Liisa Myllykangas

Liisa Myllykangas

UNVERIFIED PROFILE

Are you Liisa Myllykangas?   Register this Author

Register author
Liisa Myllykangas

Liisa Myllykangas

Publications by authors named "Liisa Myllykangas"

Are you Liisa Myllykangas?   Register this Author

52Publications

1546Reads

28Profile Views

Lewy-related pathology exhibits two anatomically and genetically distinct progression patterns: a population-based study of Finns aged 85.

Acta Neuropathol 2019 Nov 7;138(5):771-782. Epub 2019 Sep 7.

Department of Pathology, HUSLAB, Helsinki University Hospital, University of Helsinki, P.O. Box 21, 00014, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-019-02071-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800868PMC
November 2019

Hippocampal Sclerosis in the Oldest Old: A Finnish Population-Based Study.

J Alzheimers Dis 2018 ;63(1):263-272

Department of Pathology, University of Helsinki and HUSLAB, Helsinki University Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-171068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900558PMC
August 2019

Heritability and genetic variance of dementia with Lewy bodies.

Neurobiol Dis 2019 07 3;127:492-501. Epub 2019 Apr 3.

Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588425PMC
July 2019

Oligogenic basis of sporadic ALS: The example of p.Ala90Val mutation.

Neurol Genet 2019 Jun 23;5(3):e335. Epub 2019 Apr 23.

Department of Clinical Genetics (L.K.), Helsinki University Hospital; Department of Medical Genetics (L.K.), University of Helsinki, Helsinki, Finland; Molecular Neurology (K.K., M.V., P.J.T.), Research Programs Unit, Biomedicum, University of Helsinki, Helsinki, Finland; Department of Medical Genetics (S.M.), University of Helsinki, Helsinki, Finland and Turku; University Hospital (S.M.), Laboratory Division, Genetics and Saske, Department of Medical Genetics, Turku, Finland; Department of Neurology (H.L.), Helsinki University Hospital, and Molecular Neurology, Research Programs Unit, Biomedicum, University of Helsinki, Helsinki, Finland; Neuromuscular Research Center (M.J., B.U.), Tampere University Hospital and University of Tampere, Tampere, Finland; Division of Clinical Neurosciences (M.J.), Turku University Hospital and University of Turku, Turku, Finland; Folkhälsan Research Center (B.U.), Biomedicum, University of Helsinki, Helsinki, Finland; Institute of Biomedicine (P.P., J.S.), University of Turku; Turku University Hospital (P.P., J.S.), Laboratory Division, Genetics and Saske, Department of Medical Genetics, Turku, Finland; Department of Pathology (A.P.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Laboratory of Neurogenetics (B.J.T.), National Institute on Aging, National Institutes of Health, Bethesda, MD; Merck & Co. (D.J.S.), Inc., West Point, PA; Department of Clinical Genetics (M.P.), Helsinki University Hospital; Department of Medical Genetics (M.P.), University of Helsinki, Helsinki, Finland; Department of Neurology (P.J.T.), Helsinki University Hospital; and Department of Pathology (L.M.), University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXG.0000000000000335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481226PMC
June 2019

Causes of Death of Professional Musicians in the Classical Genre.

Med Probl Perform Art 2019 Jun;34(2):92-97

Dep. of Medical Genetics, Biomedicum, University of Helsinki, Haartmaninkatu 8, 00251 Helsinki, Finland. Tel 358 50 544 7030.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21091/mppa.2019.2016DOI Listing
June 2019

A comprehensive screening of copy number variability in dementia with Lewy bodies.

Neurobiol Aging 2019 03 24;75:223.e1-223.e10. Epub 2018 Oct 24.

Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01974580183038
Publisher Site
http://dx.doi.org/10.1016/j.neurobiolaging.2018.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6541211PMC
March 2019

C9orf72 hexanucleotide repeat length in older population: normal variation and effects on cognition.

Neurobiol Aging 2019 Mar 11. Epub 2019 Mar 11.

Molecular Neurology, Research Programs Unit, Department of Neurology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.026DOI Listing
March 2019

Genetics of dementia in a Finnish cohort.

Eur J Hum Genet 2018 06 23;26(6):827-837. Epub 2018 Feb 23.

Clinical Neurosciences, Neurology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-018-0117-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974394PMC
June 2018

Heterozygous TYROBP deletion (PLOSL) is not a strong risk factor for cognitive impairment.

Neurobiol Aging 2018 04 18;64:159.e1-159.e4. Epub 2017 Dec 18.

Molecular Neurology, Research Programs Unit, University of Helsinki and Department of Neurology, Helsinki University Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2017.12.008DOI Listing
April 2018

Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study.

J Alzheimers Dis 2017 ;58(3):669-674

Department of Pathology, University of Helsinkiand Helsinki University Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-170104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218117PMC
March 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

A Novel Loss-of-Function GRN Mutation p.(Tyr229*): Clinical and Neuropathological Features.

J Alzheimers Dis 2017 ;55(3):1167-1174

Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-160647DOI Listing
February 2018

Alzheimer risk loci and associated neuropathology in a population-based study (Vantaa 85+).

Neurol Genet 2018 Feb 18;4(1):e211. Epub 2018 Jan 18.

Department of Pathology (M.M., A.E.P., M.T., L.M.), University of Helsinki, and Helsinki University Hospital, Finland; Molecular Neurology (K.K., M.V., T. Peuralinna, P.J.T.), Research Programs Unit, University of Helsinki, and Department of Neurology, Helsinki University Hospital, Finland; Institute of Neuroscience (T. Polvikoski), Newcastle University, United Kingdom; Laboratory of Neurogenetics (A.B.S., B.J.T.), National Institutes on Aging, NIH, Bethesda, MD; and Merck Research Laboratories (D.J.S.), Merck & Co., Inc., West Point, PA, USA.

View Article

Download full-text PDF

Source
http://ng.neurology.org/lookup/doi/10.1212/NXG.0000000000000
Publisher Site
http://dx.doi.org/10.1212/NXG.0000000000000211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773846PMC
February 2018

"Genetic code" of brain ageing.

Duodecim 2017;133(2):201-8

View Article

Download full-text PDF

Source
January 2018

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study.

Lancet Neurol 2018 01 16;17(1):64-74. Epub 2017 Dec 16.

UK Dementia Research Institute, University College London, London, UK; Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, UK; Department of Medical Sciences and Institute of Biomedicine, iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(17)30400-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805394PMC
January 2018

Amyloid tracers binding sites in autosomal dominant and sporadic Alzheimer's disease.

Alzheimers Dement 2017 Apr 28;13(4):419-430. Epub 2016 Sep 28.

Division of Translational Alzheimer Neurobiology, Department of Neurobiology Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden; Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2016.08.006DOI Listing
April 2017

Population-based analysis of pathological correlates of dementia in the oldest old.

Ann Clin Transl Neurol 2017 03 12;4(3):154-165. Epub 2017 Feb 12.

Department of Pathology Huslab Helsinki University Hospital and Medicum University of Helsinki Helsinki Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338150PMC
March 2017

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Neurobiol Aging 2017 01 2;49:214.e13-214.e15. Epub 2016 Sep 2.

Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Department of Medical Sciences and Institute of Biomedicine-iBiMED, University of Aveiro, Aveiro, Portugal. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2016.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154872PMC
January 2017

Capillary amyloid-β protein deposition in a population-based study (Vantaa 85+).

J Alzheimers Dis 2016 ;49(1):149-57

Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-150241DOI Listing
September 2016

Genome-wide association study of neocortical Lewy-related pathology.

Ann Clin Transl Neurol 2015 Sep 18;2(9):920-31. Epub 2015 Aug 18.

Molecular Neurology, Research Program Unit, Biomedicum, University of Helsinki Helsinki, Finland ; Department of Neurology, Helsinki University Central Hospital Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574809PMC
September 2015

Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology.

Neurobiol Aging 2014 Sep 26;35(9):2180.e1-5. Epub 2014 Mar 26.

Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.024DOI Listing
September 2014

CADASIL and CARASIL.

Brain Pathol 2014 Sep;24(5):525-44

Protein Chemistry Unit, Institute of Biomedicine/Anatomy, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bpa.12181DOI Listing
September 2014

Familial frontotemporal dementia associated with C9orf72 repeat expansion and dysplastic gangliocytoma.

Neurobiol Aging 2014 Feb 27;35(2):444.e11-4. Epub 2013 Sep 27.

Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA; Institute of Neurology, University College London, Queen Square, London, UK.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01974580130035
Publisher Site
http://dx.doi.org/10.1016/j.neurobiolaging.2013.08.021DOI Listing
February 2014

Homozygosity analysis in amyotrophic lateral sclerosis.

Eur J Hum Genet 2013 Dec 24;21(12):1429-35. Epub 2013 Apr 24.

Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, and Department of Clinical Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ejhg.2013.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3829775PMC
December 2013

Amyloid precursor protein (APP) A673T mutation in the elderly Finnish population.

Neurobiol Aging 2013 May 24;34(5):1518.e1-3. Epub 2012 Oct 24.

Department of Pathology, University of Helsinki and HUSLAB, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2012.09.017DOI Listing
May 2013

Intracerebral hemorrhage in the oldest old: a population-based study (vantaa 85+).

Front Neurol 2012 28;3:103. Epub 2012 Jun 28.

Department of Pathology, Haartman Institute, University of Helsinki and HUSLAB Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fneur.2012.00103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449495PMC
October 2012

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Neuron 2011 Oct 21;72(2):257-68. Epub 2011 Sep 21.

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2011.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200438PMC
October 2011

Matrix metalloproteinase-β19 expressed in cerebral amyloid angiopathy.

Amyloid 2011 Mar 25;18(1):3-9. Epub 2011 Jan 25.

Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/13506129.2010.541960DOI Listing
March 2011

Neuropathologic findings of dementia with lewy bodies (DLB) in a population-based Vantaa 85+ study.

J Alzheimers Dis 2009 ;18(3):677-89

Department of Pathology, University of Helsinki, and Helsinki University Central Hospital, P.O. Box 21 (Haartmaninkatu 3), FI-00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-2009-1169DOI Listing
June 2010

alpha-Synuclein pathology in the spinal cord autonomic nuclei associates with alpha-synuclein pathology in the brain: a population-based Vantaa 85+ study.

Acta Neuropathol 2010 Jun;119(6):715-22

Department of Pathology, Helsinki University Central Hospital,University of Helsinki, P.O. Box 21, Haartmaninkatu 3, 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00401-009-0629-6
Publisher Site
http://dx.doi.org/10.1007/s00401-009-0629-6DOI Listing
June 2010

Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis.

Neurobiol Dis 2009 Dec 15;36(3):488-93. Epub 2009 Sep 15.

Folkhälsan Institute of Genetics, Biomedicum Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2009.09.001DOI Listing
December 2009

Apolipoprotein E (APOE) and lipoprotein lipase (LPL) gene variants and carotid atherosclerotic lesions in the oldest old: a population-based autopsy study.

Arch Gerontol Geriatr 2009 Jul-Aug;49(1):108-12. Epub 2008 Jul 10.

Folkhälsan Institute of Genetics and Department of Pathology, University of Helsinki and Helsinki University Central Hospital, POB 63, 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.archger.2008.05.007DOI Listing
August 2009

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

Mol Brain 2009 Feb 9;2. Epub 2009 Feb 9.

Center for Neurologic Diseases, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-6606-2-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2644690PMC
February 2009

Neurofibrillary tau pathology modulated by genetic variation of alpha-synuclein.

Ann Neurol 2008 Sep;64(3):348-52

Molecular Neurology Programme, Biomedicum, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.21446DOI Listing
September 2008

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

J Neurosci 2007 Mar;27(12):3338-46

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0285-07.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672466PMC
March 2007

[A fruit fly (Drosophila melanogaster) as a model organism for studies of brain diseases].

Duodecim 2006 ;122(4):443-50

Folkhälsanin perinnöllisyystieteen laitos jaa Neurotieteen tutkimuskeskus, Biomedicum Helsinki, Helsingin yliopisto.

View Article

Download full-text PDF

Source
August 2006

Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses.

Neurobiol Dis 2005 Jun-Jul;19(1-2):194-9

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB Room 652, Boston, MA 02115, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2004.12.019DOI Listing
July 2005