics, Tsinghua University, Beijing 100084, China.

Ultrathin films of intrinsic magnetic topological insulator MnBiTe exhibit fascinating quantum properties such as the quantum anomalous Hall effect and the axion insulator state. In this work, we systematically investigate the evolution of the electronic structure of MnBiTe thin films. With increasing film thickness, the electronic structure changes from an insulator type with a large energy gap to one with in-gap topological surface states, which is, however, still in drastic contrast to the bulk material. By surface doping of alkali-metal atoms, a Rashba split band gradually emerges and hybridizes with topological surface states, which not only reconciles the puzzling difference between the electronic structures of the bulk and thin-film MnBiTe but also provides an interesting platform to establish Rashba ferromagnet that is attractive for (quantum) anomalous Hall effect. Our results provide important insights into the understanding and engineering of the intriguing quantum properties of MnBiTe thin films.
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http://dx.doi.org/10.1021/acs.nanolett.2c02034DOI Listing
August 2022

Dynamic Interactions of Post Cleaved NS2B Cofactor and NS3 Protease Identified by Integrative Structural Approaches.

Viruses 2022 06 30;14(7). Epub 2022 Jun 30.

Functional Proteomics Laboratory, SingMass National Laboratory, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, 61 Biopolis Drive, #07-03, Singapore 138673, Singapore.

Diseases caused by flaviviruses such as dengue virus (DENV) and West Nile Virus (WNV), are a serious threat to public health. The flavivirus single-stranded RNA genome is translated into a polyprotein which is cleaved into three structural proteins and seven non-structural proteins by the viral and cellular proteases. Non-structural (NS) protein 3 is a multifunctional protein that has N-terminal protease and C-terminal helicase domains. The NS3 protease requires co-factor NS2B for enzymatic activity and folding. Due to its essential role in viral replication, NS2B-NS3 protease is an attractive target for antiviral drugs. Despite the availability of crystal structures, dynamic interactions of the N- and C-termini of NS2B co-factor have been elusive due to their flexible fold. In this study, we employ integrative structural approaches combined with biochemical assays to elucidate the dynamic interactions of the flexible DENV4 NS2B and NS3 N- and C-termini. We captured the crystal structure of self-cleaved DENV4 NS2BNS3 protease in post cleavage state. The intermediate conformation adopted in the reported structure can be targeted by allosteric inhibitors. Comparison of our new findings from DENV4 against previously studied ZIKV NS2B-NS3 proteins reveals differences in NS2B-NS3 function between the two viruses. No inhibition of protease activity was observed for unlinked DENV NS2B-NS3 in presence of the cleavage site while ZIKV NS2B-NS3 cleavage inhibits protease activity. Another difference is that binding of the NS2B C-terminus to DENV4 eNS2BNS3Pro active site is mediated via interactions with P4-P6 residues while for ZIKV, the binding of NS2B C-terminus to active site is mediated by P1-P3 residues. The mapping of NS2B N- and C-termini with NS3 indicates that these intermolecular interactions occur mainly on the beta-barrel 2 of the NS3 protease domain. Our integrative approach enables a comprehensive understanding of the folding and dynamic interactions of DENV NS3 protease and its cofactor NS2B.
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http://dx.doi.org/10.3390/v14071440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323329PMC
June 2022

Association between Education Attainment and Guideline-Directed Medication Therapy in Patients with Heart Failure and Reduced Ejection Fraction.

J Clin Med 2022 Jul 21;11(14). Epub 2022 Jul 21.

Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Science, Shenzhen 518001, China.

The aim of the current study was to evaluate association of education attainment and guideline-directed medications therapy (GDMT) in patients with heart failure and reduced ejection fraction (HFrEF). HFrEF patients were enrolled, and baseline characteristics were recorded. Based on highest educational attainment, patients were divided into low and high education attainment groups. Data on GDMT use at admission, discharge and follow-up were collected and between-group differences were evaluated. A total of 336 patients were recruited, and 59.8% (n = 201) were defined as low education attainment. Patients with low education attainment were older and more likely to be female, obese and smokers. In addition, they had a higher prevalence of hypertension and valvular heart disease. Patients with low education attainment also had lower physical and mental component scores (PCS, 50.5 ± 6.4 vs. 56.3 ± 7.8), (MSC, 48.4 ± 6.0 vs. 54.7 ± 5.6) but higher serum NT-proBNP levels (1148.6 ± 233.4 vs. 1050.8 ± 205.6 pg/mL). Significant differences in GDMT use at admission, discharge and follow-up were observed. In the unadjusted model, high education attainment was associated with 2-fold odds of GDMT use at discharge. With adjustment for covariates, the high education attainment group remained significantly associated with being 22% more likely to receive GMDT at discharge. Similar findings were observed in associations between high education attainment and GDMT use at follow-up. After adjustment for PCS and MCS, high education attainment was still significantly associated with GDMT use at follow-up, with odds ratio of 1.13 and a 95% confidence interval of 1.08-1.28. HFrEF patients are under-treated. Education attainment is significantly associated with GDMT use at discharge and follow-up.
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http://dx.doi.org/10.3390/jcm11144235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319771PMC
July 2022

Driving Behavior Recognition Algorithm Combining Attention Mechanism and Lightweight Network.

Entropy (Basel) 2022 Jul 16;24(7). Epub 2022 Jul 16.

School of Computer Science and Technology, Harbin University of Science and Technology, Harbin 150080, China.

In actual driving scenes, recognizing and preventing drivers' non-standard driving behavior is helpful in reducing traffic accidents. To resolve the problems of various driving behaviors, a large range of action, and the low recognition accuracy of traditional detection methods, in this paper, a driving behavior recognition algorithm was proposed that combines an attention mechanism and lightweight network. The attention module was integrated into the YOLOV4 model after improving the feature extraction network, and the structure of the attention module was also improved. According to the 20,000 images of the Kaggle dataset, 10 typical driving behaviors were analyzed, processed, and recognized. The comparison and ablation experimental results showed that the fusion of an improved attention mechanism and lightweight network model had good performance in accuracy, model size, and FLOPs.
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http://dx.doi.org/10.3390/e24070984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9321050PMC
July 2022

Mechanism of miR-760 Reversing Lung Cancer Immune Escape by Downregulating IDO1 and Eliminating Regulatory T Cells Based on Mathematical Biology.

Comput Math Methods Med 2022 14;2022:2960773. Epub 2022 Jul 14.

Department of Oncology, Chengyang District People's Hospital, Qingdao, 266100 Shandong, China.

In cancer biology, mathematical models have become indispensable. They are useful for gaining a mechanistic grasp of cancer's dynamic processes. In cancer research, mathematical modelling approaches are becoming more common. The complexity of cancer is well suited to quantitative approaches as it provides challenges and opportunities for new developments (Altrock et al., 2015). . MicroRNA-760 (miR-760), as an early discovered tumor suppressor gene, is poorly expressed in lung cancer (LC). Indoleamine 2,3-dioxygenase 1 (IDO1), as an important regulator of T cell function, is active in immune tolerance. We discovered that miR-760 has a targeted relationship with IDO1, but the regulatory mechanism between miR-760 and IDO1 is still unclear. . The miR-760 and IDO1 levels in NSCLC were tested via real-time quantitative polymerase chain reaction (qRT-PCR) and western blotting (WB). Cell growth was tested by CCK8, and NSCLC cell migration and invasion were analyzed through Transwell analysis. The binding conditions and target gene of miR-451 in NSCLC cells were determined via double luciferase reporter gene. The CD8+ T and CD4+ T cell ratio in CD45+cells was assessed by flow cytometry. . qRT-PCR revealed that miR-760 was low-expressed and IDO2 was highly expressed in LC. miR-760 mimics suppressed cell growth, invasiveness, and migration. We also observed that miR-760 could downregulate the IDO1 protein level. Significantly, we revealed that miR-760 could inhibit CD8+ T cell apoptosis by controlling IDO1 enzyme function. . Our findings show that miR-760 inhibits CD8+ T cell responses in LC through regulating IDO1, laying the groundwork for the development of novel vaccination therapies for the treatment of LC.
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http://dx.doi.org/10.1155/2022/2960773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9303114PMC
July 2022

The effect of disease anthropomorphism on compliance with health recommendations.

J Acad Mark Sci 2022 Jul 14:1-20. Epub 2022 Jul 14.

Booth School of Business, University of Chicago, Chicago, IL USA.

The present article examines how disease anthropomorphism affects compliance with recommendations for preventing the disease. We find that consumers are more likely to comply with health recommendations when the disease is described in anthropomorphic (vs. non-anthropomorphic) terms because anthropomorphism increases psychological closeness to the disease, which increases perceived vulnerability. We demonstrate the effect of disease anthropomorphism on health compliance in seven studies with several diseases (COVID-19, breast cancer), manipulations of anthropomorphism (first person and third person; with and without an image), and participant populations (the US and China). We test the proposed pathway through psychological closeness and perceived vulnerability with sequential mediation analyses and moderation-of-process approaches, and we rule out alternative accounts based on known consequences of anthropomorphism and antecedents of health compliance. This research contributes to the theory and practice of health communication and to the growing literature on how the anthropomorphism of negative entities affects consumers' judgments and behaviors.

Supplementary Information: The online version contains supplementary material available at 10.1007/s11747-022-00891-6.
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http://dx.doi.org/10.1007/s11747-022-00891-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281194PMC
July 2022

Epidemiological Trends of Coronavirus Disease 2019 in Sierra Leone From March 2020 to October 2021.

Front Public Health 2022 29;10:949425. Epub 2022 Jun 29.

Central Public Health Reference Laboratories, Ministry of Health and Sanitation, Freetown, Sierra Leone.

Coronavirus disease 2019 (COVID-19), a serious public health challenge the world over, has led to significant health concerns in Sierra Leone. In the present study, epidemic indices, such as the number of cases, positivity rate, reproduction rate (R0), case fatality rate (CFR), age, and sex, were used to characterize the epidemiological trends of COVID-19. As of October 31, 2021, a total of 6,398 cases and 121 related deaths had been confirmed. The total number of COVID-19 reverse transcription polymerase chain reaction (RT-PCR) tests conducted to October 31, 2021, was 249,534, and the average positivity rate was 2.56%. Three waves of COVID-19 were recorded, occurring during weeks 15-46 in 2020 (2,369 cases), week 47 in 2020 to week 16 in 2021 (1,665 cases), and weeks 17-43 in 2021 (2,364 cases), respectively. Remarkably, there was no increase in the numbers of confirmed COVID-19 cases despite rising test numbers throughout the three waves. Moreover, three high R0 values were observed before each wave. The number of positive cases significantly correlated with positive numbers of international arrivals ( < 0.01), deaths ( < 0.01), and the positivity rate of tested samples ( < 0.01). Moreover, all of the deaths occurred during the peak of the three waves. Our results indicate that there was a low level of COVID-19 epidemic in Sierra Leone and that COVID-19's introduction led to local transmission. It is vital to fight against the spread of SARS-CoV-2 from the source of origin by strengthening testing and management of people entering the country. Our findings will provide important clues for expanding sample screening and will contribute to the reasonable allocation of medical resources.
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http://dx.doi.org/10.3389/fpubh.2022.949425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276960PMC
July 2022

Proliferating Stem Cells are Acutely Affected by DNA Damage Induced by Sulfur Mustard.

DNA Cell Biol 2022 Aug 13;41(8):716-726. Epub 2022 Jul 13.

Center for Disease Control and Prevention of Chinese People's Liberation Army, Beijing, China.

Sulfur mustard (SM), a chemical warfare agent, can form adducts with DNA, RNA, and proteins. Reactions with DNA lead to the formation of both DNA monoadducts and interstrand cross-links, resulting in DNA damage, and is an important component of SM toxicity. Our previous studies indicated that dividing cells such as hematopoietic stem cells and intestinal villi stem cells seemed to have increased sensitivity to SM. Therefore, to compare the sensitivity of somatic and stem cells to SM and to investigate the mechanism of SM cytotoxicity, we isolated human foreskin fibroblasts, reprogrammed them into pluripotent stem cells, and then compared the DNA damage repair pathways involved upon SM treatment. Our results indicated that proliferating stem cells were more sensitive to SM-induced DNA damage, and the damage mainly comprised single-stranded breaks. Furthermore, the pathways involved in DNA repair in stem cells and somatic cells were different.
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http://dx.doi.org/10.1089/dna.2022.0073DOI Listing
August 2022

High Expression of TMEM33 Predicts Poor Prognosis and Promotes Cell Proliferation in Cervical Cancer.

Front Genet 2022 27;13:908807. Epub 2022 Jun 27.

Department of Clinical Laboratory, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, China.

The prognosis of patients with advanced cervical cancer remains unsatisfactory. A study indicated that transmembrane protein 33 (TMEM33) was implicated in tumor recurrence, while its role in cervical cancer has not been elucidated. TMEM33 expression in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) was primarily screened in The Cancer Genome Atlas (TCGA), and further validated in Gene Expression Omnibus (GEO) database. The Kaplan-Meier plotter analysis and Cox regression were constructed to evaluate the prognostic value of TMEM33 in CESC. Functional enrichment analysis was performed with GO, KEGG and GSEA tools. CCK-8 assay and colony formation assay were performed to investigate the carcinogenesis role of TMEM33 in cervical cancer cell proliferation. TMEM33 expression was significantly elevated in CESC compared with normal tissues. High expression of TMEM33 was associated with poor prognostic clinical characteristics in CESC patients. KM-plotter analysis revealed that patients with increased TMEM33 had shorter overall survival (OS), progress free interval (PFI), and disease specific survival (DSS). Moreover, Multivariate Cox analysis confirmed that high TMEM33 expression was an independent risk factor for OS in patients with CESC. TMEM33 was associated with immune infiltrates, and its expression was correlated with tumorigenesis-related genes RNF4, OCIAD1, TMED5, DHX15, MED28 and LETM1. More importantly, knockdown of TMEM33 in cervical cancer cells decreased the expression of those genes and inhibited cell proliferation. Increased TMEM33 in cervical cancer can serve as an independent prognostic marker and might play a role in tumorigenesis by promoting cell proliferation.
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http://dx.doi.org/10.3389/fgene.2022.908807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9271802PMC
June 2022

Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in postmenopausal women with persistent HPV infection with or without cervical and vaginal low-grade squamous intraepithelial lesions (CIN1/VaIN1).

Photodiagnosis Photodyn Ther 2022 Jul 10;39:103009. Epub 2022 Jul 10.

Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, No. 107 West Wenhua Road, Jinan, Shandong 250012, China. Electronic address:

Objective: To analyze the efficacy and safety of photodynamic therapy (PDT) on postmenopausal women with persistent human papillomavirus (HPV) infection with or without low-grade cervical and vaginal intraepithelial neoplasia (CIN1 and VaIN1).

Materials And Methods: The clinicopathological and follow-up data of 86 postmenopausal women with HPV infection (35 cases with chronic cervicitis and 51 cases with CIN1/VaIN1) were collected. All the women in this group met these criteria: menopausal time ≥ 1 year, HPV infection time ≥ 2 years, colposcopy and pathological diagnosis of biopsy ≤ CIN1/VaIN1 before PDT treatment, and 5-aminolaevulinic acid (5-ALA) as photosensitizer treating for 6 times with a week interval. The above patients were followed up 6 months and 12 months after PDT treatment, and the follow-up contents included HPV typing, cytology, colposcopy and pathological examinations. HPV negative conversion rate and lesion remission rate are the evaluation indicators of treatment efficacy. In addition, we also assessed the safety of PDT treatment.

Results: At 12-month follow-up, the overall HPV clearance rate was 60% (45/75), of which the negative conversion rate of 16/18 HPV was 41.38% (12/29), and non-16/18 HPV was 71.74% (33/46) (p = 0.009). In patients without lesions, the HPV clearance rate was 51.72% (15/29), while in patients with CIN1/VaIN1 (n = 46), the HPV complete remission rate and lesion regression rate were 65.22% (30/46) and 89.13% (41/46), respectively. In addition, the clearance rate of HPV in lesion regression group was significantly higher than that in lesion persistence/progression group (0.00% vs. 73.17%, p = 0.003). The adverse reactions after PDT treatment were mild, mainly manifested as increased vaginal secretions or burning/tingling.

Conclusions: Photodynamic therapy can significantly enhance the elimination rate of persistent HPV infection in postmenopausal women and reduce the progression of CIN1/VaIN1. It could be an effective conservative treatment for persistent HPV infection and CIN1/VaIN1 in postmenopausal women.
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http://dx.doi.org/10.1016/j.pdpdt.2022.103009DOI Listing
July 2022

Novel CT based clinical nomogram comparable to radiomics model for identification of occult peritoneal metastasis in advanced gastric cancer.

Eur J Surg Oncol 2022 Jun 30. Epub 2022 Jun 30.

Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, China. Electronic address:

Background: Occult peritoneal metastasis (OPM) in advanced gastric cancer (AGC) patients remains a major diagnostic challenge. The aim of this study was to develop novel predictive models for identification of OPM in AGCs.

Method: A total of 810 patients with primary AGCs from two hospitals were retrospectively selected and divided into training (n = 393), internal validation (n = 215) and external validation cohorts (n = 202). CT based machine learning models were built and tested to predict the OPM status in AGCs., which are 1) Radiomic signatures: using venous CT imaging features, 2) Clinical models: integrating tumor location, differentiation and extent of serosal exposure, and 3) Radiomics models: combining of radiomic signature, tumor location and tumor differentiation.

Result: Total incidence of OPM was 8.27% (67/810). Clinical models yielded comparable classification accuracy with the corresponding radiomics models with similar AUCs (0.902-0.969 vs. 0.896-0.975) while the radiomic signatures showed relatively low AUCs of 0.863-0.976. In the case where the specificity is higher than 90%, the overall sensitivity of clinical model and radiomics model for OPM positive cases was 76.1% (51/67) and 82.1% (55/67). A nomogram based on the logistic clinical model was drawn to facilitate the usage and verification of the clinical model.

Conclusion: Both the novel CT based clinical nomogram and radiomics model provide promising method to yield high accuracy in identification of OPM in AGC patients.
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http://dx.doi.org/10.1016/j.ejso.2022.06.034DOI Listing
June 2022

Estimating Costs of the HIV Comprehensive Intervention Using the Spectrum Model - China, 2015-2019.

China CDC Wkly 2022 Jun;4(25):554-559

Ningbo Center for Disease Control and Prevention, Ningbo City, Zhejiang Province, China.

Introduction: In order to facilitate human immunodeficiency virus (HIV) treatment and prevention, the resource needs for HIV national strategic planning in developing regions were estimated based on Spectrum, the universal HIV cost-effectiveness analysis software.

Methods: Based on the theoretical framework of Spectrum, the study developed a cost measurement tool for HIV, and calculated the cost of HIV prevention and control in 6 sampled cities in China during 2015-2019 using the Spectrum model.

Results: From 2015 to 2019, the average annual costs for HIV prevention and control for Shijiazhuang, Yantai, Ningbo, Zhenjiang, Foshan, and Wuxi cities were 46.78, 47.55, 137.49, 24.73, 74.37, and 58.30 million Chinese yuan (CNY), respectively. The per capita costs were 4.37, 6.73, 17.33, 7.77, 17.56, and 8.91 CNY, respectively. In terms of the cost structure, the ratio of preventive intervention funds to therapeutic intervention funds (antiviral treatment) varied in sampled cities.

Discussion: Developing comprehensive and systematic HIV fund calculation methods can provide a research basis for rational resource allocation in the field of HIV.
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http://dx.doi.org/10.46234/ccdcw2022.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9260083PMC
June 2022

ARID2, a Rare Cause of Coffin-Siris Syndrome: A Clinical Description of Two Cases.

Front Pediatr 2022 23;10:911954. Epub 2022 Jun 23.

Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, China.

Background: Coffin-Siris syndrome (CSS) is a multiple congenital anomaly syndrome characterized by coarse facial features, sparse scalp hair, hypertrichosis, and hypo/aplastic digital nails and phalanges. Mutations in the BAF (SWI/SNF)-complex subunits (SMARCE1, SMARCB1, SMARCA4, SMARCA2, ARID1B, and ARID1A) have been shown to cause CSS. People diagnosed with BAF pathway related diseases are increasing, and (NM_152641.4) is the least common of these genes. Mutations in the ARID2 gene is the cause for Coffin-Siris syndrome 6 (CSS6). By now only 16 individuals with CSS have been reported to have pathogenic variants in .

Case Presentation: In this article, we introduced two individuals with clinical features consistent with CSS6 (Coffin-Siris syndrome 6). This article increases the number of reported cases, provides better phenotypic information for this rare syndrome, and allows everyone to better understand the disease.

Conclusion: Our observations indicate that mutations could have variable phenotypes, even in patients from the same family.
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http://dx.doi.org/10.3389/fped.2022.911954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9265212PMC
June 2022

Predictive Value of Ionized Calcium for Prognosis of Sepsis in Very Low Birth Weight Infants.

J Inflamm Res 2022 1;15:3749-3760. Epub 2022 Jul 1.

Department of Pediatrics, the First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.

Purpose: Previous studies have shown that ionized calcium (iCa) is strongly correlated with critical illnesses, including sepsis. However, there are few studies on the association of iCa levels and sepsis in very low birth weight infants (VLBWI). Therefore, the aim of this study was to investigate the role of iCa in assessing the severity of sepsis and in predicting the prognosis of sepsis in VLBWI.

Patients And Methods: 249 eligible VLBWI with sepsis were included in the present study and were divided into good and poor prognosis groups according to prognosis. We collected complete laboratory and clinical data. The lowest iCa measured during the first 24h from sepsis onset was recorded, and the Pediatric Risk of Mortality (PRISM III) score was calculated for each newborn.

Results: Neonatal mortality was higher in the hypocalcemia group (32.80% vs 12.80%, P < 0.001), and iCa levels were negatively correlated with PRISM III scores (r= -0.819, P < 0.001). The result of multiple logistic regression analysis showed that iCa was an independent predictor of poor prognosis (odds ratio [OR]= 0.558, 95% confidence interval [CI], 0.406-0.768, P < 0.001). Furthermore, our data demonstrated that iCa was also an independent predictor for the occurrence of death in VLBWI with sepsis who have a poor prognosis (OR= 0.659, 95% CI, 0.445-0.977, P =0.038). ROC curve analysis showed that iCa had good discriminatory power in predicting the poor prognosis (AUC=0.739, 95% CI, 0.664-0.813, P <0.001) in VLBWI with sepsis.

Conclusion: iCa levels correlate with the severity of sepsis and can be an independent predictor of poor prognosis in VLBWI with sepsis.
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http://dx.doi.org/10.2147/JIR.S369431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9255904PMC
July 2022

Identification of HnRNP Family as Prognostic Biomarkers in Five Major Types of Gastrointestinal Cancer.

Curr Gene Ther 2022 Jun 13. Epub 2022 Jun 13.

Center of Tumor Immunology and Cytotherapy, Medical Research Center of the Affiliated Hospital of Qingdao University, Qingdao 266000, China.

Background: Heterogeneous nuclear ribonucleoproteins (hnRNPs), a large family of RNA-binding proteins, have been implicated in tumor progression in multiple cancer types. However, the expression pattern and prognostic value of hnRNPs in five types of gastrointestinal (GI) cancers including gastric cancer, colorectal cancer, esophageal cancer, liver cancer and pancreatic cancer remain to be investigated.

Objective: The current research aimed to identify prognostic biomarkers of hnRNP family in five major types of gastrointestinal cancer.

Methods: Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA) and Kaplan-Meier Plotter were used to explore the hnRNPs expression levels with relation to clinicopathological parameters and prognostic values. The protein level of hnRNPU was validated by immunohistochemistry (IHC) in human tissue specimens. Genetic alterations of hnRNPs were analyzed using cBioportal, and Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were employed to illustrate the biological functions of co-expressed genes of hnRNPs.

Results: The vast majority of hnRNPs were highly expressed in five types of GI cancer tissues compared to their adjacent normal tissues, and mRNA levels of hnRNPA2B1, D, Q, R and U were significantly different in various GI cancer types at different stages. In addition, Kaplan-Meier analysis revealed that the increased hnRNPs expression levels were correlated with better prognosis in gastric and rectal cancer patients (logrank p < 0.05). In contrast, patients with high levels of hnRNPs exhibited a worse prognosis in esophageal and liver cancer (logrank p < 0.05). Using Immunohistochemistry, we further confirmed that hnRNPU was over-expressed in gastric, rectal, and liver cancers. In addition, hnRNPs gene were altered in patients with GI cancers, and RNA related processing was correlated with hnRNPs alterations.

Conclusion: We identified differentially expressed genes of hnRNPs in tumor tissues versus adjacent normal tissues, which might contribute to predicting tumor types, early diagnosis and targeted therapies in five major types of GI cancer.
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http://dx.doi.org/10.2174/1566523222666220613113647DOI Listing
June 2022

Identification and integrated analysis of lncRNAs and miRNAs in IPEC-J2 cells provide novel insight into the regulation of the innate immune response by PDCoV infection.

BMC Genomics 2022 Jul 4;23(1):486. Epub 2022 Jul 4.

Tianjin Institute of Animal Husbandry and Veterinary Medicine, Tianjin Academy of Agricultural Sciences, Tianjin, 300381, China.

Background: Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are pivotal regulators involved in the pathogenic mechanism of multiple coronaviruses. Porcine deltacoronavirus (PDCoV) has evolved multiple strategies to escape the innate immune response of host cells, but whether ncRNAs are involved in this process during PDCoV infection is still unknown.

Results: In this study, the expression profiles of miRNAs, lncRNAs and mRNAs in IPEC-J2 cells infected with PDCoV at 0, 12 and 24 hours postinfection (hpi) were identified through small RNA and RNA sequencing. The differentially expressed miRNAs (DEmiRNAs), lncRNAs (DElncRNAs) and mRNAs (DEmRNAs) were screened from the comparison group of IPEC-J2 cells at 0 and 12 hpi as well as the comparison group of IPEC-J2 cells at 12 and 24 hpi. The target genes of these DEncRNAs were predicted. The bioinformatics analysis of the target genes revealed multiple significantly enriched functions and pathways. Among them, the genes that were associated with innate immunity were specifically screened. The expression of innate immunity-related ncRNAs and mRNAs was validated by RT-qPCR. Competing endogenous RNA (ceRNA) regulatory networks among innate immunity-related ncRNAs and their target mRNAs were established. Moreover, we found that the replication of PDCoV was significantly inhibited by two innate immunity-related miRNAs, ssc-miR-30c-3p and ssc-miR-374b-3p, in IPEC-J2 cells.

Conclusions: This study provides a data platform to conduct studies of the pathogenic mechanism of PDCoV from a new perspective and will be helpful for further elucidation of the functional role of ncRNAs involved in PDCoV escaping the innate immune response.
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http://dx.doi.org/10.1186/s12864-022-08722-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251034PMC
July 2022

Changes in the disease burden of breast cancer along with attributable risk factors in China from 1990 to 2019 and its projections: An analysis of the global burden of disease study 2019.

Cancer Med 2022 Jul 3. Epub 2022 Jul 3.

Dongying People's Hospital, Dongying, People's Republic of China.

Background: To investigate the secular trends in breast cancer burden with attributable risk factors, and make projections over time, which would contribute to the control and prevention of breast cancer.

Methods: We extracted detailed data on breast cancer incident cases and age-standardized incidence rate (ASIR), deaths and age-standardized mortality rate (ASMR), disability-adjusted life-years (DALYs), and age-standardized DALYs rate (ASDR), as well as the attributable risk factors in China from the Global Burden of Diseases Study 2019. The estimated annual percentage change (EAPC) was calculated to quantify the changing trends. The national DALYs attributable to Socio-demographic Index (SDI) values were also presented. Projections to 2030 were estimated using the Bayesian age-period-cohort model.

Results: From 1990 to 2019, the number of breast cancer incident cases increased fourfold to 375,484, with deaths and DALYs over doubling to 96.306 and 2,957,454, respectively. The ASIR (EAPC = 2.84; 95% CI, 2.74-2.95) and ASMR (EAPC = 0.06; 95% CI, 0.00-0.12) increased, while the ASDR decreased with the EAPC of -0.13 (95% CI, -0.19 to -0.06) at the same period. The ASDR varied across provincial regions, which appeared to be in a wave-like upcurve with SDI values increasing. High body mass index became the first contribution to breast cancer DALYs for females in 2019, and alcohol use for males. Breast Cancer incident cases and deaths would increase to 587.7 and 125.6 thousand in 2030, of which there will be 577.1 and 122.7 thousand for females, and 10.6 and 2.9 thousand for males, respectively.

Conclusion: Breast cancer remains a major public health problem in China. The absolute burden has been increasing over time, and varied across sex and regions. To control the potential risk factors and develop specific strategies will help to reduce the disease burden.
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http://dx.doi.org/10.1002/cam4.5006DOI Listing
July 2022

Investigation of the Pharmacological Effect and Mechanism of Jinbei Oral Liquid in the Treatment of Idiopathic Pulmonary Fibrosis Using Network Pharmacology and Experimental Validation.

Front Pharmacol 2022 15;13:919388. Epub 2022 Jun 15.

Shandong University of Traditional Chinese Medicine, Jinan, China.

Idiopathic pulmonary fibrosis (IPF) is a disease caused by many factors, eventually resulting in lung function failure. Jinbei oral liquid (JBOL) is a traditional Chinese clinical medicine used to treat pulmonary diseases. However, the pharmacological effects and mechanism of the action of JBOL on IPF remain unclear. This study investigated the protective effects and mechanism of the action of JBOL on IPF using network pharmacology analysis, followed by and experimental validation. The components of JBOL and their targets were screened using the TCMSP database. IPF-associated genes were obtained using DisGeNET and Drugbank. The common targets of JBOL and IPF were identified with the STRING database, and a protein-protein interaction (PPI) network was constructed. GO and KEGG analyses were performed. Sprague-Dawley rats were injected with bleomycin (BLM) to establish an IPF model and treated orally with JBOL at doses of 5.4, 10.8, and 21.6 ml/kg. A dose of 54 mg/kg of pirfenidone was used as a control. All rats were treated for 28 successive days. Dynamic pulmonary compliance (Cdyn), minute ventilation volume (MVV), vital capacity (VC), and lung resistance (LR) were used to evaluate the efficacy of JBOL. TGF-β-treated A549 cells were exposed to JBOL, and epithelial-to-mesenchymal transition (EMT) changes were assessed. Western blots were performed. Two hundred seventy-eight compounds and 374 targets were screened, and 103 targets related to IPF were identified. Core targets, including MAPK1 (ERK2), MAPK14 (p38), JUN, IL-6, AKT, and others, were identified by constructing a PPI network. Several pathways were involved, including the MAPK pathway. Experimentally, JBOL increased the levels of the pulmonary function indices (Cdyn, MVV, and VC) in a dose-dependent manner and reduced the RL level in the BLM-treated rats. JBOL increased the epithelial marker E-cadherin and suppressed the mesenchymal marker vimentin expression in the TGF-β-treated A549 cells. The suppression of ERK1/2, JNK, and p38 phosphorylation by JBOL was validated. JBOL had therapeutic effects against IPF by regulating pulmonary function and EMT through a systemic network mechanism, thus supporting the need for future clinical trials of JBOL.
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http://dx.doi.org/10.3389/fphar.2022.919388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240387PMC
June 2022

Retraction notice to "Ginsenoside Rg1 protects human retinal pigment epithelial ARPE-19 cells from toxicity of high glucose by up-regulation of miR-26a" [Life Sci. 221 (2019) 152-158].

Life Sci 2022 09 28;304:120736. Epub 2022 Jun 28.

Department of Ophthalmology, Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou 450003, China.

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http://dx.doi.org/10.1016/j.lfs.2022.120736DOI Listing
September 2022

Comparison of Neutralizing Antibody Response Kinetics in Patients with Hand, Foot, and Mouth Disease Caused by Coxsackievirus A16 or Enterovirus A71: A Longitudinal Cohort Study of Chinese Children, 2017-2019.

J Immunol 2022 07 1;209(2):280-287. Epub 2022 Jul 1.

School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China;

Hand, foot, and mouth disease (HFMD), which is mainly caused by coxsackievirus A16 (CVA16) or enterovirus A71 (EV-A71), poses a serious threat to children's health. However, the long-term dynamics of the neutralizing Ab (NAb) response and ideal paired-serum sampling time for serological diagnosis of CVA16-infected HFMD patients were unclear. In this study, 336 CVA16 and 253 EV-A71 PCR-positive HFMD inpatients were enrolled and provided 452 and 495 sera, respectively, for NAb detection. Random-intercept modeling with B-spline was conducted to characterize NAb response kinetics. The NAb titer of CVA16 infection patients was estimated to increase from negative (2.1, 95% confidence interval [CI]: 1.4-3.3) on the day of onset to a peak of 304.8 (95% CI: 233.4-398.3) on day 21 and then remained >64 until 26 mo after onset. However, the NAb response level of EV-A71-infected HFMD patients was much higher than that of CVA16-infected HFMD patients throughout. The geometric mean titer was significantly higher in severe EV-A71-infected patients than in mild patients, with a 2.0-fold (95% CI: 1.4-3.2) increase. When a 4-fold rise in titer was used as the criterion for serological diagnosis of CVA16 and EV-A71 infection, acute-phase serum needs to be collected at 0-5 d, and the corresponding convalescent serum should be respectively collected at 17.4 (95% CI: 9.6-27.4) and 24.4 d (95% CI: 15.3-38.3) after onset, respectively. In conclusion, both CVA16 and EV-A71 infection induce a persistent humoral immune response but have different NAb response levels and paired-serum sampling times for serological diagnosis. Clinical severity can affect the anti-EV-A71 NAb response.
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http://dx.doi.org/10.4049/jimmunol.2200143DOI Listing
July 2022

PPARG Silencing Improves Blood Pressure Control and Alleviates Renal Damage by Modulating RAS Circadian Rhythm in Hypertensive Rats.

Ann Clin Lab Sci 2022 May;52(3):452-461

Center of Cardiology and Hebei General Hospital, Shijiazhuang, Hebei, China.

Objective: Peroxisome proliferator-activated receptor gamma (PPARG) polymorphisms are associated with hypertension, but the role of PPARG in hypertensive nephropathy is poorly understood.

Methods: Male Sprague-Dawley rats were applied to construct renovascular hypertension model by 2-kid-ney, 1-clip (2K1C) method. Tail vein bolus injection of adeno-associated virus (rAAV)-shPPARG was performed to knockout PPARG in 2K1C rats. The heart rate (HR), systolic pressure (SBP), diastolic pressure (DBP) and activity of rats were monitored after treatments. The role of PPARG in hypertension, renal damage, and circadian rhythm of renin-angiotensin system (RAS) was explored by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR), western blot, Masson staining, hematoxylin eosin (HE) staining, Sirius red staining and enzyme-linked immunosorbent assay.

Results: PPARG was over-expressed in thoracic aortas of 2K1C rats. 2K1C treatment enhanced DBP and SBP in rats, which was reversed by PPARG silencing. PPARG silencing alleviated 2K1C-induced renal damage. 2K1C treatment reduced angiotensin II and increased angiotensin converting enzyme (ACE) and plasma renin activity (PRA) concentrations in rat plasma during the light period and decreased plasma PRA concentration during the dark period, which were all overturned by PPARG silencing. PPARG silencing effectively improved the RAS circadian rhythm in hypertension.

Conclusion: PPARG silencing improved blood pressure control and alleviated renal damage by regulating RAS circadian rhythm in hypertensive rats.
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May 2022

TiVCT MXene/Chalcogenide Heterostructure-Based High-Performance Magnesium-Ion Battery as Flexible Integrated Units.

Small 2022 Jul 1;18(30):e2202313. Epub 2022 Jul 1.

State Key Laboratory for Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, 100083, P. R. China.

Magnesium-ion batteries (MIB) have gradually attracted attention owing to their high theoretical capacity, high safety, and low cost. A bimetallic metal-organic framework self-sacrificing template and a co-assembly strategy are used to prepare a high-performance, stable cycling NiSe -CoSe @TiVCT ([email protected]) heterostructure MIB cathode that can be used as a flexible integrated unit to power future self-powered systems. Benefiting from the synergistic effect of TiVCT MXene and NCSe, the [email protected] heterostructure electrode has a discharge-specific capacity of 136 mAh g at 0.05 A g and high cycling stability of over 500 cycles; the assembled pouch-cell device as flexible integrated unit exhibits good practicability. The magnesium ion storage mechanism is also validated using quantitative kinetic analysis, ex situ XRD, and XPS techniques. Density functional theory analysis indicates the most stable Mg-atom adsorption sites in the heterostructure. This study broadens the possibilities for applying the TiVCT MXene heterostructure to energy storage materials and future self-powered flexible systems.
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http://dx.doi.org/10.1002/smll.202202313DOI Listing
July 2022
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