Publications by authors named "Liang Feng"

971 Publications

A multidrug-resistant P-glycoprotein assembly revealed by tariquidar-probe's super-resolution imaging.

Nanoscale 2021 Oct 7. Epub 2021 Oct 7.

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Research Center of Biomembranomics, 5625 Renmin Street, Changchun, Jilin 130022, China.

As an efflux pump, P-glycoproteins (P-gps) are over-expressed in many cancer cell types to confer them with multi-drug resistance. Many studies have focused on elucidating their molecular structure or protein expression; however, the relationship between the molecular assembly and dysfunction remains unclear. Super-resolution microscope is an excellent imaging tool to reveal the molecular biological details, but its high-quality imaging often suffers from the labeling method currently available. In this work, by exploiting its specificity and small size, tariquidar (specific inhibitor of P-gp) was modified by TAMRA to form a small chemical probe of P-gp. By direct stochastic optical reconstruction microscopic (dSTORM) imaging, tariquidar-TAMRA was first revealed to possess a higher labeling superiority and high binding specificity. Then, with the application of tariquidar-TAMRA labeling, we found that P-gps accumulate into larger and denser clusters on cancer cells and drug-resistant cells than on normal cells and drug-sensitive cells, indicating that P-gps can facilitate the pumping efficiency by aggregating together to form functional platforms. Moreover, these specific distribution patterns might serve as potential biomarkers for tumor and drug therapy screening.
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http://dx.doi.org/10.1039/d1nr03980fDOI Listing
October 2021

Near-infrared to ultra-violet frequency conversion in chalcogenide metasurfaces.

Nat Commun 2021 Oct 5;12(1):5833. Epub 2021 Oct 5.

Department of Electrical and Computer Engineering, Duke University, Durham, NC, 27708, USA.

Chalcogenide photonics offers unique solutions for a broad range of applications from mid-infrared sensing to integrated, ultrafast, ultrahigh-bandwidth signal processing. However, to date its usage has been limited to the infrared part of the electromagnetic spectrum, thus avoiding ultraviolet and visible ranges due to absorption of chalcogenide glasses. Here, we experimentally demonstrate and report near-infrared to ultraviolet frequency conversion in an AsS-based metasurface, enabled by a phase locking mechanism between the pump and the inhomogeneous portion of the third harmonic signal. Due to the phase locking, the inhomogeneous component co-propagates with the pump pulse and encounters the same effective dispersion as the infrared pump, and thus experiences little or no absorption, consequently opening previously unexploited spectral range for chalcogenide glass science and applications, despite the presence of strong material absorption in this range.
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http://dx.doi.org/10.1038/s41467-021-26094-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492647PMC
October 2021

The study of volatile products formation from the self-degradation of l-ascorbic acid in hot compressed water.

Food Chem 2021 Sep 17;371:131155. Epub 2021 Sep 17.

School of Chemistry & Environmental Engineering, Hubei Minzu University, Enshi, Hubei 445000, China; Hubei Key Laboratory of Biologic Resources Protection and Utilization, Hubei Minzu University, Enshi, Hubei 445000, China.

The volatile products (VPs) formation from the self-degradation of l-ascorbic acid (ASA) in hot compressed water (HCW) was investigated with different reaction parameters, such as time, temperature, pH and ratio of ASA/water. The results showed that various reaction parameters had varying degrees of influence on the reaction, while the most significant effect factor was the initial pH of the solution. Furfural was the major product under acidic conditions, while furan derivatives were the main products under alkaline conditions. The above results showed that pH played the dominant role for yields and distribution of VPs in HCW. In the HCW system, the yields and classifications of VPs and conversion rate of ASA were not the same as those of VPs and ASA under traditional conditions. Based on the experimental results, the possible formation mechanism of VPs from the self-degradation of ASA was proposed in HCW.
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http://dx.doi.org/10.1016/j.foodchem.2021.131155DOI Listing
September 2021

The added value of satellite observations of methane forunderstanding the contemporary methane budget.

Philos Trans A Math Phys Eng Sci 2021 Nov 27;379(2210):20210106. Epub 2021 Sep 27.

SRON Netherlands Institute for Space Research, Utrecht, The Netherlands.

Surface observations have recorded large and incompletely understood changes to atmospheric methane (CH) this century. However, their ability to reveal the responsible surface sources and sinks is limited by their geographical distribution, which is biased towards the northern midlatitudes. Data from Earth-orbiting satellites designed specifically to measure atmospheric CH have been available since 2009 with the launch of the Japanese Greenhouse gases Observing SATellite (GOSAT). We assess the added value of GOSAT to data collected by the US National Oceanic and Atmospheric Administration (NOAA), which have been the lynchpin for knowledge about atmospheric CH since the 1980s. To achieve that we use the GEOS-Chem atmospheric chemistry transport model and an inverse method to infer flux estimates from the NOAA and GOSAT data using common emission inventories. We find the main benefit of GOSAT data is from its additional coverage over the tropics where we report large increases since the 2014/2016 El Niño, driven by biomass burning, biogenic emissions and energy production. We use data from the European TROPOspheric Monitoring Instrument to show how better spatial coverage and resolution measurements allow us to quantify previously unattainable diffuse sources of CH, thereby opening up a new research frontier. This article is part of a discussion meeting issue 'Rising methane: is warming feeding warming? (part 1)'.
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http://dx.doi.org/10.1098/rsta.2021.0106DOI Listing
November 2021

Efficacy of single-photon emission computed tomography aided botulinum toxin injection in cervical dystonia: A double-blind, randomized study.

Parkinsonism Relat Disord 2021 Sep 9;91:77-82. Epub 2021 Sep 9.

Department of Neurology, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xincun Road, Shanghai, 200065, China; Department of Neurorehabilitation, Yangzhi Rehabilitation Hospital, Tongji University School of Medicine, 2209 Guangxing Road, Shanghai, 201619, China. Electronic address:

Background: Although single-photon emission computed tomography (SPECT/CT) could help to predetermine dystonic muscles in patients with cervical dystonia (CD), its efficacy in aiding botulinum toxin injection is undetermined. This randomized, double-blinded study aimed to assess the efficacy of SPECT/CT aided botulinum toxin injection in CD.

Methods: Patients were randomized into study group (candidate muscles selected by SPECT/CT and clinical evaluation) or control group (clinical evaluation). Follow-ups were done at two weeks (T1), one (T2), three (T3) and six months (T4). The primary outcomes included symptom improvement assessed using Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) and Tsui score at T2.

Results: A total of 122 patients were enrolled and 108 patients accomplished the study. For primary outcomes, the study group had significantly better symptom improvement at T2 (TWSTRS: β, -4.86 [95%CI -9.40 to -0.32; P = 0.036]; Tsui: β, -1.65 [95%CI -2.77 to -0.54; P = 0.004]). For secondary outcomes, the study group also showed better outcomes at T1 (TWSTRS: β, -6.33 [95%CI -10.17 to -2.49; P = 0.001]; Tsui: β, -1.42 [95%CI -2.48 to -0.37; P = 0.008]) and T3 (TWSTRS: β, -6.05 [95%CI -11.09 to -1.01; P = 0.019]; Tsui: β, -1.24 [95%CI -2.40 to -0.08; P = 0.037]). The interval of re-injection was significantly longer in the study group than the control group (159.1 ± 28.6 versus 141.8 ± 51.0 days, P = 0.032).

Conclusions: SPECT/CT could improve the efficacy of botulinum toxin in CD. It could become a useful tool to aid botulinum toxin injection.
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http://dx.doi.org/10.1016/j.parkreldis.2021.09.002DOI Listing
September 2021

Identification of solute-carrier family 27A molecules (SCL27As) as a potential biomarker of ovarian cancer based on bioinformatics and experiments.

Ann Transl Med 2021 Aug;9(15):1237

Department of Breast Surgery of the First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Ovarian cancer is one of the 3 major gynecological malignancies with high mortality, poor prognosis, and lack of specific diagnostic and prognostic markers. Solute-carrier family 27A molecules (SCL27As) play a crucial role in multiple malignant tumors via the regulation of long-chain fatty acid uptake and subsequent regulation of lipid metabolism. To date, the specific mechanisms and roles of SCL27As in epithelial ovarian cancer (EOC) have remained unclear.

Methods: The Oncomine and Gene Expression Profiling Interactive Analysis (GEPIA) databases and the Kaplan-Meier plotter were used to explore the differential expression and the prognostic value of SCL27As in EOC. The expression of in 20 normal ovarian tissues and 120 ovarian cancer tissues was detected by immunohistochemistry (IHC). Cell Counting Kit-8 (CCK8) assay and colony-forming experiments were conducted to evaluate the role of in the proliferation of ovarian cancer cells, so as to verify the clinical application value of in the diagnosis and prognosis of ovarian cancer. We extracted the data of for multiple bioinformatics analysis to identify the potential regulatory mechanism of .

Results: The expression levels of and were significantly decreased in ovarian cancer tissues. Prognostic analysis showed that , , , and expression levels were significantly correlated with overall survival (OS) in EOC patients. Moreover, the expression of the SLC27A6 protein was decreased in EOC tissues, which was related to the prognosis. Additionally, knocking down the expression of could significantly enhance the malignant biological behavior of ovarian cancer cells. The gene may be involved in the proteasome, cell cycle, Hippo signaling pathway, and so on.

Conclusions: This study revealed the abnormal expression and prognostic value of in EOC. In addition, it was highlighted that may be a novel biomarker for the diagnosis and prognostication of EOC patients.
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http://dx.doi.org/10.21037/atm-21-3026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8421936PMC
August 2021

Flexible TiCT MXene/PANI/Bacterial Cellulose Aerogel for e-Skins and Gas Sensing.

ACS Appl Mater Interfaces 2021 Sep 15;13(38):45987-45994. Epub 2021 Sep 15.

Department of Instrumentation and Analytical Chemistry, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China.

Flexible pressure sensors made of carbon materials have been used in electronic skins (e-skins), whose performance can be enhanced if composite sensing materials are used. Herein, an MXene/polyaniline/bacterial cellulose (MXene/PANI/BC) aerogel sensor has been fabricated through the self-assembly process between the MXene and one-dimensional active material. Combined with fewer-layer or single-layer MXenes, the as-fabricated aerogel could be used as the active layer of the pressure sensor, monitoring tiny motion signals of finger bending, wrist bending, and pulse beating. Bluetooth wireless transmission could also be realized to monitor the real-time spatial pressure distributions on the mobile phone, making the aerogel-based sensor an ideal candidate in e-skins. Meanwhile, the aerogel-based sensor is sensitive toward NH due to the unique three-dimensional (3D) structure of the aerogel and the abundant terminal groups (such as -O, -OH, and -F) of the MXene in the system that ensure efficient electronic transfer for the sensing process and create active sites for the absorption with the target gas. This work offers a versatile platform to develop MXenes to fabricate 3D composite aerogels for high-performance flexible multiple sensors.
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http://dx.doi.org/10.1021/acsami.1c12991DOI Listing
September 2021

The BODIPY-based chemosensor for the fluorometric determination of organochlorine pesticide dicofol.

Food Chem 2021 Sep 2;370:131033. Epub 2021 Sep 2.

Department of Instrumentation and Analytical Chemistry, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China. Electronic address:

Dicofol is an organochlorine pesticide, which is widely used in fruits, tea and other crops, and is moderately toxic to humans. Therefore, the monitoring of organochlorine pesticide-dicofol is critical for food safety. In this work, a fluorometric chemosensor based on mercaptoethanol and boron dipyrromethene (BODIPY) was first constructed to detect the dicofol. The chemosensor displayed turn-off fluorescence behavior upon dicofol with a detection limit of 200 ppb. The nucleophilicity of the glutathione and other biological thiols was studied to evaluate the reactivity of thiols with dicofol. In practical applications, an obvious color difference was observed on a paper based microfluidic device modified by phenyltriethoxysilane (PTES). We designed an integrated device for pretreatment and paper-based detection, and successfully used for the detection of dicofol in tea. The applicability was demonstrated by detection of dicofol in real tea samples with good recovery ranging from 86% to 109%. The apparatus was convenient and could be used for on-site evaluation of dicofol.
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http://dx.doi.org/10.1016/j.foodchem.2021.131033DOI Listing
September 2021

[Preparation of [email protected] magnetic solid-phase extraction material and its application to the detection of pesticide residues in tea].

Se Pu 2021 Oct;39(10):1111-1117

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

Tea is one of the most popular beverages worldwide, and its quality is often affected by the excessive pesticide residues during production. During the detection of pesticide residues in tea by chromatography-mass spectrometry and other methods, a strong matrix effect attributed to tea polyphenols and pigments is observed, which seriously impacts the analysis results. In this study, FeO magnetic nanoparticles and boric acid-functionalized metal organic framework (BA-MOF) materials were combined to prepare a highly efficient adsorbent [email protected] for capturing tea polyphenols and pigments. An effective analysis method for pesticide residues in tea samples in combination with gas chromatography-mass spectrometry was established. The introduction of boronic acid ligands into the metal organic framework, as the recognition site of -diols, enhanced the polyphenol capture ability. Adsorption of the pigment in the matrix was achieved through interactions between the MOF ligand and the pigment. This new material has significant advantages such as rapid magnetic separation, large surface area, and abundant functional sites. [email protected] was prepared by employing simple conditions and characterized by Fouriertransform infrared spectroscopy, scanning electron microscopy, and X-ray diffractometry to identify its functional groups and morphology. After investigating the adsorption effect of different doses of [email protected] adsorbents (5, 10, 30, 50, and 80 mg) on tea polyphenols, 50 mg of the adsorbent was added to the tea matrix and shaken thoroughly. The tea polyphenol content in the matrix solution was determined using an ultraviolet spectrophotometer. The polyphenols were reduced by 74.58% within 5 min. The effect of solution pH (2.0, 4.0, 6.0, and 7.0) on the adsorption efficiency was investigated, and pH 7.0 was chosen as the optimal condition. By adjusting the pH of the solution, [email protected] could be recycled, and it maintained the excellent adsorption performance after four cycles of use. The introduction of FeO magnetic nanoparticles led to rapid magnetic response characteristics during sample pretreatment and improved the pretreatment efficiency. In the actual application of tea pesticide detection, after [email protected] pretreatment, the average recovery rates of the ten pesticides were in the range of 75.8%-138.6%, and the RSD was in the range of 0.5%-18.7% (=3). The [email protected] nanocomposite prepared by introducing the boric acid ligand into the MOF structure and incorporating FeO magnetic nanoparticles could specifically adsorb the tea polyphenol matrix. When applied to the detection of pesticide residues in tea, it purifies the matrix and improves the detection efficiency, thus being suitable for the detection and analysis of pesticides in tea.
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http://dx.doi.org/10.3724/SP.J.1123.2021.06003DOI Listing
October 2021

Tuning the Adsorption Properties of Metal-Organic Frameworks through Coadsorbed Ammonia.

ACS Appl Mater Interfaces 2021 Sep 7;13(36):43661-43667. Epub 2021 Sep 7.

Department of Materials Science & Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States.

In this work, we report a novel strategy to increase the gas adsorption selectivity of metal organic framework materials by coadsorbing another molecular species. Specifically, we find that addition of tightly bound NH molecules in the well-known metal-organic framework MOF-74 dramatically alters its adsorption behavior of CH and CH. Combining in situ infrared spectroscopy and ab initio calculations, we find that-as a result of coadsorbed NH molecules attaching to the open metal sites-CH binds more strongly and diffuses much faster than CH, occupying the available space adjacent to metal-bound NH molecules. Most remarkably, CH is now almost completely excluded from entering the MOF once CH has been loaded. This finding dispels the widespread belief that strongly coadsorbed species in nanoporous materials always undermine their performance in adsorbing or separating weakly bound target molecules. Furthermore, it suggests a new route to tune the adsorption behavior of MOF materials through harnessing the interactions among coadsorbed guests.
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http://dx.doi.org/10.1021/acsami.1c11876DOI Listing
September 2021

NAD in Alzheimer's Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained .

Front Cell Dev Biol 2021 3;9:668491. Epub 2021 Aug 3.

Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Mitochondria in neurons generate adenosine triphosphate (ATP) to provide the necessary energy required for constant activity. Nicotinamide adenine dinucleotide (NAD) is a vital intermediate metabolite involved in cellular bioenergetics, ATP production, mitochondrial homeostasis, and adaptive stress responses. Exploration of the biological functions of NAD has been gaining momentum, providing many crucial insights into the pathophysiology of age-associated functional decline and diseases, such as Alzheimer's disease (AD). Here, we systematically review the key roles of NAD precursors and related metabolites in AD models and show how NAD affects the pathological hallmarks of AD and the potential mechanisms of action. Advances in understanding the molecular roles of NAD-based neuronal resilience will result in novel approaches for the treatment of AD and set the stage for determining whether the results of exciting preclinical trials can be translated into the clinic to improve AD patients' phenotypes.
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http://dx.doi.org/10.3389/fcell.2021.668491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369418PMC
August 2021

Application of flue gas desulfurization gypsum improves multiple functions of saline-sodic soils across China.

Chemosphere 2021 Aug 21;277:130345. Epub 2021 Mar 21.

Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. Electronic address:

Saline-sodic soils cover ∼10% of the global land surface and deliver various ecosystem services to human society in the arid/semiarid regions. Flue gas desulfurization gypsum (FGDG), a byproduct from coal-fired power plants, is widely used to ameliorate saline-sodic soils. Here, we aimed to quantify the impacts of FGDG application on multiple soil functions across climatic conditions, management practices, and soil types, and to explore how FGDG application affects plant productivity. We conducted a meta-analysis by compiling 2658 pairs of data points with and without FGDG application from 59 locations across China. We found that FGDG application significantly increased crop yield by 91.2% ± 22.5% (mean ± 95% CI) regardless of local climate and soil type, and improved soil quality by reducing soil exchangeable sodium percentage (ESP) by 37.4% ± 9.6% and pH by 8.1% ± 1.7%. Increases in soil productivity were strongly correlated with decreases in soil ESP and pH, suggesting that increases in soil productivity were due to alleviated stress for plant growth. Meanwhile, some heavy elements (e.g., Hg and Ni) increased after FGDG application, likely imposing threats to soil health. Overall, the FGDG application is effective in improving the quality and productivity of saline-sodic soils across China. Our findings suggest that simultaneous assessment of changes in soil water (e.g., water holding capacity and infiltration), nutrient transformation, soil organic matter dynamics, and microbial communities helps disentangle mechanisms that are responsible for optimizing ecosystem service provided by saline-sodic soils after FGDG amendment application.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130345DOI Listing
August 2021

WS635 Attenuates the Anesthesia/Surgery-Induced Cognitive Impairment in Mice.

Front Aging Neurosci 2021 21;13:688587. Epub 2021 Jul 21.

Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.

Anesthesia/surgery has been reported to be associated with perioperative neurocognitive disorder (PND) in patients and induces cognitive impairment in mice. Previous studies demonstrate cyclosporine A (CsA) attenuates the anesthesia/surgery-induced cognitive impairment in mice. However, CsA has immunosuppressive effects and may not be routinely used to prevent or treat PND in patients. WS635 is a nonimmunosuppressive CsA analog. We, therefore, set out to determine whether WS635 could mitigate the anesthesia/surgery-induced cognitive impairment in mice. We performed abdominal surgery under 1.4% isoflurane anesthesia (anesthesia/surgery) for 2 h in 9 month-old wild-type (WT) mice. We treated the mice with CsA (10 mg/kg) or different doses (13.2 mg/kg, 26.4 mg/kg and 52.8 mg/kg) of WS635 before and after the anesthesia/surgery. Barnes maze and fear conditioning system (FCS) were employed to evaluate the cognitive function in mice. We measured the amounts of postsynaptic density (PSD)-95, synaptophysin, and ATP in the hippocampus and cortex of the mice using western blot and ATP Colorimetric/Fluorometric Assay, respectively. We found that the treatment with 52.8 mg/kg, but not 13.2 mg/kg or 26.4 mg/kg, of WS635 attenuated the anesthesia/surgery-induced cognitive impairment in mice and the reductions in the amounts of PSD-95, synaptophysin, and ATP in the mice brain tissues. These results have established a system to study WS635 further and suggest that we need to perform more experiments to determine whether WS635 can ultimately be used as one of the interventions for PND in patients.
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http://dx.doi.org/10.3389/fnagi.2021.688587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335586PMC
July 2021

Structure and mechanism of blood-brain-barrier lipid transporter MFSD2A.

Nature 2021 Aug 4;596(7872):444-448. Epub 2021 Aug 4.

Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

MFSD2A is a sodium-dependent lysophosphatidylcholine symporter that is responsible for the uptake of docosahexaenoic acid into the brain, which is crucial for the development and performance of the brain. Mutations that affect MFSD2A cause microcephaly syndromes. The ability of MFSD2A to transport lipid is also a key mechanism that underlies its function as an inhibitor of transcytosis to regulate the blood-brain barrier. Thus, MFSD2A represents an attractive target for modulating the permeability of the blood-brain barrier for drug delivery. Here we report the cryo-electron microscopy structure of mouse MFSD2A. Our structure defines the architecture of this important transporter, reveals its unique extracellular domain and uncovers its substrate-binding cavity. The structure-together with our functional studies and molecular dynamics simulations-identifies a conserved sodium-binding site, reveals a potential lipid entry pathway and helps to rationalize MFSD2A mutations that underlie microcephaly syndromes. These results shed light on the critical lipid transport function of MFSD2A and provide a framework to aid in the design of specific modulators for therapeutic purposes.
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http://dx.doi.org/10.1038/s41586-021-03782-yDOI Listing
August 2021

Simultaneous biogas upgrading, CO sequestration, and biogas slurry decrement using biomass ash.

Waste Manag 2021 Sep 29;133:1-9. Epub 2021 Jul 29.

College of Engineering, Huazhong Agricultural University, No.1, Shizishan Street, Hongshan District, Wuhan 430070, PR China; Key Laboratory of Agricultural Equipment in Mid-lower Yangtze River, Ministry of Agriculture and Rural Affairs, Wuhan 430070, PR China. Electronic address:

A novel system for simultaneous biogas upgrading, CO sequestration, and biogas slurry decrement was established by adding biomass ash into biogas slurry to form a renewable CO mixture absorbent. After CO saturation, the CO-rich mixture absorbent could be applied for plant growth. When the mass ratio of liquid to solid was 4:1, CO absorption capacity of this mixture absorbent reached up to 97.33 g-CO/kg-biomass-ash, which was about 135% higher than that of the biomass ash-water mixture. The highest value of 129.94 g-CO/kg-biomass-ash was obtained at a liquid-solid ratio of 99:1. When the TS concentration of anaerobic digestion feedstock was higher than 16 wt% and the water content of CO-rich absorbent was about 50 wt%, more than 80% of biogas slurry can be adsorbed by the biomass ash. If the biomass ash with a CO absorption capacity of 100 g-CO/kg was adopted and its transportation distance was less than 45 km, the biogas upgrading cost could be lower than the global average level (about RMB¥ 0.7/Nm-biogas) when using the novel system proposed in this study.
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http://dx.doi.org/10.1016/j.wasman.2021.07.029DOI Listing
September 2021

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion.

Nat Commun 2021 07 16;12(1):4358. Epub 2021 Jul 16.

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.

Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination at PTCs. Poor efficacy of current readthrough agents prompted us to search for better compounds. An NMD-sensitive NanoLuc readthrough reporter was used to screen 771,345 compounds. Among the 180 compounds identified with readthrough activity, SRI-37240 and its more potent derivative SRI-41315, induce a prolonged pause at stop codons and suppress PTCs associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity. Combining readthrough agents that target distinct components of the translation machinery is a promising treatment strategy for diseases caused by PTCs.
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http://dx.doi.org/10.1038/s41467-021-24575-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285393PMC
July 2021

Effects of posterior hemivertebra resection and short segment fusion on the evolution of sagittal balance in children with congenital scoliosis.

J Pediatr Orthop B 2021 Jul 8. Epub 2021 Jul 8.

Department of Pediatric Orthopedics, GuangZhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China Department of Pediatric Orthopedic Surgery, Lille University Center, Jeanne de Flandre Hospital, Lille, France Clinical Data Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

There is a paucity of data describing sagittal alignment changes in children with congenital scoliosis (CS) treated by hemivertebra (HV) resection. This study aimed to evaluate the effects of posterior HV resection on spine sagittal alignment in children with CS. This is a retrospective analysis of 31 children with CS (mean age at surgery: 49.61 ± 10.21 months; range, 39-72; mean follow-up time: 5.16 ± 1.21 years; range: 3-7) treated at our Institution. Only patients with single thoracic or single lumbar, fully segmented HV managed by posterior HV resection and two segments fusion with four screws and two robs were included. According to the anatomical location of the HV, patients were divided into two groups: thoracic (group A) and lumbar (group B). Thoracic kyphosis (T1-T12; TK) and lumbar lordosis (L1-S1; LL) were measured pre- and postoperatively at 6 months interval. Postoperative TK and LL were 30.3 ± 11.47 and 28.8 ± 9.47, and were 31.98 ± 9.66 and 46.7 ± 11.37 at the last follow-up visit, respectively. The incidence of thoracic hypokyphosis in group B was 53.3%, and it was significantly higher compared to group A (12.5%, P = 0.04). During follow-up, TK changes were comparable between the two groups of patients while LL improved in all patients 6 months after surgery, and continued to improve thereafter. Posterior HV resection and short segment fusion have limited impact on the evolution of TK; in particular, children with lumbar HV were more likely to be hypokyphotic preoperatively, but less likely postoperatively with an increase in LL and a stabilization of TK.
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http://dx.doi.org/10.1097/BPB.0000000000000894DOI Listing
July 2021

Recent advances in chiral discrimination on host-guest functionalized interfaces.

Chem Commun (Camb) 2021 Aug 15;57(61):7480-7492. Epub 2021 Jul 15.

Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China.

Chiral discrimination has gained much focus in supramolecular chemistry, since it is one of the fundamental processes in biological systems, enantiomeric separation and biochemical sensors. Though most of the biochemical processes can routinely recognize biological enantiomers, enantioselective identification of chiral molecules in artificial systems is currently one of the challenging topics in the field of chiral discrimination. Inaccuracy, low separation efficiency and expensive instrumentation were considered typical problems in artificial systems. Recently, chiral recognition on the interfaces has been widely used in the fields of electrochemical detection and biochemical sensing. For the moment, a series of macrocyclic host functionalized interfaces have been developed for use as chiral catalysts or for enantiomeric separation. Here, we have briefly exposited the most recent advances in the fabrication of supramolecular functionalized interfaces and their application for chiral recognition.
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http://dx.doi.org/10.1039/d1cc01501jDOI Listing
August 2021

Ultrathin mesoporous graphitic carbon nitride nanosheets with functional cyano group decoration and nitrogen-vacancy defects for an efficient selective CO photoreduction.

Nanoscale 2021 Aug 15;13(29):12634-12641. Epub 2021 Jul 15.

The State Key Laboratory of Refractories and Metallurgy, Wuhan University of Science and Technology, Wuhan 430081, China.

Graphitic carbon nitrides have CO photoreduction ability, but their activities are limited by the low potential and mobility of photogenerated carriers. Herein, ultrathin mesoporous graphitic carbon nitride nanosheets (CNNS) synchronously decorated with functional cyano groups and nitrogen vacancies were prepared by a facile molten salt route. The CNNS presented unprecedentedly excellent gas-phase CO photoreduction performance under visible light irradiation without any co-catalyst or a sacrificial agent, and have a CH-yielding rate of 23.0 μmol g h and a selectivity of 97.9%. This boosted performance can be attributed to the synergistic effect of cyano group decoration, abundant nitrogen vacancies and extremely high surface area, which improve electron storage, charge carrier mobility, CO affinity, and optimize the energy band structure. This work demonstrates that a structural optimization combined with defect design of carbon nitride framework is a powerful approach to improve the photocatalytic activity, providing an accessible way to design highly efficient carbon-based photocatalysts.
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http://dx.doi.org/10.1039/d1nr02639aDOI Listing
August 2021

HMGB2 orchestrates mitotic clonal expansion by binding to the promoter of C/EBPβ to facilitate adipogenesis.

Cell Death Dis 2021 07 2;12(7):666. Epub 2021 Jul 2.

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.

High-mobility group box 2 (HMGB2) is an abundant, chromatin-associated protein that plays an essential role in the regulation of transcription, cell proliferation, differentiation, and tumorigenesis. However, the underlying mechanism of HMGB2 in adipogenesis remains poorly known. Here, we provide evidence that HMGB2 deficiency in preadipocytes impedes adipogenesis, while overexpression of HMGB2 increases the potential for adipogenic differentiation. Besides, depletion of HMGB2 in vivo caused the decrease in body weight, white adipose tissue (WAT) mass, and adipocyte size. Consistently, the stromal vascular fraction (SVF) of adipose tissue derived from hmgb2 mice presented impaired adipogenesis. When hmgb2 mice were fed with high-fat diet (HFD), the body size, and WAT mass were increased, but at a lower rate. Mechanistically, HMGB2 mediates adipogenesis via enhancing expression of C/EBPβ by binding to its promoter at "GGGTCTCAC" specifically during mitotic clonal expansion (MCE) stage, and exogenous expression of C/EBPβ can rescue adipogenic abilities of preadipocytes in response to HMGB2 inhibition. In general, our findings provide a novel mechanism of HMGB2-C/EBPβ axis in adipogenesis and a potential therapeutic target for obesity.
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http://dx.doi.org/10.1038/s41419-021-03959-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253743PMC
July 2021

Multiscale Investigation into Chemically Stable NASICON Solid Electrolyte in Acidic Solutions.

ACS Appl Mater Interfaces 2021 Jul 2;13(28):33262-33271. Epub 2021 Jul 2.

Multiscale Crystal Materials Research Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Natrium superionic conductor (NASICON) solid electrolyte has been attracting wide attention due to its high ionic conductivity, low cost, and environmental friendliness. In this work, the chemical stability of the NASICON solid electrolyte with the composition of NaZrSiPO was evaluated in acidic solutions with different pH values, and the corrosion mechanism of the NASICON solid electrolyte was revealed at the multiscale level. Variations in bulk impedance, grain boundary impedance, and surface crack impedance with immersion time were determined by an AC impedance method. Comprehensive studies upon scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) etching, X-ray diffraction (XRD), and Raman spectroscopy, the morphological transformation, degradation limit depth, Cl penetration effect, and proton exchange between HO and Na were examined ranging from macro- and meso- to microscales, respectively. With the decrease of the pH of the solution, the exchange rate between HO and Na protons increases. The lack of Na within the crystallographic lattice leads to the shrinkage of phosphorus-oxygen tetrahedra, which is the main reason for the decrease of unit cell volume, grain refinement, and surface cracks gradually. This work features multiscale characterizations of crystal structure, grain boundaries, surface morphology changes, and Na transport, which deepens our physicochemical understanding of solid electrolytes with high chemical stability.
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http://dx.doi.org/10.1021/acsami.1c07601DOI Listing
July 2021

[Functionalization of carbon dots and their applications in food safety].

Se Pu 2020 Jul;38(7):732-740

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

Almost two decades have passed since the discovery of carbon nanodots (CDs). As a promising family of optical nanomaterials, CDs have high emission efficiency, excellent water solubility, and good bio-compatibility; in addition, they are inexpensive and can be produced by a facile synthesis process. Because of these advantages, CDs have drawn tremendous attention for use in the development of novel optochemical sensors. However, the application scope of chemical sensors based on pristine CDs is restricted because the synthetic methods and starting materials for the CDs give rise to a great limitation of their surface chemical structures. Therefore, pristine CDs need to be functionalized so that they can be employed in sensing applications, with high sensing capability. Typically, functionalization can be classified into two types: doping and surface modification. Doping, as an effective method for introducing new elements to the skeleton of CDs, not only helps manipulate the energy bang-gap of pristine CDs, but also brings the specific acceptor of the target analyte to the CD matrix. Surface modification is a conventional functionalization method that allows one to manipulate the surface chemical structure of CDs in a covalent or non-covalent fashion, so that the selectivity and sensitivity of pristine CDs can be sequentially improved. In this paper, we review the research progress in the functionalization of CDs over the last eight years based on the publications from Web of Science, and systematically summarize the applications of CD-based sensors in the area of food safety. Although this review is incomprehensive due to space restrictions, it can shed fresh light on the development of CD-based rapid sensors for food safety applications in the near future.
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http://dx.doi.org/10.3724/SP.J.1123.2019.12003DOI Listing
July 2020

Puerarin attenuates intracerebral hemorrhage-induced early brain injury possibly by PI3K/Akt signal activation-mediated suppression of NF-κB pathway.

J Cell Mol Med 2021 Aug 27;25(16):7809-7824. Epub 2021 Jun 27.

Department of Neurosurgery, Zhujiang Hospital, The Engineering Technology Research Center of Education Ministry of China, The National Key Clinical Specialty, The Neurosurgery Institute of Guangdong Province, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Southern Medical University, Guangzhou, China.

Intracerebral hemorrhage (ICH) can induce intensively oxidative stress, neuroinflammation, and brain cell apoptosis. However, currently, there is no highly effective treatment available. Puerarin (PUE) possesses excellent neuroprotective effects by suppressing the NF-κB pathway and activating the PI3K/Akt signal, but its role and related mechanisms in ICH-induced early brain injury (EBI) remain unclear. In this study, we intended to observe the effects of PUE and molecular mechanisms on ICH-induced EBI. ICH was induced in rats by collagenase IV injection. PUE was intraperitoneally administrated alone or with simultaneously intracerebroventricular injection of LY294002 (a specific inhibitor of the PI3K/Akt signal). Neurological deficiency, histological impairment, brain edema, hematoma volume, blood-brain barrier destruction, and brain cell apoptosis were evaluated. Western blot, immunohistochemistry staining, reactive oxygen species (ROS) measurement, and enzyme-linked immunosorbent assay were performed. PUE administration at 50 mg/kg and 100 mg/kg could significantly reduce ICH-induced neurological deficits and EBI. Moreover, PUE could notably restrain ICH-induced upregulation of the NF-κB pathway, pro-inflammatory cytokines, ROS level, and apoptotic pathway and activate the PI3K/Akt signal. However, LY294002 delivery could efficaciously weaken these neuroprotective effects of PUE. Overall, PUE could attenuate ICH-induced behavioral defects and EBI possibly by PI3K/Akt signal stimulation-mediated inhibition of the NF-κB pathway, and this made PUE a potential candidate as a promising therapeutic option for ICH-induced EBI.
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http://dx.doi.org/10.1111/jcmm.16679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358853PMC
August 2021

A new anesthesia scheme for parathyroidectomy under neuromonitoring: a retrospective cohort study.

Gland Surg 2021 May;10(5):1576-1586

Department of Anesthesiology, China-Japan Union Hospital of Jilin University, Changchun, China.

Background: Parathyroidectomy under nerve monitoring has been carried out for nearly ten years in the China-Japan Union Hospital of Jilin University. We retrospectively evaluated patients' prognosis with secondary hyperparathyroidism (SH) under neuro- and non-neuro-monitored parathyroidectomy anesthesia. The purpose of this study is to summarize and introduce a new anesthesia scheme for parathyroidectomy under nerve monitoring.

Methods: From January 2000 to December 2019, 200 patients with SH in the China-Japan Union Hospital of Jilin University were retrospectively analyzed. Among them, 100 patients underwent parathyroidectomy under neurological monitoring (Group A), and 100 patients underwent parathyroidectomy without neurological monitoring (Group B). The dosage of muscle relaxant, parathyroid hormone (PTH), serum calcium, phosphorus, urea, creatinine, and alkaline phosphatase (ALP) was recorded before surgery (T0), after surgery (T1), at discharge (T2), during skin incision (Ta), at four parathyroidectomies (Tb), and 10 min after total removal. The levels of PTH were measured at four-time points (Tc) and 30 minutes (Td) after complete resection.

Results: After screening and propensity score match (PSM), the data of 92 patients were analyzed. Group A's muscle relaxant dose was significantly less than Group B; the length of hospital stay in Group A was significantly lower than in Group B (P<0.05). The serum calcium levels, phosphorus, urea, and creatinine at T2 in Group A were lower than those in Group B (P<0.05).

Conclusions: Parathyroid nerve monitoring technology combined with preoperative complete anesthesia scheme, anesthesia induction with one time ED95 (95% effective drug dose) cis-atracurium, end breath gas, and sevoflurane maintenance anesthesia under BIS monitoring can improve the prognosis of patients, shorten the length of hospital stay, and is effective and safe.
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http://dx.doi.org/10.21037/gs-21-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184376PMC
May 2021

Recent Development of Electrocatalytic CO Reduction Application to Energy Conversion.

Small 2021 Jun 21:e2100323. Epub 2021 Jun 21.

Department of Mechanical and Materials Engineering, University of Western Ontario, London, Ontario, N6A 5B9, Canada.

Carbon dioxide (CO ) emission has caused greenhouse gas pollution worldwide. Hence, strengthening CO recycling is necessary. CO electroreduction reaction (CRR) is recognized as a promising approach to utilize waste CO . Electrocatalysts in the CRR process play a critical role in determining the selectivity and activity of CRR. Different types of electrocatalysts are introduced in this review: noble metals and their derived compounds, transition metals and their derived compounds, organic polymer, and carbon-based materials, as well as their major products, Faradaic efficiency, current density, and onset potential. Furthermore, this paper overviews the recent progress of the following two major applications of CRR according to the different energy conversion methods: electricity generation and formation of valuable carbonaceous products. Considering electricity generation devices, the electrochemical properties of metal-CO batteries, including Li-CO , Na-CO , Al-CO , and Zn-CO batteries, are mainly summarized. Finally, different pathways of CO electroreduction to carbon-based fuels is presented, and their reaction mechanisms are illustrated. This review provides a clear and innovative insight into the entire reaction process of CRR, guiding the new electrocatalysts design, state-of-the-art analysis technique application, and reaction system innovation.
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http://dx.doi.org/10.1002/smll.202100323DOI Listing
June 2021

Detecting Individual Bond Switching within Amides in a Tunneling Junction.

Nano Lett 2021 06 14;21(12):5409-5414. Epub 2021 Jun 14.

The State Key Laboratory of Refractories and Metallurgy, the Institute of Advanced Materials and Nanotechnology, Wuhan University of Science and Technology, Wuhan, Hubei 430081, China.

Amides are essential in the chemistry of life. Detecting the chemical bond states within amides could unravel the nature of amide stabilization and planarity, which is critical to the structure and reactivity of such molecules. Yet, so far, no work has been reported to detect or measure the bond changes at the single-molecule level within amides. Here, we show that a transition between single and double bonds between N and C atoms in an amide can be monitored in real time in a nanogap between gold electrodes via the generation of distinctive conductance features. Density functional theory simulations show that the switching between amide isomers proceeds via a proton transfer process facilitated by a water molecule bridge, and the resulting molecular junctions display bimodal conductance states with a difference as much as nine times.
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http://dx.doi.org/10.1021/acs.nanolett.1c01882DOI Listing
June 2021

Delineating the Role of Mitophagy Inducers for Alzheimer Disease Patients.

Aging Dis 2021 Jun 1;12(3):852-867. Epub 2021 Jun 1.

2Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Alzheimer's disease (AD) is the most common cause of dementia in elderly that serves to be a formidable socio-economic and healthcare challenge in the 21 century. Mitochondrial dysfunction and impairment of mitochondrial-specific autophagy, namely mitophagy, have emerged as important components of the cellular processes contributing to the development of AD pathologies, namely amyloid-β plaques (Aβ) and neurofibrillary tangles (NFT). Here, we highlight the recent advances in the association between impaired mitophagy and AD, as well as delineate the potential underlying mechanisms. Furthermore, we conduct a systematic review the current status of mitophagy modulators and analyzed their relevant mechanisms, evaluating on their advantages, limitations and current applications in clinical trials for AD patients. Finally, we describe how deep learning may be a promising method to rapid and efficient discovery of mitophagy inducers as well as general guidance for the workflow of the process.
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http://dx.doi.org/10.14336/AD.2020.0913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139196PMC
June 2021

Genome-wide identification and expression analysis of the bHLH transcription factor family and its response to abiotic stress in sorghum [Sorghum bicolor (L.) Moench].

BMC Genomics 2021 Jun 5;22(1):415. Epub 2021 Jun 5.

College of Agriculture, Guizhou University, Huaxi District, Guiyang City, 550025, Guizhou Province, P.R. China.

Background: Basic helix-loop-helix (bHLH) is a superfamily of transcription factors that is widely found in plants and animals, and is the second largest transcription factor family in eukaryotes after MYB. They have been shown to be important regulatory components in tissue development and many different biological processes. However, no systemic analysis of the bHLH transcription factor family has yet been reported in Sorghum bicolor.

Results: We conducted the first genome-wide analysis of the bHLH transcription factor family of Sorghum bicolor and identified 174 SbbHLH genes. Phylogenetic analysis of SbbHLH proteins and 158 Arabidopsis thaliana bHLH proteins was performed to determine their homology. In addition, conserved motifs, gene structure, chromosomal spread, and gene duplication of SbbHLH genes were studied in depth. To further infer the phylogenetic mechanisms in the SbbHLH family, we constructed six comparative syntenic maps of S. bicolor associated with six representative species. Finally, we analyzed the gene-expression response and tissue-development characteristics of 12 typical SbbHLH genes in plants subjected to six different abiotic stresses. Gene expression during flower and fruit development was also examined.

Conclusions: This study is of great significance for functional identification and confirmation of the S. bicolor bHLH superfamily and for our understanding of the bHLH superfamily in higher plants.
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http://dx.doi.org/10.1186/s12864-021-07652-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8178921PMC
June 2021

The immediate trends in atrial electrical remodeling for paroxysmal atrial fibrillation across different modes of catheter ablation.

Clin Cardiol 2021 Jul 1;44(7):938-945. Epub 2021 Jun 1.

Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Catheter ablation has emerged as a major strategy for paroxysmal atrial fibrillation (PAF). Atrial electrical remodeling (AER) plays a critical role in the recurrence of PAF after ablation.

Hypothesis: To characterize the immediate trends of AER during ablations in patients with PAF, and assess the relationship between immediate trends and recurrence.

Methods: We performed this prospective observational study of 135 patients to investigate AER following three ablation modes: radiofrequency ablation (RFA), cryoablation (CA) and 3D mapping-guided cryoablation (3D-CA). The atrial effective refractory period (AERP) and atrial conduction time (ACT) were measured via electrophysiology before and immediately after ablation, and P-wave indices were measured via electrocardiography before and within 24 h after ablation. Follow-up visits were conducted for at least 1 year or until relapse.

Results: Different approaches of ablation caused a fairly significant increase in the shortest P-wave duration and AERP in both the proximal coronary sinus (PCS) and distal coronary sinus (DCS) but caused a shortened P-wave dispersion. No different effect was found at the AERP among the three modes. Compared to patients who received CA, among patients who received RFA, a significant reduction in total ACT and right ACT was seen. Statistically, there was a weakly positive association between changes in total ACT and early recurrence.

Conclusions: Injury during ablation for PAF was associated with an increase in the AERP but not in the ACT. Total ACT and right ACT were shorter after RFA than after CA. The increase in total ACT were slightly predictive of early recurrence.
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http://dx.doi.org/10.1002/clc.23617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8259153PMC
July 2021

Green Synthesis of Leaning Tower[6]arene-Mediated Gold Nanoparticles for Label-Free Detection.

Org Lett 2021 06 28;23(12):4677-4682. Epub 2021 May 28.

The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, P. R. China.

Here a facile synthesis strategy toward carboxylated leaning tower[6]arene (CLT6)-mediated gold nanoparticles (CLT6-AuNPs) without external energy sources and reducing agents has been developed. Due to the cavity structure of CLT6, CLT6-AuNPs with a controllable particle size show good stability and excellent performance in label-free detection of diquat. Significantly, we reveal the reduction mechanism of AuNP formation, which is the cleavage of some phenyl ether bonds of CLT6 to produce reductive phenols, thus reducing Au to AuNPs.
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http://dx.doi.org/10.1021/acs.orglett.1c01300DOI Listing
June 2021
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