Publications

Synthesis and biological evaluation of NH2-acyl oseltamivir analogues as potent neuraminidase inhibitors.
Eur J Med Chem 2017 Dec 5;141:648-656. Epub 2017 Oct 5.
Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China. Electronic address:

Toxic effects of microcystin-LR on the development of prostate in mice.
Toxicology 2017 Apr 8;380:50-61. Epub 2017 Feb 8.
Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, Jiangsu 210093, China. Electronic address:

Cisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activity.
Cell Death Dis 2017 Apr 13;8(4):e2746. Epub 2017 Apr 13.
Department of Pharmacology, Shenyang Pharmaceutical University College of Life Science and Biopharmaceutical, Shenyang, China.

[Baicalein attenuates acute lung injury induced by intestinal ischemia/reperfusion via inhibition of nuclear factor-κB pathway in mice].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 Mar;29(3):228-232
Clinical Laboratory, Danyang People's Hospital, Danyang 212300, Jiangsu, China (Chu L, Zhu FY, Zhou WJ, Du ZX); Department of Neurosurgery, Danyang People's Hospital, Danyang 212300, Jiangsu, China (Li J); Department of Gastroenterology, Danyang People's Hospital, Danyang 212300, Jiangsu, China (Wang XH); Central Laboratory, Danyang People's Hospital, Danyang 212300, Jiangsu, China (Wang LH); Experimental Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China (Liu AD). Corresponding author: Chu Lei, Email:


Novel cinnamohydroxamic acid derivatives as HDAC inhibitors with anticancer activity in vitro and in vivo.
Chem Biol Interact 2016 Apr 2;249:64-70. Epub 2016 Mar 2.
Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China. Electronic address:


TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells.
Sci Rep 2016 Mar 3;6:22484. Epub 2016 Mar 3.
Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons.
Sci Rep 2016 Feb 3;6:20033. Epub 2016 Feb 3.
Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

YeastFab: the design and construction of standard biological parts for metabolic engineering in Saccharomyces cerevisiae.
Nucleic Acids Res 2015 Jul 8;43(13):e88. Epub 2015 May 8.
MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China

TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo.
Steroids 2015 Feb 30;94:51-9. Epub 2014 Dec 30.
Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Label-free fluorometric detection of S1 nuclease activity by using polycytosine oligonucleotide-templated silver nanoclusters.
Anal Biochem 2015 Jan 28;468:34-8. Epub 2014 Sep 28.
Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China; Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710062, China. Electronic address:

Minor cytotoxic cardenolide glycosides from the root of Streptocaulon juventas.
Steroids 2015 Jan 18;93:39-46. Epub 2014 Nov 18.
Development and Utilization Key Laboratory of Northeast Plant Materials, Key Laboratory of Northeast Authentic Materials Research and Development in Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Novel chalcone derivatives as hypoxia-inducible factor (HIF)-1 inhibitor: synthesis, anti-invasive and anti-angiogenic properties.
Eur J Med Chem 2015 Jan 14;89:88-97. Epub 2014 Oct 14.
Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China; Benxi Institute of Pharmaceutical Research, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China. Electronic address:

A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts.
Mol Oncol 2014 Dec 3;8(8):1640-52. Epub 2014 Jul 3.
Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, PR China. Electronic address:

Synthesis and biological evaluation of benzothiazole derivatives bearing the ortho-hydroxy-N-acylhydrazone moiety as potent antitumor agents.
Arch Pharm (Weinheim) 2014 Dec 17;347(12):936-49. Epub 2014 Sep 17.
Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenhe District, Shenyang, P. R. China.

Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives possessing diaryl semicarbazone scaffolds as potent antitumor agents.
Eur J Med Chem 2014 Nov 13;87:782-93. Epub 2014 Oct 13.
Key Lab of New Drug Design and Discovery of Liaoning Province, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 110016 Shenyang, PR China. Electronic address:

A new graphene oxide/polypyrrole foam material with pipette-tip solid-phase extraction for determination of three auxins in papaya juice.
J Chromatogr A 2014 Nov 2;1368:37-43. Epub 2014 Oct 2.
Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding 071002, China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, Hebei University, Baoding 071002, China.

Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice.
Prog Neuropsychopharmacol Biol Psychiatry 2014 Oct 5;54:92-102. Epub 2014 Apr 5.
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, PR China. Electronic address:

Design, synthesis and biological evaluation of novel thieno[3,2-d]pyrimidine derivatives containing diaryl urea moiety as potent antitumor agents.
Eur J Med Chem 2014 Oct 28;85:215-27. Epub 2014 Jul 28.
Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China. Electronic address:

Design, synthesis, and structure-activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents.
Eur J Med Chem 2014 Oct 17;86:257-69. Epub 2014 Aug 17.
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning 110016, PR China. Electronic address:


Isolation and characterization of lung resident mesenchymal stem cells capable of differentiating into alveolar epithelial type II cells.
Cell Biol Int 2014 Apr 10;38(4):405-11. Epub 2014 Feb 10.
Immunology and Reproductive Biology Laboratory, Medical College of Nanjing University, Nanjing, 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing, 210093, China; State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, 210093, China.

N-Ethyl-N-nitrosourea mutagenesis in the mouse provides strong genetic and in vivo evidence for the role of the Caspase Recruitment Domain (CARD) of CARD-MAGUK1 in T regulatory cell development.
Immunology 2014 Mar;141(3):446-56
Section of Immunobiology, Division of Immunology and Inflammation, Department of Medicine, Faculty of Medicine, Imperial College London, London, UK.

Neural progenitor cells from human induced pluripotent stem cells generated less autogenous immune response.
Sci China Life Sci 2014 Feb 17;57(2):162-70. Epub 2014 Jan 17.
Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

Metal-enhanced fluorescence-based core-shell Ag@SiO₂ nanoflares for affinity biosensing via target-induced structure switching of aptamer.
ACS Appl Mater Interfaces 2014 Feb 30;6(3):1944-50. Epub 2014 Jan 30.
Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education and ‡Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University , Xi'an 710062, China.

Transplanted motoneurons derived from human induced pluripotent stem cells form functional connections with target muscle.
Stem Cell Res 2013 Jul 5;11(1):529-39. Epub 2013 Mar 5.
Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.


Immediate expression of Cdh2 is essential for efficient neural differentiation of mouse induced pluripotent stem cells.
Stem Cell Res 2013 May 13;10(3):338-48. Epub 2013 Jan 13.
Stem Cell and Cancer Biology Group, Chinese Academy of Sciences Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.


Identification of oligomer proanthocyanidins (F2) isolated from grape seeds as a formyl peptide receptor 1 partial agonist.
Int Immunopharmacol 2013 Apr 21;15(4):756-63. Epub 2013 Mar 21.
Department of Pharmacology, Shenyang Pharmaceutical University, 110016, Shenyang, Engineering Technology and Research Center for Plant Polyphenols of Liaoning Province, 110016 Shenyang, PR China.

Generation of integration-free neural progenitor cells from cells in human urine.
Nat Methods 2013 Jan 9;10(1):84-9. Epub 2012 Dec 9.
Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.


Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells.
Cell Regen (Lond) 2013 30;2(1). Epub 2013 Jul 30.
CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell Biology and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Science Park, Guangzhou, 510530 P.R.China.

Low immunogenicity of neural progenitor cells differentiated from induced pluripotent stem cells derived from less immunogenic somatic cells.
PLoS One 2013 26;8(7):e69617. Epub 2013 Jul 26.
Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong Province, PR China.

T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration.
Science 2015 05 16;348(6238):995-1001. Epub 2015 Apr 16.
Section of Immunobiology, Division of Inflammation and Immunology, Department of Medicine, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK. Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA.

Phosphodiesterase-5 inhibition suppresses colonic inflammation-induced tumorigenesis via blocking the recruitment of MDSC.
Am J Cancer Res 2017 1;7(1):41-52. Epub 2017 Jan 1.
Guangdong Provincial Key Laboratory of Gastroenterology; Inst. of Gastroenterology of Guangdong Province; Department of Gastroenterology, Nanfang Hospital, Southern Medical University Guangzhou 510515, Guangdong Province, China.



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