Liangcheng Du

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Liangcheng Du

Publications by authors named "Liangcheng Du"

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60Publications

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Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A-E.

Org Lett 2018 Jun 24;20(12):3504-3508. Epub 2018 May 24.

Key Laboratory of Chemical Biology (Ministry of Education) , School of Pharmaceutical Sciences, Shandong University , Jinan , Shandong 250012 , P. R. China.

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June 2018

Biosynthesis of the Polycyclic System in the Antifungal HSAF and Analogues from Lysobacter enzymogenes.

Angew Chem Int Ed Engl 2018 May 25;57(21):6221-6225. Epub 2018 Apr 25.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.

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May 2018

Functional and Structural Analysis of Phenazine O-Methyltransferase LaPhzM from Lysobacter antibioticus OH13 and One-Pot Enzymatic Synthesis of the Antibiotic Myxin.

ACS Chem Biol 2018 Apr 12;13(4):1003-1012. Epub 2018 Mar 12.

Department of Chemistry , University of Nebraska-Lincoln , Lincoln , Nebraska 68588 , United States.

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April 2018

Yield Improvement of the Anti-MRSA Antibiotics WAP-8294A by CRISPR/dCas9 Combined with Refactoring Self-Protection Genes in Lysobacter enzymogenes OH11.

ACS Synth Biol 2018 01 20;7(1):258-266. Epub 2017 Nov 20.

Department of Chemistry, University of Nebraska-Lincoln , Lincoln, Nebraska 68588, United States.

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January 2018

Activation of a Cryptic Gene Cluster in Lysobacter enzymogenes Reveals a Module/Domain Portable Mechanism of Nonribosomal Peptide Synthetases in the Biosynthesis of Pyrrolopyrazines.

Org Lett 2017 10 12;19(19):5010-5013. Epub 2017 Sep 12.

State Key Laboratory of Microbial Technology, College of Life Sciences, Shandong University , Jinan 250100, China.

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October 2017

Indole-Induced Reversion of Intrinsic Multiantibiotic Resistance in Lysobacter enzymogenes.

Appl Environ Microbiol 2017 09 17;83(17). Epub 2017 Aug 17.

State Key Laboratory of Microbial Technology and Key Laboratory of Chemical Biology, College of Life Sciences and School of Pharmaceutical Sciences, Shandong University, Jinan, China

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September 2017

Cytotoxic Polyketides with an Oxygen-Bridged Cyclooctadiene Core Skeleton from the Mangrove Endophytic Fungus Phomosis sp. A818.

Molecules 2017 Sep 14;22(9). Epub 2017 Sep 14.

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.

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September 2017

Unusual acylation of chloramphenicol in Lysobacter enzymogenes, a biocontrol agent with intrinsic resistance to multiple antibiotics.

BMC Biotechnol 2017 07 4;17(1):59. Epub 2017 Jul 4.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588-0304, USA.

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July 2017

Transcriptional and Antagonistic Responses of Biocontrol Strain OH11 to the Plant Pathogenic Oomycete .

Front Microbiol 2017 6;8:1025. Epub 2017 Jun 6.

Institute of Plant Protection, Jiangsu Academy of Agricultural SciencesNanjing, China.

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June 2017

4-Hydroxybenzoic acid is a diffusible factor that connects metabolic shikimate pathway to the biosynthesis of a unique antifungal metabolite in Lysobacter enzymogenes.

Mol Microbiol 2017 04 15;104(1):163-178. Epub 2017 Feb 15.

Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, Key Laboratory of Integrated Management of Crop Diseases and Pests (Nanjing Agricultural University), Ministry of Education Nanjing, 210095, People's Republic of China.

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April 2017

Alteramide B is a microtubule antagonist of inhibiting Candida albicans.

Biochim Biophys Acta 2016 10 29;1860(10):2097-106. Epub 2016 Jun 29.

State Key laboratory of Microbial Technology, Shandong University, No. 27 South Shanda Road, Jinan, Shandong 250100, PR China; Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. Electronic address:

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October 2016

Visualizing small differences using subtractive chromatographic analysis.

J Chromatogr A 2016 Oct 13;1468:245-249. Epub 2016 Sep 13.

Department of Process Research & Development, Merck Research Laboratories, Rahway, NJ, USA. Electronic address:

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October 2016

Optimization of genome shuffling for high-yield production of the antitumor deacetylmycoepoxydiene in an endophytic fungus of mangrove plants.

Appl Microbiol Biotechnol 2016 Sep 11;100(17):7491-8. Epub 2016 Apr 11.

Departments of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.

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September 2016

Direct Regulation of Extracellular Chitinase Production by the Transcription Factor LeClp in Lysobacter enzymogenes OH11.

Phytopathology 2016 09 7;106(9):971-7. Epub 2016 Jul 7.

First, second, sixth, seventh, and eighth authors: College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, P.R. China and Key Laboratory of Integrated Management of Crop Diseases and Pests (Nanjing Agricultural University), Ministry of Education; third author: Key Laboratory of Chemical Biology, School of Pharmaceutical Sciences, Shandong University, 250100 Jinan, P.R. China; fourth author: Department of Chemistry, University of Nebraska-Lincoln, Lincoln 68588; fifth author: Institute of Biochemistry, and NCHU Agricultural Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, ROC; and eighth author: Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, P.R. China.

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September 2016

Heterocyclic Aromatic N-Oxidation in the Biosynthesis of Phenazine Antibiotics from Lysobacter antibioticus.

Org Lett 2016 05 4;18(10):2495-8. Epub 2016 May 4.

Department of Chemistry, University of Nebraska-Lincoln , Lincoln, Nebraska 68588, United States.

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May 2016

A TonB-dependent receptor regulates antifungal HSAF biosynthesis in Lysobacter.

Sci Rep 2016 05 31;6:26881. Epub 2016 May 31.

College of Plant Protection (Key Laboratory of Integrated Management of Crop Diseases and Pests), Nanjing Agricultural University, Nanjing 210095, P.R. China.

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May 2016

HSAF-induced antifungal effects in through ROS-mediated apoptosis.

RSC Adv 2016;6(37):30895-30904. Epub 2016 Mar 21.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.

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March 2016

Iterative polyketide biosynthesis by modular polyketide synthases in bacteria.

Appl Microbiol Biotechnol 2016 Jan 9;100(2):541-57. Epub 2015 Nov 9.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588, USA.

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January 2016

Fatty Acyl Incorporation in the Biosynthesis of WAP-8294A, a Group of Potent Anti-MRSA Cyclic Lipodepsipeptides.

RSC Adv 2015;5:105753-105759. Epub 2015 Dec 9.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE, 68588-0304, USA.

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December 2015

PilG is Involved in the Regulation of Twitching Motility and Antifungal Antibiotic Biosynthesis in the Biological Control Agent Lysobacter enzymogenes.

Phytopathology 2015 Oct 11;105(10):1318-24. Epub 2015 Sep 11.

First, second, third, and fifth authors: College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China/Key Laboratory of Integrated Management of Crop Diseases and Pests (Nanjing Agricultural University), Ministry of Education; fourth author: Department of Chemistry, University of Nebraska-Lincoln, 68588; fifth author: Institute of Plant Protection, Jiangsu Academy of Agricultural Science, Nanjing 210014, P.R. China; and sixth author: Department of Plant Pathology, University of Nebraska-Lincoln.

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October 2015

Bioactive Polycyclic Tetramate Macrolactams from Lysobacter enzymogenes and Their Absolute Configurations by Theoretical ECD Calculations.

J Nat Prod 2015 Aug 22;78(8):1841-7. Epub 2015 Jul 22.

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences , Guangzhou 510650, People's Republic of China.

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August 2015

Hfq regulates antibacterial antibiotic biosynthesis and extracellular lytic-enzyme production in Lysobacter enzymogenes OH11.

Microb Biotechnol 2015 May 13;8(3):499-509. Epub 2015 Feb 13.

College of Plant Protection, Nanjing Agricultural University, China/Key Laboratory of Integrated Management of Crop Diseases and Pests (Nanjing Agricultural University), Ministry of Education, Nanjing, 210095, China.

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May 2015

Complete genome sequence and transcriptomics analyses reveal pigment biosynthesis and regulatory mechanisms in an industrial strain, Monascus purpureus YY-1.

Sci Rep 2015 Feb 9;5:8331. Epub 2015 Feb 9.

Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin 300457, China.

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February 2015

Synthesis of a 2,4,6,8,10-dodecapentanoic acid thioester as a substrate for biosynthesis of Heat Stable Antifungal Factor (HSAF).

RSC Adv 2015;5:11644-11648

Department of Chemistry, University of Nebraska-Lincoln Lincoln, NE 68588-0304.

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January 2015

Transcriptomic analysis reveals new regulatory roles of Clp signaling in secondary metabolite biosynthesis and surface motility in Lysobacter enzymogenes OH11.

Appl Microbiol Biotechnol 2014 Nov 19;98(21):9009-20. Epub 2014 Sep 19.

College of Plant Protection, Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing Agricultural University, Nanjing, 210095, China.

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November 2014

Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF.

Angew Chem Int Ed Engl 2014 Jul 30;53(29):7524-7530. Epub 2014 May 30.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.

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July 2014

Involvement of both PKS and NRPS in antibacterial activity in Lysobacter enzymogenes OH11.

FEMS Microbiol Lett 2014 Jun 3;355(2):170-6. Epub 2014 Jun 3.

College of Plant Protection, Nanjing Agricultural University, Nanjing, China; Key Laboratory of Integrated Management of Crop Diseases and Pests, Nanjing Agricultural University, Ministry of Education, Nanjing, China.

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June 2014

Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes.

PLoS One 2013 24;8(6):e66633. Epub 2013 Jun 24.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.

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March 2014

Tricarballylic ester formation during biosynthesis of fumonisin mycotoxins in

Mycology 2013 Dec 2;4(4):179-186. Epub 2014 Jan 2.

School of Pharmaceutical Sciences, Shandong University, Jinan 250100, China.

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December 2013

Facile method for site-specific gene integration in Lysobacter enzymogenes for yield improvement of the anti-MRSA antibiotics WAP-8294A and the antifungal antibiotic HSAF.

ACS Synth Biol 2013 Nov 27;2(11):670-8. Epub 2013 Aug 27.

Department of Chemistry, University of Nebraska-Lincoln , Lincoln, Nebraska 68588, United States.

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November 2013

Lysobacter enzymogenes uses two distinct cell-cell signaling systems for differential regulation of secondary-metabolite biosynthesis and colony morphology.

Appl Environ Microbiol 2013 Nov 23;79(21):6604-16. Epub 2013 Aug 23.

College of Plant Protection and Key Laboratory of Integrated Management of Crop Diseases and Pests, Nanjing Agricultural University, Nanjing, China.

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November 2013

Elucidating the biosynthetic pathway for vibralactone: a pancreatic lipase inhibitor with a fused bicyclic β-lactone.

Angew Chem Int Ed Engl 2013 Feb 21;52(8):2298-302. Epub 2013 Jan 21.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China.

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February 2013

Bioactive natural products from Lysobacter.

Nat Prod Rep 2012 Nov;29(11):1277-87

Department of Chemistry, University of Nebraska-Lincoln, NE 68588, USA.

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November 2012

Unusual activities of the thioesterase domain for the biosynthesis of the polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes C3.

Biochemistry 2012 Jan 23;51(1):4-6. Epub 2011 Dec 23.

Department of Chemistry, University of Nebraska, Lincoln, Nebraska 68588, United States.

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January 2012

Identification and characterization of the anti-methicillin-resistant Staphylococcus aureus WAP-8294A2 biosynthetic gene cluster from Lysobacter enzymogenes OH11.

Antimicrob Agents Chemother 2011 Dec 19;55(12):5581-9. Epub 2011 Sep 19.

Department of Chemistry, University of Nebraska—Lincoln, Lincoln, Nebraska 68588-0304, USA.

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December 2011

Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases.

Acta Biochim Biophys Sin (Shanghai) 2011 Oct 14;43(10):757-62. Epub 2011 Jul 14.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China.

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October 2011

Induction of cell wall thickening by the antifungal compound dihydromaltophilin disrupts fungal growth and is mediated by sphingolipid biosynthesis.

J Eukaryot Microbiol 2009 Mar-Apr;56(2):182-7

Department of Plant Pathology, University of Nebraska, Lincoln, Nebraska 68583, USA.

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June 2011

Research in bioanalysis and separations at the University of Nebraska - Lincoln.

Bioanalysis 2011 May;3(10):1065-76

Chemistry Department, University of Nebraska - Lincoln, NE 68588-0304, USA.

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May 2011

Biosynthesis of HSAF, a tetramic acid-containing macrolactam from Lysobacter enzymogenes.

J Am Chem Soc 2011 Feb 20;133(4):643-5. Epub 2010 Dec 20.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, United States.

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February 2011

Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins.

Biopolymers 2010 Sep;93(9):764-76

Department of Chemistry, University of Nebraska-Lincoln, NE 68588, USA.

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September 2010

Fumonisin detection and analysis of potential fumonisin-producing Fusarium spp. in asparagus (Asparagus officinalis L.) in Zhejiang Province of China.

J Sci Food Agric 2010 Apr;90(5):836-42

Department of Horticulture, Zhejiang University, The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Hangzhou 310029, China.

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April 2010

PKS and NRPS release mechanisms.

Nat Prod Rep 2010 Feb 4;27(2):255-78. Epub 2009 Dec 4.

Department of Chemistry, University of Nebraska-Lincoln, NE 68588, USA.

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February 2010

A PLP-dependent polyketide chain releasing mechanism in the biosynthesis of mycotoxin fumonisins in Fusarium verticillioides.

J Am Chem Soc 2009 Mar;131(9):3148-9

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA.

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March 2009

Functional complementation of fumonisin biosynthesis in FUM1-disrupted fusarium verticillioides by the AAL-toxin polyketide synthase gene ALT1 from Alternaria alternata f. sp. Lycopersici.

J Nat Prod 2008 Jun 25;71(6):957-60. Epub 2008 Apr 25.

Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588, USA.

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June 2008

Structure and biosynthesis of heat-stable antifungal factor (HSAF), a broad-spectrum antimycotic with a novel mode of action.

Antimicrob Agents Chemother 2007 Jan 30;51(1):64-72. Epub 2006 Oct 30.

Department of Chemistry, University of Nebraska--Lincoln, 729 Hamilton Hall, Lincoln, NE 68588-0304, USA.

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January 2007

Direct detection and quantification of Alternaria alternata lycopersici toxins using high-performance liquid chromatography-evaporative light-scattering detection.

Authors:
Li Xu Liangcheng Du

J Microbiol Methods 2006 Mar 12;64(3):398-405. Epub 2005 Jul 12.

Department of Chemistry, University of Nebraska, Lincoln, NE 68588-0304, USA.

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March 2006

Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans.

Mol Biol Cell 2006 Mar 4;17(3):1218-27. Epub 2006 Jan 4.

Department of Plant Pathology, University of Nebraska, Lincoln, NE 68588-0660, USA.

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March 2006

Developing a genetic system for functional manipulations of FUM1, a polyketide synthase gene for the biosynthesis of fumonisins in Fusarium verticillioides.

FEMS Microbiol Lett 2005 Jul;248(2):257-64

Chemistry Department, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, USA.

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July 2005

Direct evidence for the function of FUM13 in 3-ketoreduction of mycotoxin fumonisins in Fusarium verticillioides.

J Agric Food Chem 2005 Jun;53(13):5456-60

Chemistry Department, University of Nebraska-Lincoln, Lincoln, 68588-0304, USA.

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June 2005

Hybrid peptide-polyketide natural products: biosynthesis and prospects towards engineering novel molecules.

Genet Eng (N Y) 2003 ;25:227-67

Department of Chemistry, University of Nebraska, Lincoln, NE 68588, USA.

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August 2004

Determining the biosynthetic sequence in the early steps of the fumonisin pathway by use of three gene-disruption mutants of Fusarium verticillioides.

J Agric Food Chem 2004 May;52(10):2855-60

Chemistry Department, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, USA.

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May 2004

Fum3p, a 2-ketoglutarate-dependent dioxygenase required for C-5 hydroxylation of fumonisins in Fusarium verticillioides.

Appl Environ Microbiol 2004 Apr;70(4):1931-4

Chemistry Department, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, USA.

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April 2004

BlmIII and BlmIV nonribosomal peptide synthetase-catalyzed biosynthesis of the bleomycin bithiazole moiety involving both in cis and in trans aminoacylation.

Biochemistry 2003 Aug;42(32):9731-40

Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.

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August 2003

Cloning and characterization of the bleomycin biosynthetic gene cluster from Streptomyces verticillus ATCC15003.

J Nat Prod 2002 Mar;65(3):422-31

Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.

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March 2002