Publications by authors named "Liam P Keegan"

37Publications

The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

Cell Mol Life Sci 2020 May 2;77(9):1793-1810. Epub 2019 Aug 2.

CEITEC, Masaryk University, Kamenice 753/5, Pavilion A35, Brno, 62 500, Czech Republic.

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http://dx.doi.org/10.1007/s00018-019-03251-wDOI Listing
May 2020

ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep.

Biochim Biophys Acta Gene Regul Mech 2019 03 31;1862(3):356-369. Epub 2018 Oct 31.

CEITEC, Masaryk University Brno, Kamenice 753/5, Pavilion A35, Brno CZ-62500, Czech Republic. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18749399183023
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http://dx.doi.org/10.1016/j.bbagrm.2018.10.011DOI Listing
March 2019

ADAR RNA editing in human disease; more to it than meets the I.

Hum Genet 2017 09 14;136(9):1265-1278. Epub 2017 Sep 14.

CEITEC, Masaryk University, Kamenice 753/5, Pavilion A35, Brno, 62 500, Czech Republic.

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http://dx.doi.org/10.1007/s00439-017-1837-0DOI Listing
September 2017

The Epitranscriptome and Innate Immunity.

PLoS Genet 2015 Dec 10;11(12):e1005687. Epub 2015 Dec 10.

CEITEC Masaryk University, Brno, Czech Republic.

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http://dx.doi.org/10.1371/journal.pgen.1005687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675516PMC
December 2015

New Insights into the Biological Role of Mammalian ADARs; the RNA Editing Proteins.

Biomolecules 2015 Sep 30;5(4):2338-62. Epub 2015 Sep 30.

CEITEC-Central European Institute of Technology, Masaryk University, Kamenice 5, Brno 625 00, Czech Republic.

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http://dx.doi.org/10.3390/biom5042338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693238PMC
September 2015

The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.

Cell Rep 2014 Nov 13;9(4):1482-94. Epub 2014 Nov 13.

MRC Human Genetics Unit, IGMM, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK; Department of Molecular Biosciences, Wenner Gren Institute, Stockholm University, 106 91 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542304PMC
November 2014

Conflict RNA modification, host-parasite co-evolution, and the origins of DNA and DNA-binding proteins1.

Biochem Soc Trans 2014 Aug;42(4):1159-67

*Institute of Structural and Molecular Biology, Michael Swann Building, School of Biological Sciences, Kings Buildings, University of Edinburgh, Edinburgh EH9 3JR, U.K.

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http://dx.doi.org/10.1042/BST20140147DOI Listing
August 2014

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster.

Nucleic Acids Res 2014 Jan 16;42(2):1139-51. Epub 2013 Oct 16.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine at the University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, Scotland, UK, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK and Department of Molecular Biosciences, The Wenner Gren Institute, Stockholm University, Svante Arrhenius väg 20C, 106 91 Stockholm, Sweden.

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http://dx.doi.org/10.1093/nar/gkt909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902911PMC
January 2014

Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects.

EMBO J 2011 Aug 16;30(20):4211-22. Epub 2011 Aug 16.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1038/emboj.2011.303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199391PMC
August 2011

Regulation and functions of ADAR in drosophila.

Curr Top Microbiol Immunol 2012 ;353:221-36

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.

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http://dx.doi.org/10.1007/82_2011_152DOI Listing
February 2012

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects.

Nucleic Acids Res 2011 Sep 27;39(16):7249-62. Epub 2011 May 27.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1093/nar/gkr423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167634PMC
September 2011

Laser microdissection and pressure catapulting of single human motor neurons for RNA editing analysis.

Methods Mol Biol 2011 ;718:75-87

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1007/978-1-61779-018-8_4DOI Listing
June 2011

RNA editing by mammalian ADARs.

Adv Genet 2011 ;73:87-120

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1016/B978-0-12-380860-8.00003-3DOI Listing
June 2011

The effect of RNA editing and ADARs on miRNA biogenesis and function.

Adv Exp Med Biol 2010 ;700:76-84

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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June 2011

ADARs have effects beyond RNA editing.

Cell Cycle 2009 Dec 30;8(24):4011-2. Epub 2009 Dec 30.

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http://dx.doi.org/10.4161/cc.8.24.10214DOI Listing
December 2009

Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae).

BMC Genet 2009 Nov 26;10:75. Epub 2009 Nov 26.

Institute of Evolutionary Biology, University of Edinburgh, West Mains Rd, Edinburgh EH9 3JT, UK.

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http://dx.doi.org/10.1186/1471-2156-10-75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790459PMC
November 2009

Editing independent effects of ADARs on the miRNA/siRNA pathways.

EMBO J 2009 Oct 27;28(20):3145-56. Epub 2009 Aug 27.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1038/emboj.2009.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735678PMC
October 2009

Three-dimensional imaging of Drosophila melanogaster.

PLoS One 2007 Sep 5;2(9):e834. Epub 2007 Sep 5.

Medical Research Council Human Genetics Unit, Edinburgh, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000834PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952176PMC
September 2007

Purification and assay of ADAR activity.

Methods Enzymol 2007 ;424:301-17

MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(07)24014-5DOI Listing
September 2007

Drosha versus ADAR: wrangling over pri-miRNA.

Nat Struct Mol Biol 2006 Jan;13(1):3-4

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http://www.nature.com/articles/nsmb0106-3
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http://dx.doi.org/10.1038/nsmb0106-3DOI Listing
January 2006

SUMO-1 modification alters ADAR1 editing activity.

Mol Biol Cell 2005 Nov 24;16(11):5115-26. Epub 2005 Aug 24.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.

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http://dx.doi.org/10.1091/mbc.e05-06-0536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266412PMC
November 2005

Tuning of RNA editing by ADAR is required in Drosophila.

EMBO J 2005 Jun 26;24(12):2183-93. Epub 2005 May 26.

MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.

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http://dx.doi.org/10.1038/sj.emboj.7600691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1150885PMC
June 2005

Purification and assay of recombinant ADAR proteins expressed in the yeast Pichia pastoris or in Escherichia coli.

Methods Mol Biol 2004 ;265:219-38

MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom.

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http://link.springer.com/10.1385/1-59259-775-0:219
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http://dx.doi.org/10.1385/1-59259-775-0:219DOI Listing
July 2004

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes.

Genome Biol 2004 2;5(2):209. Epub 2004 Feb 2.

Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://genomebiology.biomedcentral.com/articles/10.1186/gb-2
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http://dx.doi.org/10.1186/gb-2004-5-2-209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC395743PMC
March 2005

An ADAR that edits transcripts encoding ion channel subunits functions as a dimer.

EMBO J 2003 Jul;22(13):3421-30

MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://dx.doi.org/10.1093/emboj/cdg327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165651PMC
July 2003

Dynamic association of RNA-editing enzymes with the nucleolus.

J Cell Sci 2003 May;116(Pt 9):1805-18

Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.

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http://dx.doi.org/10.1242/jcs.00371DOI Listing
May 2003

Micro-processing events in mRNAs identified by DHPLC analysis.

Nucleic Acids Res 2002 Sep;30(18):3945-53

MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137101PMC
http://dx.doi.org/10.1093/nar/gkf516DOI Listing
September 2002