Dr. Lijuan Yuan, MS, PhD - Virginia Polytechnic Institute and State University - Associate Professor

Dr. Lijuan Yuan

MS, PhD

Virginia Polytechnic Institute and State University

Associate Professor

Blacksburg, VA | United States

Main Specialties: Pediatric Infectious Diseases

Additional Specialties: Immunology and Virology

ORCID logohttps://orcid.org/0000-0003-0709-5228


Top Author

Dr. Lijuan Yuan, MS, PhD - Virginia Polytechnic Institute and State University - Associate Professor

Dr. Lijuan Yuan

MS, PhD

Education

Jul 2002
National Institute of Allergy and Infectious Diseases, NIH
Post-doc
Jun 2000
The Ohio State University
PhD
Jun 1991
Capital Institute of Pediatrics
MS

Publications

57Publications

1824Reads

923Profile Views

575PubMed Central Citations

Infection Dynamics of Hepatitis E Virus in Wild-Type and Immunoglobulin Heavy Chain Knockout J Gnotobiotic Piglets.

J Virol 2018 11 12;92(21). Epub 2018 Oct 12.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

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http://dx.doi.org/10.1128/JVI.01208-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189505PMC
November 2018
19 Reads
4.440 Impact Factor

A Luciferase Immunoprecipitation System (LIPS) assay for profiling human norovirus antibodies.

J Virol Methods 2017 10 1;248:116-129. Epub 2017 Jul 1.

Caliciviruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2017.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592151PMC
October 2017
35 Reads
1.883 Impact Factor

Immunomodulation and signaling mechanism of Lactobacillus rhamnosus GG and its components on porcine intestinal epithelial cells stimulated by lipopolysaccharide.

J Microbiol Immunol Infect 2017 Oct 14;50(5):700-713. Epub 2015 May 14.

College of Animal Science and Technology, Zhejiang A & F University, Lin'an, Zhejiang Province, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2015.05.002DOI Listing
October 2017
28 Reads
5 Citations
2.350 Impact Factor

Pig model mimicking chronic hepatitis E virus infection in immunocompromised patients to assess immune correlates during chronicity.

Proc Natl Acad Sci U S A 2017 07 19;114(27):6914-6923. Epub 2017 Jun 19.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061;

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http://dx.doi.org/10.1073/pnas.1705446114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502641PMC
July 2017
68 Reads
6 Citations
9.810 Impact Factor

The Association Between Fecal Biomarkers of Environmental Enteropathy and Rotavirus Vaccine Response in Nicaraguan Infants.

Pediatr Infect Dis J 2017 04;36(4):412-416

From the *Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; †Department of Microbiology and Parasitology, National Autonomous University of Nicaragua-León, León, Nicaragua; ‡Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia; and §Department of Biostatistics, UNC-Gillings School of Global Public Health, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1097/INF.0000000000001457DOI Listing
April 2017
40 Reads
8 Citations
2.723 Impact Factor

Rice Bran and Probiotics Alter the Porcine Large Intestine and Serum Metabolomes for Protection against Human Rotavirus Diarrhea.

Front Microbiol 2017 21;8:653. Epub 2017 Apr 21.

Nutrition and Toxicology Laboratory, Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort CollinsCO, USA.

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http://dx.doi.org/10.3389/fmicb.2017.00653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399067PMC
April 2017
41 Reads
3.941 Impact Factor

Effects of Racecadotril on Weight Loss and Diarrhea Due to Human Rotavirus in Neonatal Gnotobiotic Pigs ().

Comp Med 2017 Mar;67(2):157-164

Departments of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia;, Email:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402735PMC
March 2017
29 Reads
0.760 Impact Factor

Real-time PCR-based infectivity assay for the titration of turkey hemorrhagic enteritis virus, an adenovirus, in live vaccines.

J Virol Methods 2017 01 6;239:42-49. Epub 2016 Nov 6.

Department of Population Health Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, 205 Duck Pond Drive, Blacksburg, VA 24061-0442, USA,; Center for Molecular Medicine and Infectious Diseases, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, 1410 Prices Fork Road, Blacksburg, VA 24061-0342, USA,. Electronic address:

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http://dx.doi.org/10.1016/j.jviromet.2016.11.002DOI Listing
January 2017
31 Reads
1.883 Impact Factor

High Protective Efficacy of Probiotics and Rice Bran against Human Norovirus Infection and Diarrhea in Gnotobiotic Pigs.

Front Microbiol 2016 2;7:1699. Epub 2016 Nov 2.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg VA, USA.

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http://dx.doi.org/10.3389/fmicb.2016.01699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090003PMC
November 2016
21 Reads
5 Citations
3.941 Impact Factor

Modeling human enteric dysbiosis and rotavirus immunity in gnotobiotic pigs.

Gut Pathog 2016 8;8:51. Epub 2016 Nov 8.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA USA.

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http://dx.doi.org/10.1186/s13099-016-0136-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100090PMC
November 2016
258 Reads
7 Citations
2.070 Impact Factor

Lactobacillus rhamnosus GG modulates innate signaling pathway and cytokine responses to rotavirus vaccine in intestinal mononuclear cells of gnotobiotic pigs transplanted with human gut microbiota.

BMC Microbiol 2016 06 14;16(1):109. Epub 2016 Jun 14.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Integrated Life Science Building (0913), 1981 Kraft Drive, Blacksburg, VA, 24061, USA.

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http://dx.doi.org/10.1186/s12866-016-0727-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908676PMC
June 2016
50 Reads
5 Citations
2.730 Impact Factor

Tandem truncated rotavirus VP8* subunit protein with T cell epitope as non-replicating parenteral vaccine is highly immunogenic.

Hum Vaccin Immunother 2015 ;11(10):2483-9

b Department of Biomedical Sciences and Pathobiology ; Virginia-Maryland College of Veterinary Medicine; Virginia Polytechnic Institute and State University ; Blacksburg , VA USA.

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http://dx.doi.org/10.1080/21645515.2015.1054583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635725PMC
June 2016
46 Reads
1 Citation
2.131 Impact Factor

Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency.

Sci Rep 2016 04 27;6:25222. Epub 2016 Apr 27.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1038/srep25222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846862PMC
April 2016
14 Reads
10 Citations
5.080 Impact Factor

Enterobacter cloacae inhibits human norovirus infectivity in gnotobiotic pigs.

Sci Rep 2016 04 26;6:25017. Epub 2016 Apr 26.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1038/srep25017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845002PMC
April 2016
30 Reads
6 Citations
5.080 Impact Factor

B-Cell-Deficient and CD8 T-Cell-Depleted Gnotobiotic Pigs for the Study of Human Rotavirus Vaccine-Induced Protective Immune Responses.

Viral Immunol 2016 Mar 29;29(2):112-27. Epub 2016 Jan 29.

1 Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University , Blacksburg, Virginia.

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http://dx.doi.org/10.1089/vim.2015.0105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782039PMC
March 2016
36 Reads
1.640 Impact Factor

High protective efficacy of rice bran against human rotavirus diarrhea via enhancing probiotic growth, gut barrier function, and innate immunity.

Sci Rep 2015 Oct 13;5:15004. Epub 2015 Oct 13.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.

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http://dx.doi.org/10.1038/srep15004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602212PMC
October 2015
20 Reads
10 Citations
5.080 Impact Factor

Targeted sequencing of cancer-associated genes in hepatocellular carcinoma using next generation sequencing.

Mol Med Rep 2015 Sep 17;12(3):4678-4682. Epub 2015 Jun 17.

Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China.

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http://dx.doi.org/10.3892/mmr.2015.3952DOI Listing
September 2015
26 Reads
4 Citations
1.484 Impact Factor

Lactobacillus rhamnosus GG Dosage Affects the Adjuvanticity and Protection Against Rotavirus Diarrhea in Gnotobiotic Pigs.

J Pediatr Gastroenterol Nutr 2015 Jun;60(6):834-43

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg.

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http://dx.doi.org/10.1097/MPG.0000000000000694DOI Listing
June 2015
21 Reads
8 Citations
2.625 Impact Factor

Norovirus vaccines and potential antinorovirus drugs: recent advances and future perspectives.

Future Virol 2015;10(7):899-913

Department of Biomedical Sciences & Pathobiology, Center for Molecular Medicine & Infectious Diseases, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute & State University, Blacksburg, VA 24061-0913, USA.

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http://dx.doi.org/10.2217/fvl.15.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643286PMC
January 2015
24 Reads
12 Citations
1.000 Impact Factor

Probiotic Lactobacillus rhamnosus GG enhanced Th1 cellular immunity but did not affect antibody responses in a human gut microbiota transplanted neonatal gnotobiotic pig model.

PLoS One 2014 10;9(4):e94504. Epub 2014 Apr 10.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Viginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094504PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983166PMC
December 2014
32 Reads
14 Citations
3.234 Impact Factor

Dietary rice bran protects against rotavirus diarrhea and promotes Th1-type immune responses to human rotavirus vaccine in gnotobiotic pigs.

Clin Vaccine Immunol 2014 Oct 30;21(10):1396-403. Epub 2014 Jul 30.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

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http://dx.doi.org/10.1128/CVI.00210-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266357PMC
October 2014
19 Reads
4 Citations

Probiotics and virulent human rotavirus modulate the transplanted human gut microbiota in gnotobiotic pigs.

Gut Pathog 2014 9;6:39. Epub 2014 Sep 9.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061, VA, USA.

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http://dx.doi.org/10.1186/s13099-014-0039-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209515PMC
October 2014
36 Reads
16 Citations
2.070 Impact Factor

Intranasal P particle vaccine provided partial cross-variant protection against human GII.4 norovirus diarrhea in gnotobiotic pigs.

J Virol 2014 Sep 11;88(17):9728-43. Epub 2014 Jun 11.

Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA

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http://jvi.asm.org/content/88/17/9728.full.pdf
Web Search
http://jvi.asm.org/cgi/doi/10.1128/JVI.01249-14
Publisher Site
http://dx.doi.org/10.1128/JVI.01249-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136312PMC
September 2014
68 Reads
11 Citations
4.440 Impact Factor

Inclusion of a universal tetanus toxoid CD4(+) T cell epitope P2 significantly enhanced the immunogenicity of recombinant rotavirus ΔVP8* subunit parenteral vaccines.

Vaccine 2014 Jul 21;32(35):4420-7. Epub 2014 Jun 21.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, 1981 Kraft Drive, Integrated Life Science Building, Blacksburg, VA 24061, United States. Electronic address:

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http://dx.doi.org/10.1016/j.vaccine.2014.06.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104241PMC
July 2014
40 Reads
5 Citations
3.624 Impact Factor

A neonatal gnotobiotic pig model of human enterovirus 71 infection and associated immune responses.

Emerg Microbes Infect 2014 May 21;3(5):e35. Epub 2014 May 21.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University , Blacksburg, VA 24061-0913, USA.

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http://dx.doi.org/10.1038/emi.2014.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051366PMC
May 2014
24 Reads
8 Citations

Dual functions of Lactobacillus acidophilus NCFM as protection against rotavirus diarrhea.

J Pediatr Gastroenterol Nutr 2014 Feb;58(2):169-76

*Department of Biomedical Sciences and Pathobiology †Department of Large Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA.

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http://dx.doi.org/10.1097/MPG.0000000000000197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908657PMC
February 2014
25 Reads
6 Citations
2.625 Impact Factor

Lactobacillus rhamnosus GG on rotavirus-induced injury of ileal epithelium in gnotobiotic pigs.

J Pediatr Gastroenterol Nutr 2013 Dec;57(6):750-8

*Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA †Department of Biochemistry, Rush University, Chicago, IL.

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http://dx.doi.org/10.1097/MPG.0b013e3182a356e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3843150PMC
December 2013
15 Reads
13 Citations
2.625 Impact Factor

Consensus sequence determination and elucidation of the evolutionary history of a rotavirus Wa variant reveal a close relationship to various Wa variants derived from the original Wa strain.

Infect Genet Evol 2013 Dec 20;20:276-83. Epub 2013 Sep 20.

Biochemistry Division, North-West University, Potchefstroom, South Africa.

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http://dx.doi.org/10.1016/j.meegid.2013.09.007DOI Listing
December 2013
27 Reads
1 Citation
3.020 Impact Factor

Median infectious dose of human norovirus GII.4 in gnotobiotic pigs is decreased by simvastatin treatment and increased by age.

J Gen Virol 2013 Sep 26;94(Pt 9):2005-16. Epub 2013 Jun 26.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Integrated Life Science Building, 1981 Kraft Drive, Blacksburg, VA 24061-0913, USA.

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http://dx.doi.org/10.1099/vir.0.054080-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749057PMC
September 2013
42 Reads
14 Citations
3.183 Impact Factor

Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine.

Gut Pathog 2013 Aug 7;5(1):22. Epub 2013 Aug 7.

Department of Biochemistry, Rush University, Cohn Research Building, 1735 W, Harrison Street, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1186/1757-4749-5-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750464PMC
August 2013
21 Reads
9 Citations
2.070 Impact Factor

Nutritional protective mechanisms against gut inflammation.

J Nutr Biochem 2013 Jun 27;24(6):929-39. Epub 2013 Mar 27.

Nutritional Immunology and Molecular Medicine Laboratory, Virginia Bioinformatics Institute, Blacksburg, VA 24060, USA.

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http://dx.doi.org/10.1016/j.jnutbio.2013.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730123PMC
June 2013
41 Reads
22 Citations
3.794 Impact Factor

CD4+ CD25- FoxP3+ regulatory cells are the predominant responding regulatory T cells after human rotavirus infection or vaccination in gnotobiotic pigs.

Immunology 2012 Oct;137(2):160-71

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA24061-0913, USA.

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http://dx.doi.org/10.1111/j.1365-2567.2012.03617.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461397PMC
October 2012
22 Reads
10 Citations
3.800 Impact Factor

The synthetic futures of vesicular stomatitis virus.

Trends Biotechnol 2012 Oct 11;30(10):497-8. Epub 2012 Jul 11.

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http://dx.doi.org/10.1016/j.tibtech.2012.06.002DOI Listing
October 2012
21 Reads
2 Citations
11.960 Impact Factor

Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection.

Comp Immunol Microbiol Infect Dis 2012 Jul 12;35(4):289-301. Epub 2012 Feb 12.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Integrated Life Science Building (0913), 1981 Kraft Dr, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1016/j.cimid.2012.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366054PMC
July 2012
17 Reads
3 Citations
2.020 Impact Factor

High dose and low dose Lactobacillus acidophilus exerted differential immune modulating effects on T cell immune responses induced by an oral human rotavirus vaccine in gnotobiotic pigs.

Vaccine 2012 Feb 14;30(6):1198-207. Epub 2011 Dec 14.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Integrated Life Science Building, 1981 Kraft Dr, Blacksburg, VA 24061-0913, USA.

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http://dx.doi.org/10.1016/j.vaccine.2011.11.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269528PMC
February 2012
89 Reads
27 Citations
3.624 Impact Factor

Development of γδ T cell subset responses in gnotobiotic pigs infected with human rotaviruses and colonized with probiotic lactobacilli.

Vet Immunol Immunopathol 2011 Jun 23;141(3-4):267-75. Epub 2011 Mar 23.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Integrated Life Science Building (0913), 1981 Kraft Dr, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1016/j.vetimm.2011.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090517PMC
June 2011
24 Reads
8 Citations
1.535 Impact Factor

Simian rotaviruses possess divergent gene constellations that originated from interspecies transmission and reassortment.

J Virol 2010 Feb 25;84(4):2013-26. Epub 2009 Nov 25.

Laboratory of Clinical and Epidemiological Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1128/JVI.02081-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812371PMC
February 2010
16 Reads
13 Citations
4.440 Impact Factor

Resistance to rotavirus infection in adult volunteers challenged with a virulent G1P1A[8] virus correlated with serum immunoglobulin G antibodies to homotypic viral proteins 7 and 4.

J Infect Dis 2009 Nov;200(9):1443-51

Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-8026, USA.

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http://dx.doi.org/10.1086/606116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760642PMC
November 2009
16 Reads
3 Citations
6.000 Impact Factor

A longitudinal cohort study in calves evaluated for rotavirus infections from 1 to 12 months of age by sequential serological assays.

Arch Virol 2009 3;154(5):755-63. Epub 2009 Apr 3.

Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00705-009-0331-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679849PMC
May 2009
16 Reads
3 Citations
2.282 Impact Factor

Toll-like receptor and innate cytokine responses induced by lactobacilli colonization and human rotavirus infection in gnotobiotic pigs.

Vet Immunol Immunopathol 2009 Feb 31;127(3-4):304-15. Epub 2008 Oct 31.

Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.

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http://dx.doi.org/10.1016/j.vetimm.2008.10.322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653198PMC
February 2009
25 Reads
15 Citations
1.535 Impact Factor

Next-generation vaccines - An IBC Conference. Harnessing innovative technologies and processes to speed up your research, development & production of novel vaccines part 1.

Authors:
Lijuan Yuan

IDrugs 2008 Sep;11(9):630-2

Virginia Polytechnic Institute and State University, Department of Biomedical Sciences & Pathobiology, Blacksburg, VA 24061, USA.

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September 2008
12 Reads

Next-generation vaccines - An IBC Conference. Harnessing innovative technologies and processes to speed up your research, development & production of novel vaccines part 2.

Authors:
Lijuan Yuan

IDrugs 2008 Sep;11(9):633-5

Virginia Polytechnic Institute and State University, Department of Biomedical Sciences & Pathobiology, Blacksburg, VA 24061, USA.

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September 2008
9 Reads

Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs.

Vaccine 2008 Jul 19;26(29-30):3655-61. Epub 2008 May 19.

Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691-4096, USA.

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http://dx.doi.org/10.1016/j.vaccine.2008.04.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2491559PMC
July 2008
18 Reads
33 Citations
3.624 Impact Factor

Virus-specific intestinal IFN-gamma producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs.

Vaccine 2008 Jun 18;26(26):3322-31. Epub 2008 Apr 18.

Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH 44691, USA.

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http://dx.doi.org/10.1016/j.vaccine.2008.03.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574896PMC
June 2008
16 Reads
31 Citations
3.624 Impact Factor

Influence of probiotic Lactobacilli colonization on neonatal B cell responses in a gnotobiotic pig model of human rotavirus infection and disease.

Vet Immunol Immunopathol 2008 Mar 10;122(1-2):175-81. Epub 2007 Oct 10.

Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691-4096, USA.

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http://dx.doi.org/10.1016/j.vetimm.2007.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268606PMC
March 2008
14 Reads
30 Citations
1.535 Impact Factor

Lactic acid bacterial colonization and human rotavirus infection influence distribution and frequencies of monocytes/macrophages and dendritic cells in neonatal gnotobiotic pigs.

Vet Immunol Immunopathol 2008 Feb 10;121(3-4):222-31. Epub 2007 Oct 10.

Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691-4096, USA.

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http://dx.doi.org/10.1016/j.vetimm.2007.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268605PMC
February 2008
20 Reads
27 Citations
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Transfer of maternal cytokines to suckling piglets: in vivo and in vitro models with implications for immunomodulation of neonatal immunity.

Vet Immunol Immunopathol 2007 Jun 1;117(3-4):236-48. Epub 2007 Mar 1.

Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691-4096, USA.

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http://dx.doi.org/10.1016/j.vetimm.2007.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094377PMC
June 2007
15 Reads
15 Citations
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High titers of circulating maternal antibodies suppress effector and memory B-cell responses induced by an attenuated rotavirus priming and rotavirus-like particle-immunostimulating complex boosting vaccine regimen.

Clin Vaccine Immunol 2006 Apr;13(4):475-85

Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691-4096, USA.

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http://dx.doi.org/10.1128/CVI.13.4.475-485.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1459641PMC
April 2006
22 Reads
13 Citations

Low titer maternal antibodies can both enhance and suppress B cell responses to a combined live attenuated human rotavirus and VLP-ISCOM vaccine.

Vaccine 2006 Mar 1;24(13):2302-16. Epub 2005 Dec 1.

Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691-4096, USA.

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http://dx.doi.org/10.1016/j.vaccine.2005.11.043DOI Listing
March 2006
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Mucosal and systemic antibody responses and protection induced by a prime/boost rotavirus-DNA vaccine in a gnotobiotic pig model.

Vaccine 2005 Jun 9;23(30):3925-36. Epub 2005 Apr 9.

Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster OH 44691, USA.

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http://dx.doi.org/10.1016/j.vaccine.2005.03.009DOI Listing
June 2005
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6 Citations
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Species-specific but not genotype-specific primary and secondary isotype-specific NSP4 antibody responses in gnotobiotic calves and piglets infected with homologous host bovine (NSP4[A]) or porcine (NSP4[B]) rotavirus.

Virology 2004 Dec;330(1):92-104

Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.virol.2004.09.021DOI Listing
December 2004
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Homotypic and heterotypic serum isotype-specific antibody responses to rotavirus nonstructural protein 4 and viral protein (VP) 4, VP6, and VP7 in infants who received selected live oral rotavirus vaccines.

J Infect Dis 2004 May 29;189(10):1833-45. Epub 2004 Apr 29.

Epidemiology Section, Laboratory of Infectious Disease, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1086/383416DOI Listing
May 2004
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11 Citations
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Magnitude of serum and intestinal antibody responses induced by sequential replicating and nonreplicating rotavirus vaccines in gnotobiotic pigs and correlation with protection.

Clin Diagn Lab Immunol 2004 Jan;11(1):12-20

Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC321356PMC
January 2004
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Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model.

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Epidemiology Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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September 2002
20 Reads
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Systemic and intestinal antibody secreting cell responses and protection in gnotobiotic pigs immunized orally with attenuated Wa human rotavirus and Wa 2/6-rotavirus-like-particles associated with immunostimulating complexes.

Vaccine 2002 Mar;20(13-14):1741-53

Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691-4096, USA.

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March 2002
15 Reads
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Top co-authors

Ke Wen
Ke Wen

Virginia-Maryland Regional College of Veterinary Medicine

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Guohua Li
Guohua Li

Columbia University Mailman School of Public Health

27
Xingdong Yang
Xingdong Yang

Virginia-Maryland College of Veterinary Medicine

20
Tammy Bui
Tammy Bui

Virginia-Maryland College of Veterinary Medicine

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Jacob Kocher
Jacob Kocher

Virginia-Maryland Regional College of Veterinary Medicine

18
Linda J Saif
Linda J Saif

Ohio Agricultural Research and Development Center

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Fangning Liu
Fangning Liu

College of Veterinary Medicine

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Yasutaka Hoshino
Yasutaka Hoshino

Laboratory of Infectious Diseases

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