Publications by authors named "Libin Liu"

113 Publications

Development and Validation of a Prediction Model for Elevated Arterial Stiffness in Chinese Patients With Diabetes Using Machine Learning.

Front Physiol 2021 23;12:714195. Epub 2021 Aug 23.

Fujian Key Laboratory of Vascular Aging, Department of Geriatrics, Department of Cardiology, Department of Cardiac Surgery, Fujian Heart Disease Center, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, Fuzhou, China.

Background: Arterial stiffness assessed by pulse wave velocity is a major risk factor for cardiovascular diseases. The incidence of cardiovascular events remains high in diabetics. However, a clinical prediction model for elevated arterial stiffness using machine learning to identify subjects consequently at higher risk remains to be developed.

Methods: Least absolute shrinkage and selection operator and support vector machine-recursive feature elimination were used for feature selection. Four machine learning algorithms were used to construct a prediction model, and their performance was compared based on the area under the receiver operating characteristic curve metric in a discovery dataset ( = 760). The model with the best performance was selected and validated in an independent dataset ( = 912) from the Dryad Digital Repository (https://doi.org/10.5061/dryad.m484p). To apply our model to clinical practice, we built a free and user-friendly web online tool.

Results: The predictive model includes the predictors: age, systolic blood pressure, diastolic blood pressure, and body mass index. In the discovery cohort, the gradient boosting-based model outperformed other methods in the elevated arterial stiffness prediction. In the validation cohort, the gradient boosting model showed a good discrimination capacity. A cutoff value of 0.46 for the elevated arterial stiffness risk score in the gradient boosting model resulted in a good specificity (0.813 in the discovery data and 0.761 in the validation data) and sensitivity (0.875 and 0.738, respectively) trade-off points.

Conclusion: The gradient boosting-based prediction system presents a good classification in elevated arterial stiffness prediction. The web online tool makes our gradient boosting-based model easily accessible for further clinical studies and utilization.
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http://dx.doi.org/10.3389/fphys.2021.714195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419456PMC
August 2021

Understanding the sorption behaviors of heavy metal ions in the interlayer and nanopore of montmorillonite: A molecular dynamics study.

J Hazard Mater 2021 Aug 30;416:125976. Epub 2021 Apr 30.

Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, College of Natural Resources and Environment, Northwest A & F University, Yangling 712100, China; State Key Laboratory of Soil Erosion and Dryland Farming on Loess Plateau, Northwest A&F University, Yangling 712100, China. Electronic address:

The molecular-scale adsorption mechanism of heavy metal ions in the interlayer and nanopore regions of montmorillonite (MMT) were investigated by molecular dynamics simulations. Three typical heavy metals (zinc, cadmium, and lead) were selected as the model ions, and two types of MMT (Arizona and Wyoming) were considered. The results showed that Cd and Pb can form both inner- and outer-sphere complexes on Wyoming MMT, while Zn only formed outer-sphere complex due to the stronger hydration interaction of Zn than Cd and Pb. For Arizona MMT, all of the three ions only formed outer-sphere complexes on its interlayer and external basal surface in which the cations remained a fully hydrated state. The calculated diffusion coefficients of three cations in interlayer and nanopore indicated that their diffusion abilities were significantly impaired, implying that MMT adsorbents have a strong ability to fix and retard heavy metal ions. The derived results and mechanisms are instrumental to a profound understanding of the transport and retention of heavy metal elements in subsurface environments, and provide guidance for the management of heavy metal pollution.
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http://dx.doi.org/10.1016/j.jhazmat.2021.125976DOI Listing
August 2021

The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65.

Endocrinol Metab (Seoul) 2021 Aug 10;36(4):778-789. Epub 2021 Aug 10.

Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension.

Methods: Based on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Patients with a history of hypertension or thyroid disease were excluded. SCH was determined by manufacturer reference range. Overall hypertension and stage 1 and 2 hypertension were diagnosed according to the guidelines issued by the American College of Cardiology/American Heart Association in 2017.

Results: The prevalence of overall hypertension (48.7%), including stage 1 (28.9%) and 2 (19.8%) hypertension, increased significantly in SCH patients compared with euthyroid subjects. With elevated serum thyroid stimulating hormone (TSH) level, the hypertension prevalence also increased significantly from the euthyroid to different SCH subgroups, which was more profound in females or subjects aged <65 years. The age- and sex-specific regression analysis further demonstrated the same trends in the general population and in the 1:1 propensity matched population. Similarly, several BP components (i.e., systolic, diastolic, and mean arterial BP) were positively associated with TSH elevation, and regression analysis also confirmed that all BP components were closely related with SCH in female subjects aged <65 years.

Conclusion: The prevalence of hypertension increases for patients with SCH. SCH tends to be associated with hypertension and BP components in females younger than 65 years.
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http://dx.doi.org/10.3803/EnM.2021.1101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419610PMC
August 2021

Biomass-based superhydrophobic coating with tunable colors and excellent robustness.

Carbohydr Polym 2021 Oct 3;270:118401. Epub 2021 Jul 3.

School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China. Electronic address:

Multicolored superhydrophobic coating with high durability has been receiving tremendous attention in decorative applications. Herein, a facile method to fabricate multicolored superhydrophobic coating with excellent robustness has been developed by using cellulose and chitosan. The multicolored coatings can be obtained through single dyeing or mixed dyeing based on three primary dyes. The coating can be applied on hard substrates (e.g. glass, aluminum sheet) and soft substrates (e.g. cotton fabric) by diverse methods including spraying, dip-coating and painting. The colorful coating firmly adheres to the substrates due to the multiple interactions (siloxane covalent bonds and hydrogen bonds). The colorful coating exhibits water-repellant behaviors and can withstand sandpaper abrasion, tape-peeling cycles, water impact, salt spray test and UV environments. Furthermore, the multicolored coating can be used as a new type of pigment for painting on different substrates and is expected to have a huge potential application in technological design or decoration.
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http://dx.doi.org/10.1016/j.carbpol.2021.118401DOI Listing
October 2021

Lactoferrin ameliorates pathological cardiac hypertrophy related to mitochondrial quality control in aged mice.

Food Funct 2021 Aug 5;12(16):7514-7526. Epub 2021 Jul 5.

School of Pharmacy, Fujian Medical University, Fuzhou, China.

Pathological myocardial hypertrophy, which lacks effective prevention and treatment strategies, makes the elderly susceptible to various cardiovascular diseases. Based on the beneficial attributes of lactoferrin in aging-related diseases, we aimed to investigate whether lactoferrin could exert protection against aging-related cardiac hypertrophy and further explore the underlying mechanisms. Here, we assessed the effects of lactoferrin on myocardial pathology, apoptotic proteins, mitochondrial morphology, kinetics, autophagy, and aging-related markers, including lipofuscin deposition, overloaded iron, and oxidative stress, which are known to destabilize the mitochondrial-lysosomal axis in aged mice. Upon the administration of lactoferrin, aged hearts showed amelioration of pathological cardiac hypertrophy, which was associated with decreased apoptosis, improved morphology, rearrangement of mitochondrial dynamics, increased lysosome-dependent autophagy, and inhibition of factors detrimental to the mitochondrial-lysosomal axis. In conclusion, lactoferrin ameliorated pathological cardiac hypertrophy, potentially by improving the mitochondrial quality related to mitochondrial dynamics and the mitochondrial-lysosomal axis, thus reducing mitochondria-dependent apoptosis, which is the pivotal factor for cardiac hypertrophy in aged mice.
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http://dx.doi.org/10.1039/d0fo03346dDOI Listing
August 2021

Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research.

Int J Endocrinol 2021 29;2021:6663553. Epub 2021 May 29.

Department of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China.

Objective: It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population.

Methods: Our study consisted of a community-based and cross-sectional study from the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 193 subjects with SCH (90 males and 103 females) without a history of treatment of thyroid disease, such as surgery, radiation, and thyroid hormone or antithyroid medication, were included in the present study. Indices of obesity, including body mass index (BMI), waist circumference (WC), and waist-height ratio (WHtR) were measured.

Results: Our results showed that the secretory capacity of the thyroid gland (SPINA-GT) and Jostel's thyrotropin index (TSHI) were negatively correlated with BMI, WC, and WHtR, whereas the reciprocal of the thyrotroph thyroid hormone resistance index (TTSI-1) was positively correlated with BMI (all < 0.05). After adjustment for age, sex, smoking, iodine status, and glucolipid metabolism, the associations between TSHI, TTSI (reciprocal transformation), and BMI still persisted (all < 0.05).

Conclusions: These results suggest that low levels of thyroid homeostasis indexes may be associated with overall obesity in SCH, rather than central adiposity.
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http://dx.doi.org/10.1155/2021/6663553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179776PMC
May 2021

Hyperthyroidism Prevalence in China After Universal Salt Iodization.

Front Endocrinol (Lausanne) 2021 28;12:651534. Epub 2021 May 28.

Zhejiang Center for Disease Control and Prevention (Zhejiang CDC), Hangzhou, China.

Background: Universal salt iodization (USI) was implemented in mainland China in 1996. The prevalence of hyperthyroidism and its risk factors now require examination.

Methods: Data were acquired from a nationwide Thyroid, Iodine, and Diabetes Epidemiological survey (TIDE 2015-2017) of 78,470 subjects from 31 provinces. Iodine status, and thyroid hormones and antibodies were measured.

Results: After two decades of USI, the prevalence of overt hyperthyroidism (OH), Graves' disease (GD), severe subclinical hyperthyroidism (severe SCH), and mild subclinical hyperthyroidism (mild SCH) in mainland China was 0.78%, 0.53%, 0.22%, and 0.22%, respectively. OH and GD prevalence were higher in women than in men (OH: 1.16% . 0.64%, P<0.001; GD: 0.65% . 0.37%, P<0.001).Prevalence was significantly decreased after 60 years-of-age compared with 30-39 years-of-age (OH:0.61% . 0.81%, P<0.001; GD: 0.38% . 0.57%, P<0.001).Excessive iodine(EI) and deficient iodine(DI) were both related to increased prevalence of OH (odds ratio [OR] 2.09, 95% confidence interval [CI] 1.68-2.59; OR1.35, 95%CI 1.07-1.72, respectively); however, only deficient iodine was associated with increased prevalence of GD (OR1.67, 95%CI 1.30-2.15). Increased thyroid peroxidase antibody and thyroglobulin antibody levels were significantly associated with prevalence of OH and GD, but not severe SCH and mild SCH. Although hyperthyroidism was more prevalent in women, the association disappeared after adjusting for other factors such as antibody levels.

Conclusion: OH and GD prevalences in mainland China are stable after two decades of USI. Iodine deficiency, elevated thyroid antibody levels, and middle age are the main risk factors for OH and GD. The severe SCH population, rather than the mild SCH population, shows similar characteristics to the OH population.
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http://dx.doi.org/10.3389/fendo.2021.651534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194401PMC
May 2021

Design of Low-Cost and High-Strength Titanium Alloys Using Pseudo-Spinodal Mechanism through Diffusion Couple Technology and CALPHAD.

Materials (Basel) 2021 May 28;14(11). Epub 2021 May 28.

School of Material Science and Engineering, Central South University, Changsha 410083, China.

The high cost of development and raw materials have been obstacles to the widespread use of titanium alloys. In the present study, the high-throughput experimental method of diffusion couple combined with CALPHAD calculation was used to design and prepare the low-cost and high-strength Ti-Al-Cr system titanium alloy. The results showed that ultra-fine α phase was obtained in Ti-6Al-10.9Cr alloy designed through the pseudo-spinodal mechanism, and it has a high yield strength of 1437 ± 7 MPa. Furthermore, application of the 3D strength model of Ti-6Al-xCr alloy showed that the strength of the alloy depended on the volume fraction and thickness of the α phase. The large number of α/β interfaces produced by ultra-fine α phase greatly improved the strength of the alloy but limited its ductility. Thus, we have demonstrated that the pseudo-spinodal mechanism combined with high-throughput diffusion couple technology and CALPHAD was an efficient method to design low-cost and high-strength titanium alloys.
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http://dx.doi.org/10.3390/ma14112910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198148PMC
May 2021

Lifestyle is associated with thyroid function in subclinical hypothyroidism: a cross-sectional study.

BMC Endocr Disord 2021 May 28;21(1):112. Epub 2021 May 28.

Department of Endocrinology and Metabolism, Fujian Medical University Union Hospital, 29 Xinquan Road, Fujian, 350001, Fuzhou, China.

Background: Few studies have focused on the association between lifestyle and subclinical hypothyroidism (SCH). The purpose of this study was to investigate the association between lifestyle and thyroid function in SCH.

Methods: This study was a part of a community-based and cross-sectional study, the Epidemiological Survey of Thyroid Diseases in Fujian Province, China. A total of 159 participants with SCH (81 males and 78 females) and 159 euthyroid (87 males and 72 females) participants without any missing data were included in the analysis. General information and lifestyle information including sleep, exercise, diet and smoking habits of the participants was collected by questionnaire and Pittsburgh sleep quality index scale (PSQI) was collected. Thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), thyroid globulin antibody (TgAb) and urine iodine concentration (UIC) were tested. Thyroid homeostasis parameter thyroid' s secretory capacity (SPINA-GT), Jostel's TSH index (TSHI), thyrotroph T4 sensitivity index (TTSI) were calculated. Logistic regression and multiple linear regression were performed to assess associations.

Results: Compared with euthyroid subjects, patients with SCH were more likely to have poor overall sleep quality (15.1 vs.25.8 %, P = 0.018) and l less likely to stay up late on weekdays (54.7 vs. 23.9 % P < 0.001). In SCH group, exercise was the influencing factor of TSH (β= -0.224, P = 0.004), thyroid secretory capacity (β = 0.244, P = 0.006) and thyrotropin resistance (β = 0.206, P = 0.009). Iodine excess was the influencing factor of thyroid secretory capacity (β = 0.209, P = 0.001) and pituitary thyroid stimulating function (β = 0.167, P = 0.034). Smoking was the influencing factor of pituitary thyroid stimulating function (β = 0.161, P = 0.040). Staying up late on weekends was the influencing factor of thyroid secretory capacity (β = 0.151, P = 0.047). After adjusting for possible confounders, logistic regression showed that those with poor overall sleep quality assessed by PSQI and iodine excess had an increased risk of SCH (OR 2.159, 95 %CI 1.186-3.928, P = 0.012 and OR 2.119, 95 %CI 1.008-4.456, P = 0.048, respectively).

Conclusions: Lifestyle including sleep, smoking, diet and exercise was closely related to thyroid function especially thyroid homeostasis in SCH.
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http://dx.doi.org/10.1186/s12902-021-00772-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161919PMC
May 2021

GLP-1 improves the neuronal supportive ability of astrocytes in Alzheimer's disease by regulating mitochondrial dysfunction via the cAMP/PKA pathway.

Biochem Pharmacol 2021 06 22;188:114578. Epub 2021 Apr 22.

School of Pharmacy, Fujian Medical University, Fuzhou 350122, China; Fujian Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou 350122, China. Electronic address:

The glucagon-like peptide-1 (GLP-1) was shown to have neuroprotective effects in Alzheimer's disease (AD). However, the underlying mechanism remains elusive. Astrocytic mitochondrial abnormalities have been revealed to constitute important pathologies. In the present study, we investigated the role of astrocytic mitochondria in the neuroprotective effect of GLP-1 in AD. To this end, 6-month-old 5 × FAD mice were subcutaneously treated with liraglutide, a GLP-1 analogue (25 nmol/kg/qd) for 8 weeks. Liraglutide ameliorated mitochondrial dysfunction and prevented neuronal loss with activation of the cyclic adenosine 3',5'-monophosphate (cAMP)/phosphorylate protein kinase A (PKA) pathway in the brain of 5 × FAD mice. Next, we exposed astrocytes to β-amyloid (Aβ) in vitro and treated them with GLP-1. By activating the cAMP/PKA pathway, GLP-1 increased the phosphorylation of DRP-1 at the s637 site and mitigated mitochondrial fragmentation in Aβ-treated astrocytes. GLP-1 further improved the Aβ-induced energy failure, mitochondrial reactive oxygen species (ROS) overproduction, mitochondrial membrane potential (MMP) collapse, and cell toxicity in astrocytes. Moreover, GLP-1 also promoted the neuronal supportive ability of Aβ-treated astrocytes via the cAMP/PKA pathway. This study revealed a new mechanism behind the neuroprotective effect of GLP-1 in AD.
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http://dx.doi.org/10.1016/j.bcp.2021.114578DOI Listing
June 2021

Cost-effectiveness analysis of screening for primary aldosteronism in China.

Clin Endocrinol (Oxf) 2021 Sep 21;95(3):414-422. Epub 2021 Jun 21.

Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, China.

Objective: Primary aldosteronism (PA) is an underdiagnosed cause of hypertension. Although the medical costs will increase if all patients with elevated blood pressure are screened, the number of missed diagnosed patients with PA and the medical resources subsequently consumed by adverse cardiovascular and cerebrovascular events can be reduced. This study aimed to conduct economic evaluation PA screening strategies in Chinese patients with hypertension, that is PA screening in patients with high-risk hypertension and all patients with hypertension, to determine the cost-effective method.

Methods: The decision tree and Markov model were constructed using TreeAge Pro 2020. Using the latter, a 30-year course of hypertension after different screening strategies was simulated, with a cycle of one year. The model parameters included epidemiological data, clinical efficacy, cost and effectiveness. The total cost of treatment and quality-adjusted life year (QALY) were simulated to conduct a cost-effectiveness analysis. Univariate and probabilistic sensitivity analyses of the model were also performed.

Results: PA screening patients with high-risk hypertension and all patients with hypertension obtained 15.75 and 15.77 QALYs and the costs were $2488.39 and $2482.15, respectively. The strategy of PA screening in all patients with hypertension is cost-saving and produces more health outcomes. The sensitivity analysis showed that the results were reliable.

Conclusion: From the perspective of China's health system, the strategy of screening all hypertensive patients for PA may be more cost-effective than screening only high-risk patients and providing standard antihypertensive treatment for low-risk hypertensive patients.
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http://dx.doi.org/10.1111/cen.14478DOI Listing
September 2021

Flame-Retardant, Highly Conductive, and Low-Temperature-Resistant Organic Gel Electrolyte for High-Performance All-Solid Supercapacitors.

ChemSusChem 2021 May 22;14(9):2056-2066. Epub 2021 Mar 22.

School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, P.R. China.

Traditional liquid electrolytes are volatile, flammable, and easy to leak, which makes the energy storage device easy to burn and explode in the case of overcharge and short circuit. Here, by utilizing the active P-H bond of a flame retardant (DOPO) to graft onto the polymer chain, flame-retardant organic gel electrolytes were fabricated to address these issues. The gel electrolyte had good ionic conductivity of 4 mS cm at 20 °C and good flame retardant ability. By changing the molar ratio of the monomers and the salt concentrations, the mechanical strength of the gel electrolyte could be adjusted (maximum stress≈28 KPa, maximum strain≈305 %). The transport mechanism of lithium ions in the gel polymer electrolyte was proposed. The gel electrolyte-assembled supercapacitor (SC) possessed better electrochemical properties than that of SC assembled by liquid electrolyte. Importantly, the gel-based SC remained basically unchanged under multiple bending cycles. Additionally, the gel electrolyte had good low-temperature tolerance (0.1 mS cm at -40 °C). The gel electrolyte-assembled SC could work normally in the temperature range of -20 to 60 °C. The multiple advantages of gel electrolyte expand the applications in ionic conductor and energy storage devices.
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http://dx.doi.org/10.1002/cssc.202100141DOI Listing
May 2021

Pilot study on long-term simulation of PCB-153 human body burden in the Tibetan Plateau.

Chemosphere 2021 Aug 6;276:130184. Epub 2021 Mar 6.

State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang, 550081, China. Electronic address:

The historical body burden of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB-153) in the Tibet Autonomous Region (TAR) population was simulated on the basis of localized exposure factors and dietary data, which present a preliminary attempt to quantify the influence of high lipid dietary patterns, grain transported from inland China, and atmospheric transport on human exposure to polychlorinated biphenyls (PCBs). Herdsman with large animal-based food consumption exhibited the highest body burden that was comparable with that in inland China. The body burden of other residents was within the range of low-to-moderate level. High-lipid diet of urban residents caused their body burden being 1.5--2.5 times higher than that of rural residents. The consumption of grain transported from higher polluted areas can also result in 50%-115% increase in the body burden of Tibetan rural residents compared with when local produced grain is consumed, suggesting that the influence of grain logistic can be as important as dietary patterns. The exposure risk for rural residents associated with grain logistic should not be ignored even if they consumed less high-lipid food. By splitting the inventory, over 80% of the PCB-153 pollution in the TAR was identified to be induced by atmospheric transport from foreign countries. However, the grain logistic contributed approximately half of the overall human body burden of Tibetan residents recently if assuming that the grain shortage was supplied by adjacent Sichuan Province. The combined influence of high-lipid diet, atmospheric transport and food logistic highlights the difficulties of risk control in remote regions that accumulate POPs, such as TAR.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130184DOI Listing
August 2021

GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease.

Mol Metab 2021 05 6;47:101180. Epub 2021 Feb 6.

Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 350001, China. Electronic address:

Objective: Astrocytes actively participate in energy metabolism in the brain, and astrocytic aerobic glycolysis disorder is associated with the pathology of Alzheimer's disease (AD). GLP-1 has been shown to improve cognition in AD; however, the mechanism remains unclear. The objectives of this study were to assess GLP-1's glycolytic regulation effects in AD and reveal its neuroprotective mechanisms.

Methods: The Morris water maze test was used to evaluate the effects of liraglutide (an analog of GLP-1) on the cognition of 4-month-old 5×FAD mice, and a proteomic analysis and Western blotting were used to assess the proteomic profile changes. We constructed an astrocytic model of AD by treating primary astrocytes with Aβ. The levels of NAD+ and lactate were examined, and the oxidative levels were assessed by a Seahorse examination. Astrocyte-neuron co-culture was performed to evaluate the effects of GLP-1 on astrocytes' neuronal support.

Results: GLP-1 improved cognition in 4-month-old 5×FAD mice by enhancing aerobic glycolysis and reducing oxidative phosphorylation (OXPHOS) levels and oxidative stress in the brain. GLP-1 also alleviated Aβ-induced glycolysis declines in astrocytes, which resulted in reduced OXPHOS levels and reactive oxygen species (ROS) production. The mechanism involved the activation of the PI3K/Akt pathway by GLP-1. Elevation in astrocytic glycolysis improved astrocyte cells' support of neurons and promoted neuronal survival and axon growth.

Conclusions: Taken together, we revealed GLP-1's capacity to regulate astrocytic glycolysis, providing mechanistic insight into one of its neuroprotective roles in AD and support for the feasibility of energy regulation treatments for AD.
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http://dx.doi.org/10.1016/j.molmet.2021.101180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905479PMC
May 2021

Recurrent non-severe hypoglycemia aggravates cognitive decline in diabetes and induces mitochondrial dysfunction in cultured astrocytes.

Mol Cell Endocrinol 2021 04 2;526:111192. Epub 2021 Feb 2.

Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 350001, China. Electronic address:

The present study aimed to determine the relationship between astrocytes and recurrent non-severe hypoglycemia (RH) -associated cognitive decline in diabetes. RH induced cognitive impairment and neuronal cell death in the cerebral cortex of diabetic mice, accompanied by excessive activation of astrocytes. Levels of the neurotrophins BDNF and GDNF, together with BDNF and GDNF- related signaling, were downregulated by RH. In vitro, recurrent low glucose (RLG) impaired cell viability and induced apoptosis of high-glucose cultured astrocytes. Accumulating mitochondrial ROS and dysregulated mitochondrial functions, including abnormal morphology, decreased membrane potential, downregulated ATP levels, and disrupted bioenergetic status, were observed in these cells. SS-31 mediated protection of mitochondrial functions reversed RLG-induced cell viability defects and neurotrophin production. These findings demonstrate that RH induced astrocyte overactivation and mitochondrial dysfunction, leading to astrocyte-derived neurotrophin disturbance, which might contribute to diabetic cognitive decline. Targeting astrocyte mitochondria might represent a neuroprotective therapy for hypoglycemia-associated neurodegeneration in diabetes.
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http://dx.doi.org/10.1016/j.mce.2021.111192DOI Listing
April 2021

The Correlation Between Metabolic Disorders And Tpoab/Tgab: A Cross-Sectional Population-Based Study.

Endocr Pract 2020 Aug;26(8):869-882

Department of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, Guizhou, P.R. China.

Objective: Studies have shown that metabolic abnormalities influence the immune system. Because the prevalence of metabolic and autoimmune thyroid diseases has increased synchronously, the correlation between them was worth exploring. The study objective was to investigate the relationship between metabolic disorders and thyroid auto-antibodies in euthyroid subjects.

Methods: Data were obtained from the Thyroid Diseases and Diabetes Mellitus project survey of 55,891 subjects from 31 provinces in China. The body mass index (BMI), waist circumference (WC), blood pressure, thyroid peroxidase antibodies (TPOAbs), thyroglobulin antibodies (TgAbs), thyroid-stimulating hormone (TSH), urinary iodine concentration, blood glucose, lipid profile, and uric acid levels were evaluated. Free thyroxine and free triiodothyronine levels were measured in patients with abnormal serum TSH levels.

Results: In males, the BMI, WC, systolic blood pressure (SBP), diastolic blood pressure (DBP), and 2-hour post-glucose oral glucose tolerance test results of the TPOAb-/TgAb-positive group were significantly higher than those of the TPOAb-/TgAb-negative group. In females, the BMI, WC, SBP, DBP, total cholesterol, and low-density-lipoprotein cholesterol (LDL-C) in the TPOAb-/TgAb-positive group were significantly increased compared to the TPOAb-/TgAb-negative group. Multivariate analysis showed that in males, the odds ratio (OR) of positive TgAbs in the abdominal obesity group was 1.175 (95% confidence interval [CI], 1.016 to 1.359; P = .03), and the OR of positive TPOAbs in the hyperuricemia group was 1.195 (95% CI, 1.041 to 1.372; P = .011). In females, the OR of positive TgAbs was 1.19 (95% CI, 1.068 to 1.326; P = .002) in the high LDL-C group.

Conclusion: Obesity, high LDL-C, and hyperuricemia were positively correlated with the prevalence of positive thyroid autoantibodies in euthyroid subjects in a gender-dependent manner. This cross-sectional survey showed that metabolic disorders are associated with increased positive thyroid autoantibody levels in euthyroid subjects in a gender-dependent manner.

Abbreviations: AIT = autoimmune thyroiditis; BMI = body mass index; CI = confidence interval; DBP = diastolic blood pressure; FPG = fasting plasma glucose; FT3 = free triiodothyronine; FT4 = free thyroxine; HbA1c = glycated hemoglobin; HDL-C = high-density-lipoprotein cholesterol; LDL-C = low-density-lipoprotein cholesterol; OGTT2hPG = oral glucose tolerance test 2-hours post-glucose; OR = odds ratio; SBP = systolic blood pressure; TC = total cholesterol; TG = triglycerides; TgAb = thyroglobulin antibody; TPOAb = thyroid peroxidase antibody; TSH = thyroid-stimulating hormone; UA = uric acid; WC = waist circumference.
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http://dx.doi.org/10.4158/EP-2020-0008DOI Listing
August 2020

Corrigendum to "Salvianolic Acid A Inhibits OX-LDL Effects on Exacerbating Choroidal Neovascularization via Downregulating CYLD".

Oxid Med Cell Longev 2020 12;2020:1769871. Epub 2020 Dec 12.

Department of Ophthalmology, Affiliated First People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

[This corrects the article DOI: 10.1155/2017/6210694.].
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http://dx.doi.org/10.1155/2020/1769871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769678PMC
December 2020

Alkyl Chain Grafted-Reduced Graphene Oxide Membrane for Effective Separation of Water/Alcohol Miscible Mixtures.

Front Chem 2020 3;8:598562. Epub 2020 Dec 3.

State Key Laboratory of Biobased Material and Green Papermaking, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.

Separation of water/alcohol miscible mixtures via direct filtration only under gravity is a great challenge. Here, different alkyl chain grafted-reduced graphene oxide (alkyl-RGO) is synthesized and characterized. The hydrophobic alkyl chains can considerably modify the oil-wettability of the membranes and avoid water permeation. The alkyl-RGO membrane obtained by vacuum filtration can separate water/oil immiscible mixtures. Importantly, water/alcohol miscible mixtures could also be separated solely under gravity, where alcohols efficiently permeate the alkyl-RGO membrane while water is prevented through the membrane. The separation efficiency of CH-RGO membrane reaches up to about 0.04 vol% of water content for the case of separating an n-propanol/water (90:10 v/v) mixture with high n-propanol permeability of approx. 685 mL m h. Molecular simulations indicate that the selective absorption ability and diffusion rate also affect water/alcohol separation. The alkyl-RGO membranes via gravity driven filtration can extend the applications of separation of water/alcohol miscible mixtures.
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http://dx.doi.org/10.3389/fchem.2020.598562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7744741PMC
December 2020

Strengthening gelatin hydrogels using the Hofmeister effect.

Soft Matter 2021 Feb;17(6):1558-1565

School of Materials Science and Engineering, State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology (Shandong Academy of Sciences), Daxue Rd. 3501, Jinan 250353, P. R. China.

A simple yet effective soaking treatment has been proposed to fabricate hydrogels with desirable mechanical properties, but the strengthening mechanism of hydrogels lacks an in-depth study. Here, we investigated the influence of kosmotropic citrate anion on the structure and properties of immersed gelatin hydrogels. The obtained hydrogels possessed the properties of high strength, modulus and toughness simultaneously. The dehydration of hydrogels facilitated the interactions among gelatin molecules, resulting in the formation of helix structures. Both the content and length of the triple helices increase with an increase in citrate concentration, which in turn contributes to the strengthening of hydrogels. The excellent mechanical performances of these hydrogels may open up new applications for protein materials.
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http://dx.doi.org/10.1039/d0sm01923bDOI Listing
February 2021

An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming.

Elife 2020 12 15;9. Epub 2020 Dec 15.

Departments of Pharmacology & Experimental Therapeutics, Boston University, School of Medicine, Boston, United States.

It has been known adipocytes increase p53 expression and activity in obesity, however, only canonical p53 functions (i.e. senescence and apoptosis) are attributed to inflammation-associated metabolic phenotypes. Whether or not p53 is directly involved in mature adipocyte metabolic regulation remains unclear. Here we show p53 protein expression can be up-regulated in adipocytes by nutrient starvation without activating cell senescence, apoptosis, or a death-related p53 canonical pathway. Inducing the loss of p53 in mature adipocytes significantly reprograms energy metabolism and this effect is primarily mediated through a AMP-activated protein kinase (AMPK) pathway and a novel downstream transcriptional target, lysosomal acid lipase (LAL). The pathophysiological relevance is further demonstrated in a conditional and adipocyte-specific p53 knockout mouse model. Overall, these data support a non-canonical p53 function in the regulation of adipocyte energy homeostasis and indicate that the dysregulation of this pathway may be involved in developing metabolic dysfunction in obesity.
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http://dx.doi.org/10.7554/eLife.63665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758072PMC
December 2020

Novel Biocompatible Zr-Based Alloy with Low Young's Modulus and Magnetic Susceptibility for Biomedical Implants.

Materials (Basel) 2020 Nov 13;13(22). Epub 2020 Nov 13.

School of Material Science and Engineering, Central South University, Changsha 410083, China.

The microstructure, mechanical properties, magnetic susceptibility, electrochemical corrosion performance, in vitro cell compatibility and blood consistency of Zr-16Nb-xTi (x = 0, 4, 8, 12 and 16 wt.%) materials were investigated as potential materials for biomedical implants. X-ray diffraction (XRD) and Transmission electron microscopy (TEM) analyses revealed the secondary phase martensite α' formed during the quenching process. The phase composition contained metastable β and martensite α', resulting from Ti addition. These phase constitutions were the main causes of a low Young's modulus and magnetic susceptibility. The in vitro cytocompatibility analysis illustrated that the MG63 cells maintained high activity (from 91% to 97%) after culturing in Zr-16Nb-xTi extraction media for 12 days due to the high internal biocompatibility of Zr, Nb and Ti elements, as well as the optimal corrosion resistance of Zr-16Nb-xTi. On the basis of Inductively coupled plasma optical emission spectrometry (ICP-OES) ion release studies, the concentration of Zr, Nb and Ti was noted to reach the equipment detective limit of 0.001 mg/L, which was much lower than pure Ti. With respect to the corrosion behavior in Hank's solution, Zr-16Nb-16Ti displayed superior properties, possessing the lowest corrosion current density and widest passivation region, attributed to the addition of Ti. The blood compatibility test illustrated that the Zr-16Nb-xTi materials were nonhemolytic, and the platelets maintained a spherical shape, with no aggregation or activation on Zr-16Nb-xTi. Overall, Ti addition has obvious effects on the developed Zr-16Nb-xTi alloys, and Zr-16Nb-4Ti exhibited low magnetic susceptibility, low modulus, good biocompatibility and proper corrosion properties, demonstrating the potential of use as implant biomaterials.
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http://dx.doi.org/10.3390/ma13225130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696516PMC
November 2020

Exposure to the Chinese Great Famine in Early Life and Thyroid Function and Disorders in Adulthood: A Cross-Sectional Study.

Thyroid 2021 04 23;31(4):563-571. Epub 2020 Dec 23.

Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, P.R. China.

Malnutrition in early life may permanently change the structure and function of the body, which lead to a number of diseases in adulthood. The effect of famine exposure during the early life on thyroid function and disorders remains unclear. This study investigated the association between exposure to the Great Chinese Famine (1959-1961) in early life and thyroid function and disorders in adulthood. Nine thousand eight hundred eighty-one subjects with appropriate birth dates derived from the Thyroid disorders, Iodine status, and Diabetes Epidemiological survey were included. Thyroid function and disorders were defined by the test results of blood sample and ultrasonography of all participants. Associations between famine exposure in early life and thyroid function and disorders in adulthood were assessed with binary logistic regression and linear regression. Participants exposed to the Great Chinese Famine during the fetal stage was associated with a higher thyrotropin (TSH) level in adulthood ( = 0.024;  = 0.038), compared with the nonexposed participants. The association was significant among rural participants ( = 0.039;  = 0.02) but not in urban participants ( = 0.005;  = 0.77). Fetal-exposed group did not show a higher risk of thyroid disorders than the age-matched balanced control group, including overt hyperthyroidism, subclinical hyperthyroidism, overt hypothyroidism, subclinical hypothyroidism, autoimmune thyroiditis, and thyroid nodules ( > 0.05). Famine exposure during the fetal stage was associated with a higher TSH level in adulthood. The fetal stage could be the critical period for programming the pituitary-thyroid axis.
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http://dx.doi.org/10.1089/thy.2020.0325DOI Listing
April 2021

An Atomic-Scale Understanding of the Solution Chemistry of Antimony(V): Insights from First-Principles Molecular Dynamics Simulation.

Inorg Chem 2020 Nov 11;59(21):15741-15750. Epub 2020 Oct 11.

Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, College of Natural Resources and Environment, Northwest A & F University, Yangling 712100, People's Republic of China.

In this study, the structure, hydrolysis, and complexation of Sb(V) in aqueous solution has been elucidated by using first-principles molecular dynamics (FPMD) simulations. The results show that both antimonic acid and its deprotonated form have an octahedral configuration, with average Sb-OH and Sb-OH distances of 2.25 and 2.05 Å, respectively. The computed p of [Sb(OH)(OH)] is 1.8, while [Sb(OH)] has an extremely high p. Consequently, [Sb(OH)] is the most dominant species of Sb(V) under common environmental conditions. A stable aqueous complex can form between [Sb(OH)] and common cations, and an Sb-Al bidentate complex has the largest dissociation free energy, followed by a Sb-Mg bidentate complex, indicating that they have significantly higher stabilities. For Na and Ca, their respective monodentate and bidentate complexes have similar dissociation free energies, indicating very close possibilities. These findings provide a comprehensive understanding of the solution chemistry of Sb(V) from a quantitative and microscopic perspective.
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http://dx.doi.org/10.1021/acs.inorgchem.0c02162DOI Listing
November 2020

Insufficient nocturnal sleep was associated with a higher risk of fibrosis in patients with diabetes with metabolic associated fatty liver disease.

Ther Adv Endocrinol Metab 2020 14;11:2042018820947550. Epub 2020 Sep 14.

Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou, 350001, China.

Background: Metabolic associated fatty liver disease (MAFLD) refers to metabolic dysfunction associated with fatty liver disease, and liver fibrosis stage is closely connected with liver-related and all-cause mortality. This study aimed to explore the association of sleep duration with liver fibrosis in the diabetic subgroup of the MAFLD population.

Methods: This retrospective study analyzed 342 patients with MAFLD. Anthropometric measurements, clinical and biochemical markers, and lifestyle parameters were collected. Fibrosis was defined as fibrosis-4 ⩾1.3. Propensity score matching (PSM) was performed to match cases. Student's -test and chi-square tests were applied for group comparisons, and binary regression models were used to explore the independent risk factors of liver fibrosis.

Results: Among the 342 subjects, 87 (25.4%) were diagnosed with fibrosis and 255 (74.6%) without. Baseline characteristic comparisons showed differences in age and diabetes duration between the two groups, and adjustment was made by PSM. Ultimately, the fibrosis group and nonfibrosis group each had 87 patients. The fibrosis group had shorter duration of nocturnal sleep (6.77 ± 1.59 h) than the nonfibrosis group (7.77 ± 1.92 h,  < 0.001). More patients in the fibrosis group stayed up late at night (32.2% 14.9%,  < 0.01). Visceral adipose tissue (VAT) areas were larger in the fibrosis group than in the nonfibrosis group ( < 0.001). Glycemic profile, lipid profile, gamma-glutamyl transferase level, and serum uric acid level were not significantly different between the two groups. In the multivariate regression analysis, nocturnal sleep and VAT areas were independently associated with liver fibrosis, with odds ratios of 0.694 [95% confidence interval (CI) 0.551-0.875,  < 0.01] for nocturnal sleep and 1.031 (95% CI 1.014-1.048,  < 0.001) for VAT areas.

Conclusion: Insufficient nocturnal sleep was independently related to a higher risk of fibrosis. Sleep modification might be beneficial in promoting the health of patients with MAFLD.
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http://dx.doi.org/10.1177/2042018820947550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493234PMC
September 2020

Fatigue-Resistant, Notch-Insensitive Zwitterionic Polymer Hydrogels with High Self-Healing Ability.

Chempluschem 2020 09;85(9):2158-2165

School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, P. R. China.

Introducing self-healing properties into hydrogels can prolong their application lifetime. However, achieving mechanical strength without sacrificing self-healing properties is still a major challenge. We prepared a series of zwitterionic polymer hydrogels by random copolymerization of zwitterionic ionic monomer (SBMA), cationic monomer (DAC) and hydrophilic monomer (HEMA). The ionic bonds and hydrogen bonds formed in the hydrogels can efficiently dissipate energy and rebuild the network. The resulting hydrogels show high mechanical strength (289-396 KPa of fracture stress, 433-864 % of fracture stress) and have great fatigue resistance. The hydrogel with a 1 : 1 molar ratio of SBMA:DAC possesses the best self-healing properties (self-healing efficiency up to 96.5 % at room temperature for 10 h). The self-healing process is completely spontaneous and does not require external factors to assist. In addition, the hydrogel also possesses notch insensitivity with a fracture energy of 12000 J m . After combining the conductivity of RGO aerogel, the hydrogel/RGO composites show good strain sensitivity with high reliability and self-healing ability, which has certain significance in broadening the application of these zwitterionic hydrogels.
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http://dx.doi.org/10.1002/cplu.202000520DOI Listing
September 2020

The Effect of Increased Iodine Intake on Serum Thyrotropin: A Cross-Sectional, Chinese Nationwide Study.

Thyroid 2020 12 21;30(12):1810-1819. Epub 2020 Sep 21.

Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, P.R. China.

Subclinical hypothyroidism is diagnosed based on serum thyrotropin (TSH) reference intervals, which in turn are affected by many factors. Data were acquired from a Chinese nationally representative cross-sectional study of 78,470 participants (TIDE study). The total study population were participants from the TIDE program, and the reference population was a subset of the total population defined by the National Academy of Clinical Biochemistry (NACB) guidelines. Serum concentrations of thyroid hormones, TSH, thyroid antibodies, and urine iodine concentration (UIC) were measured. The geometric mean serum TSH (2.5th-97.5th) for the reference population (defined by the NACB) and total population was 2.28 mIU/L (0.74-7.04 mIU/L) and 2.34 mIU/L (0.61-8.33 mIU/L), respectively. In the reference population, increase in UIC was significantly associated with increase in the 50th and 97.5th centiles and decrease in the 2.5th centile of TSH. The median TSH was significantly higher in women than in men (2.41 mIU/L vs. 2.16 mIU/L, -value <0.001). Increased age was significantly associated with an increased TSH, 97.5th centile. For each 10-year increase in the population age, the TSH 97.5th centile increased by 0.534 mIU/L. The prevalence of subclinical hypothyroidism diagnosed according to the assay-recommended interval (Roche 0.27-4.2 mIU/L) and NACB standard interval in the TIDE study (0.74-7.04 mIU/L) differed significantly (Roche 13.61% vs. TIDE 3.00%,  < 0.05). However, there was no significant difference in future cardiovascular disease, reflected by the Framingham risk score, between the 0.27-4.2 and 4.2-7.04 mIU/L TSH groups. Serum TSH concentration significantly increased with increase in iodine intake. Thus, iodine intake must be considered in establishing TSH reference intervals. To avoid overdiagnosis and overtreatment of subclinical hypothyroidism, different areas should use individual serum TSH reference intervals.
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http://dx.doi.org/10.1089/thy.2019.0842DOI Listing
December 2020

Fabrication of noble metal nanoparticles decorated on one dimensional hierarchical [email protected] microtubes.

J Mater Chem B 2020 09 4;8(34):7801-7811. Epub 2020 Aug 4.

College of Chemistry and Chemical Enginerring, Shanghai University of Engineering Science, Shanghai 201620, P. R. China.

MoS-based hybrids have aroused great interest for their outstanding performance in the application fields of biochemical sensing, catalysis and energy storage. Herein, we present a facile strategy to fabricate hierarchical microtubes by cultivating a MoS sheet-like nanostructure on polypyrrole microtubes (designated as [email protected] microtubes) using [email protected] micro-cables as self-sacrificial templates. Such a dissolution-regrowth mechanism is demonstrated for the formation of hierarchical [email protected] microtubes by studying the morphology of the intermediate products in the process of the sulfidation reaction. The PPy microtubes are able to effectively improve the electrical conductivity of the hybrid architecture and greatly alleviate the agglomeration of the MoS nanosheets. Notably, the sheet-like MoS nanostructure can load more noble metal nanoparticles (NPs) owing to MoS released photogenerated electrons irradiated by light. Then, metal (Ag, Au, and Pd) NPs are reduced and in situ decorated on [email protected] microtubes, thus forming ternary [email protected]@Ag, Au, and Pd nanohybrids, respectively. This decoration method also expands the wide range of application fields of [email protected] As a proof of application, the ternary [email protected]@Au hybrids reveal excellent enzyme-like catalytic performance. Owing to the high coverage of Au NPs as well as one dimensional hierarchical MoS-based ternary unique structures, the resultant [email protected]@Au hybrid composites exhibited synergistically enhanced peroxidase-like catalytic activity relative to MoS, [email protected], and [email protected] alone, demonstrating the remarkable prospects of MoS-based hybrids in chemical/biological molecule sensing application.
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http://dx.doi.org/10.1039/d0tb01387kDOI Listing
September 2020

A facile synthesis of one-dimensional hierarchical magnetic metal silicate microtubes with enhanced adsorption performance.

Dalton Trans 2020 Aug;49(32):11120-11128

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, PR China.

One-dimensional (1D) hierarchical magnetic hollow micro/nanotubes have attracted special attention in the field of adsorption owing to their high surface area, easy separation and short mass diffusion. Here, we report a facile approach for synthesizing one-dimensional hierarchical magnetic metal silicate microtubes through an extended Stöber method, carbonization treatment and subsequent hydrothermal reaction with metal ions in an alkaline solution. The unique 1D hierarchical magnetic microtubes have a large surface area, good structural stability and high magnetic response. Benefiting from these advantages, the resultant microtubes display excellent performance as good adsorbents for bovine hemoglobin (BHb) and methylene blue (MB). Furthermore, this strategy can also be applied to prepare other 1D hierarchical magnetic metal silicate composites.
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http://dx.doi.org/10.1039/d0dt02317eDOI Listing
August 2020

An Inverse Relationship Between Iodine Intake and Thyroid Antibodies: A National Cross-Sectional Survey in Mainland China.

Thyroid 2020 11 23;30(11):1656-1665. Epub 2020 Jul 23.

Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, P.R. China.

Iodine intake is associated with thyroid autoimmunity. In this study, we evaluated the changes in thyroid autoimmunity after 20 years of universal salt iodization (USI) in China. A total of 78,470 subjects (18 years or older) from 31 provincial regions of mainland China participated in the study. Serum thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), TSH receptor antibody, thyrotropin (TSH), and urinary iodine concentration (UIC) were measured. Positive TPOAb and TgAb were detected in 10.19% [CI 9.80-10.59] and 9.70% [CI 9.28-10.13] of the subjects, respectively. The prevalence of positive isolated TPOAb (i-TPOAb), positive isolated TgAb (i-TgAb), and double positive TPOAb and TgAb (d-Ab) was 4.52%, 4.16%, and 5.94%, respectively. The prevalence of thyroid antibody positivity was the highest in the iodine-deficient (UIC <100 μg/L) groups. The prevalence of i-TPOAb was inversely associated with more than adequate iodine intake (MAI) and excessive iodine intake (EI); the odds ratio (OR) was 0.89 [CI 0.81-0.98] for MAI and 0.90 [CI 0.81-0.99] for EI. We observed that i-TgAb, like i-TPOAb, was a high-risk factor for subnormal TSH levels (OR = 3.64 [CI 2.62-5.05]) and elevated TSH levels (OR = 1.62 [CI 1.49-1.77]). The prevalence of thyroid antibody positivity varied among five ethnic groups. After two decades of USI, the prevalence of thyroid antibody positivity has remained low. MAI and EI had an inverse relationship with TPOAb positivity, which reveals that UIC between 100 and 299 μg/L is optimal and safe for thyroid autoimmunity. These conclusions need to be confirmed in a follow-up study because this study was a cross-sectional study.
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http://dx.doi.org/10.1089/thy.2020.0037DOI Listing
November 2020

Structural Evolution of CuO-Derived Hybrids Comprised of Copper Cores, a Silica Interlayer, and Carbon as the Outlayer.

Inorg Chem 2020 Jul 14;59(13):9356-9363. Epub 2020 Jun 14.

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, P. R. China.

Constructing yolk-shell-structured non-noble-metal composites is very important for improving their activity and stability in catalytic performance. Herein, we report a facile strategy for the synthesis of ternary [email protected]@C yolk-shell composites by converting the resorcinol-formaldehyde (RF) resin-coated [email protected] with a core-shell structure via a thermal treatment under a N atmosphere. Notably, the annealing temperature and silica interlayer play vital roles in modulating their structures and catalytic performance. Moreover, this strategy may pave a new way to constructing non-noble-metal-based composites with yolk-shell structures.
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http://dx.doi.org/10.1021/acs.inorgchem.0c01227DOI Listing
July 2020
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