Lijian Shao

Lijian Shao

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Lijian Shao

Publications by authors named "Lijian Shao"

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Polyinosinic-polycytidylic acid accelerates intestinal stem cell proliferation via modulating Myc expression.

J Cell Physiol 2020 Apr 26;235(4):3646-3656. Epub 2019 Sep 26.

Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, Nanchang, China.

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http://dx.doi.org/10.1002/jcp.29254DOI Listing
April 2020

Insights into cognitive deficits caused by low-dose toxic heavy metal mixtures and their remediation through a postnatal enriched environment in rats.

J Hazard Mater 2020 04 13;388:122081. Epub 2020 Jan 13.

Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, Nanchang 330006, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jhazmat.2020.122081DOI Listing
April 2020

Isoprenaline protects intestinal stem cells from chemotherapy-induced damage.

Br J Pharmacol 2020 Feb 3;177(3):687-700. Epub 2020 Jan 3.

Department of Occupational Health and Toxicology, Medical College of Nanchang University, Nanchang, China.

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http://dx.doi.org/10.1111/bph.14883DOI Listing
February 2020

RyRs mediate lead-induced neurodegenerative disorders through calcium signaling pathways.

Sci Total Environ 2020 Jan 1;701:134901. Epub 2019 Nov 1.

Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, Nanchang 330006, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.scitotenv.2019.134901DOI Listing
January 2020

Toxicity assessment due to prenatal and lactational exposure to lead, cadmium and mercury mixtures.

Environ Int 2019 12 19;133(Pt B):105192. Epub 2019 Oct 19.

Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang 330006, PR China; Jiangxi Provincial Key Laboratory of Preventive Medicine, Nanchang University, Nanchang 330006, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2019.105192DOI Listing
December 2019

Lead exposure-induced cognitive impairment through RyR-modulating intracellular calcium signaling in aged rats.

Toxicology 2019 05 21;419:55-64. Epub 2019 Mar 21.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China; Jiangxi provincial key laboratory of preventive medicine, Nanchang University, Nanchang, 330006, China; Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, Nanchang, 330006, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X183066
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http://dx.doi.org/10.1016/j.tox.2019.03.005DOI Listing
May 2019

Droxinostat sensitizes human colon cancer cells to apoptotic cell death via induction of oxidative stress.

Cell Mol Biol Lett 2018 28;23:34. Epub 2018 Jul 28.

2Medical School of Nanchang University, 461 Bayi Road, Nanchang, 330006 Jiangxi China.

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http://dx.doi.org/10.1186/s11658-018-0101-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064062PMC
October 2018

Inhibition of mTORC1 signaling protects kidney from irradiation-induced toxicity via accelerating recovery of renal stem-like cells.

Stem Cell Res Ther 2018 08 14;9(1):219. Epub 2018 Aug 14.

Department of Histology and Embryology, Basic Medical School of Nanchang University, No. 461 Bayi Road, Nanchang, 330006, China.

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http://dx.doi.org/10.1186/s13287-018-0963-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092808PMC
August 2018

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow.

Nat Commun 2018 06 18;9(1):2377. Epub 2018 Jun 18.

Office of the Dean and the Cancer Center, Long School of Medicine, University of Texas Health Science Center, San Antonio, TX, 78229, USA.

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http://dx.doi.org/10.1038/s41467-018-04716-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006146PMC
June 2018

NOS2 deficiency has no influence on the radiosensitivity of the hematopoietic system.

Cell Biosci 2018 27;8:33. Epub 2018 Apr 27.

2Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR USA.

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http://dx.doi.org/10.1186/s13578-018-0228-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922011PMC
April 2018

Low doses of oxygen ion irradiation cause long-term damage to bone marrow hematopoietic progenitor and stem cells in mice.

PLoS One 2017 12;12(12):e0189466. Epub 2017 Dec 12.

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189466PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726652PMC
January 2018

Whole body proton irradiation causes acute damage to bone marrow hematopoietic progenitor and stem cells in mice.

Int J Radiat Biol 2017 12 7;93(12):1312-1320. Epub 2017 Aug 7.

a Division of Radiation Health, Department of Pharmaceutical Sciences , University of Arkansas for Medical Sciences , Little Rock , AR , U.S.A.

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http://dx.doi.org/10.1080/09553002.2017.1356941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693495PMC
December 2017

DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.

Aging Cell 2017 08 12;16(4):693-703. Epub 2017 Apr 12.

Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

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http://dx.doi.org/10.1111/acel.12597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506444PMC
August 2017

Low Doses of Oxygen Ion Irradiation Cause Acute Damage to Hematopoietic Cells in Mice.

PLoS One 2016 1;11(7):e0158097. Epub 2016 Jul 1.

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158097PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930193PMC
July 2017

Si total body irradiation injures bone marrow hematopoietic stem cells via induction of cellular apoptosis.

Life Sci Space Res (Amst) 2017 May 5;13:39-44. Epub 2017 Apr 5.

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.lssr.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711775PMC
May 2017

Synthesis of (2,8' ,3' )-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol.

Tetrahedron 2016 Jul 12;72(27-28):4001-4006. Epub 2016 May 12.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070675PMC
http://dx.doi.org/10.1016/j.tet.2016.05.028DOI Listing
July 2016

Hematopoietic Stem Cells from Ts65Dn Mice Are Deficient in the Repair of DNA Double-Strand Breaks.

Radiat Res 2016 06 31;185(6):630-7. Epub 2016 May 31.

b   Division of Radiation Health, Department of Pharmaceutical Sciences and.

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http://dx.doi.org/10.1667/RR14407.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943077PMC
June 2016

Timing of the loss of Pten protein determines disease severity in a mouse model of myeloid malignancy.

Blood 2016 Apr 13;127(15):1912-22. Epub 2016 Jan 13.

Division of Hematology/Oncology, Department of Internal Medicine, College of Medicine, Winthrop P. Rockefeller Cancer Institute.

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http://dx.doi.org/10.1182/blood-2015-05-646216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832508PMC
April 2016

Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.

PLoS One 2015 10;10(4):e0122511. Epub 2015 Apr 10.

Division of Radiation Health, Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, United States of America; Surgical Service, Central Arkansas Veterans Healthcare System, Little Rock, AR, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122511PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393275PMC
December 2015

Reactive oxygen species in normal and tumor stem cells.

Adv Cancer Res 2014 ;122:1-67

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-420117-0.00001-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207279PMC
February 2015

C/EBPδ deficiency sensitizes mice to ionizing radiation-induced hematopoietic and intestinal injury.

PLoS One 2014 18;9(4):e94967. Epub 2014 Apr 18.

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America; Surgical Service, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094967PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991713PMC
January 2015

Long-term epigenetic effects of exposure to low doses of 56Fe in the mouse lung.

J Radiat Res 2014 Jul 28;55(4):823-8. Epub 2014 Feb 28.

Department of Environmental and Occupational Health, College of Public Health, University of Arkansas for Medical Sciences, 4301 West Markham Street, #820-11, Little Rock, 72205-7199, AR, USA

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http://dx.doi.org/10.1093/jrr/rru010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100002PMC
July 2014

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.

Blood 2014 May 12;123(20):3105-15. Epub 2014 Mar 12.

Division of Radiation Health, Department of Pharmaceutical Sciences and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR;

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http://dx.doi.org/10.1182/blood-2013-07-515619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023419PMC
May 2014

Hematopoietic stem cell injury induced by ionizing radiation.

Antioxid Redox Signal 2014 Mar 10;20(9):1447-62. Epub 2014 Feb 10.

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences , Little Rock, Arkansas.

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http://www.liebertpub.com/doi/10.1089/ars.2013.5635
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http://dx.doi.org/10.1089/ars.2013.5635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936513PMC
March 2014

Chronic mTOR activation promotes cell survival in Merkel cell carcinoma.

Cancer Lett 2014 Mar 19;344(2):272-281. Epub 2013 Nov 19.

Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205.

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http://dx.doi.org/10.1016/j.canlet.2013.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080622PMC
March 2014

Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence.

Transplantation 2014 Jan;97(1):20-9

1 Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 2 Division of Radiation Health, Department of Pharmaceutical Sciences and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR. 3 Institute of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 4 Address correspondence to: Lingbo Liu, M.D., Ph.D., Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China and Daohong Zhou, M.D., Division of Radiation Health, Department of Pharmaceutical Sciences and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, 4301 West Markham, #607, Little Rock, AR 72205.

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http://dx.doi.org/10.1097/TP.0b013e3182a7fcf8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877183PMC
January 2014

Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.

Transl Cancer Res 2013 Oct;2(5):397-411

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.

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http://dx.doi.org/10.3978/j.issn.2218-676X.2013.07.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941916PMC
October 2013

BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks.

Radiat Res 2013 Feb 21;179(2):160-70. Epub 2012 Dec 21.

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.1667/RR3034.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607209PMC
February 2013

A sensitive and quantitative polymerase chain reaction-based cell free in vitro non-homologous end joining assay for hematopoietic stem cells.

PLoS One 2012 20;7(3):e33499. Epub 2012 Mar 20.

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033499PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308962PMC
August 2012

Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase.

Transl Cancer Res 2012 Aug;1(2):100-108

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

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http://www.thetcr.org/article/view/378
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http://dx.doi.org/10.3978/j.issn.2218-676X.2012.05.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432498PMC
August 2012

Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression.

Free Radic Biol Med 2011 Jul 14;51(1):30-7. Epub 2011 Apr 14.

Institute of Radiation Medicine, Department of Biochemistry and Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.

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http://linkinghub.elsevier.com/retrieve/pii/S089158491100242
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http://dx.doi.org/10.1016/j.freeradbiomed.2011.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390209PMC
July 2011

Reactive oxygen species and hematopoietic stem cell senescence.

Int J Hematol 2011 Jul 13;94(1):24-32. Epub 2011 May 13.

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

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http://dx.doi.org/10.1007/s12185-011-0872-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390185PMC
July 2011

IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells.

PLoS One 2011 Apr 7;6(4):e18447. Epub 2011 Apr 7.

Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018447PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072401PMC
April 2011

Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation.

Blood 2010 Jun 1;115(23):4707-14. Epub 2010 Apr 1.

COBRE in Stem Biology and Regenerative Medicine Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, USA.

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http://dx.doi.org/10.1182/blood-2009-10-248872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890171PMC
June 2010

Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration.

Blood 2010 Mar 23;115(9):1709-17. Epub 2009 Dec 23.

Center of Biomedical Research Excellence (COBRE) in Stem Biology and Regenerative Medicine, Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough, ME, USA.

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http://dx.doi.org/10.1182/blood-2009-07-232934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832807PMC
March 2010

Gene-delivery systems for iPS cell generation.

Expert Opin Biol Ther 2010 Feb;10(2):231-42

Maine Medical Center Research Institute, Maine Medical Center, COBRE in Stem Biology and Regenerative Medicine, 81 Research Drive, Scarborough, Maine 04074, USA.

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http://dx.doi.org/10.1517/14712590903455989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811526PMC
February 2010

Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame.

Cell Res 2009 Mar;19(3):296-306

Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA.

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http://dx.doi.org/10.1038/cr.2009.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821711PMC
March 2009

Protective effects of sasanquasaponin on injury of endothelial cells induced by anoxia and reoxygenation in vitro.

Basic Clin Pharmacol Toxicol 2007 Nov;101(5):301-8

Jiangxi Provincial Key Laboratory of Molecular Medicine at the Second Affiliated Hospital, Nanchang University, Nanchang, China.

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http://dx.doi.org/10.1111/j.1742-7843.2007.00119.xDOI Listing
November 2007

Observation of microvasculature in intestinal wall after burn in rats.

Anal Quant Cytol Histol 2007 Jun;29(3):166-72

Department of Human Anatomy, Medical College of Nanchang University, Nanchang, Jiangxi, People's Republic of China.

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June 2007

Upregulation of 14-3-3 isoforms in acute rat myocardial injuries induced by burn and lipopolysaccharide.

Clin Exp Pharmacol Physiol 2006 Apr;33(4):374-80

Jiangxi Provincial Key Laboratory of Molecular Medicine at the Second Affiliated Hospital, Department of Pharmacology, Nanchang University School of Medicine, Nanchang, PR China.

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http://dx.doi.org/10.1111/j.1440-1681.2006.04378.xDOI Listing
April 2006

Changes of occludin expression in intestinal mucosa after burn in rats.

Burns 2005 Nov 11;31(7):838-44. Epub 2005 Jul 11.

Department of Human Anatomy, Jiangxi Medical College, No. 603, BaYi Road, Nanchang 330006, Jiangxi, PR China.

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http://dx.doi.org/10.1016/j.burns.2005.05.005DOI Listing
November 2005

Inhibitory effects of sasanquasaponin on over-expression of ICAM-1 and on enhancement of capillary permeability induced by burns in rats.

Burns 2005 Aug 19;31(5):637-42. Epub 2005 Mar 19.

Department of Pharmacology, Jiangxi Medical College, Ba-Yi Road 603, Nanchang 330006, PR China.

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http://dx.doi.org/10.1016/j.burns.2005.02.006DOI Listing
August 2005