Publications by authors named "Lijuan Zhang"

895 Publications

Multiple adsorption systems and electron-scale insights into the high efficiency coadsorption of a novel assembled cellulose via experiments and DFT calculations.

J Hazard Mater 2021 Mar 27;416:125748. Epub 2021 Mar 27.

College of Environment, Jinan University, Guangzhou 510632, PR China.

In view of the characteristics of heavy metal and antibiotic compound pollution in the Pearl River Basin in Guangzhou. More scientifically modified cellulose, named HVUC, is characterized by multiple hydrophilic groups, long chains and large space and displays highly efficient adsorption of both Cd and sulfamethoxazole (SMZ) and good adaptability in a wide pH range and at high ion strength. Furthermore, the coadsorption mechanism was elaborated from multiple angles. Multiple adsorption experiments explained the competition and synergy effect in the adsorption process. The electrostatic potential maps indicated that HVUC had advantageous adsorption sites for both Cd and SMZ and that electrostatic interactions had the greatest impact on the adsorption of Cd and SMZ. The electron density and differential charge density images proved that Cd more easily overlapped electron clouds and transferred electrons with HVUC and that SMZ and could act as a bridge for SMZ. The equilibrium configuration indicated that the formation of Cd-SMZ complexes led to the bending and folding of SMZ, which was not conducive to overall adsorption when SMZ was close to HVUC and could lead to the release of SMZ when Cd was close to HVUC, which confirmed the proposed mechanism of complexation-decomplexation-complexation.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125748DOI Listing
March 2021

Anti-inflammatory and anti-rheumatic activities of alkaloids separated from .

Exp Ther Med 2021 May 17;21(5):493. Epub 2021 Mar 17.

Department of Pharmacy, Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China.

The aim of the present study was to investigate the cell proliferation-inhibiting and anti-rheumatic activities of chemical components from Chemical constituents of were separated and purified by silica gel and Sephadex LH-20 chromatography. Structure was identified by spectroscopic technique, and physical/chemical properties were analyzed. The following four compounds were identified: i) Aconitine, ii) songorine, iii) 16, 17-dihydro-12β, 16β-epoxynapelline, and iv) 12-epi-napelline. Cell Counting kit-8 assay was performed to assess cell proliferation. ELISA was conducted to determine the cytokine contents, and reverse transcription-quantitative polymerase chain reaction and Western blot analysis were performed to detect the mRNA and protein expression levels. Compared with the lipopolysaccharide (LPS) group, the contents of IL-6, IL-1β, TNF-α and PGE-2 in the culture supernatant were significantly declined in the leflunomide + LPS and intervention+LPS groups, as well as the mRNA expression levels of HIF-1α, VEGFA and TLR4. Treatments with songorine, benzoylaconine and aconitine (at different concentrations) significantly inhibited the proliferation of HFLS-RA cells. Compared with the LPS group, the contents of PGE-2, IL-6, IL-1β and TNF-α in the culture supernatant were significantly decreased in the intervention groups, and the mRNA expression levels of TLR4, HIF-1α and VEGFA in the cells in the intervention groups. Songorine, benzoylaconine and aconitine from have anti-rheumatic activities , which may inhibit the proliferation of HFLS-RA cells, and the underlying mechanisms may be associated with inhibiting the inflammatory cytokine production and downregulating the expression levels of HIF-1α, VEGF and TLR4.
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http://dx.doi.org/10.3892/etm.2021.9924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8005664PMC
May 2021

Study on the roles of melatonin in regulating dermal fibroblast growth in Liaoning cashmere goats by transcriptome sequencing.

Anim Biotechnol 2021 Mar 28:1-13. Epub 2021 Mar 28.

Liaoning Provincial Key Laboratory of Biotechnology and Drug Discovery, Department of Life Sciences, Liaoning Normal University, Dalian, China.

In this study, the genes related to the Downy growth of Liaoning cashmere goats were screened for their expression with simultaneous melatonin administration, so as to investigate the effects of target genes on the proliferation of skin fibroblasts in this animal species. Genes related to the villus growth of skin fibroblasts were screened by in vitro transcriptome sequencing and verified by qPCR. In addition, gene overexpression and interference were used to study the effects of target genes on the proliferation of skin fibroblasts. Groups treated with M1_24H, M2_24H and M2_72H exhibited significant differences compared with the control group. Among them, the differentially expressed transcripts in the M2_72H group were significantly enriched in the TNF and NOD-like receptor signaling pathways, which are associated with the villus. In addition, eight differentially expressed genes were screened from the TNF and the NOD-like receptor signaling pathways. Verification by qPCR showed that the expression of TNF-α, IL-6, TNFAIP3, PYCARD and NFKBIA genes were significantly upregulated, which was consistent with the sequencing results. Melatonin treatments can significantly lead to an increase in the expression of IL-6 and TNF-α genes. Besides, melatonin treatments can affect cashmere growth in Liaoning cashmere goats by regulating several signaling pathways, including TNF, NOD-like receptor and NF-κB.
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http://dx.doi.org/10.1080/10495398.2021.1886940DOI Listing
March 2021

Early pregnancy stage 1 hypertension and high mean arterial pressure increased risk of adverse pregnancy outcomes in Shanghai, China.

J Hum Hypertens 2021 Mar 23. Epub 2021 Mar 23.

Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, Tongji University, Shanghai, China.

We aimed to evaluate the influence of early pregnancy stage 1 hypertension and mean arterial pressure (MAP) on the risk of pregnancy complications, including gestational diabetes mellitus (GDM) and adverse pregnancy outcomes. Pregnant women without early pregnancy hypertension were consecutively recruited in 2010 in Shanghai, China. Total 6104 women with blood pressure (BP) < 140/90 mmHg were categorized according to early pregnancy BP and MAP levels, respectively. Multivariate adjusted logistic regression and cox regression was used to test the potential associations.
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http://dx.doi.org/10.1038/s41371-021-00523-6DOI Listing
March 2021

Impacts of Chemical Degradation on the Global Budget of Atmospheric Levoglucosan and Its Use As a Biomass Burning Tracer.

Environ Sci Technol 2021 Mar 23. Epub 2021 Mar 23.

School of Environmental Sciences and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong Province 518055, China.

Levoglucosan has been widely used to quantitatively assess biomass burning's contribution to ambient aerosols, but previous such assessments have not accounted for levoglucosan's degradation in the atmosphere. We develop the first global simulation of atmospheric levoglucosan, explicitly accounting for its chemical degradation, to evaluate the impacts on levoglucosan's use in quantitative aerosol source apportionment. Levoglucosan is emitted into the atmosphere from the burning of plant matter in open fires (1.7 Tg yr) and as biofuels (2.1 Tg yr). Sinks of atmospheric levoglucosan include aqueous-phase oxidation (2.9 Tg yr), heterogeneous oxidation (0.16 Tg yr), gas-phase oxidation (1.4 × 10 Tg yr), and dry and wet deposition (0.27 and 0.43 Tg yr ). The global atmospheric burden of levoglucosan is 19 Gg with a lifetime of 1.8 days. Observations show a sharp decline in levoglucosan's concentrations and its relative abundance to organic carbon aerosol (OC) and particulate K from near-source to remote sites. We show that such features can only be reproduced when levoglucosan's chemical degradation is included in the model. Using model results, we develop statistical parametrizations to account for the atmospheric degradation in levoglucosan measurements, improving their use for quantitative aerosol source apportionment.
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http://dx.doi.org/10.1021/acs.est.0c07313DOI Listing
March 2021

Efficacy and safety of anti-epidermal growth factor receptor agents for the treatment of oesophageal cancer: a systematic review and meta-analysis.

BMJ Open 2021 Mar 22;11(3):e046352. Epub 2021 Mar 22.

Department of Science and Technology, Liaoning University of Traditional Chinese Medicine, Shenyang, China

Objectives: Despite remarkable advances in the treatment of oesophageal cancer (OC), the role of antiepidermal growth factor receptor (anti-EGFR) agents in treating OC remains controversial. Herein, a systematic review and meta-analysis were conducted to elucidate the efficacy and safety of anti-EGFR agents in patients with OC.

Design: Meta-analysis of randomised controlled trials (RCTs) identified by searching the PubMed, Embase, Web of Science, ClinicalTrials.gov, Cochrane Library, Chinese Biology Medicine, China National Knowledge Infrastructure and Wanfang Data Knowledge Service Platform databases from inception to December 2019. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Setting: RCTs from any country and healthcare setting.

Participants: Patients with OC.

Interventions: Combination therapy with anti-EGFR agents and conventional treatments versus conventional treatments alone in patients with OC.

Primary And Secondary Outcome Measures: Overall survival (OS) and progression-free survival (PFS) were primary outcome measures, and objective response rate (ORR), disease control rate (DCR) and treatment toxicities were secondary outcome measures.

Results: In total, 25 RCTs comprising 3406 patients with OC were included. Overall, anti-EGFR treatment significantly improved the OS (HR: 0.81, 95% CI 0.74 to 0.89, p<0.00001), ORR (relative risk (RR): 1.33, 95% CI 1.16 to 1.52, p<0.0001) and DCR (RR: 1.22, 95% CI 1.11 to 1.34, p<0.0001) but not PFS (HR: 0.91, 95% CI 0.76 to 1.08, p=0.26). Anti-EGFR treatment was significantly associated with higher incidences of myelosuppression, diarrhoea, acne-like rash and hypomagnesaemia.

Conclusions: Overall, anti-EGFR agents have positive effects on OS, the ORR and DCR in OC. However, considering the high incidence of adverse effects, such as myelosuppression, diarrhoea, acne-like rashes and hypomagnesaemia, careful monitoring of patients with OC is recommended during anti-EGFR treatment.

Trial Registration Number: CRD42020169230.
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http://dx.doi.org/10.1136/bmjopen-2020-046352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7986677PMC
March 2021

Hemangioma Mimicking Left Atrial Mass in the Posterior Mediastinum.

Int Heart J 2021 Mar 17;62(2):453-457. Epub 2021 Mar 17.

Department of Cardiac Ultrasound, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University.

Primary hemangioma of the mediastinum is extremely rare. Herein, we present a unique case of hemangioma mimicking left atrial mass in the posterior mediastinum. We reviewed the literature and found 17 other hemangiomas in the posterior mediastinum. Herein, we summarize the age, gender, symptoms, diagnostic methods, image diagnosis, size, treatments, histologic features, outcomes, and follow-up of 17 cases. Most of the cases were asymptomatic and were accidentally detected in chest radiographs. Diagnostic methods mainly included chest X-ray, computed tomography (CT), and magnetic resonance imaging (MRI). All patients underwent surgical resection, recovered well, and had no recurrence during follow-up.
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http://dx.doi.org/10.1536/ihj.20-547DOI Listing
March 2021

IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis.

Sci Adv 2021 Mar 17;7(12). Epub 2021 Mar 17.

School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China.

Adult neurogenesis in the dentate gyrus of the hippocampus is regulated by specific microglia groups and functionally implicated in behavioral responses to stress. However, the role of microglia in hippocampal neurogenesis and stress resilience remains unclear. We identified interleukin 4 (IL4)-driven microglia characterized by high expression of Arg1, which is critical in maintaining hippocampal neurogenesis and stress resistance. Decreasing Arg1 microglia in the hippocampus by knocking down the microglial IL4R suppressed hippocampal neurogenesis and enhanced stress vulnerability. Increasing Arg1 microglia in the hippocampus by enhancing IL4 signaling restored hippocampal neurogenesis and the resilience to stress-induced depression. Brain-derived neurotrophic factor (BDNF) was found necessary for the proneurogenesis effects of IL4-driven microglia. Together, our findings suggest that IL4-driven microglia in the hippocampus trigger BDNF-dependent neurogenesis responding to chronic stress, helping protect against depressive-like symptoms. These findings identify the modulation of a specific microglial phenotype as a treatment strategy for mood disorders.
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http://dx.doi.org/10.1126/sciadv.abb9888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7968840PMC
March 2021

By targeting apoptosis facilitator BCL2L13, microRNA miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice.

Bioengineered 2021 Dec;12(1):948-959

Department of Cerebrovascular Disease, The Second Affiliated Hospital of Guilin Medical University, Guilin City, Guangxi Zhuang Autonomous Region, China.

Neuronal apoptosis was considered as one of the main factors of cerebral ischemia/reperfusion injury. Understanding the molecular regulatory mechanism of neuronal apoptosis under the cerebral ischemia/reperfusion injury may provide the novel therapeutic targets for cerebral ischemia/reperfusion injury. However, the molecular regulatory mechanism of neurons fate determination under the cerebral ischemia/reperfusion injury remains poorly understood. This study was aimed to delve into the related molecular mechanism of miR-484 on the regulation of cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice. In this study, quantitative real-time polymerase chain reaction assays revealed that the expression level of miR-484 was down-regulated in neurons following OGD. Then, CCK8 assay western blot assay, and flow cytometry assay verified that upregulation of miR-484 increased viability and inhibited apoptosis of neurons following OGD. Further bioinformatics methods and dual-luciferase reporter assay were applied together to anticipate and certify the interaction between miR-484 and BCL2L13. Finally, cerebral infarct size assessment and TUNEL staining confirmed that overexpression of miR-484 alleviated cerebral ischemia/reperfusion injury in mice, and overexpression of BCL2L13 could abolish the effect of miR-484-suppressed cell apoptosis. All these results suggested that miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice by targeting apoptosis facilitator BCL2L13.
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http://dx.doi.org/10.1080/21655979.2021.1898134DOI Listing
December 2021

Research progress on the pharmacological effect and clinical application of Tongqiao Huoxue Decoction in the treatment of ischaemic stroke.

Biomed Pharmacother 2021 Mar 10;138:111460. Epub 2021 Mar 10.

College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China; Shandong Co-Innovation Center of Classic TCM Formula, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China. Electronic address:

Ischaemic stroke (IS) is a common type of stroke characterised by sudden fainting and communication disorders, alongside a number of other symptoms. It is characterised by high morbidity, disability, and mortality rates. Tongqiao Huoxue Decoction (THD) is effective in the treatment of stroke. As a representative prescription for promoting blood circulation and removing blood stasis, THD has been widely used clinically. This paper systematically introduces clinical and experimental studies of THD in the treatment of IS, summarising its clinical application, pharmacological mechanisms, and active components in the treatment of IS. It also explores its key pathways in the treatment of IS through network pharmacology analyses, thereby speculating on its underlying mechanisms. It is of great significance for the secondary development of this classic prescription as well as for the research and development of new drugs.
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http://dx.doi.org/10.1016/j.biopha.2021.111460DOI Listing
March 2021

The effects of dyadic coping and marital satisfaction on posttraumatic growth among breast cancer couples.

Support Care Cancer 2021 Mar 11. Epub 2021 Mar 11.

School of Nursing, Sun Yat-Sen University, No. 74, Zhongshan II Road, Guangzhou, Guangdong Province, People's Republic of China.

Objectives: To examine the dyadic relationships of dyadic coping, marital satisfaction, and posttraumatic growth and to confirm the mediating effect of marital satisfaction between dyadic coping and posttraumatic growth among breast cancer patients and their spouses.

Methods: A total of 206 pairs of female breast cancer patients and their spouses from one tertiary hospital in Guangzhou, China, from August 2018 to July 2019 were invited to complete the demographics and disease-related information questionnaire, the Posttraumatic Growth Inventory, the Marital Adjustment Scale, and the Dyadic Coping Inventory.

Results: Patients' and spouses' positive/negative dyadic coping exerted actor effects and partner effects on marital satisfaction, while their marital satisfaction and positive dyadic coping only exerted actor effects on posttraumatic growth. In addition, the mediating effects of marital satisfaction on the impact of dyadic coping on posttraumatic growth were confirmed in both patients and spouses.

Conclusion: Our findings provide a new perspective on the relationships between dyadic coping, marital satisfaction, and posttraumatic growth at the individual and dyadic levels. Promoting positive dyadic coping and decreasing negative dyadic coping among breast cancer patients and spouses can improve their marital satisfaction and posttraumatic growth.
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http://dx.doi.org/10.1007/s00520-021-06121-zDOI Listing
March 2021

Double sulfur vacancies by lithium tuning enhance CO electroreduction to n-propanol.

Nat Commun 2021 Mar 11;12(1):1580. Epub 2021 Mar 11.

Laboratory of Advanced Materials, Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Faculty of Chemistry and Materials Science, Fudan University, Shanghai, 200438, China.

Electrochemical CO reduction can produce valuable products with high energy densities but the process is plagued by poor selectivities and low yields. Propanol represents a challenging product to obtain due to the complicated C forming mechanism that requires both stabilization of *C intermediates and subsequent C-C coupling. Herein, density function theory calculations revealed that double sulfur vacancies formed on hexagonal copper sulfide can feature as efficient electrocatalytic centers for stabilizing both CO* and OCCO* dimer, and further CO-OCCO coupling to form C species, which cannot be realized on CuS with single or no sulfur vacancies. The double sulfur vacancies were then experimentally synthesized by an electrochemical lithium tuning strategy, during which the density of sulfur vacancies was well-tuned by the charge/discharge cycle number. The double sulfur vacancy-rich CuS catalyst exhibited a Faradaic efficiency toward n-propanol of 15.4 ± 1% at -1.05 V versus reversible hydrogen electrode in H-cells, and a high partial current density of 9.9 mA cm at -0.85 V in flow-cells, comparable to the best reported electrochemical CO reduction toward n-propanol. Our work suggests an attractive approach to create anion vacancy pairs as catalytic centers for multi-carbon-products.
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http://dx.doi.org/10.1038/s41467-021-21901-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952561PMC
March 2021

Emergence of two AcrB substitutions conferring multidrug resistance to .

Antimicrob Agents Chemother 2021 Mar 8. Epub 2021 Mar 8.

Guangdong Key Laboratory for Veterinary Drug Development and Safety evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China

AcrAB-TolC is a major tripartite multidrug efflux pump conferring resistance to a wide variety of compounds in Gram-negative pathogens. Many AcrB mutants have been constructed through site-directed mutagenesis to probe the mechanism of AcrB function in antibiotic resistance. However, much less is known about the actual drug resistance related mutants that naturally occur in clinically isolated pathogens. Here, we report two novel AcrB substitutions, M78I and P319L, in clinically isolated strains with high-level ciprofloxacin resistance. Plasmids expressing the detected mutations were constructed and introduced into SL1344△ Antimicrobial susceptibility assay showed that all AcrB M78I, AcrB P319L and AcrB M78I/319L conferred reduced susceptibilities to multiple substrates, including fluoroquinolones, erythromycin, tetracyclines, bile salts and dyes. Site-directed mutagenesis and MIC results revealed that increased hydrophobicity of M78I was one of the reasons why AcrB M78I had lower susceptibility to fluoroquinolones. Fluorescence labeling experiments suggested that the AcrB M78I substitution enhanced the binding of substrates to certain amino acid sites in the efflux pathway (e.g., site Q89, E673 and F617) and weakened the binding to other amino acids (e.g., S134 and N274). Structural modeling disclosed the increased flexibility of Leu was favorable for the functional rotation of AcrB compared to the original Pro. AcrA 319L makes the functional rotation of AcrB more flexible, this enables substrate efflux more efficiently. In order to understand the mechanism of AcrAB-TolC drug efflux well, interaction between AcrA and AcrB in the role of substrate efflux of AcrAB-TolC should be further investigated.
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http://dx.doi.org/10.1128/AAC.01589-20DOI Listing
March 2021

Ultrasensitive Chemodynamic Therapy: Bimetallic Peroxide Triggers High pH-Activated, Synergistic Effect/H O Self-Supply-Mediated Cascade Fenton Chemistry.

Adv Healthc Mater 2021 Feb 28:e2002126. Epub 2021 Feb 28.

Institute of Engineering Ceramics, School of Materials Science and Engineering, Shandong University of Technology, Zibo, 255000, China.

Recently, nanoparticle-triggered in situ catalytic Fenton/Fenton-like reaction is widely explored for tumor-specific chemodynamic therapy (CDT). However, despite the great potential of CDT in tumor treatment, insensitive response to the relatively high pH of the tumor sites and the insufficient intratumoral H O level leads to limited efficiency of most Fenton/Fenton-like reactions, which greatly imped its clinical conversion. This paper reports the fabrication of Fenton-type bimetallic peroxides for ultrasensitive chemodynamic therapy with high pH-activated, synergistic effect/H O self-supply-mediated cascade Fenton chemistry for the first time. The observations reveal that these bimetallic peroxides exhibit an ultrasensitive acid-activated decomposition-mediated Fenton-like reaction at the relatively high pH of 6.5-7.0, accompanied with highly increased •OH generation efficiency (especially, 40-60-fold increase at pH 7.0) by the metal-mediated synergistic effect-enhanced Fenton chemistry as well as in situ self-generated H O supplement. Moreover, the bimetallic peroxides exhibit high tumor accumulation which along with a high-efficiency tumor catalytic-therapeutic with negligible side effects in vivo. Developing these novel bimetallic peroxides, together with the already demonstrated capacity of the key metals (Fe, Mn, Cu, etc.) for magnetic resonance imaging or photodynamic/immune-enhanced therapy, will propel interest in development of smart high-efficiency nanoplatform for cancer theranostics.
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http://dx.doi.org/10.1002/adhm.202002126DOI Listing
February 2021

Diagnostic and Prognostic Biomarkers for Myocardial Infarction.

Front Cardiovasc Med 2020 3;7:617277. Epub 2021 Feb 3.

Systems Biology & Medicine Center for Complex Diseases, Center for Clinical Research, Affiliated Hospital of Qingdao University, Qingdao, China.

The incidence of myocardial infarction (MI) increases every year worldwide. Better diagnostic and prognostic biomarkers for clinical applications are the consistent pursuit of MI research. In addition to electrocardiogram, echocardiography, coronary angiography, etc., circulating biomarkers are essential for the diagnosis, prognosis, and treatment effect monitoring of MI patients. In this review, we assessed both strength and weakness of MI circulating biomarkers including: (1) originated from damaged myocardial tissues including current golden standard cardiac troponin, (2) released from non-myocardial tissues due to MI-induced systems reactions, and (3) preexisted in blood circulation before the occurrence of MI event. We also summarized newly reported MI biomarkers. We proposed that the biomarkers preexisting in blood circulation before MI incidents should be emphasized in research and development for MI prevention in near future.
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http://dx.doi.org/10.3389/fcvm.2020.617277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886815PMC
February 2021

Bioleaching of Copper-Containing Electroplating Sludge.

J Environ Manage 2021 May 16;285:112133. Epub 2021 Feb 16.

School of Minerals Processing and Bioengineering, Central South University, Changsha, 410083, Hunan, PR China; Key Laboratory of Biohydrometallurgy of Ministry of Education, Changsha, 410083, Hunan, PR China.

The recovery of precious metals from solid waste through bioleaching has become a research hotspot in recent years. Thus, in this study, different strategies, such as chemical sulfuric acid leaching and mixed consortium bioleaching, were adopted to extract copper from Copper-Containing Electroplating Sludge. The results showed that, compared to chemical leaching, bioleaching showed a much better performance. Indeed, copper bioleaching efficiency reached 94.3% on day 7 (21.1% higher than that of chemical leaching). The results also indicated that the process of bioleaching involved more mechanisms and reactions than that of chemical leaching. The SEM and EDX tests showed that the surface morphology of the sludge changed significantly after bioleaching, and that an insignificant amount of copper remained in the leached residues. Furthermore, the leached residues passed the characteristic leaching toxic test and thus can be considered as non-hazardous raw materials for the construction industry. Hence, adopting a mixed consortium leaching process to extract copper from Copper-Containing Electroplating Sludge will not only significantly reduce environmental pollution, but will also use metal resources more efficiently.
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http://dx.doi.org/10.1016/j.jenvman.2021.112133DOI Listing
May 2021

Ultra-thin two-dimensional molecular crystals grown on a liquid surface for high-performance phototransistors.

Chem Commun (Camb) 2021 Mar 17;57(21):2669-2672. Epub 2021 Feb 17.

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science, Tianjin University & Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.

A novel strategy for the growth of molecularly thin two-dimensional molecular crystals (2DMCs) of organic semiconductors with poor solubility was developed. Large-area bilayer 2DMCs were grown on a liquid surface at elevated temperatures, with record mobility and superior photoresponse.
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http://dx.doi.org/10.1039/d0cc07545kDOI Listing
March 2021

A case report of congenital idiopathic hypogonadotropic hypogonadism caused by novel mutation of GNRHR gene.

Medicine (Baltimore) 2021 Feb;100(5):e24007

Peking University Shenzhen Hospital.

Rationale: This study aimed to investigate the genetic mutation characteristics of congenital idiopathic hypogonadotropic hypogonadism (IHH) through the clinical features and genetic analysis of 2 patients with IHH in 1 pedigree.

Patient Concerns: A 23-year-old girl presented with primary amenorrhea, sparse pubic hair, lack of breast development, and delayed sexual development.

Diagnoses: Combined with the clinical characteristics, auxiliary examinations, and molecular genetic analysis, the patient was diagnosed as IHH.

Interventions: Whole exome and Sanger sequencing were performed to validate the mutation in family members.

Outcomes: A novel homozygous missense mutation c.521A > G (p.Q174R) in the GNRHR gene was identified in the 2 affected sisters. Familial segregation showed that the homozygous variant was inherited from their parents respectively and the eldest sister was the carrier without correlative symptom.

Lessons: We reported a novel GNRHR mutation in a pedigree with congenital idiopathic hypogonadotropic hypogonadism. Glutamine at amino acid position 174 was highly conserved among various species. The molecular structure of GNRHR protein showed that p.Q174R mutation brought in a new stable hydrogen bond between position 174 and 215, may impede conformational mobility of the TMD4 and TMD5. It suggests that the missense mutation c.521A > G related to congenital idiopathic hypogonadotropic hypogonadism was probably a causative factor for both sisters. Through high-throughput sequencing and experimental verification, we had basically determined the patient's pathogenic mutation and inheritance, which could better guide doctors for treatment.
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http://dx.doi.org/10.1097/MD.0000000000024007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7870162PMC
February 2021

Adsorption behavior of Cd (II) on TEMPO-oxidized cellulose in inorganic/ organic complex systems.

Environ Res 2021 Apr 12;195:110848. Epub 2021 Feb 12.

College of Environment, Jinan University, Guangzhou, 510632, PR China.

2,2,6,6-Tetramethylpiperidine-1-oxyl (TEMPO) was oxidized to produce TEMPO-oxidized cellulose (TOCS) with a nanofunctionalized surface and abundant carboxyl groups. In a batch experiment, three pH values (2, 5 and 7), three modes (single, binary and multiple systems), and systems with inorganic and organic materials were applied to explore the adsorption of coexisting metals and antibiotics on TOCS. The adsorption capacity of TOCS was substantially influenced by these factors, and the adsorption behaviors were also different in these systems. In general, the coordination behaviors and electrostatic attraction between Cd(II) and carboxyl groups were identified as the mechanism employed by the single system, while hydrophobic interactions, π interactions, hydrogen bonding and pore filling contributed to the adsorption of sulfonamides (SAs) on TOCS in the binary system. The bridging effect was determined to be the key mechanism; i.e., most Cd(II) and SAs in the form of [SA-Cd] complexes interacted with carboxyl groups, especially in the presence of high concentrations of Cd(II) and SAs. These adsorption behaviors were determined quantitatively by performing density functional theory (DFT) calculations. In addition, TOCS showed excellent adsorption capacity in a more complex interference system, and the maximum adsorption capacity was 5.83 mg/g.
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http://dx.doi.org/10.1016/j.envres.2021.110848DOI Listing
April 2021

Estrogen Receptor 1 Expression Patterns Have Different Effects on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors' Treatment Response in Epidermal Growth Factor Receptor Mutant Lung Adenocarcinoma.

Front Oncol 2020 29;10:603883. Epub 2021 Jan 29.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Estrogen receptor (ER) can regulate cellular signaling through non-genomic mechanisms, potentially promoting resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, the mechanisms underlying the ER-mediated resistance to EGFR TKIs remain poorly understood. In this study, we investigated the role of the interaction between ER1 and ER5 in non-genomic signaling in lung adenocarcinoma. We established PC9 cell lines stably overexpressing ER1 or ER1/ER5. Immunofluorescence revealed that ER5 overexpression partly retained ER1 in the cytoplasm. Immunoblotting analyses revealed that EGFR pathway activation levels were higher in PC9/ER1/5 cells than those in PC9/ER1 or control PC9 cells. In the presence of estradiol, PI3K/AKT/mTOR pathway activation levels were higher in ER1/5-expressing cells than those in ER1-expressing cells. Additionally, PC9/ER1/5 cells were less prone to the cytotoxic and pro-apoptotic effects of gefitinib compared with PC9/ER1 or control PC9 cells. Cytoplasmic ER1 was associated with poor progression-free survival in lung cancer patients treated with EGFR TKIs. These results suggest that cytoplasmic ER1 was responsible for EGFR TKI resistance slightly through non-genomic mechanism in EGFR mutant lung adenocarcinoma.
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http://dx.doi.org/10.3389/fonc.2020.603883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879979PMC
January 2021

Predictors of Quality of Life in Patients with Breast Cancer-Related Lymphedema: Effect of Age, Lymphedema Severity, and Anxiety.

Lymphat Res Biol 2021 Feb 8. Epub 2021 Feb 8.

State Key Laboratory of Oncology in South China, Guangzhou, China.

Patients with breast cancer-related lymphedema (BCRL) have lower quality of life (QOL). However, some important predictors, such as the effect of age, lymphedema severity, depression, and anxiety, have not yet been discovered. The overall objective of this study is to explore the QOL predictors associated with BCRL in China. A cross-sectional design was conducted. Data were collected before treatment, including sociodemographic characteristics (height, heaviness, age, education level, work status, marital status, and economic status), clinical characteristics (surgical method, clinical cancer stage, lymphedema severity, and lymphedema duration), the hospital anxiety (HA) and depression scale, and the functional assessment of cancer therapy-breast quality of life instrument. Univariate analysis or bivariate correlation was first made to explore the correlation of QOL with sociodemographic/clinical characteristics, anxiety, and depression. The multiple linear regression model was used to identify the independent QOL predictors. Seventy-one patients with BCRL were recruited. Age, education level, work status, family income, lymphedema duration, lymphedema severity, and HA and hospital depression scale scores are significantly correlated with QOL ( < 0.05). Age, lymphedema severity, and HA accounted for 85.9% in QOL ( = 62.76,  < 0.001). Age, lymphedema, and anxiety are the most important QOL predictors. Therefore, it is very important to establish a BCRL prevention system and pay attention to psychological distress in the patients with BCRL.
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http://dx.doi.org/10.1089/lrb.2020.0073DOI Listing
February 2021

Generating Bulk Nanobubbles in Alcohol Systems.

ACS Omega 2021 Feb 15;6(4):2873-2881. Epub 2021 Jan 15.

Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.

Bulk nanobubbles (NBs) have attracted wide attention due to their peculiar physicochemical properties and great potential in applications in various fields. However, so far there are no reports on bulk NBs generated in pure organic systems, which we think is very important as NBs would largely improve the efficiency of gas-liquid mass transfer and facilitate chemical reactions to take place. In this paper, we verified that air and N NBs could be generated in a series of alcohol solutions by using various methods including acoustical cavitation, pressurization-depressurization, and vibration. The experiments proved that NBs existed in alcohol solutions, with a highest density of 5.8 × 10 bubble/mL in propanol. Our results also indicated that bulk NBs could stably exist for at least hours in alcohol systems. The parameters in generating NBs in alcohols were optimized. Our findings open up an opportunity for improving gas-liquid mass transfer efficiency in the field of the chemical industry.
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http://dx.doi.org/10.1021/acsomega.0c05222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860054PMC
February 2021

Hemisphere-Specific Functional Remodeling and Its Relevance to Tumor Malignancy of Cerebral Glioma Based on Resting-State Functional Network Analysis.

Front Neurosci 2020 13;14:611075. Epub 2021 Jan 13.

Paul. C. Lauterbur Research Centers for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Background: Functional remodeling may vary with tumor aggressiveness of glioma. Investigation of the functional remodeling is expected to provide scientific relevance of tumor characterization and disease management of glioma. In this study, we aimed to investigate the functional remodeling of the contralesional hemisphere and its utility in predicting the malignant grade of glioma at the individual level with multivariate logistic regression (MLR) analysis.

Subjects And Methods: One hundred and twenty-six right-handed subjects with histologically confirmed cerebral glioma were included with 80 tumors located in the left hemisphere (LH) and 46 tumors located in the right hemisphere (RH). Resting-state functional networks of the contralesional hemisphere were constructed using the human brainnetome atlas based on resting-state fMRI data. Functional connectivity and topological features of functional networks were quantified. The performance of functional features in predicting the glioma grade was evaluated using area under (AUC) the receiver operating characteristic curve (ROC). The dataset was divided into training and validation datasets. Features with high AUC values in malignancy classification in the training dataset were determined as predictive features. An MLR model was constructed based on predictive features and its classification performance was evaluated on the training and validation datasets with 10-fold cross validation.

Results: Predictive functional features showed apparent hemispheric specifications. MLR classification models constructed with age and predictive functional connectivity features (AUC of 0.853 ± 0.079 and 1.000 ± 0.000 for LH and RH group, respectively) and topological features (AUC of 0.788 ± 0.150 and 0.897 ± 0.165 for LH and RH group, respectively) achieved efficient performance in predicting the malignant grade of gliomas.

Conclusion: Functional remodeling of the contralesional hemisphere was hemisphere-specific and highly predictive of the malignant grade of glioma. Network approach provides a novel pathway that may innovate glioma characterization and management at the individual level.
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http://dx.doi.org/10.3389/fnins.2020.611075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7838505PMC
January 2021

MiR-195-5p inhibits proliferation and invasion of nerve cells in Hirschsprung disease by targeting GFRA4.

Mol Cell Biochem 2021 Jan 30. Epub 2021 Jan 30.

Department of Pediatric Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Road, Huaiyin District, Jinan, 250021, Shandong, China.

Studies have reported that miR-195-5p plays a role in the Hirschsprung disease (HSCR). Our previous work found GDNF family receptor alpha 4 (GFRA4) is also associated with HSCR. In this study, we focused on whether miR-195-5p induces the absence of enteric neurons and enteric neural crest in HSCR by regulating GFRA4. The expression levels of GFRA4 and miR-195-5p in colon tissues were evaluated by real-time PCR (RT-PCR) assay. We overexpressed GFRA4 or miR-195-5p in SH-SY5Y cells, the cell proliferation, cell cycle, apoptosis and invasion were subsequently investigated by CCK-8 assay, EdU staining, Flow cytometry analysis and Transwell assay, respectively. We also established the xenograft model to detect the effect of miR-195-5p on tumor growth and GFRA4 and p-RET expressions. GFRA4 expression was significantly downregulated in the HSCR colon tissues when compared with that in the control tissues. Overexpression of GFRA4 significantly promoted proliferation, invasion and cell cycle arrest, and inhibited apoptosis of SH-SY5Y cells. We also proved that GFRA4 is a direct target of miR-195-5p, and miR-195-5p inhibited proliferation, invasion, cell cycle arrest and differentiation, and accelerated apoptosis in SH-SY5Y cells which can be reversed by GFRA4 overexpression. Furthermore, we demonstrated that miR-195-5p suppressed tumor growth, and observably decreased GFRA4 and p-RET expressions. Our findings suggest that miR-195-5p plays an important role in the pathogenesis of HSCR. MiR-195-5p inhibited proliferation, invasion and cell cycle arrest, and accelerated apoptosis of nerve cells by targeting GFRA4.
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http://dx.doi.org/10.1007/s11010-021-04055-yDOI Listing
January 2021

Bifurcation Analysis of a Micro-Machined Gyroscope with Nonlinear Stiffness and Electrostatic Forces.

Micromachines (Basel) 2021 Jan 22;12(2). Epub 2021 Jan 22.

School of Automobile and Transportation, Tianjin University of Technology and Education, Tianjin 300222, China.

The bifurcation of the periodic response of a micro-machined gyroscope with cubic supporting stiffness and fractional electrostatic forces is investigated. The pull-in phenomenon is analyzed to show that the system can have a stable periodic response when the detecting voltage is kept within a certain range. The method of averaging and the residue theorem are employed to give the averaging equations for the case of primary resonance and 1:1 internal resonance. Transition sets on the driving/detecting voltage plane that divide the parameter plane into 12 persistent regions and the corresponding bifurcation diagrams are obtained via the singularity theory. The results show that multiple solutions of the resonance curves appear with a large driving voltage and a small detecting voltage, which may lead to an uncertain output of the gyroscope. The effects of driving and detecting voltages on mechanical sensitivity and nonlinearity are analyzed for three persistent regions considering the operation requirements of the micro-machined gyroscope. The results indicate that in the region with a small driving voltage, the mechanical sensitivity is much smaller. In the other two regions, the variations in the mechanical sensitivity and nonlinearity are analogous. It is possible that the system has a maximum mechanical sensitivity and minimum nonlinearity for an appropriate range of detecting voltages.
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http://dx.doi.org/10.3390/mi12020107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910899PMC
January 2021

Association of Early-Phase In-Hospital Glycemic Fluctuation With Mortality in Adult Patients With Coronavirus Disease 2019.

Diabetes Care 2021 04 21;44(4):865-873. Epub 2021 Jan 21.

Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, and Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Objective: To investigate the association of in-hospital early-phase glycemic control with adverse outcomes among inpatients with coronavirus disease 2019 (COVID-19) in Wuhan, China.

Research Design And Methods: The study is a large case series, and data were obtained regarding consecutive patients hospitalized with COVID-19 in the Central Hospital of Wuhan between 2 January and 15 February 2020. All patients with definite outcomes (death or discharge) were included. Demographic, clinical, treatment, and laboratory information were extracted from electronic medical records. We collected daily fasting glucose data from standard morning fasting blood biochemistry to determine glycemic status and fluctuation (calculated as the square root of the variance of daily fasting glucose levels) during the 1st week of hospitalization.

Results: A total of 548 patients were included in the study (median age 57 years; 298 [54%] were women, and = 99 had diabetes [18%]), 215 suffered acute respiratory distress syndrome (ARDS), 489 survived, and 59 died. Patients who had higher mean levels of glucose during their 1st week of hospitalization were older and more likely to have a comorbidity and abnormal laboratory markers, prolonged hospital stays, increased expenses, and greater risks of severe pneumonia, ARDS, and death. Compared with patients with the lowest quartile of glycemic fluctuation, those who had the highest quartile of fluctuation magnitude had an increased risk of ARDS (risk ratio 1.97 [95% CI 1.01, 4.04]) and mortality (hazard ratio 2.73 [95% CI 1.06, 7.73]).

Conclusions: These results may have implications for optimizing glycemic control strategies in COVID-19 patients during the early phase of hospitalization.
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http://dx.doi.org/10.2337/dc20-0780DOI Listing
April 2021

Effectiveness comparisons of acupuncture treatments for vascular dementia: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Jan;100(2):e24079

Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province.

Background: Vascular dementia (VD) is the second most common form of dementia in the world. Acupuncture therapy has been widely used in clinical treatment. Based on the available evidence, we will rank different acupuncture therapy to determine the most effective acupuncture therapy.

Methods: We will search the following database, including PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Literature Database and Chinese Scientific Journals Database database, in order to collect randomized controlled trials on acupuncture in the treatment of VD. We will use Stata 14.2 and WinBUGS 1.4.3 software for Bayesian network meta-analysis and finally evaluated the level of evidence of the results.

Results: This study will compare and rank the effectiveness of acupuncture in the treatment of vascular dementia. Outcome indicators included Alzheimer Disease Assessment Scale-Cognitive section and Mini-mental State Examination, Activity of Daily Living, Blessed dementia scale, Hastgawa Dementia Scale, and adverse events.

Conclusion: Our study will provide support for clinical practice.

Inplasy Registration Number: INPLASY2020110088.
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http://dx.doi.org/10.1097/MD.0000000000024079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7808480PMC
January 2021

AFF4 facilitates melanoma cell progression by regulating c-Jun activity.

Exp Cell Res 2021 Feb 5;399(2):112445. Epub 2021 Jan 5.

Yunnan Key Laboratory of Lung Cancer Research, Kunming, China. Electronic address:

Melanoma is characterized by high mortality and poor prognosis due to metastasis. AFF4 (AF4/FMR2 family member 4), as a scaffold protein, is a component of the super elongation complex (SEC), and is involved in the progression of tumors, e.g., leukemia, head and neck squamous cell carcinoma (HNSCC). However, few studies on AFF4 have focused on melanoma. Here, AFF4 expression levels and clinicopathological features were evaluated in melanoma tissue samples. Then, we performed cell proliferation, migration and invasion assays in A375 and A2058 cells lines in vitro to evaluate the role of AFF4 in melanoma. The effects of AFF4 knockdown in vivo were characterized via a xenograft mouse model. Finally, the correlation between c-Jun and AFF4 protein levels in melanoma was analyzed by rescue assay and immunohistochemistry (IHC). We found that AFF4 expression was upregulated in melanoma tumor tissues and that AFF4 protein expression was also closely related to the prognosis of patients with cutaneous melanoma. Moreover, AFF4 could promote the invasion and migration of melanoma cells by mediating epithelial to mesenchymal transition (EMT). AFF4 might regulate c-Jun activity to promote the invasion and migration of melanoma cells. Importantly, c-Jun was regulated by the AFF4 promoted melanoma tumorigenesis in vivo. Taken together, AFF4 may be a novel oncogene that promotes melanoma progression through regulation of c-Jun activity.
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http://dx.doi.org/10.1016/j.yexcr.2020.112445DOI Listing
February 2021

Toxic epidermal necrolysis after therapeutic plasma exchange in pediatric lupus patients and associated risk factors analysis.

Lupus 2021 Mar 7;30(3):465-472. Epub 2021 Jan 7.

Department of pediatric nephrology, West China Second Hospital of Sichuan University, Sichuan, China.

Background: Therapeutic plasma exchange (TPE) is an effective means of treating systemic lupus erythematosus in children and is safe for most pediatric patients with systemic lupus erythematosus, but severe complications such as toxic epidermal necrolysis (TEN) may occur, which is a life-threatening condition.

Methods: In this study, three systemic lupus erythematosus (SLE) children developed toxic epidermal necrolysis after TPE. We analyzed their medical history, clinical manifestations, SLEDAI scores, and immunological characteristics, compared to 117 cases of SLE patients without TEN after TPE, trying to find the possible risk factors.

Results: The three children with TEN after plasma exchange appeared to have a higher proportion of male (male: female = 2:1), fever (100% Vs 32.5%), erythema on the cheek (100% Vs 54.7%), itching rash (100% Vs 54.7%), ruptured rash (100% Vs 54.7%), oral ulcer (100% Vs 54.7%) and higher LDH level (1826.0 ± 1113.1 Vs 721.1 ± 799.5 U/L), but lower white blood cell count (5.5 ± 3.3 Vs 7.2 ± 4.2 × 10/L), neutrophil count (4.7 ± 3.7 Vs 5.2 ± 3.6 × 10/L), lymphocyte count (0.6 ± 0.5 Vs 1.5 ± 0.8 × 10/L), platelet count (133.7 ± 58.1 Vs 178.5 ± 103.1 × 10/L) and C-reactive protein (all normal Vs 47.9% elevated). Autoantibody spectrum revealed that positive anti-SSA seemed more common (100% Vs 42.7%) in the three children. Relative risk analysis revealed that male (OR 21.4, 95%CI 1.78-257.186), ruptured skin rash (OR 56.5, 95%CI 4.199-760.196) and rash with itching (OR 24, 95%CI 1.98-290.896) are the risk factors of SLE patients developing TEN after plasma exchange.

Conclusions: We should pay particular attention to TEN after plasma exchange in SLE patients (3/120, 2.5%). This condition may be related to male, ruptured skin rash and rash with itching. For SLE patients with risk factors. We should arrange plasmapheresis more carefully.
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http://dx.doi.org/10.1177/0961203320981128DOI Listing
March 2021

Adsorption of Organic Compounds by Biomass Chars: Direct Role of Aromatic Condensation (Ring Cluster Size) Revealed by Experimental and Theoretical Studies.

Environ Sci Technol 2021 Feb 7;55(3):1594-1603. Epub 2021 Jan 7.

School of Environment and Energy, South China University of Technology, Guangzhou 510006, P. R. China.

Biomass chars are a major component of the soil environmental black carbon pool and prepared forms are a potentially useful tool in remediation. A function critical to the roles of both environmental and prepared chars is sorption of organic compounds. Char properties known to control sorption include surface area, porosity, functional group composition, and percent aromatic carbon. Here, we show that sorption affinity (but not maximum capacity) of organic compounds is directly related to the degree of condensation of the aromatic fraction. The Dubinin-Ashtakov characteristic sorption energy (, kJ mol) of 22 compounds on a thermoseries of bamboo chars correlates strongly with the DP/MAS-C NMR-determined bridgehead aromatic carbon fraction (χ), which relates to the mean ring cluster size. Density functional theory-computed binding energy () for five of the compounds on a representative series of polybenzenoid hydrocarbon open-face sheets also correlates positively with χ, leveling off for rings larger than ∼C. The , in turn, correlates strongly with . An increase in with cluster size is also found for sorption, both monolayer and bilayer, between parallel sheets representing slit micropores. The increasing sorption energy with cluster size is shown to be due to increasing cluster polarizability, which strengthens dispersion forces with the sorbate. The findings underscore a previously overlooked explicit role of aromatic condensation in sorption energy, and illustrate the utility of - comparison for predicting sorption.
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http://dx.doi.org/10.1021/acs.est.0c04852DOI Listing
February 2021