Publications

Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.
Nucleic Acids Res 2016 Oct 5;44(18):8897-8907. Epub 2016 Aug 5.
Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA Department of Pharmaceutical Chemistry, University of California San Francisco, 600 16th St, MC2280 San Francisco, CA 94158, USA

Insights into the evolution of enzyme substrate promiscuity after the discovery of (βα)₈ isomerase evolutionary intermediates from a diverse metagenome.
BMC Evol Biol 2015 Jun 10;15:107. Epub 2015 Jun 10.
Evolution of Metabolic Diversity, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato - León, CP 36821, Irapuato, México.

Identification and analysis of residues contained on beta --> alpha loops of the dual-substrate (beta alpha)8 phosphoribosyl isomerase A specific for its phosphoribosyl anthranilate isomerase activity.
Protein Sci 2010 Mar;19(3):535-43
Evolution of Metabolic Diversity Laboratory, Laboratorio Nacional de Genómica para la Biodiversidad (Langebio), CINVESTAV-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato-León, Irapuato, C.P. 36822, México.



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