Publications by authors named "Liang He"

544 Publications

Lymph node-resident dendritic cells drive T2 cell development involving MARCH1.

Sci Immunol 2021 Oct 15;6(64):eabh0707. Epub 2021 Oct 15.

Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, University of California, San Francisco, San Francisco, CA 94143, USA.

[Figure: see text].
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http://dx.doi.org/10.1126/sciimmunol.abh0707DOI Listing
October 2021

Energy Band Alignment and Redox-active Sites in Metalloporphyrin-Spaced Metal-Catechol Frameworks for Enhanced CO2 Photoreduction.

Angew Chem Int Ed Engl 2021 Oct 15. Epub 2021 Oct 15.

Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, State Key Laboratory of Structural Chemistry, 155 Yangqiao Road West, 350002, Fuzhou, CHINA.

Two new chemically-stable metalloporphyrin-bridged metal-catechol frameworks, InTCP-Co and FeTCP-Co, are constructed to achieve artificial photosynthesis without additional sacrificial agents and photosensitizers. The CO 2 photoreduction rate over FeTCP-Co considerably exceeds that obtained over InTCP-Co, and the incorporation of an uncoordinated hydroxyl group per catechol into the network further greatly promotes the photocatalytic activity. It could be explained by the fact that the iron-oxo coordination chain helps the energy band alignment and provides a redox-active site, and the uncoordinated hydroxyl group contributes to the visible-light absorptance, charge carrier transfer, and CO 2 -scaffold affinity. With a formic acid selectivity of 97.8%, FeTCP-OH-Co affords CO 2 photoconversion with a reaction rate 4.3 and 15.7 times higher than those of FeTCP- Co and InTCP-Co, respectively. These findings are also consistent with the spectroscopic study and DFT calculation.
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http://dx.doi.org/10.1002/anie.202111622DOI Listing
October 2021

Flexible Temperature Sensors.

Front Chem 2021 22;9:539678. Epub 2021 Sep 22.

Beijing Institute of Graphic Communication, Beijing, China.

Temperature reflects the balance between production and dissipate of heat. Flexible temperature sensors are primary sensors used for temperature monitoring. To obtain real-time and accurate information of temperature, different flexible temperature sensors are developed according to the principle of flexible resistance temperature detector (FRTC), flexible thermocouple, flexible thermistor and flexible thermochromic, showing great potential in energy conversion and storage. In order to obtain high integration and multifunction, various flexible temperature sensors are studied and optimized, including active-matrix flexible temperature sensor, self-powered flexible temperature sensor, self-healing flexible temperature sensor and self-cleaning flexible temperature sensor. This review focuses on the structure, material, fabrication and performance of flexible temperature sensors. Also, some typical applications of flexible temperature sensors are discussed and summarized.
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http://dx.doi.org/10.3389/fchem.2021.539678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492987PMC
September 2021

Assessment of Clinicopathological Characteristics and Development of an Individualized Prognostic Model for Patients With Hepatoid Adenocarcinoma of the Stomach.

JAMA Netw Open 2021 Oct 1;4(10):e2128217. Epub 2021 Oct 1.

Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Importance: Few studies have examined the clinicopathological characteristics and prognoses of patients with hepatoid adenocarcinoma of the stomach (HAS).

Objective: To explore the clinicopathological characteristics and prognoses of patients with HAS and develop a nomogram to predict overall survival (OS).

Design, Setting, And Participants: This prognostic study involved a retrospective analysis of data from 315 patients who received a diagnosis of primary HAS between April 1, 2004, and December 31, 2019, at 14 centers in China.

Main Outcomes And Measures: OS and prognostic factors. Patients were randomly assigned to a derivation cohort (n = 220) and a validation cohort (n = 95). A nomogram was developed based on independent prognostic factors identified through a multivariable Cox mixed-effects model.

Results: Among 315 patients with HAS (mean [SD] age, 61.9 [10.2] years; 240 men [76.2%]), 137 patients had simple HAS (defined as the presence of histologically contained hepatoid differentiation areas only), and 178 patients had mixed HAS (defined as the presence of hepatoid differentiation areas plus common adenocarcinoma areas). Patients with simple HAS had a higher median preoperative α-fetoprotein level than those with mixed HAS (195.9 ng/mL vs 48.9 ng/mL, respectively; P < .001) and a higher rate of preoperative liver metastasis (23 of 137 patients [16.8%] vs 11 of 178 patients [6.2%]; P = .003). The 3-year OS rates of patients with simple vs mixed HAS were comparable (56.0% vs 60.0%; log-rank P = .98). A multivariable Cox analysis of the derivation cohort found that the presence of perineural invasion (hazard ratio [HR], 2.13; 95% CI, 1.27-3.55; P = .009), preoperative carcinoembryonic antigen levels of 5 ng/mL or greater (HR, 1.72; 95% CI, 1.08-2.74; P = .03), and pathological node category 3b (HR, 3.72; 95% CI, 1.34-10.32; P = .01) were independent risk factors for worse OS. Based on these factors, a nomogram to predict postoperative OS was developed. The concordance indices of the nomogram (derivation cohort: 0.72 [95% CI, 0.66-0.78]; validation cohort: 0.72 [95% CI, 0.63-0.81]; whole cohort: 0.71 [95% CI, 0.66-0.76]) were higher than those derived using the American Joint Committee on Cancer's AJCC Cancer Staging Manual (8th edition) pathological tumor-node-metastasis (pTNM) staging system (derivation cohort: 0.63 [95% CI, 0.57-0.69]; validation cohort: 0.65 [95% CI, 0.56-0.75]; whole cohort: 0.64 [95% CI, 0.59-0.69]) and those derived using a clinical model that included pTNM stage and receipt of adjuvant chemotherapy (derivation cohort: 0.64 [95% CI, 0.58-0.69]; validation cohort: 0.65 [95% CI, 0.56-0.75]; whole cohort: 0.64 [95% CI, 0.59-0.69]). Based on the nomogram cutoff of 10 points, the whole cohort was divided into high-risk and low-risk groups. The 3-year OS rate of patients in the high-risk group was significantly lower than that of patients in the low-risk group (29.7% vs 75.9%, respectively; log-rank P < .001), and the 3-year prognosis of high-risk and low-risk groups could be further distinguished into pTNM stage I to II (33.3% vs 80.2%; exact log-rank P = .15), stage III (34.3% vs 71.3%; log-rank P < .001), and stage IV (15.5% vs 70.3%; log-rank P = .009).

Conclusions And Relevance: This study found that perineural invasion, preoperative carcinoembryonic antigen levels of 5 ng/mL or greater, and pathological node category 3b were independent risk factors associated with worse OS. An individualized nomogram was developed to predict OS among patients with HAS. This nomogram had good prognostic value and may be useful as a supplement to the current American Joint Committee on Cancer TNM staging system.
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http://dx.doi.org/10.1001/jamanetworkopen.2021.28217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493440PMC
October 2021

Risk Assessment of Liquefied Petroleum Gas Explosion in a Limited Space.

ACS Omega 2021 Sep 13;6(38):24683-24692. Epub 2021 Sep 13.

Shaanxi Key Laboratory of Prevention and Control of Coal Fire, 58, Yanta Mid. Road, Xi'an 710054, Shaanxi, PR China.

In recent years, the explosion accidents of liquefied petroleum gas (LPG) have induced tremendous losses. To analyze the deflagration danger of LPG, the explosion pressure and flame propagation features of the premixed LPG-air mixture in a closed pipeline at increased initial pressures and temperatures were examined by the numerical method. It has been shown that with an increase in the initial temperature, the highest explosion pressure and explosion induction period decrease, while the maximum flame temperature increases. As the initial temperature rises, the formation of the tulip flame accelerates, and the depression of the flame front increases at the same time. The elevated initial pressure raises the highest explosion pressure and the maximum flame temperature. Nevertheless, when the initial pressure exceeds 0.5 MPa, its impact on the flame temperature slowly diminishes. In addition, the gray relational analysis approach was utilized to evaluate the correlation between the initial condition and the derived parameters. The findings indicate that the initial pressure exerts the largest influence on the four explosion parameters. The research finding is important for exposing the deflagration risk features of LPG under complicated working situations, evaluating the explosion risk of correlated procedures and devices, and formulating scientific and effective explosion-proof measures.
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http://dx.doi.org/10.1021/acsomega.1c03430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482491PMC
September 2021

The Differences Between Multifocal and Unifocal Papillary Thyroid Carcinoma in Unilateral Lobe: A Meta-Analysis.

Front Oncol 2021 16;11:657237. Epub 2021 Sep 16.

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, China.

Background: As many inconsistent reports on the clinical manifestations and prognosis between unilateral unifocal PTC (UUPTC) and unilateral multifocal PTC (UMPTC), identifying the difference should guide management. The purpose of this study was to investigate other additional differences between UUPTC and UMPTC in addition to their difference in the number of cancer foci.

Data Sources: A systematic literature search was conducted in the PubMed and Web of Science databases for relevant studies published before December 31, 2020. Their reference lists were also reviewed.

Review Methods: Two reviewers independently extracted data and assessed the quality of eligible studies. Studies on patients who underwent an open thyroidectomy with or without neck dissection were included. Data were analyzed using the RevMan 5.3 software.

Results: Fifteen studies comprising 9,665 patients were selected for the meta-analysis. UMPTC occurred in 10% to 36% of all PTC cases. There were no significant differences between UMPTC and UUPTC patients in age, gender, tumor size, and extrathyroidal extension (ETE). However, significant differences (P < 0.05) between UMPTC and UUPTC patients were observed in central lymph node metastasis (CLNM), lateral lymph node metastasis (LLNM), tumor-node-metastasis (TNM) stage I+II, TNM stage III+IV, the recurrence/persistence of the UMPTC group after total thyroidectomy and overall recurrence/persistence.

Conclusion: UMPTC patients are more likely to have CLNM, LLNM, more advanced TNM stage, and recurrence/persistence than UUPTC patients. Compared with UUPTC, UMPTC patients should undergo central lymph node dissection, and pay more attention to LLNM, TNM stage and recurrence/persistence during the follow-up.
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http://dx.doi.org/10.3389/fonc.2021.657237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8483575PMC
September 2021

Pure Thalamic Infarct: 8-Year Follow-Up Study in a Hospital in China.

Front Neurol 2021 14;12:715317. Epub 2021 Sep 14.

Department of Neurology, Dalian Municipal Central Hospital, Affiliated Hospital of Dalian Medical University, Dalian, China.

Pure thalamic infarct is a rare lacunar stroke type, with little known about long-term outcomes. This 8-year, single-center, retrospective study evaluated the clinical background, etiology, Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification, and 8-year follow-up results in 27 patients with pure thalamic infarcts identified by MR diffusion-weighted imaging in Dalian, China. All patients presented chief complaints of limb weakness or sensory disturbances. Hypertension (24/27, 88.9%), diabetes (12/27, 44.4%), atrial fibrillation (1/27, 3.7%), hyperlipidemia (10/27, 37%), hyperhomocysteinemia (6/27, 22.2%), smoking history (10/27, 37%; 9/15, 60% for men; 1/12, 8.3% for women), and excessive alcohol consumption history (7/27, 25.9%; 7/15, 46.7% for men; 0 for women) were observed in our patient population. Based on TOAST classification, 1 patient had large artery atherosclerosis (7.14%), 23 had small vessel occlusion (SVO; 85.2%), and 3 patients were unidentified due to lack of cerebral angiography. The thalamic blood supply classification were as follows: 23 (85.2%), inferolateral territory; 1 (3.7%), tuberothalamic territory; 2 (7.4%), combination of tuberothalamic and paramedian arteries; 1 (3.7%), combination of inferolateral and paramedian arteries; 0, posterior choroidal arteries. During the 8-year follow-up, 3 patients died of colon cancer, multi-organ failure, and kidney failure, respectively; 7 presented with a recurrent stroke; while 10 recovered well with their risk factors under control. In conclusion, our cohort of pure thalamic infarcts were mainly due to SVO (TOAST), with hypertension as the main risk factor, and the inferolateral artery as the most implicated arterial territory. Less severe outcome or stroke recurrence are identified in long-term follow-up of pure thalamic infarcts. Other comorbidities would be cause of death in aged patients.
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http://dx.doi.org/10.3389/fneur.2021.715317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477660PMC
September 2021

Comparison of accuracy and safety between robot-assisted and conventional fluoroscope assisted placement of pedicle screws in thoracolumbar spine: A meta-analysis.

Medicine (Baltimore) 2021 Sep;100(38):e27282

Hebei Medical University, Shijiazhuang, Hebei, China.

Objective: The purpose of this systematic review and meta-analysis is to explore the screw positioning accuracy, complications related to pedicle screw implantation, revision rate and radiation exposure between robot screw placement and traditional fluoroscopic screw placement.

Methods: We searched several databases, including CNKI, Wanfang database, cqvip datebase, PubMed, Cochrane library and EMBASE, to identify articles that might meet the criteria. Meta-analysis was performed using Revman 5.3 software.

Results: A total of 13 randomized controlled trial were included. The results showed that the pedicle screw accuracy of the robot assisted group was significantly better than that of the conventional freehand (FH) group (OR = 3.5, 95% confidence interval [CI] [2.75,4.45], P < .0001). There was no significant difference in the complications caused by pedicle screw implantation between the robot-assisted group and the conventional FH group [OR = 0.39, 95%CI (0.10,1.48), P = .17]. The rate of facet joint invasion in the robot-assisted group was significantly lower than that in the conventional FH group (OR = 0.06, 95%CI [0.01,0.29], P = .0006). The revision rate in the robot-assisted group was significantly lower than that in the conventional FH group (OR = 0.19, 95%CI [0.05,0.71], P = 0.0.01). There was no significant difference in the average radiation of pedicle screws implantation between the robot-assisted group and the conventional FH (mean difference = -7.94, 95%CI [-20.18,4.30], P = .20).

Conclusion: The robot-assisted group was significantly better than the conventional FH in the accuracy of pedicle screw placement and facet joint invasion rate and revision rate. There was no significant difference in the complication and fluoroscopy time between the two groups.
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http://dx.doi.org/10.1097/MD.0000000000027282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8462633PMC
September 2021

Adsorption of uremic toxins using biochar for dialysate regeneration.

Biomass Convers Biorefin 2021 Sep 16:1-13. Epub 2021 Sep 16.

Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming, China.

Numerous studies have shown that patients with COVID-19 have a high incidence of renal dysfunction. However, the dialysis supplies, including dialysates, are also severely inadequate in hospitals at the pandemic centers. Therefore, there is an urgent need to develop materials that can efficiently and rapidly remove toxins and thus regenerate dialysate to make this vital resource remains readily available. In this work, by simple carbonization and activation treatment, the porous activated carbon from waste rubber seed shell (RAC) was prepared. The adsorption results showed that the maximum adsorption capacities of the obtained RAC for creatinine and uric acid were 430 mg/g and 504 mg/g, respectively. Significantly, the adsorption process can be close to the equilibrium state within 0.5 h, which proved the ultra-fast adsorption response capacity of RAC. Further, the thermodynamics analysis results showed that both the creatinine and uric acid adsorption processes were monolayer, exothermic, and spontaneous. The adsorption kinetics results indicated that the adsorption process of the two uremic toxins followed the pseudo-second-order rate model and was dominated by chemisorption. The instrument analysis results reflected the efficient adsorption of the RAC for the above uremic toxins which might be due to the dipole-dipole interaction between the dipolar oxygen-containing groups of the surface of RAC and the dipoles of the toxins. Moreover, the formed hydrogen bonds between the oxygen groups and the toxins also played an important role. In all, the as-prepared RAC has the potential to efficiently remove major toxins from the dialysate and can be used in in vitro dialysis of numerous patients during the current COVID-19 pandemic.
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http://dx.doi.org/10.1007/s13399-021-01946-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445020PMC
September 2021

A Durable Ni-Zn Microbattery with Ultrahigh-Rate Capability Enabled by In Situ Reconstructed Nanoporous Nickel with Epitaxial Phase.

Small 2021 Oct 15;17(42):e2103136. Epub 2021 Sep 15.

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, China.

Powering device for miniaturized electronics is highly desired with well-maintained capacity and high-rate performance. Though Ni-Zn microbattery can meet the demand to some extent with intrinsic fast kinetic, it still suffers irreversible structure degradation due to the repeated lattice strain. Herein, a stable Ni-Zn microbattery with ultrahigh-rate performance is rationally constructed through in situ electrochemical approaches, including the reconstruction of nanoporous nickel and the introduction of epitaxial Zn(OH) nanophase. With the enhanced ionic adsorption effect, the superior reactivity of the superficial nickel-based nanostructure is well stabilized. Based on facile miniaturization and electrochemical techniques, the fabricated nickel microelectrode exhibits 63.8% capacity retention when the current density is 500 times folded, and the modified hydroxides contribute to the great stability of the porous structure (92% capacity retention after 10 000 cycles). Furthermore, when the constructed Ni-Zn microbattery is measured in a practical metric, excellent power density (320.17 mW cm ) and stable fast-charging performance (over 90% capacity retention in 3500 cycles) are obtained. This surface reconstruction strategy for nanostructure provides a new direction for the optimization of electrode structure and enriches high-performance output units for integrated microelectronics.
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http://dx.doi.org/10.1002/smll.202103136DOI Listing
October 2021

Enhanced adsorption of aqueous chlorinated aromatic compounds by nitrogen auto-doped biochar produced through pyrolysis of rubber-seed shell.

Environ Technol 2021 Oct 6:1-16. Epub 2021 Oct 6.

Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming, People's Republic of China.

The adsorption of chlorinated aromatic compounds (CACs) on pristine biochar was often limited. Surface modification can greatly improve the adsorption capacity of biochar. In this work, by pyrolysis activation of rubber-seed shell wastes, nitrogen auto-doped biochar (RSS-NBC) was synthesized and used for purifying CACs-containing wastewater. Systematic characterization results showed that after proper treatment, the as-prepared RSS-NBC had high specific surface area, abundant surface oxygen- and nitrogen-containing functional groups, and nano-scale pore structure. Batch adsorption experiments were conducted with using three typical CACs probing pollutants, i.e. 1,2-dichlorobenzene (1,2-DCB), 2,4-dichlorophenol (2,4-DCP) and 2,4-dichlorobenzoic acid (2,4-DCBA). The adsorption experiments results showed that the maximum adsorption amounts of 1, 2-DCB, 2,4-DCP, and 2,4-DCBA could reach 2284, 1921, and 1142 mg/g at 298.15 K. Moreover, 90% of the equilibrium adsorption amount can be reached within 0.5 h. The adsorption kinetic results showed that the adsorption processes of the three CACs followed the pseudo-second-order rate model and were dominated by chemisorption. Also, the adsorption isotherms of 1, 2-DCB and 2, 4-DCP belonged to the Freundlich model and were valid for multilayer adsorption, while the adsorption of 2,4-DCBA followed Langmuir model and single-layer adsorption. The thermodynamics data indicated that the spontaneous adsorption process of 1, 2-DCB and 2, 4-DCP was endothermic while that of 2,4-DCBA was exothermic. After 5 cycles of adsorption-regeneration, the removal efficiency of RSS-NBC particles still remained more than 80% for the three typical CACs, indicating that it could be reused as an effective and retrievable adsorbent in the treatment of CACs-containing effluents.
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http://dx.doi.org/10.1080/09593330.2021.1980829DOI Listing
October 2021

Photoactivated Osmium Arene Anticancer Complexes.

Inorg Chem 2021 Sep 9. Epub 2021 Sep 9.

Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.

Half-sandwich Os-arene complexes exhibit promising anticancer activity, but their photochemistry has hardly been explored. To exploit the photocytotoxicity and photochemistry of Os-arenes, -chelated complexes [Os(η--cymene)(Curc)Cl] (, Curc = curcumin) and [Os(η-biphenyl)(Curc)Cl] (), and -chelated complexes [Os(η-biphenyl)(dpq)I]PF (, dpq = pyrazino[2,3-][1,10]phenanthroline) and [Os(η-biphenyl)(bpy)I]PF (, bpy = 2,2'-bipyridine), have been investigated. The Os-arene curcumin complexes showed remarkable photocytotoxicity toward a range of cancer cell lines (blue light IC: 2.6-5.8 μM, photocytotoxicity index PI = 23-34), especially toward cisplatin-resistant cancer cells, but were nontoxic to normal cells. They localized mainly in mitochondria in the dark but translocated to the nucleus upon photoirradiation, generating DNA and mitochondrial damage, which might contribute toward overcoming cisplatin resistance. Mitochondrial damage, apoptosis, ROS generation, DNA damage, angiogenesis inhibition, and colony formation were observed when A549 lung cancer cells were treated with . The photochemistry of these Os-arene complexes was investigated by a combination of NMR, HPLC-MS, high energy resolution fluorescence detected (HERFD), X-ray adsorption near edge structure (XANES) spectroscopy, total fluorescence yield (TFY) XANES spectra, and theoretical computation. Selective photodissociation of the arene ligand and oxidation of Os(II) to Os(III) occurred under blue light or UVA excitation. This new approach to the design of novel Os-arene complexes as phototherapeutic agents suggests that the novel curcumin complex , in particular, is a potential candidate for further development as a photosensitizer for anticancer photoactivated chemotherapy (PACT).
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http://dx.doi.org/10.1021/acs.inorgchem.1c00241DOI Listing
September 2021

Progress in Iron Oxides Based Nanostructures for Applications in Energy Storage.

Nanoscale Res Lett 2021 Aug 31;16(1):138. Epub 2021 Aug 31.

School of Mechanical Engineering, Sichuan University, Chengdu, 610065, People's Republic of China.

The demand for green and efficient energy storage devices in daily life is constantly rising, which is caused by the global environment and energy problems. Lithium-ion batteries (LIBs), an important kind of energy storage devices, are attracting much attention. Graphite is used as LIBs anode, however, its theoretical capacity is low, so it is necessary to develop LIBs anode with higher capacity. Application strategies and research progresses of novel iron oxides and their composites as LIBs anode in recent years are summarized in this review. Herein we enumerate several typical synthesis methods to obtain a variety of iron oxides based nanostructures, such as gas phase deposition, co-precipitation, electrochemical method, etc. For characterization of the iron oxides based nanostructures, especially the in-situ X-ray diffraction and Fe Mössbauer spectroscopy are elaborated. Furthermore, the electrochemical applications of iron oxides based nanostructures and their composites are discussed and summarized.Graphic Abstract.
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http://dx.doi.org/10.1186/s11671-021-03594-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8408304PMC
August 2021

Giant Topological Hall Effect in van der Waals Heterostructures of CrTe/BiTe.

ACS Nano 2021 Aug 30. Epub 2021 Aug 30.

Department of Physics and Astronomy, University of Missouri, Columbia, Missouri 65211, United States.

Discoveries of the interfacial topological Hall effect (THE) provide an ideal platform for exploring the physics arising from the interplay between topology and magnetism. The interfacial topological Hall effect is closely related to the Dzyaloshinskii-Moriya interaction (DMI) at an interface and topological spin textures. However, it is difficult to achieve a sizable THE in heterostructures due to the stringent constraints on the constituents of THE heterostructures, such as strong spin-orbit coupling (SOC). Here, we report the observation of a giant THE signal of 1.39 μΩ·cm in the van der Waals heterostructures of CrTe/BiTe fabricated by molecular beam epitaxy, a prototype of two-dimensional (2D) ferromagnet (FM)/topological insulator (TI). This large magnitude of THE is attributed to an optimized combination of 2D ferromagnetism in CrTe, strong SOC in BiTe, and an atomically sharp interface. Our work reveals CrTe/BiTe as a convenient platform for achieving large interfacial THE in hybrid systems, which could be utilized to develop quantum science and high-density information storage devices.
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http://dx.doi.org/10.1021/acsnano.1c05519DOI Listing
August 2021

Action Augmentation of Tactile Perception for Soft-Body Palpation.

Soft Robot 2021 Aug 24. Epub 2021 Aug 24.

Bio-Inspired Robotics Laboratory, Department of Engineering, University of Cambridge, Cambridge, United Kingdom.

Medical palpation is a diagnostic technique in which physicians use the sense of touch to manipulate the soft human tissue. This can be done to enable the diagnosis of possibly life-threatening conditions, such as cancer. Palpation is still poorly understood because of the complex interaction dynamics between the practitioners' hands and the soft human body. To understand this complex of soft body interactions, we explore robotic palpation for the purpose of diagnosing the presence of abnormal inclusions, or tumors. Using a Bayesian framework for training and classification, we show that the exploration of soft bodies requires complex, multi-axis, palpation trajectories. We also find that this probabilistic approach is capable of rapidly searching the large action space of the robot. This work progresses "robotic" palpation, and it provides frameworks for understanding and exploiting soft body interactions.
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http://dx.doi.org/10.1089/soro.2020.0129DOI Listing
August 2021

Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth.

J Exp Med 2021 Oct 25;218(10). Epub 2021 Aug 25.

Institute of Physiology, University of Zurich, Zurich, Switzerland.

Programs defining tissue-resident macrophage identity depend on local environmental cues. For alveolar macrophages (AMs), these signals are provided by immune and nonimmune cells and include GM-CSF (CSF2). However, evidence to functionally link components of this intercellular cross talk remains scarce. We thus developed new transgenic mice to profile pulmonary GM-CSF expression, which we detected in both immune cells, including group 2 innate lymphoid cells and γδ T cells, as well as AT2s. AMs were unaffected by constitutive deletion of hematopoietic Csf2 and basophil depletion. Instead, AT2 lineage-specific constitutive and inducible Csf2 deletion revealed the nonredundant function of AT2-derived GM-CSF in instructing AM fate, establishing the postnatal AM compartment, and maintaining AMs in adult lungs. This AT2-AM relationship begins during embryogenesis, where nascent AT2s timely induce GM-CSF expression to support the proliferation and differentiation of fetal monocytes contemporaneously seeding the tissue, and persists into adulthood, when epithelial GM-CSF remains restricted to AT2s.
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http://dx.doi.org/10.1084/jem.20210745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404471PMC
October 2021

Molecular characterization, expression, and apoptosis regulation of siva1 in protogynous hermaphrodite fish ricefield eel (Monopterus albus).

Fish Physiol Biochem 2021 Oct 20;47(5):1585-1596. Epub 2021 Aug 20.

College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, China.

Siva1, which induces extensive apoptosis, has been well characterized. To elucidate the molecular function of Siva1 in ricefield eel, molecular characterization and phylogenetic analysis were performed, and the mRNA expression in the ovary at different developmental stages and ovary tissues exposed to HO and Z-VAD-FMK in vitro were also evaluated. The results indicated that ricefield eel Siva1 was highly conserved and contains three conserved motifs, despite 83 amino acid differences upstream of the initiation codon. Phylogenetic analysis demonstrated that ricefield eel Siva1 clusters together with the Siva1 protein of the other fish, with high sequence homology with that of Lates calcarifer. Quantitative real-time polymerase chain reaction analysis showed high siva1 expression levels in the ovary and low expression levels in the liver. The higher mRNA levels of siva1 were detected in the IE and IM, and the lower siva1 mRNA levels were found in the OM, IL, and TE during gonadal development. Additionally, siva1 expression levels in the ovarian tissues were significantly increased at 1 h post incubation (hpi) with HO and then significantly decreased at 2 hpi; however, siva1 expression was upregulated significantly at 4 and 8 hpi, similar to the patterns observed with caspase3, which was used as a molecular marker of apoptosis. Moreover, the siva1 mRNAs were elevated significantly than that in control groups at 1 hpi, but the expression of siva1 was down-regulated dramatically at 2, 4, and 8 hpi, which were similar with that of caspase3 expression profiles after Z-VAD-FMK incubation. What's more, Pearson's correlation coefficients showed strongly positive relationships between siva1 and caspase3. These findings suggest that Siva1 plays an important apoptosis role in gonadal development of ricefield eel.
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http://dx.doi.org/10.1007/s10695-021-00997-8DOI Listing
October 2021

Effects of lipid emulsions on the formation of Escherichia coli-Candida albicans mixed-species biofilms on PVC.

Sci Rep 2021 Aug 19;11(1):16929. Epub 2021 Aug 19.

Department of Thoracic Surgery I, Key Laboratory of Lung Cancer Research of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University (Yunnan Cancer Hospital, Yunnan Cancer Center), No. 519, Kunzhou Road, Kunming, 650106, China.

Patients receiving lipid emulsions are at increased risk of contracting catheter-related bloodstream infections (CRBSIs) in the clinic. More than 15% of CRBSIs are polymicrobial. The objective of this study was to explore the effects of lipid emulsions on the formation of Escherichia coli (E. coli)-Candida albicans (C. albicans) mixed-species biofilms (BFs) on polyvinyl chloride (PVC) surfaces and the underlying mechanism. Mixed-species BFs were produced by coculturing E. coli and C. albicans with PVC in various concentrations of lipid emulsions. Crystal violet staining and XTT assays were performed to test the mixed-species BF biomass and the viability of microbes in the BFs. The microstructures of the BFs were observed by an approach that combined confocal laser scanning microscopy, fluorescence in situ hybridization, and scanning electron microscopy. The study found that lipid emulsions could promote the formation of E. coli-C. albicans mixed-species BFs, especially with 10% lipid emulsions. The mechanism by which lipid emulsions promote mixed-species BF formation may involve significant upregulation of the expression of the flhDC, iha, HTA1, and HWP1 genes, which are associated with bacterial motility, adhesion, and BF formation. The results derived from this study necessitate strict aseptic precautions when handling lipid emulsions and avoiding the use of high concentrations of lipid emulsions for as long as possible.
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http://dx.doi.org/10.1038/s41598-021-96385-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376934PMC
August 2021

Synergistic effects of warming and eutrophication alert zooplankton predator-prey interactions along the benthic-pelagic interface.

Glob Chang Biol 2021 Nov 23;27(22):5907-5919. Epub 2021 Aug 23.

State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.

Contemporary evidence suggests that climate change and other co-occurring large-scale environmental changes, such as eutrophication, will have a considerable impact on aquatic communities. However, the interactions of these environmental changes on trophic interactions among zooplankton remain largely unknown. Here we present results of a mesocosm experiment examining how a couple of zooplankton predator and prey taxa with different life-history strategies respond to the combined effect of an increase in temperature (4.5°C) and in eutrophication (phosphorus addition), during the crucial recruiting and growing season. We show that the addition of phosphorus alone significantly weakened the top-down effects by the cyclopoid copepod predators on their rotifer prey. In contrast, warming strengthened the top-down effects from the predator, leading to a reduction in the abundance of the rotifer prey. These effects of warming were enhanced by phosphorus addition. Together, our results demonstrate that warming made plankton prey organisms more susceptible to top-down effects from predators, but reduced their sensitivity to nutrient enrichment. In terms of the phenological effects, warming advanced the termination of diapause for both rotifers and cyclopoid copepods by about 2 weeks, but these temporal shifts, akin for both groups, resulted in no apparent trophic mismatch. Hence, from a future perspective, cyclopoid copepods are likely to benefit more from the combination of nutrient enrichment and climate warming to the detriment of their rotifer prey.
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http://dx.doi.org/10.1111/gcb.15838DOI Listing
November 2021

Novel EGFRvIII-CAR transgenic mice for rigorous preclinical studies in syngeneic mice.

Neuro Oncol 2021 Aug 4. Epub 2021 Aug 4.

Department of Neurological Surgery.

Background: Rigorous preclinical studies of chimeric antigen receptor (CAR) immunotherapy will require large quantities of consistent and high-quality CAR-transduced T (CART)-cells that can be used in syngeneic mouse glioblastoma (GBM) models. To this end, we developed a novel transgenic (Tg) mouse strain with a fully murinized CAR targeting epidermal growth factor receptor variant III (EGFRvIII).

Methods: We first established the murinized version of EGFRvIII-CAR and validated its function using a retroviral vector (RV) in C57BL/6J mice bearing syngeneic SB28 GBM expressing EGFRvIII. Next, we created C57BL/6J-background Tg mice carrying the anti-EGFRvIII-CAR downstream of a Lox-Stop-Lox cassette in the Rosa26 locus. We bred these mice with CD4-Cre Tg mice to allow CAR expression on T-cells and evaluated the function of the CART-cells both in vitro and in vivo. To inhibit immunosuppressive myeloid cells within SB28 GBM, we also evaluated a combination approach of CART and an anti-EP4 compound (ONO-AE3-208).

Results: Both RV- and Tg-CART-cells demonstrated specific cytotoxic activities against SB28-EGFRvIII cells. A single intravenous infusion of EGFRvIII-CART-cells prolonged the survival of glioma-bearing mice when preceded by a lymphodepletion regimen with recurrent tumors displaying profound EGFRvIII loss. The addition of ONO-AE3-208 resulted in long-term survival in a fraction of CART-treated mice and those survivors demonstrated delayed growth of subcutaneously re-challenged both EGFRvIII + and parental EGFRvIII - SB28.

Conclusion: Our new syngeneic CAR Tg mouse model can serve as a useful tool to address clinically relevant questions and develop future immunotherapeutic strategies.
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http://dx.doi.org/10.1093/neuonc/noab182DOI Listing
August 2021

The trans-omics landscape of COVID-19.

Nat Commun 2021 07 27;12(1):4543. Epub 2021 Jul 27.

BGI-Shenzhen, Shenzhen, China.

The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.
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http://dx.doi.org/10.1038/s41467-021-24482-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316550PMC
July 2021

The Medial Border of Laparoscopic D3 Lymphadenectomy for Right Colon Cancer: Results from an Exploratory Pilot Study.

Dis Colon Rectum 2021 Oct;64(10):1286-1296

Department of Colorectal, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Opinions vary on the medial border of D3 lymphadenectomy for right colon cancer. Most surgeons place the medial border along the left side of the superior mesenteric vein, but some consider the left side of the superior mesenteric artery as the medial border.

Objectives: This study investigated the clinical outcomes of laparoscopic D3 lymphadenectomy for right colon cancer with the medial border along the left side of superior mesenteric artery.

Design: This was a retrospective study.

Settings: The study was conducted in specialized colorectal cancer department of 5 tertiary hospitals.

Patients: Patients receiving laparoscopic D3 lymphadenectomy for right colon cancer from January 2013 to December 2018 were included.

Main Outcome Measures: After propensity score matching, 307 patients receiving laparoscopic D3 lymphadenectomy along the left side of the superior mesenteric artery were assigned to the superior mesenteric artery group and 614 patients were assigned to the superior mesenteric vein group. Univariate, multivariate, and Kaplan-Meier analyses were performed to assess the clinical data.

Results: The short-term outcomes were similar between the 2 groups; however, the superior mesenteric artery group had a higher rate of chylous leakage (p < 0.001). More lymph nodes were harvested from the superior mesenteric artery group than from the superior mesenteric vein group (p = 0.001). The number (p = 0.005) of metastatic lymph nodes and the lymph node ratio (p = 0.041) in main nodes were both higher in the superior mesenteric artery group. The 2 groups had similar long-term survival, but the superior mesenteric artery group tended to show better disease-free survival in patients with stage disease III (p = 0.056).

Limitations: This was a retrospective, nonrandomized study.

Conclusion: Laparoscopic D3 lymphadenectomy along the left side of the superior mesenteric artery, except for a higher rate of chylous leakage, had short-term outcomes comparable to the superior mesenteric vein group. The superior mesenteric artery group tended to achieve better disease-free survival in patients with stage III disease, but further study is required to better elucidate differences in these approaches because risks/benefits do exist.
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http://dx.doi.org/10.1097/DCR.0000000000002046DOI Listing
October 2021

Protective association of the ε2/ε3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men.

Alzheimers Dement 2021 Jul 26. Epub 2021 Jul 26.

Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina, USA.

Introduction: Despite advances, understanding the protective role of the apolipoprotein E (APOE) ε2 allele in Alzheimer's disease (AD) remains elusive.

Methods: We examined associations of variants comprised of the TOMM40 rs8106922 and APOE rs405509, rs440446, and ε2-encoding rs7412 polymorphisms with AD in a sample of 2862 AD-affected and 169,516 AD-unaffected non-carriers of the ε4 allele.

Results: Association of the ε2/ε3 heterozygote of men with AD is 38% (P = 1.65 × 10 ) more beneficial when it is accompanied by rs8106922 major allele homozygote and rs405509 and rs440446 heterozygotes than by rs8106922 heterozygote and rs405509 and rs440446 major allele homozygotes. No difference in the beneficial associations of these two most common ε2/ε3-bearing variants with AD was identified in women. The role of ε2/ε3 heterozygote may be affected by different immunomodulation functions of rs8106922, rs405509, and rs440446 variants in a sex-specific manner.

Discussion: Combination of TOMM40 and APOE variants defines a more homogeneous AD-protective ε2/ε3-bearing profile in men.
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http://dx.doi.org/10.1002/alz.12413DOI Listing
July 2021

Resource utilization of agricultural residues: one-step preparation of biochar derived from Pennisetum giganteum for efficiently removing chromium from water in a wide pH range.

Environ Sci Pollut Res Int 2021 Jul 23. Epub 2021 Jul 23.

Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming, China.

Biochars derived from agricultural residues, Pennisetum giganteum, were prepared by a one-step activation method after impregnated with HPO. The effects of activation temperature and the HPO impregnation method on the structure and performance of biochar were investigated. The characterization results of XPS, FTIR, and N adsorption-desorption showed that the P-containing biochar prepared by the one-step method had a large specific surface area, large pores, and abundant surface functional groups. And, the groups including C-P, O-P, and C-O participated in the adsorption of Cr(VI). Moreover, the target adsorbent has a good removal effect on Cr (VI) in a wide range of pH. The Cr(VI) removal efficiency was more than 55.92% at pH≤9. Interestingly, the adsorption results also showed that the adsorbent could offer acid groups for regulating the pH of the bulk solution and thus keep the adsorption surroundings in a narrow pH range. In addition, the target adsorbent has been proved to have good selective removal of Cr(VI). Even after repeated use for 5 times, the removal capacity of Cr(VI) is still 77.4%. This work provides a simple scheme for the high-value utilization of Pennisetum agricultural solid waste, and also confirms that the biochar activated by phosphoric acid can effectively remove Cr(VI) in the solution with wide pH range.
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http://dx.doi.org/10.1007/s11356-021-15388-yDOI Listing
July 2021

Molecular Dynamics Simulations of Lubricant Outflow in Porous Polyimide Retainers of Bearings.

Langmuir 2021 Aug 23;37(30):9162-9169. Epub 2021 Jul 23.

School of Mechanical Engineering, Beijing Institute of Technology, Beijing 10081, PR China.

The retainer of a space rolling bearing widely made of porous polyimide (PI) materials is oil-impregnated and can continuously release lubricants for lubrication. Understanding the lubricant supply mechanism in porous polyimide retainers is important to improve the lubrication performance of space bearings and therefore extends the bearing life. In this work, molecular dynamics simulations are adopted to model the lubricant outflow process from the pore of the PI material. Coarse-grained models are constructed to investigate the lubricant migration behaviors with different pore sizes and radii of rotation. At rest, a lubricant within the pore fails to outflow due to the capillary effect, which decreases with the increase of the pore size. However, for the rotating pores, if the inertial forces generated by the rotational motion exceed the capillary forces, the lubricants will begin to accumulate and some of the lubricants will flow out. Furthermore, the lubricant in the larger pore is easier to outflow due to the smaller capillary forces. This study quantifies the inertial effect and reveals that the centrifugal force is the main mechanism of lubricant outflow from the pores.
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http://dx.doi.org/10.1021/acs.langmuir.1c01331DOI Listing
August 2021

CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone.

Mucosal Immunol 2021 Nov 21;14(6):1295-1305. Epub 2021 Jul 21.

Department of Medicine, University of California, San Francisco, CA, USA.

Innate lymphoid cells (ILCs) are tissue-resident effectors poised to activate rapidly in response to local signals such as cytokines. To preserve homeostasis, ILCs must employ multiple pathways, including tonic suppressive mechanisms, to regulate their primed state and prevent inappropriate activation and immunopathology. Such mechanisms remain incompletely characterized. Here we show that cytokine-inducible SH2-containing protein (CISH), a suppressor of cytokine signaling (SOCS) family member, is highly and constitutively expressed in type 2 innate lymphoid cells (ILC2s). Mice that lack CISH either globally or conditionally in ILC2s show increased ILC2 expansion and activation, in association with reduced expression of genes inhibiting cell-cycle progression. Augmented proliferation and activation of CISH-deficient ILC2s increases basal and inflammation-induced numbers of intestinal tuft cells and accelerates clearance of the model helminth, Nippostrongylus brasiliensis, but compromises innate control of Salmonella typhimurium. Thus, CISH constrains ILC2 activity both tonically and after perturbation, and contributes to the regulation of immunity in mucosal tissue.
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http://dx.doi.org/10.1038/s41385-021-00430-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528700PMC
November 2021

Impact of fertilization with reducing in nitrogen and phosphorous application on growth, yield and biomass accumulation of rice ( L.) under a dual cropping system.

PeerJ 2021 7;9:e11668. Epub 2021 Jul 7.

College of Agriculture, Guangxi University, Nanning, Guangxi, China.

The current farming system in China is heavily reliant on synthetic fertilizers, which adversely affect soil quality and crop production. Therefore, the aim of this study was to assess the effect of different nitrogen (N) and phosphorous (P) fertilizer application rate on the growth, yield, and yield components of rice cultivars in the Binyang, Beiliu and Liucheng sites of southern China in the early (March to July) and late season (August to December). The study consisted of three fertilization regimes-CK (NP); NP (180 kg N + 90 kg PO ha) and NP (90 kg N ha + 45 kg PO)-conducted at each of three different experimental sites with four cultivars (Baixang 139, Y Liangyou 1, Guiyu 9, and Teyou 582). Results showed that the leaf area index (LAI) was 38.8% found higher in Guiyu 9 compared with Baxiang at reduced fertilization (NP). NP resulted higher dry matter production at the heading (9411.2 kg ha) and maturity (15319.5 kg ha) stages in Teyou 582 at Beiliu. Fertilization (NP) had higher effective panicle number (4,158,800 panicle ha) and grains panicle (113.84 grains) compared with other treatments. Teyou 582 treated with NP and Y Liangyou 1 treated with NP improved seed setting rate average by 82.91% and 72.17% compared with other treatments at Beiliu in both seasons, respectively. NP and NP increased the thousand-grain weight (TGW) of Y Liangyou 1 at Binyang (27.07 g) and Liucheng (27.84 g) during the early and late seasons, respectively. In Beiliu, the NP treatment (6611.7 kg ha) of Teyou 582 increased grain yield compared with other treatments. Overall, our results suggested that reducing N and P at the ratio of 90:45 kg ha in Teyou 582 and Y Liangyou 1 could increase rice grain yield and yield components.
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http://dx.doi.org/10.7717/peerj.11668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8272461PMC
July 2021

Design consideration of an x-ray imaging crystal spectrometer for China Fusion Engineering Test Reactor.

Rev Sci Instrum 2021 Apr;92(4):043544

Institute of Plasma Physics, HFIPS, Chinese Academy of Science, Hefei 230031, China.

The x-ray imaging crystal spectrometer (XICS) is proposed as the principal method of diagnostics for plasma ion temperature and rotation for the China Fusion Engineering Test Reactor (CFETR) for its simplicity in implementation and no reliance on neutral beams. For D-T experiments with the electron temperature as high as 35-40 keV at the core region, highly charged high-Z ions can serve as the diagnostic ions for the XICS. For the CFETR, Xe, Xe, and W are selected as the impurity ions. Appropriate crystal parameters are selected, as well as the preliminary layout for the spectrometer. We estimated the general performance of the spectrometer, including the emissivity of the impurities, the spatial resolution of the x-ray detector, and the expected count rate of line emissions. For the application in the fusion reactor environment, the effect of neutron irradiation on the crystal is briefly discussed.
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http://dx.doi.org/10.1063/5.0040527DOI Listing
April 2021

ASPECT scores of patients with focal intracerebral hemorrhage were correlated with their short- and medium-term functional outcomes.

Neurol Res 2021 Jul 9:1-7. Epub 2021 Jul 9.

The Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu China.

Purpose: The Alberta Stroke Program Early CT Score (ASPECTS) is widely used to guide thrombolytic therapy and predict the functional outcome of patients with acute ischemic stroke (AIS). Whether ASPECTS can predict the functional outcome of patients with intracerebral hemorrhage (ASPECTS-H) remains unclear.

Methods: Patients with primary intracerebral hemorrhage (ICH) were collected and retrospectively analyzed. ASPECTS-H was assessed at admission. Patients were followed up at 30 days and 90 days after the onset of ICH. Occurrence of death within 90 days after ICH was the primary endpoint. Modified Rankin Scale (mRS) ≥ 3 was considered a poor functional outcome.

Results: A total of 149 patients met eligibility criteria; 61 (40.9%) had poor functional outcome at 30 days, and 37 (24.8%) had poor functional outcome at 90 days. Using binary logistic regression modeling, we found that a low ASPECTS-H was associated with a poor functional outcome. The risk ratio of a low ASPECTS-H was 2.31 at 30 days ( = 0.000; 95% CI, 1.560-3.421) and 2.711 at 90 days ( = 0.000; 95% CI, 1.677-4.381). The optimal cutoff value of ASPECTS-H to discriminate good and poor 30-day and 90-day outcomes was 7.5 (Sensitivity = 0.636, 1-Specificity = 0.311; Sensitivity = 0.580, 1-Specificity = 0.270).

Conclusions: A low ASPECTS-H was an indicator of poor short-term and long-term functional outcomes of ICH.
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http://dx.doi.org/10.1080/01616412.2021.1948747DOI Listing
July 2021
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