Publications by authors named "Liang Cheng"

1,754 Publications

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Novel genes/loci validate the small effect size of ERBB2 in patients with myasthenia gravis.

Proc Natl Acad Sci U S A 2022 Sep 15;119(36):e2207273119. Epub 2022 Aug 15.

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China.

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http://dx.doi.org/10.1073/pnas.2207273119DOI Listing
September 2022

Soil pH Determines the Spatial Distribution, Assembly Processes, and Co-existence Networks of Microeukaryotic Community in Wheat Fields of the North China Plain.

Front Microbiol 2022 25;13:911116. Epub 2022 Jul 25.

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, China.

Soil microeukaryotes play a pivotal role in soil nutrient cycling and crop growth in agroecosystems. However, knowledge of microeukaryotic community distribution patterns, assembly processes, and co-existence networks is greatly limited. Here, microbial eukaryotes in bulk and rhizosphere soils of the North China Plain were investigated. The results showed that soil pH was the driving factor for the microeukaryotic community composition in the bulk and rhizosphere soils. The soil microeukaryotic community could significantly differ between alkaline and acidic soils. The results indicated that the soil pH had a stronger effect than niche differences on community composition. Partial Mantel tests showed that soil pH and spatial distance had similar effects on the microeukaryotic community composition in the bulk soil. However, in the rhizosphere soil, spatial distance had a stronger effect than soil pH. Infer Community Assembly Mechanisms by Phylogenetic bin-based null model (iCAMP) analysis revealed that drift was the most important process driving microeukaryotic community assembly, with an average relative importance of 37.4-71.1%. Dispersal limitation displayed slightly greater importance in alkaline rhizosphere than in alkaline bulk soils. Meanwhile, the opposite trend was observed in acidic soils. In addition, the contribution of each assembly process to each iCAMP lineage "bin" varied according to the acidic or alkaline conditions of the soil and the niche environment. High proportions of positive links were found within the four ecological networks. Alkaline soil networks, especially the alkaline bulk soil network, showed greater complexity than the acidic soil networks. Natural connectivity analysis revealed that the rhizosphere community had a greater stability than the bulk soil community in alkaline soil. This study provides a foundation for understanding the potential roles of microbial eukaryotes in agricultural soil ecosystem functioning.
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http://dx.doi.org/10.3389/fmicb.2022.911116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358722PMC
July 2022

Screening and identification of immune-related genes for immunotherapy and prognostic assessment in colorectal cancer patients.

BMC Med Genomics 2022 08 8;15(1):177. Epub 2022 Aug 8.

Department of General Surgery, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, 214000, China.

Background: Increasing evidence indicates that the immune microenvironment plays a key role in the genesis and progression of colorectal cancer (CRC). This study aimed to establish an immune-related gene (IRG) signature and determine its clinical prognostic value in patients with CRC.

Methods: The RNA sequencing and associated clinical data of CRC were downloaded from The Cancer Genome Atlas (TCGA) database. We then screened for differentially expressed IRGs by intersecting with IRGs obtained from the Immunology Database and Analysis Portal. Functional enrichment analyses were carried out to determine the potential biological functions and pathways of the IRGs. We also explored the specific molecular mechanisms of the IRGs by constructing regulatory networks. Prognostic IRGs were obtained by LASSO regression analysis, and subsequently, gene models were constructed in the TCGA dataset to confirm the predictive capacity of these IRGs. Finally, we used the TIMER tool to assess the immune properties of prognostic IRGs and correlate them with immune cells.

Results: We identified 409 differentially expressed IRGs in patients with CRC. Kyoto Encyclopaedia of Genes and Genomes and Gene Ontology enrichment analyses suggested that these differentially expressed IRGs were significantly related to 102 cancer signalling pathways and various biological functions. Based on the prediction and interaction results, we obtained 59 TF-IRG, 48 miRNA-IRG, and 214 drug-IRG interaction networks for CRC. Four prognostic genes (POMC, TNFRSF19, FGF2, and SCG2) were developed by integrating 47 survival-related IRGs and 42 characteristic CRC genes. The results of gene model showed that patients in the low risk group had better survival outcomes compared to those in the high risk group. The expression of POMC, TNFRSF19, FGF2, and SCG2 was significantly correlated with immune cells.

Conclusion: This study identified some valid IRGs, and these findings can provide strong evidence for precision immunotherapy in patients with CRC.
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http://dx.doi.org/10.1186/s12920-022-01329-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358808PMC
August 2022

HXV2O5 Nanocatalysts Combined with Ultrasound for Triple Amplification of Oxidative Stress to Enhance Cancer Catalytic Therapy.

Angew Chem Int Ed Engl 2022 Aug 5. Epub 2022 Aug 5.

Soochow University, No 199, Ren'ai Road, 215123, Suzhou, CHINA.

Multiple amplification of tumor oxidative stress has been demonstrated as efficient strategy to enhance the reactive oxygen species (ROS)-mediated cancer therapy. Herein, vanadium-based nanocatalysts, hydrogen vanadium bronzes (HXV2O5 , for short HVO), were constructed and employed as novel biocatalysts for amplifying tumor oxidative stress and enhancing cancer catalytic therapy. Such HVO nanocatalysts harboring multivalent V element possessed multi-functional catalytic activity in decomposing H2O2 into •OH and depleting endogenous glutathione (GSH) to dually amplify tumor oxidative stress. Meanwhile, HVO nanocatalysts could also be activated by ultrasound to further triply amplify oxidative stress. The massive intracellular ROS caused mitochondrial dysfunction, DNA damage, cell cycle arrest, and cell proliferation inhibition, further realizing cancer cell death and tumor growth inhibition. Collectively, HVO nanocatalysts highlight the remarkable value of ROS-mediated cancer therapies.
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http://dx.doi.org/10.1002/anie.202208849DOI Listing
August 2022

Oxygen-deficient titanium dioxide-loaded black phosphorus nanosheets for synergistic photothermal and sonodynamic cancer therapy.

Biomater Adv 2022 May 9;136:212794. Epub 2022 Apr 9.

Department of Thyroid and Breast Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, PR China; Division of Life Sciences and Medicine, University of Science and Technology of China, Huangshan Road 443, Hefei, Anhui, PR China. Electronic address:

Malignant tumors, particularly those located in deep tissues, have always been a grievous threat to human health. Sonodynamic therapy (SDT) has recently attracted great attention due to deep tissue penetration. However, the lack of effective sonosensitizers and the poor therapeutic efficacy severely limit their wider use. Herein, dual-functionalized black phosphorus nanosheets ([email protected], i.e., PPBP) integrating black oxygen-deficient titanium dioxide particles (B-TiO) were successfully constructed (PPBP-B-TiO) for synergistic photothermal (PTT)/sonodynamic therapy. In these nanocomposites, black titanium dioxide can enhance the separation of electrons (e) and holes (h) due to the oxygen-deficient structure and significantly improves the production of reactive oxygen species (ROS) for SDT, while the BP nanosheets endow the nanocomposites with a higher photothermal conversion capability for photothermal therapy (η = 44.1%) which can prolong the blood circulation and improve the O supply. In vivo experiments prove that PPBP-B-TiO nanocomposites exhibited outstanding tumor inhibition efficacy and excellent biocompatibility. This work provides a prospective platform for combined photothermal/sonodynamic cancer therapy.
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http://dx.doi.org/10.1016/j.bioadv.2022.212794DOI Listing
May 2022

Predicting individual muscle fatigue tolerance by resting-state EEG brain network.

J Neural Eng 2022 Aug 11;19(4). Epub 2022 Aug 11.

The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu 611731, People's Republic of China.

Exercise-induced muscle fatigue is a complex physiological phenomenon involving the central and peripheral nervous systems, and fatigue tolerance varies across individuals. Various studies have emphasized the close relationships between muscle fatigue and the brain. However, the relationships between the resting-state electroencephalogram (rsEEG) brain network and individual muscle fatigue tolerance remain unexplored.Eighteen elite water polo athletes took part in our experiment. Five-minute before- and after-fatigue-exercise rsEEG and fatiguing task (i.e. elbow flexion and extension) electromyography (EMG) data were recorded. Based on the graph theory, we constructed the before- and after-task rsEEG coherence network and compared the network differences between them. Then, the correlation between the before-fatigue rsEEG network properties and the EMG fatigue indexes when a subject cannot keep on exercising anymore was profiled. Finally, a prediction model based on the before-fatigue rsEEG network properties was established to predict fatigue tolerance.. Results of this study revealed the significant differences between the before- and after-exercise rsEEG brain network and found significant high correlations between before-exercise rsEEG network properties in the beta band and individual muscle fatigue tolerance. Finally, an efficient support vector regression (SVR) model based on the before-exercise rsEEG network properties in the beta band was constructed and achieved the accurate prediction of individual fatigue tolerance. Similar results were also revealed on another 30 subject swimmer data set further demonstrating the reliability of predicting fatigue tolerance based on the rsEEG network.Our study investigates the relationship between the rsEEG brain network and individual muscle fatigue tolerance and provides a potential objective physiological biomarker for tolerance prediction and the regulation of muscle fatigue.
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http://dx.doi.org/10.1088/1741-2552/ac8502DOI Listing
August 2022

Long-Term, Low-Level Microwave Radiation Impairs Learning and Memory Synbindin: Molecular Basis and Underlying Mechanism.

Biomed Environ Sci 2022 06;35(6):552-557

State Key Lab of Space Medicine Fundamentals and Application (SMFA), Astronaut Research and Training Center, Beijing 100094, China.

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http://dx.doi.org/10.3967/bes2022.074DOI Listing
June 2022

Biomechanical comparison of the new cross-locking intramedullary nail with tension band wiring for transverse olecranon fractures.

Injury 2022 Jul 8. Epub 2022 Jul 8.

Department of Orthopedics, The Affiliated Hospital of Southwest Medical University, LuZhou, China; Sichuan Provincial Laboratory of Orthopaedic Engineering, LuZhou, China. Electronic address:

Background: In the treatment of transverse olecranon fractures, complicated tension band wiring (TBW) has high rates of re-operations. Besides, plate fixation (PF) and TBW both have large surgical incisions and soft-tissue irritation. Therefore, the new cross-locking intramedullary nail (CIN) with easy handling and minimally invasive features is significantly advantageous. The goal of this study was to biomechanically compare CIN with TBW for fixing transverse olecranon fracture.

Methods: The transverse olecranon fracture models were created with 15 fresh-frozen cadaveric ulnae which were randomly divided into 3 groups: one group for TBW fixation, another for CIN fixation with 1 conical locking screw (CIN-1), and the last for CIN fixation with 3 conical locking screws (CIN-3). The stiffness, cyclic stability, and failure strength of the fixed fracture models were compared after the corresponding experimental tests.

Results: The failure strength of TBW, CIN-1 and CIN-3 were (313.38±27.68) N, (528.56±53.58) N and (871.04±94.95) N. There was a significant difference between them. However, as for dynamic stability and stiffness, CIN-3 was higher and TBW was lower, with no significant differences between the groups.

Conclusion: The biomechanical properties of CIN were superior to those of TBW, and CIN was more stable and solid for fixing transverse olecranon fracture, of which CIN-3 was the strongest.
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http://dx.doi.org/10.1016/j.injury.2022.07.010DOI Listing
July 2022

Bone morphogenetic protein 7 mediates stem cells migration and angiogenesis: therapeutic potential for endogenous pulp regeneration.

Int J Oral Sci 2022 Jul 20;14(1):38. Epub 2022 Jul 20.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Pulp loss is accompanied by the functional impairment of defense, sensory, and nutrition supply. The approach based on endogenous stem cells is a potential strategy for pulp regeneration. However, endogenous stem cell sources, exogenous regenerative signals, and neovascularization are major difficulties for pulp regeneration based on endogenous stem cells. Therefore, the purpose of our research is to seek an effective cytokines delivery strategy and bioactive materials to reestablish an ideal regenerative microenvironment for pulp regeneration. In in vitro study, we investigated the effects of Wnt3a, transforming growth factor-beta 1, and bone morphogenetic protein 7 (BMP7) on human dental pulp stem cells (h-DPSCs) and human umbilical vein endothelial cells. 2D and 3D culture systems based on collagen gel, matrigel, and gelatin methacryloyl were fabricated to evaluate the morphology and viability of h-DPSCs. In in vivo study, an ectopic nude mouse model and an in situ beagle dog model were established to investigate the possibility of pulp regeneration by implanting collagen gel loading BMP7. We concluded that BMP7 promoted the migration and odontogenic differentiation of h-DPSCs and vessel formation. Collagen gel maintained the cell adhesion, cell spreading, and cell viability of h-DPSCs in 2D or 3D culture. The transplantation of collagen gel loading BMP7 induced vascularized pulp-like tissue regeneration in vivo. The injectable approach based on collagen gel loading BMP7 might exert promising therapeutic application in endogenous pulp regeneration.
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http://dx.doi.org/10.1038/s41368-022-00188-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9300630PMC
July 2022

Olfactory Bulb Integrity in Frontotemporal Dementia and Alzheimer's Disease.

J Alzheimers Dis 2022 Jul 11. Epub 2022 Jul 11.

University of Sydney, School of Psychology, Sydney, New South Wales, Australia.

Background: Olfactory dysfunction is highly prevalent in dementia syndromes, including Alzheimer's disease (AD) and frontotemporal dementia (FTD). The structural integrity of the olfactory bulb (OB) is thought to play a critical role in odor detection and identification, but no MRI study has measured OB volume in FTD, or measured OB volume longitudinally in AD.

Objective: To measure OB volume in FTD and AD patients longitudinally using MRI.

Methods: This study measured OB volumes using MRI in patients diagnosed with behavioral-variant FTD (n = 55), semantic dementia (n = 34), progressive non-fluent aphasia (n = 30), AD (n = 50), and healthy age-matched controls (n = 55) at their first visit to a dementia research clinic ('baseline'). Imaging data in patients 12-months later were analyzed where available (n = 84) for longitudinal assessment. Volumes of subcortical and cortical olfactory regions ('olfactory network') were obtained via surface-based morphometry.

Results: Results revealed that in AD and FTD at baseline, OB volumes were similar to controls, whereas volumes of olfactory network regions were significantly reduced in all patient groups except in progressive non-fluent aphasia. Longitudinal data revealed that OB volume became significantly reduced (10-25% volume reduction) in all dementia groups with disease progression.

Conclusion: Olfactory dysfunction is common in patients diagnosed with AD or FTD, but our results indicate that there is no detectable volume loss to the OBs upon first presentation to the clinic. Our findings indicate that the OBs become detectably atrophied later in the disease process. OB atrophy indicates the potential usefulness for OBs to be targeted in interventions to improve olfactory function.
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http://dx.doi.org/10.3233/JAD-220080DOI Listing
July 2022

An anti-inflammatory and neuroprotective biomimetic nanoplatform for repairing spinal cord injury.

Bioact Mater 2022 Dec 2;18:569-582. Epub 2022 Jun 2.

Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, China.

Spinal cord regeneration after a spinal cord injury (SCI) remains a difficult challenge due to the complicated inflammatory microenvironment and neuronal damage at the injury sites. In this study, retinoic acid (RA) and curcumin (Cur) were co-loaded with bovine serum albumin (BSA) self-assembly to obtain [email protected]@Cur nanoparticles (NPs) for SCI treatment. Cur, as an antioxidant drug, facilitated reactive oxygen species (ROS) scavenging, and decreased the amount of inflammatory factors secreted by macrophages, while RA could enhance neurite extensions and neural differentiation. The constructed [email protected]@Cur NPs not only induced polarization of macrophages toward pro-regenerative phenotypes and markedly reduced the inflammatory response of macrophages or microglia, but also increased neurite length in PC12 cells and neuronal differentiation of bone marrow mesenchymal stem cells, improved the differentiation of neural stem cells (NSCs) into β3-tubulin neurons, and reversed the pro-astrocyte differentiation effect of inflammatory cytokines on NSCs. experiments revealed that [email protected]@Cur NPs regulated the phenotypic polarization of macrophages, inhibited the release of inflammatory mediators, promoted functional neuron regeneration and motor function, and further inhibited scar tissue formation. This study highlighted that the BSA-based biomimetic nanomaterials could be used as ROS scavengers and nerve regeneration promoters for treating SCI.
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http://dx.doi.org/10.1016/j.bioactmat.2022.05.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256979PMC
December 2022

Pathologic Findings and Clinical Outcomes in Patients who Required Neoadjuvant Chemotherapy Prior to Orchiectomy for Testicular Germ Cell Tumors.

Hum Pathol 2022 Jul 8. Epub 2022 Jul 8.

Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Urology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

Treatment for testicular germ cell tumors (GCT) includes orchiectomy followed potentially by adjuvant chemotherapy. Rarely, patients with testicular GCT have significant metastatic disease, requiring neoadjuvant chemotherapy prior to orchiectomy. We investigated the pathologic findings and clinical outcomes in patients who underwent neoadjuvant chemotherapy prior to orchiectomy for testicular GCT. We identified 45 patients, mean age of 34 years (range 15-66 years). Orchiectomy findings included pure teratoma (n=23), no residual tumor (n=13), mixed GCT (n=5), pure seminoma (n=2), pure yolk sac tumor (YST) (n=1), and pure germ cell neoplasia in situ (GCNIS) (n=1). Cancer specific death occurred in 4/45 (9%) patients. 17/45 (38%) patients experienced disease progression after initial chemotherapy. 11/45 (24%) patients underwent salvage chemotherapy. Retroperitoneal lymph nodes were the most common site of metastases followed by lung. Overall, the most common type of tumor found in metastases was YST (12/45, 27%) and teratoma (11/45, 24%). Of the 23 patients with residual pure teratoma in the testis, 9/23 (39%) had disease recurrence/progression and 3/23 (13%) died. In the metastases of these patients, non-teratoma GCT was found in 17/23 (74%) patients. 9/45 (20%) patients had residual testicular non-teratoma GCT, of which 6/9 (67%) had disease recurrence/progression and 1/9 (11%) died. Patients with no residual testicular disease (ypT0) had a lower risk of disease recurrence/progression (p=0.046) and had no deaths. In patients who have undergone neoadjuvant chemotherapy for testicular GCT, the orchiectomy histology often does not correlate with histology of metastases. No residual testicular disease indicates a better prognosis in these patients.
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http://dx.doi.org/10.1016/j.humpath.2022.06.026DOI Listing
July 2022

A Bibliometric Analysis of the Association Between Compassion Fatigue and Psychological Resilience From 2008 to 2021.

Front Psychol 2022 22;13:890327. Epub 2022 Jun 22.

Department of Nursing, Universitat Rovira I Virgili, Tarragona, Spain.

Aims: A negative association between the lower level of psychological resilience (PR) and increased risk of compassion fatigue (CF) and higher Coronavirus disease 2019 (COVID-19) stress has been revealed. However, bibliometric studies have not been performed to comprehensively investigate this topic. This study aimed to identify the status and trends in the CF and PR field from 2008 to 2021 and during the COVID-19 pandemic.

Methods: We identified relevant literature from the Web of Science Core Collection database using "resilience" and "compassion fatigue" on September 30, 2021. All search results were exported in plain text format for collaboration network analysis, reference-based co-citation analysis, analysis of journals, and keywords-based co-occurrence analysis, which were performed using Citespace 5.8.R1.

Results: A total of 388 publications were identified finally, and there has been an increasing trend in the annual number of publications with light fluctuations. The analysis of journals and keywords indicated that nurses and social workers are the main research targets, and their mental problems are the main research topics. The turnover intention of health care providers has been a research focus, particularly during the COVID-19.

Conclusion: The results of the present study help us understand the status of the CF and PR field and its recent developments.
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http://dx.doi.org/10.3389/fpsyg.2022.890327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258720PMC
June 2022

GGAECDA: Predicting circRNA-disease associations using graph autoencoder based on graph representation learning.

Comput Biol Chem 2022 Aug 4;99:107722. Epub 2022 Jul 4.

School of Information Science and Engineering, Shandong Normal University, Jinan, China.

Numerous studies have shown that circular RNAs (circRNAs) can serve as ideal disease markers as they are involved in most cellular activities of organisms and are key regulators in various pathological processes. Therefore, the association analysis of circRNAs and diseases can explore the role of circRNAs in diseases and provide help for practical medical research. However, the traditional biotechnology are not convenient for identifying unconfirmed interactions between circRNAs and diseases, which need too many resources and long experimental period. In this work, a new deep learning model is advanced, which is based on graph autoencoder (GAE) constructed with graph attention network (GAT) and random walk with restart (RWR) for predicting circRNA-disease associations (GGAECDA). In detail, GAT is designed to learn the hidden representations of circRNAs and diseases through using low-order neighbor information from circRNA similarity network and disease similarity network respectively, while RWR is employed to learn the latent features of circRNAs and diseases via using high-order neighbor information from the same two networks respectively. After that, these two parts of features of circRNAs and diseases are combined to form new feature representations of circRNAs and diseases respectively. Finally, two GAEs are constructed for co-training to fully integrate information from circRNA space and disease space and calculate potential association prediction scores. Unlike previous models, GGAECDA deeply mines low-dimensional representations from node similarity network through using GAT and RWR. The average AUC value obtained from GGAECDA with a five-fold cross-validation result is 0.9359. Furthermore, case studies demonstrate the ability of GGAECDA to detect potential candidate circRNAs for human diseases. The above results show that the GGAECDA model can be used as a reliable tool to guide subsequent studies on the regulatory functions of circRNAs.
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http://dx.doi.org/10.1016/j.compbiolchem.2022.107722DOI Listing
August 2022

Multivariate Analysis on Development of Lung Adenocarcinoma Lesion from Solitary Pulmonary Nodule.

Contrast Media Mol Imaging 2022 24;2022:8330111. Epub 2022 May 24.

Cardio-Thoracic Surgery, Affiliated Hospital of Nanjing University of Chinese Medicine, 210029 Nanjing, Jiangsu Province, China.

Objective: To analyze multiple factors developing lung adenocarcinoma lesion from solitary pulmonary nodule (SPN).

Methods: A total of 70 patients diagnosed with lung adenocarcinoma after finding SPN by chest CT and treated in our hospital (01, 2018-01, 2021) were selected as the malignant lesion group, and another 70 patients diagnosed with benign lesion after finding SPN by CT in the same period were included in the benign lesion group. All patients had complete medical records. With univariate analysis and multivariate logistic regression, the independent risk factors for developing lung adenocarcinoma lesions from SPN were analyzed.

Results: By conducting univariate analysis of patients' general information (age, course of disease, BMI, nodule diameter, and gender), smoking status (smoking history and number of cigarettes smoked per year), medical history (family history of lung cancer, history of extrapulmonary malignant tumor, and history of autoimmune diseases), basic complications (hypertension and diabetes), and laboratory examinations (CEA, NSE, CYFRA21-1, SCC-Ag, and CA125), it was concluded that age, course of disease, nodule diameter, CEA positive, CYFRA21-1 positive, and CA125 positive were significantly different between the two groups ( < 0.05); the logistic regression results showed that high age, increased nodule diameter, and CYFRA21-1 positive were the independent risk factors developing lung adenocarcinoma from SPN ( < 0.05).

Conclusion: In patients with SPN, higher age, longer course of disease, greater nodule diameter, and CYFRA21-1 positive imply increased risk for triggering lung adenocarcinoma lesion. Therefore, high attention should be paid in the clinic to such SPN patients for early diagnosis and treatment.
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http://dx.doi.org/10.1155/2022/8330111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155859PMC
July 2022

Ultrafast Internal Exciton Dissociation through Edge States in MoS Nanosheets with Diffusion Blocking.

Nano Lett 2022 Jul 5;22(14):5651-5658. Epub 2022 Jul 5.

CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nanoscience and Technology, Beijing 100190, P. R. China.

Edge states of two-dimensional transition-metal dichalcogenides (TMDCs) are crucial to quantum circuits and optoelectronics. However, their dynamics are pivotal but remain unclear due to the edge states being obscured by their bulk counterparts. Herein, we study the state-resolved transient absorption spectra of ball-milling-produced MoS nanosheets with 10 nm lateral size with highly exposed free edges. Electron energy loss spectroscopy and first-principles calculations confirm that the edge states are located in the range from 1.23 to 1.78 eV. Upon above bandgap excitations, excitons populate and diffuse toward the boundary, where the potential gradient blocks excitons and the edge states are formed through interband transitions within 400 fs. With below bandgap excitations, edge states are slowed down to 1.1 ps due to the weakened valence orbital coupling. These results shed light on the fundamental exciton dissociation processes on the boundary of functionalized TMDCs, enabling the ground work for applications in optoelectronics and light-harvesting.
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http://dx.doi.org/10.1021/acs.nanolett.1c04987DOI Listing
July 2022

Liquid exfoliation of VC nanodots as peroxidase-like nanozymes for photothermal-catalytic synergistic antibacterial treatment.

Acta Biomater 2022 Sep 30;149:359-372. Epub 2022 Jun 30.

School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei 230032, China. Electronic address:

Nanozymes are effective antibiotics that use reactive oxygen species (ROS) produced by Fenton/Fenton-like reactions to kill bacteria. However, its activity is still not satisfactory and requires large amounts of hydrogen peroxide (HO) with side effects on normal tissues. Herein, ultrasmall VC nanodots (NDs) are successfully constructed by the liquid-phase exfoliation method for photothermal-catalytic synergistic antibacterial treatment. The prepared VC NDs are horseradish peroxidase (HRP)-like nanozymes that can efficiently catalyze HO to produce a large amount of ROS. Unlike traditional HRP-like nanozymes, VC NDs can have a good catalytic effect under slightly acidic conditions (pH=5.5). Moreover, VC NDs have good near-infrared (NIR) absorption and high photothermal conversion efficiency (PTCE, 50.39%), which can be used for photothermal treatment (PTT) of bacteria. In addition, the mild photothermal effect can further enhance the HRP-like catalytic activity of VC NDs, thereby further enhancing the antibacterial performance of VC NDs. In vitro results show that VC NDs can effectively eradicate Escherichia coli (E. coli, gram-negative) and methicillin-resistant Staphylococcus aureus (MRSA, gram-positive) under laser irradiation and the presence of HO, possessing spectral antibacterial properties. More importantly, VC NDs display satisfactory therapeutic effects on wounds infected by MRSA in vivo, and their toxicity is negligible, suggesting that they may have great potential for application as powerful and safe antibacterial agents. This work presents a practical antibacterial strategy by combining PTT and catalytic therapy to achieve efficient treatment of bacteria-infected wounds. STATEMENT OF SIGNIFICANCE: (1) Ultrasmall VC NDs were prepared by the liquid-phase exfoliation method. (2) VC NDs showed good photothermal, catalytic properties. (3) VC NDs achieved satisfactory photothermal-catalytic synergistic antibacterial treatment.
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http://dx.doi.org/10.1016/j.actbio.2022.06.031DOI Listing
September 2022

Specific Effects of Characteristics of Enriched Environment on Innovative Problem Solving by Animals.

Psychol Sci 2022 Jul 1;33(7):1097-1111. Epub 2022 Jul 1.

School of Psychology, Central China Normal University.

Numerous studies have revealed that an enriched environment can enhance the survival-related behaviors and brain functions of animals. However, the effects and specific roles of the enrichment characteristics on animals' innovative capability, a cognitive ability crucial for survival in nature, are still not well known. In this study, we assigned mice to environment-manipulation groups ( = 15 each) to investigate the specific effects of environmental novelty (novel vs. familiar) and environmental complexity (complex vs. normal) on innovative problem solving and its possible neural mechanisms. Results showed that mice in only the novel-environment group performed better at innovative-problem-solving tasks and showed greater numbers of novel explorations and dopaminergic projections from the ventral tegmental area to the nucleus accumbens in the brain. These findings indicate that an enriched environment has the potential to promote the innovative capability of mice by enhancing their novel exploratory motivation, which depends on the novelty of the environment but not its complexity.
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http://dx.doi.org/10.1177/09567976211070562DOI Listing
July 2022

A brief review of protein-ligand interaction prediction.

Comput Struct Biotechnol J 2022 3;20:2831-2838. Epub 2022 Jun 3.

College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.

The task of identifying protein-ligand interactions (PLIs) plays a prominent role in the field of drug discovery. However, it is infeasible to identify potential PLIs via costly and laborious experiments. There is a need to develop PLI computational prediction approaches to speed up the drug discovery process. In this review, we summarize a brief introduction to various computation-based PLIs. We discuss these approaches, in particular, machine learning-based methods, with illustrations of different emphases based on mainstream trends. Moreover, we analyzed three research dynamics that can be further explored in future studies.
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http://dx.doi.org/10.1016/j.csbj.2022.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189993PMC
June 2022

Boosting the singlet oxygen production from HO activation with highly dispersed Co-N-graphene for pollutant removal.

RSC Adv 2022 Jun 16;12(28):17864-17872. Epub 2022 Jun 16.

School of the Environment and Safety Engineering, Jiangsu University 301 Xuefu Road Zhenjiang 212013 China

Singlet oxygen (O) is a promising reactive species for the selective degradation of organic pollutants. However, it is difficult to generate O from HO activation with high efficiency and selectivity. In this work, a graphene-supported highly dispersed cobalt catalyst with abundant Co-N active sites (Co-N-graphene) was synthesized for activating HO. The Co-N-graphene catalyzed HO reaction system selectively catalyzed O production associated with the superoxide radical (O˙) as the critical intermediate, as proven by scavenger experiments, electron spin resonance (ESR) spin trapping and a kinetic solvent isotope effect study. This resulted in excellent degradation efficiency towards the model organic pollutant methylene blue (MB), with an outstanding pseudo-first-order kinetic rate constant of 0.432 min (g L ) under optimal reaction conditions ( = 400 mM, initial pH = 9). Furthermore, this Co-N-graphene catalyst enabled strong synergy with HCO in accelerating MB degradation, whereas the scavenger experiment implied that the synergy herein differed significantly from the current Co-HCO reaction system, in which contribution of O˙ was only validated with a Co-N-graphene catalyst. Therefore, this work developed a novel catalyst for boosting O production from HO activation and will extend the inventory of catalysts for advanced oxidation processes.
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http://dx.doi.org/10.1039/d2ra02491hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201703PMC
June 2022

Lateral Pterygoid Muscle Ossification After Intraoral Condylectomy.

J Craniofac Surg 2022 Jun 29. Epub 2022 Jun 29.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.

Purpose: Lateral pterygoid muscle ossification has not been reported in condylectomy patients. This study aimed to explore the incidence, risk factors, and imaging characteristics of 38 cases with lateral pterygoid muscle ossification among 54 patients after condylectomy via intraoral approach.

Methods: This retrospective study included 54 patients following simultaneous orthognathic surgery and condylectomy with coronoid process resection via intraoral approach. The authors evaluated the preoperative, 1 week, 6 months, and 1 year or more postoperative computed tomographic (CT) scans for the presence of lateral pterygoid muscle ossification and its characteristics. Sex, age at the time of surgery, disease course, affected side, preoperative alkaline phosphatase, pathology diagnosis, the height of the removed condyle, condylar shape, operator, preoperative temporomandibular joint movement, and clinical symptoms were assessed as risk factors for ossification.

Results: No incidence of lateral pterygoid muscle ossification was found on preoperative CT images. Various small-size osseous masses were observed in the lateral pterygoid muscles on postoperative 6 months CT images in 38/54 patients (70.37%) after condylectomy. But no apparent enlargement of the osseous masses was found. No patients complained of clinical discomfort or functional disorder during the follow-up period (23.11 ± 13.16 months). No significant risk factors for ossification were found.

Conclusions: Lateral pterygoid muscle ossification is relatively common in patients after condylectomy via intraoral approach. However, its enlargement is self-limited and remains stable 6 months after surgery. it has no adverse effects on the temporomandibular joint functional movement.
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http://dx.doi.org/10.1097/SCS.0000000000008666DOI Listing
June 2022

Case-based malaria surveillance and response: implementation of 1-3-7 approach in Jiangsu Province, China.

Adv Parasitol 2022 20;116:1-31. Epub 2022 May 20.

Key Laboratory of National Health Commission (NHC) on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, PR China; Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, PR China. Electronic address:

Following initiation of China's National Malaria Elimination Action Plan (NMEAP) in 2010, China's 1-3-7 surveillance and response approach was developed and rolled out in China to facilitate the malaria control programme and accelerate the progress of malaria elimination. Innovative strategies and interventions have been developed and implemented in Jiangsu Province to facilitate case-based malaria surveillance and response. A total of 9879 malaria cases were reported in Jiangsu Province from 2001 to 2020. Since 2012, no indigenous malaria cases have been reported in Jiangsu Province. However, in recent years, there has been a substantial increase of imported cases from abroad. To continue improving the malaria surveillance and response system, Jiangsu Province has conducted population-based health education to improve the healthcare seeking behaviour of malaria patients, strengthened the capacity of health facilities to improve the performance of malaria diagnosis and treatment, and strengthened health workforce capacity to improve the implementation of 1-3-7 approach. Continually improving surveillance and response system can play a critical role in the early detection and rapid response of individual malaria cases and prevent the re-establishment of malaria.
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http://dx.doi.org/10.1016/bs.apar.2022.04.003DOI Listing
June 2022

A meta-analytic study of the effects of early maternal separation on cognitive flexibility in rodent offspring.

Dev Cogn Neurosci 2022 Aug 16;56:101126. Epub 2022 Jun 16.

School of Psychology, Central China Normal University, Wuhan 430079, China. Electronic address:

Adverse early life experiences, such as maternal separation, are associated with an increased risk for several mental health problems. Symptoms induced by maternal separation that mirror clinically relevant aspects of mental problems, such as cognitive inflexibility, open the possibility of testing putative therapeutics prior to clinical development. Although several animal (e.g., rodent) studies have evaluated the effects of early maternal separation on cognitive flexibility, no consistent conclusions have been drawn. To clarify this issue, in this study, a meta-analysis method was used to systematically explore the relationship between early maternal separation and cognitive flexibility in rodent offspring. Results indicate that early maternal separation could significantly impair cognitive flexibility in rodent offspring. Moderator analyses further showed that the relationship between early maternal separation and cognitive flexibility was not consistent in any case, but was moderated by variations in the experimental procedures, such as the deprivation levels, task characteristics, and rodent strains. These clarify the inconsistent effects of maternal separation on cognitive flexibility in rodents and help us better understand the association between early life adversity and cognitive development.
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http://dx.doi.org/10.1016/j.dcn.2022.101126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243050PMC
August 2022

A Displacement Sensing Method Based on Permanent Magnet and Magnetic Flux Measurement.

Sensors (Basel) 2022 Jun 7;22(12). Epub 2022 Jun 7.

School of Mechanical Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

This paper proposes a displacement sensing method based on magnetic flux measurement. A bridge-structured magnetic circuit, formed by permanent magnets and two ferromagnetic cores, is designed and discussed. The analyses of the equivalent magnetic circuit and three-dimensional finite element simulations showed that the magnetic flux density changes linearly with the reciprocal of the sum of a constant and the displacement. A prototype sensor of the bridge structure is developed that consists of four permanent magnets as excitation, a Hall sensor as reception, and two ferromagnetic cores as the connection. Experiments have validated the feasibility of this method. The measured results show a good linearity between the sensor's output and the reciprocal of the sum of a constant and the displacement, with a correlation coefficient greater than 0.9995 across different measurement ranges. Additionally, the measured results significantly indicate that the proposed sensor is compatible with different ferromagnetic materials with a worst-case error of less than 5%. The proposed sensor has the advantages of low cost and good linearity; however, the test object is limited to ferromagnetic materials.
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http://dx.doi.org/10.3390/s22124326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228415PMC
June 2022

Predicting miRNA-disease associations based on graph attention network with multi-source information.

BMC Bioinformatics 2022 Jun 21;23(1):244. Epub 2022 Jun 21.

College of Computer Science and Electronic Engineering, Hunan University, Changsha, China.

Background: There is a growing body of evidence from biological experiments suggesting that microRNAs (miRNAs) play a significant regulatory role in both diverse cellular activities and pathological processes. Exploring miRNA-disease associations not only can decipher pathogenic mechanisms but also provide treatment solutions for diseases. As it is inefficient to identify undiscovered relationships between diseases and miRNAs using biotechnology, an explosion of computational methods have been advanced. However, the prediction accuracy of existing models is hampered by the sparsity of known association network and single-category feature, which is hard to model the complicated relationships between diseases and miRNAs.

Results: In this study, we advance a new computational framework (GATMDA) to discover unknown miRNA-disease associations based on graph attention network with multi-source information, which effectively fuses linear and non-linear features. In our method, the linear features of diseases and miRNAs are constructed by disease-lncRNA correlation profiles and miRNA-lncRNA correlation profiles, respectively. Then, the graph attention network is employed to extract the non-linear features of diseases and miRNAs by aggregating information of each neighbor with different weights. Finally, the random forest algorithm is applied to infer the disease-miRNA correlation pairs through fusing linear and non-linear features of diseases and miRNAs. As a result, GATMDA achieves impressive performance: an average AUC of 0.9566 with five-fold cross validation, which is superior to other previous models. In addition, case studies conducted on breast cancer, colon cancer and lymphoma indicate that 50, 50 and 48 out of the top fifty prioritized candidates are verified by biological experiments.

Conclusions: The extensive experimental results justify the accuracy and utility of GATMDA and we could anticipate that it may regard as a utility tool for identifying unobserved disease-miRNA relationships.
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http://dx.doi.org/10.1186/s12859-022-04796-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9215044PMC
June 2022

Immunosonodynamic Therapy Designed with Activatable Sonosensitizer and Immune Stimulant Imiquimod.

ACS Nano 2022 Jun 17. Epub 2022 Jun 17.

Department of Chemistry, Korea University, Seoul 02841, Republic of Korea.

Sonodynamic therapy (SDT) has garnered extensive attention as a noninvasive treatment for deep tumors. Furthermore, imiquimod (R837), an FDA-approved toll-like receptor 7 agonist, is commonly used in clinical settings as an immune adjuvant. We prepared an activatable sonodynamic sensitizer platform (MR) based on glutathione-sensitive disulfide bonds linking Leu-MB, the reduced form of methylene blue (MB), and R837 to achieve efficient combinatory SDT and immunotherapy for tumors without harming normal tissues. We also used the amphiphilic polymer CPMH-PEG to create self-assembled MB-R837-PEG (MRP) nanoparticles for immunosonodynamic therapy (iSDT). iSDT is a cancer treatment that combines activatable SDT and immunotherapy. Our iSDT demonstrated an excellent sonodynamic effect only at the tumor site, demonstrating high specificity in killing tumor cells when compared to SDT reported in the literature. The iSDT improves its tumor-killing effect by inducing an immune response, which is accomplished by secreted immune adjuvants in the tumor site. MRP was selectively activated by glutathione in the tumor microenvironment to release MB and R837, exhibiting excellent antitumor sonodynamic and immune responses. In addition, when combined with an α-PD-L1 antibody for immune checkpoint blockade, this therapy effectively inhibited tumor metastasis. Furthermore, mice treated with iSDT and α-PD-L1 antibody did not develop tumors even after tumor reinoculation, indicating that long-term immune memory was achieved. The concept of sonodynamic sensitizer preparation as a next-generation iSDT based on a noninvasive synergistic therapeutic modality applicable in the near future is presented in this study.
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http://dx.doi.org/10.1021/acsnano.2c03395DOI Listing
June 2022

Terahertz wave emission from the trigonal layered PtBi.

iScience 2022 Jul 2;25(7):104511. Epub 2022 Jun 2.

State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu 610054, China.

In this work, broadband terahertz (THz) wave emissions have been detected from the trigonal layered PtBi on the excitation of the femtosecond laser pulses. Such THz generation is found to arise from the dominated linear photogalvanic effect, which is further discovered to strongly depend on the unique electronic structures of PtBi. Furthermore, an effective nonlinear susceptibility of PtBi is also obtained and is nearly two orders of magnitude larger than that of the traditional nonlinear crystal for THz generation.
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http://dx.doi.org/10.1016/j.isci.2022.104511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9204749PMC
July 2022

Morphologic spectrum of treatment-related changes in prostate tissue and prostate cancer: an updated review.

Hum Pathol 2022 Jun 16;127:56-66. Epub 2022 Jun 16.

Department of Pathology, Indiana University, Indianapolis, IN 46202, USA.

A wide range of treatment options are available to patients with prostate cancer. Some treatments are standard (currently used) while some are emerging therapies. Androgen deprivation therapy is typically reserved for localized or metastatic prostate cancer not amenable to surgery. Radiation therapy may be offered to individuals for local therapy with curative intent in low- or intermediate-risk disease that may have a high probability of progression on active surveillance or where surgery is not suitable. Focal therapy/ablation treatment is an alternative approach for those who prefer to avoid radical prostatectomy for localized disease of low- or intermediate-risk or as salvage therapy after failed radiation therapy. Chemotherapy and immunotherapy remain under investigation and are currently used for androgen-independent disease or hormone-refractory prostate cancer; however, a better understanding of therapeutic efficacy is needed. Histopathologic changes observed in benign and malignant prostate tissue induced by hormonal therapies and radiation therapy are well described, whereas treatment-related effects secondary to novel therapies continue to be documented although their clinical significance is not absolutely clear. An informed and accurate evaluation of post-treatment prostate specimens requires pathologists with diagnostic acumen and knowledge relating to the histopathologic spectrum associated with each treatment option. In situations when clinical history is lacking, but morphologic features are suggestive of prior treatment, pathologists are encouraged to consult clinical colleagues regarding prior treatment history including details of when treatment was initiated and duration of therapy. This review aims to provide a concise update of current and emerging therapies for prostate cancer, histologic alterations and recommendations on Gleason grading.
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http://dx.doi.org/10.1016/j.humpath.2022.06.004DOI Listing
June 2022

Biological and clinical perspectives of TERT promoter mutation detection on bladder cancer diagnosis and management.

Hum Pathol 2022 Jun 11. Epub 2022 Jun 11.

Department of Morphological Sciences, University of Cordoba Medical School, Cordoba, E-14004, Spain.

The telomerase reverse transcriptase (TERT) promoter mutations are associated with increased TERT mRNA and TERT protein levels, telomerase activity, and shorter but stable telomere length. TERT promoter mutation is the most common mutation that occurs in approximately 60-80% of patients with bladder cancer. The TERT promoter mutations occur in a wide spectrum of urothelial lesions, including benign urothelial proliferation and tumor-like conditions, benign urothelial tumors, premalignant and putative precursor lesions, urothelial carcinoma and its variants, and nonurothelial malignancies. The prevalence and incidence of TERT promoter mutations in a total of 7259 cases from the urinary tract were systematically reviewed. Different platforms of TERT promoter mutation detection were presented. In this review, we also discussed the significance and clinical implications of TERT promoter mutation detection in urothelial tumorigenesis, surveillance and early detection, diagnosis, differential diagnosis, prognosis, prediction of treatment responses, and clinical outcome. Identification of TERT promoter mutations from urine or plasma cell-free DNA (liquid biopsy) will facilitate bladder cancer screening program and optimal clinical management. A better understanding of TERT promoter mutation and its pathway would open new therapeutic avenues for patients with bladder cancer.
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http://dx.doi.org/10.1016/j.humpath.2022.06.005DOI Listing
June 2022

Mixed epithelial and stromal tumours of the kidney with malignant transformation: a clinicopathological study of four cases.

Pathology 2022 Jun 10. Epub 2022 Jun 10.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Mixed epithelial and stromal tumour of the kidney is a complex benign neoplasm in which malignancy rarely arises. In this study, we report four mixed epithelial and stromal tumours in which sarcoma or carcinoma developed. In the first, a multifocal adenocarcinoma arose and areas of transition from benign to malignant epithelium were observed. Oestrogen and progesterone receptors were diffusely present in the nuclei of the spindle cell stroma of the benign component. The second was a sarcoma in which benign epithelial elements were intermixed. Outside the renal parenchyma, clusters of small benign glands surrounded by oestrogen receptor-positive benign stroma were present, supporting the diagnosis of mixed epithelial and stromal tumour. Fluorescence in situ hybridisation for SYT-SSX translocation and immunohistochemical results, specifically TLE1 -ativity, argued against primary renal synovial sarcoma. The patient died 24 months after surgery. The third tumour consisted of small blue round cells, positive for epithelial membrane antigen, BCL2, CD99, and FLI1. Throughout the tumour, the presence of benign appearing branching tubules in fibromuscular stroma, reactive for smooth muscle actin, desmin and progesterone receptor, supported the diagnosis of mixed epithelial and stromal tumour in which a small round blue cell sarcoma with EWSR1 rearrangement arose. In the fourth tumour, adenocarcinoma with papillary architecture arose in a typical mixed epithelial and stromal tumour. In summary, we present four cases of mixed epithelial and stromal tumour with malignant transformation, two showing carcinomatous and the other two with sarcomatous transformation. Identification of typical benign looking elements and the absence of SYT-SSX translocation are helpful in recognition of this entity.
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http://dx.doi.org/10.1016/j.pathol.2022.03.011DOI Listing
June 2022
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