Publications by authors named "Liguo Jin"

7 Publications

  • Page 1 of 1

Gallium (Ga)-strontium (Sr) layered double hydroxide composite coating on titanium substrates for enhanced osteogenic and antibacterial abilities.

J Biomed Mater Res A 2021 Jul 29. Epub 2021 Jul 29.

Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Bacterial infection and poor osteogenic capacity can result in the loosing or failure of titanium (Ti)-based implants in the clinic. Therefore, it is urgent to design an effective approach to enhance the osteogenic property and restrict bacterial activity. In this study, a layered double hydroxide (LDH) composed of Ga and Sr ions on Ti substrates by a hydrothermal method, then calcined in 250°C and denoted as LDH250. The scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) were confirmed that the LDH films were successfully formed on the Ti substrates. Importantly, the obtained LDH films can induce an alkaline microenvironment around the Ti surface and regulate the behaviors of osteogenic cells and bacteria. In vitro cellular experiments, the LDH250 can enhance the differentiation of both MC3T3-E1 cells and osteoblasts, stimulate alkaline phosphatase activity (ALP), collagen secretion, and mineralization levels. Meanwhile, antimicrobial assay against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) demonstrated that the LDH250 samples had strong antibacterial abilities, which attributed to the release profile of Ga could act as a "Trojan horse" to destroy the bacterial iron metabolism, inducing of local alkaline environment, and producing reactive oxygen species. Hence, this study provides an effective method for reducing antibacterial infection and enhancing the bone integrative capacity of Ti-based implants for orthopedic applications.
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http://dx.doi.org/10.1002/jbm.a.37284DOI Listing
July 2021

A versatile and low-toxicity material for photothermal therapy in deeper tissues.

J Mater Chem B 2021 Aug 28;9(31):6155-6162. Epub 2021 Jul 28.

College of Chemistry, Nanchang University, Nanchang, Jiangxi 330088, China.

The limited depth of the near infrared (NIR) response is one of the major flaws of the present photothermal therapy (PTT). In this article, thermosensitive polyurethane urea (TPUU) was synthesized by polymerization. Subsequent experiments showed that, compared with classical photosensitizers, TPUU has higher photothermal effects and lower cytotoxicity. These valuable properties could make the present PTT research provide more therapeutic options among different tissues and organs. As a practical example, TPUU was applied to regulate the intestinal flora through external NIR irradiation, which implied its promising expanded applications in deeper tissues.
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http://dx.doi.org/10.1039/d0tb03000gDOI Listing
August 2021

ZnO/CPAN Modified Contact Lens with Antibacterial and Harmful Light Reduction Capabilities.

Adv Healthc Mater 2021 07 19;10(13):e2100259. Epub 2021 Apr 19.

College of Chemistry, Nanchang University, Nanchang, Jiangxi, 330088, China.

Compared with traditional glasses, the comfortable and convenient contact lens (CL) has seen an upsurge among the public. However, due to the lack of antibacterial properties of ordinary CLs, the risk of eye infection is greatly increased accordingly. On the other hand, ordinary CLs also cannot effectively reduce the short-wavelength blue light emitted from electronic products, such as mobile phones and computers. Aiming at the above two problems, zinc oxide (ZnO)/cyclized polyacrylonitrile (CPAN) composites are developed for CL modification. After loading with ZnO/CPAN (ZC), the CL shows a broad-spectrum antibacterial property. Further experiments also prove that it can block UVB, UVA, as well as blue light selectively, under the premise of ensuring hydrophilicity and certain transparency. Theoretically, this ZC-decorated CL can fundamentally reduce the damage to the eyes from harmful light emitted by light-emitting diodes and the secretion of pro-inflammatory factors, which is thus a promising eye protection strategy for modern society.
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http://dx.doi.org/10.1002/adhm.202100259DOI Listing
July 2021

Dual-Effective Chronic Wounds Management System through a Monoglyceride Binary Blend Matrix Based Thermal-Responsive Phase-Transition Substrate.

Adv Healthc Mater 2021 04 26;10(8):e2001966. Epub 2021 Jan 26.

College of Chemistry, Nanchang University, Nanchang, Jiangxi, 330088, China.

A new monoglyceride-based heat-sensitive substrate is proposed, for the first time, as a wound management system. First, an appropriate portion of glyceryl monooleate (GMO) and glyceryl monostearate (GMS) is mixed to provide a thermal phase responsive matrix (GMO-GMS, GG). Subsequently, to improve the photothermal responsive and antibacterial performance, silver nanoparticles (Ag) decorated reduced graphene oxide (rGO) nanocomposite (rGO-Ag) is added to the GG matrix to obtain (GG-rGO-Ag). According to the systematic studies from uninfected, infected, and diabetic wound models, by applying near infrared (NIR) laser, the phase change of GG-rGO-Ag can be triggered to release Ag on demand for sterilization. More importantly, this smart GG substrate can also promote the production of vascular endothelial growth factor protein, thus serving as a NIR defined mufti-effective wound management system.
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http://dx.doi.org/10.1002/adhm.202001966DOI Listing
April 2021

A multi-effective and long-acting immunotherapy through one single hydrogel based injection.

Biomater Sci 2021 Feb 24;9(4):1374-1380. Epub 2020 Dec 24.

The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330088, China.

A dual-effective (photothermal and immune) therapy employing gold nanorods (AuNRs) with a drug (two macrophage migration inhibitory factor (MIF) inhibitors) sustained release hydrogel was designed in this paper. The subsequent cellular and animal studies demonstrated that the proposed therapy can not only inhibit the proliferation, migration, and recurrence of cancer cells, but also improve the immune function (increase the infiltration of CD8 killer T cells in tumors) without the traditional multiple injections of expensive immune drugs.
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http://dx.doi.org/10.1039/d0bm01974gDOI Listing
February 2021

Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity.

Adv Mater 2020 Jan 28;32(2):e1906050. Epub 2019 Nov 28.

College of Chemistry, Nanchang University, Nanchang, Jiangxi, 330088, China.

A black phosphorus (BP)-nanosheet-based drug-delivery system containing a therapeutic drug (Fluoxetine, Flu) is synthesized. According to subsequent behavioral, biochemical, and electrophysiological analysis, BP-Flu, after irradiated with near-infrared light (808 nm), can significantly reduce the therapy time of depression. Meanwhile, the inherent biotoxicity of Flu is also alleviated.
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http://dx.doi.org/10.1002/adma.201906050DOI Listing
January 2020

Dye-sensitized solar cell based on blood mimetic thixotropy sol-gel electrolyte.

Chem Commun (Camb) 2011 Jan 25;47(3):997-9. Epub 2010 Nov 25.

Key Laboratory of Cluster Science of Ministry of Education, Beijing Institute of Technology, Beijing, 100081, PR China.

Blood mimetic thixotropy sol-gel electrolytes were prepared and sandwiched between dye-coated porous TiO(2) and a platinum counter-electrode to form a dye-sensitized solar cell. The highest overall conversion efficiency of 6.45%, and the fill factor of 0.74 under the white light irradiation AM 1.5 (100 mW cm(-2)) were obtained.
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http://dx.doi.org/10.1039/c0cc04285dDOI Listing
January 2011
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