Lia Gore

Lia Gore

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Lia Gore

Publications by authors named "Lia Gore"

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Safety and activity of ivosidenib in patients with IDH1-mutant advanced cholangiocarcinoma: a phase 1 study.

Lancet Gastroenterol Hepatol 2019 Sep 9;4(9):711-720. Epub 2019 Jul 9.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Medicine, Weill Cornell Medical College, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(19)30189-XDOI Listing
September 2019

Accelerating drug development in pediatric cancer: a novel Phase I study design of venetoclax in relapsed/refractory malignancies.

Future Oncol 2018 Sep 29;14(21):2115-2129. Epub 2018 Mar 29.

Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University & Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.2217/fon-2018-0121DOI Listing
September 2018

Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial.

J Clin Oncol 2018 05 2;36(13):1330-1338. Epub 2018 Mar 2.

Lia Gore, University of Colorado School of Medicine/Children's Hospital Colorado, Aurora, CO; Pamela R. Kearns, University of Birmingham, Birmingham, West Midlands; Donna Lancaster, Royal Marsden Hospital, Sutton, Surrey, United Kingdom; Maria Lucia de Martino Lee, Support Group for Children and Adolescents with Cancer; Carmino Antonio De Souza, University of Campinas, São Paulo, Brazil; Yves Bertrand, L'Institut d'Hématologie et d'Oncologie Pédiatrique, Lyon, France; Nobuko Hijiya, Ann and Robert H. Lurie Children's Hospital of Chicago, and Northwestern University Feinberg School of Medicine, Chicago, IL; Linda C. Stork, Oregon Health & Science University, Portland, OR; Nack-Gyun Chung, The Catholic University of Korea, Seoul St. Mary's Hospital; Jong Jin Seo, University of Ulsan College of Medicine, and Asan Medical Center, Seoul, Republic of Korea; Rocio Cardenas Cardos, Instituto Nacional De Pediatria, Mexico City, Mexico; Tapan Saikia, Prince Aly Khan Hospital, Mumbai, India; Franca Fagioli, Regina Margherita Hospital, Turin, Italy; Judith Landman-Parker, Hôpital Enfants Armand-Trousseau, Paris, France; Andrew E. Place, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA; Karen R. Rabin, Texas Children's Cancer Center, and Baylor College of Medicine, Houston, TX; Mariana Sacchi and Rene Swanink, Bristol-Myers Squibb, Princeton, NJ; C. Michel Zwaan, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands; Pamela R. Kearns and C. Michel Zwaan, Innovative Therapies for Children with Cancer Consortium, European Union.

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http://dx.doi.org/10.1200/JCO.2017.75.9597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929218PMC
May 2018

Agents in Development for Childhood Acute Lymphoblastic Leukemia.

Paediatr Drugs 2018 Apr;20(2):111-120

Center for Cancer and Blood Disorders, Children's Hospital Colorado, Pediatric Hematology/Oncology/Bone Marrow Transplant, University of Colorado School of Medicine, 13123 East 16th Av, Box B115, Aurora, CO, 80045, USA.

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http://dx.doi.org/10.1007/s40272-017-0268-7DOI Listing
April 2018

Long-Term Follow-Up of Desmoid Fibromatosis Treated with PF-03084014, an Oral Gamma Secretase Inhibitor.

Ann Surg Oncol 2018 Mar 8;25(3):768-775. Epub 2017 Sep 8.

Division of Medical Oncology, University of Colorado Denver School of Medicine - Anschutz Medical Campus, Aurora, CO, USA.

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http://dx.doi.org/10.1245/s10434-017-6082-1DOI Listing
March 2018

Modernizing Clinical Trial Eligibility: Recommendations of the American Society of Clinical Oncology-Friends of Cancer Research Minimum Age Working Group.

J Clin Oncol 2017 Nov 2;35(33):3781-3787. Epub 2017 Oct 2.

Lia Gore, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO; S. Percy Ivy, National Cancer Institute, Bethesda; Martha Donoghue and Gregory Reaman, US Food and Drug Administration, Silver Spring, MD; Frank M. Balis, Children's Hospital of Philadelphia, Philadelphia, PA; Eric Rubin, Merck Research Laboratories, Kenilworth, NJ; Katherine Thornton, Dana-Farber Cancer Institute, Boston, MA; Samantha Roberts, Friends of Cancer Research and Genentech; Nancy Goodman, Kids v Cancer, Washington, DC; Suanna Bruinooge and Caroline Schenkel, ASCO, Alexandria, VA; and Jennifer Ersek, Levine Cancer Institute, Charlotte, NC.

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http://ascopubs.org/doi/10.1200/JCO.2017.74.4144
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http://dx.doi.org/10.1200/JCO.2017.74.4144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692725PMC
November 2017

Broadening Eligibility Criteria to Make Clinical Trials More Representative: American Society of Clinical Oncology and Friends of Cancer Research Joint Research Statement.

J Clin Oncol 2017 Nov 2;35(33):3737-3744. Epub 2017 Oct 2.

Edward S. Kim, Levine Cancer Institute, Carolinas HealthCare System, Charlotte, NC; Suanna S. Bruinooge, Caroline Schenkel, and Richard L. Schilsky, ASCO, Alexandria, VA; Samantha Roberts, Marina Kozak, Jeff Allen, and Ellen Sigal, Friends of Cancer Research; Samantha Roberts, Genentech, Washington, DC; Gwynn Ison, Julia A. Beaver, Rajeshwari Sridhara, and Tatiana M. Prowell, US Food and Drug Administration, Silver Spring; Thomas S. Uldrick and Andrea M. Denicoff, National Cancer Institute, Bethesda, MD; Nancy U. Lin, Dana-Farber Cancer Institute, Boston; Paul J. Hesketh, Lahey Health Cancer Institute, Burlington, MA; Lia Gore, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; Stuart M. Lichtman, Memorial Sloan-Kettering Cancer Center, New York, NY; Nancy Roach, Fight Colorectal Cancer, Springfield, MO; Elizabeth Garrett-Mayer, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC; Eric Rubin, Merck Research Laboratories, Kenilworth, NJ; and Pratik Multani, Ignyta, San Diego, CA.

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http://dx.doi.org/10.1200/JCO.2017.73.7916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692724PMC
November 2017

Molecular Analyses Reveal Inflammatory Mediators in the Solid Component and Cyst Fluid of Human Adamantinomatous Craniopharyngioma.

J Neuropathol Exp Neurol 2017 Sep;76(9):779-788

Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Developmental Biology and Cancer Programme, Great Ormond Street UCL Institute of Child Health, London, UK; Department of Neurological Surgery, Columbia University Medical Center, New York, New York; Division of Pediatric Neurosurgery, Department of Neurosurgery, Miami Children's Hospital, University of Miami/Miller School of Medicine, Miami, Florida; Department of Neurosurgery, Stanford University Medical Center, Palo Alto, California; Department of Neurological Surgery, Weill Medical College of Cornell University and Memorial Sloan-Kettering Cancer Center, New York, New York; Department of Neurosurgery, Children's Hospital Alabama, Birmingham, Alabama; Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, Maryland; Department of Pathology; Department of Neurosurgery; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Department of Histopathology, Great Ormond Street Hospital, NHS Trust, London, UK; Morgan Adams Foundation Pediatric Brain Tumor Research Program; Pediatric Neurosurgery, Children's Hospital Colorado; and Adult and Child Center for Health Outcomes Research, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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http://dx.doi.org/10.1093/jnen/nlx061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005018PMC
September 2017

Drug development for rare cancers in children.

Authors:
Lia Gore

Clin Adv Hematol Oncol 2017 Jun;15(6):441-443

University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Center for Cancer and Blood Disorders, Aurora, Colorado.

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June 2017

Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia.

J Clin Oncol 2016 12 31;34(36):4381-4389. Epub 2016 Oct 31.

Arend von Stackelberg, Charité Campus Virchow, Berlin; Gerhard Zugmaier, Amgen Research (Munich), Munich; Rupert Handgretinger, University of Tübingen, Tübingen; Peter Bader, Hospital for Children and Adolescents III, University of Frankfurt, Frankfurt; Paul Gerhardt Schlegel, University Children's Hospital Würzburg, Würzburg; Arndt Borkhardt, University of Düsseldorf Medical Faculty, Düsseldorf, Germany; Franco Locatelli, Ospedale Pediatrico Bambino Gesù, Rome, University of Pavia, Pavia; Carmelo Rizzari, San Gerardo Hospital, University of Milano-Bicocca, Monza; Chiara Messina, Clinica di Oncoematologia Pediatrica, Università degli Studi di Padova, Padova, Italy; Benoît Brethon, Hôpital Robert Debré, Service Hématologie-Immunologie Pédiatrique, Paris; Gérard Michel, Hôpital de la Timone, Marseille, France; Christian M. Zwaan, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands; Tanya M. Trippett, Memorial Sloan Kettering Cancer Center, New York, NY; Maureen M. O'Brien, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Deepa Bhojwani, Children's Hospital of Los Angeles; Kuolung Hu and Min Zhu, Amgen, Thousand Oaks, CA; Susan R. Rheingold, Children's Hospital of Philadelphia, Philadelphia, PA; Todd Michael Cooper, Seattle Children's Hospital, Seattle, WA; Phillip Barnette, Primary Children's Medical Center, Salt Lake City, UT; Steven G. DuBois, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA; Lia Gore, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO; and James A. Whitlock, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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http://ascopubs.org/doi/10.1200/JCO.2016.67.3301
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http://dx.doi.org/10.1200/JCO.2016.67.3301DOI Listing
December 2016

Phase 1 study of dalotuzumab monotherapy and ridaforolimus-dalotuzumab combination therapy in paediatric patients with advanced solid tumours.

Eur J Cancer 2016 07 10;62:9-17. Epub 2016 May 10.

Department of Pediatric and Adolescent Oncology, Gustave Roussy, Univ. Paris-Sud, 114, rue Edouard Vaillant, 94805 Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.03.084DOI Listing
July 2016

Accepting risk in the acceleration of drug development for rare cancers.

Lancet Oncol 2015 Apr;16(4):e190-4

Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S1470-2045(14)71153-2DOI Listing
April 2015

Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma.

Neuro Oncol 2014 Nov 20;16(11):1554-9. Epub 2014 May 20.

The Hospital for Sick Children, Toronto, Ontario, Canada (U.B., S.B., J.G., E.B.); The MD Anderson Cancer Center, Houston, Texas (J.W.); Children's Hospital Colorado, Anschutz Medical Campus, Aurora, Colorado (L.G.); Memorial Sloan Kettering Cancer Center, New York, New York (I.D., S.G.); NYU Langone Medical Center, New York, New York (J.A.); Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine, Chicago, Illinois (S.G.); Sheba Medical Center, Tel Hashomer, Israel (M.Y.); Children's National Medical Center, Washington, DC (R.J.P.); University of Rochester Medical Center, Rochester, New York (D.N.K.); University of Florida, Gainesville, Florida (A.S.); Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland (K.C.); Vanderbilt Children Hospital, Nashville, Tenneessee (J.K.); Alberta Children's Hospital, Calgary, Alberta, Canada (D.S.); YM Biosciences Inc, Mississauga, Ontario, Canada (M.K.).

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http://dx.doi.org/10.1093/neuonc/nou091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201068PMC
November 2014

Phase 1 evaluation of EZN-2208, a polyethylene glycol conjugate of SN38, in children adolescents and young adults with relapsed or refractory solid tumors.

Pediatr Blood Cancer 2014 Oct 24;61(10):1792-7. Epub 2014 Jun 24.

Division of Pediatric Hematology/Oncology, University Hospitals Case Medical Center Rainbow Babies & Children's Hospital, Cleveland, Ohio.

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http://doi.wiley.com/10.1002/pbc.25105
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http://dx.doi.org/10.1002/pbc.25105DOI Listing
October 2014

A phase I study of the human monoclonal anti-NRP1 antibody MNRP1685A in patients with advanced solid tumors.

Invest New Drugs 2014 Aug 7;32(4):653-60. Epub 2014 Mar 7.

University of Colorado School of Medicine and Developmental Therapeutics Program, University of Colorado Cancer Center, Mail Stop 8117, RC1 South, Rm 8123, 12801 E. 17th Avenue, Aurora, CO, 80045, USA,

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http://dx.doi.org/10.1007/s10637-014-0071-zDOI Listing
August 2014

Overview of therapy and strategies for optimizing outcomes in de novo pediatric acute myeloid leukemia.

Paediatr Drugs 2014 Jun;16(3):213-27

Department of Pediatrics, University of Colorado School of Medicine/Anschutz Medical Campus, Aurora, CO, USA.

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http://link.springer.com/10.1007/s40272-014-0067-3
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http://dx.doi.org/10.1007/s40272-014-0067-3DOI Listing
June 2014

Blinatumomab, a Bi-Specific Anti-CD19/CD3 BiTE(®) Antibody for the Treatment of Acute Lymphoblastic Leukemia: Perspectives and Current Pediatric Applications.

Front Oncol 2014 31;4:63. Epub 2014 Mar 31.

The Center for Cancer and Blood Disorders, Children's Hospital Colorado, School of Medicine, University of Colorado Cancer Center , Aurora, CO , USA.

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http://dx.doi.org/10.3389/fonc.2014.00063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978294PMC
June 2014

Pulmonary presentation of relapsed acute myeloid leukemia.

J Pediatr Hematol Oncol 2014 Apr;36(3):228-30

University of Colorado School of Medicine, Denver, CO.

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http://dx.doi.org/10.1097/MPH.0b013e31828e5077DOI Listing
April 2014

A phase I trial of arsenic trioxide chemoradiotherapy for infiltrating astrocytomas of childhood.

Neuro Oncol 2013 Jun 3;15(6):783-7. Epub 2013 Mar 3.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bloomberg 11379, 1800 Orleans St, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1093/neuonc/not021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661102PMC
June 2013

Targeting developmental pathways in children with cancer: what price success?

Lancet Oncol 2013 Feb;14(2):e70-8

Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO 80045, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S14702045127053
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http://dx.doi.org/10.1016/S1470-2045(12)70530-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673778PMC
February 2013

Phase I dose-escalation trial of clofarabine followed by escalating doses of fractionated cyclophosphamide in children with relapsed or refractory acute leukemias.

Pediatr Blood Cancer 2012 Dec 8;59(7):1252-8. Epub 2012 Aug 8.

Kimmel Comprehensive Cancer Center at Johns Hopkins, The Bunting & Blaustein Cancer Research Building, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1002/pbc.24264DOI Listing
December 2012

Phase I combination study of trabectedin and capecitabine in patients with advanced malignancies.

Invest New Drugs 2012 Oct 20;30(5):1942-9. Epub 2011 Sep 20.

University of Colorado Cancer Center, Aurora, CO 80045, USA.

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http://link.springer.com/10.1007/s10637-011-9747-9
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http://dx.doi.org/10.1007/s10637-011-9747-9DOI Listing
October 2012

Vandetanib mediates anti-leukemia activity by multiple mechanisms and interacts synergistically with DNA damaging agents.

Invest New Drugs 2012 Apr 3;30(2):468-79. Epub 2010 Nov 3.

Department of Pediatrics, Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Denver, 13123 East 16th Avenue B-115, Aurora, CO 80045, USA.

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http://link.springer.com/10.1007/s10637-010-9572-6
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http://dx.doi.org/10.1007/s10637-010-9572-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222724PMC
April 2012

Entinostat for treatment of solid tumors and hematologic malignancies.

Expert Opin Investig Drugs 2011 Oct 2;20(10):1455-67. Epub 2011 Sep 2.

Instructor in Pediatrics, The University of Colorado School of Medicine, Department of Pediatrics and Children's Hospital Colorado, Center for Cancer and Blood Disorders, Box B115 TCH, 13123 East 16th Avenue, Aurora, CO 80045, USA.

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http://dx.doi.org/10.1517/13543784.2011.613822DOI Listing
October 2011

Targeting paediatric acute lymphoblastic leukaemia: novel therapies currently in development.

Br J Haematol 2010 Nov 31;151(4):295-311. Epub 2010 Aug 31.

Department of Paediatrics, Section of Haematology, Oncology, and Bone Marrow Transplantation, University of Colorado Denver School of Medicine, Aurora, CO, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08282.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354740PMC
November 2010

Emerging non-transplant-based strategies in treating pediatric non-Hodgkin's lymphoma.

Curr Hematol Malig Rep 2010 Oct;5(4):177-84

Center for Cancer and Blood Disorders, The Children's Hospital, The University of Colorado Cancer Center, Denver, 80045, USA.

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http://dx.doi.org/10.1007/s11899-010-0058-6DOI Listing
October 2010

PARP1 expression in pediatric central nervous system tumors.

Pediatr Blood Cancer 2009 Dec;53(7):1227-30

Department of Pediatrics, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.1002/pbc.22141DOI Listing
December 2009

Small cell undifferentiated variant of hepatoblastoma: adverse clinical and molecular features similar to rhabdoid tumors.

Pediatr Blood Cancer 2009 Mar;52(3):328-34

Department of Hematology/Oncology, Sacred Heart Children's Hospital, Spokane, Washington 99204, USA.

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http://doi.wiley.com/10.1002/pbc.21834
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http://dx.doi.org/10.1002/pbc.21834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946187PMC
March 2009

Aprepitant in adolescent patients for prevention of chemotherapy-induced nausea and vomiting: a randomized, double-blind, placebo-controlled study of efficacy and tolerability.

Pediatr Blood Cancer 2009 Feb;52(2):242-7

Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, Children's Hospital and The University of Colorado Denver, Aurora, Colorado, USA.

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http://dx.doi.org/10.1002/pbc.21811DOI Listing
February 2009

Oncogenic and angiogenic growth factors accumulate during routine storage of apheresis platelet concentrates.

Clin Cancer Res 2008 Jun;14(12):3942-7

Department of Pediatrics, Washington University, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-4824DOI Listing
June 2008

Forodesine treatment and post-transplant graft-versus-host disease in two patients with acute leukemia: facilitation of graft-versus-leukemia effect?

Semin Oncol 2007 Dec;34(6 Suppl 5):S35-9

Section of Hematology/Oncology/BMT, Department of Pediatrics, University of Colorado School of Medicine and The Children's Hospital, Denver, CO, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2007.11.005DOI Listing
December 2007

MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma.

Pediatr Blood Cancer 2007 Apr;48(4):403-7

University of Colorado at Denver and Health Sciences Center and Denver Children's Hospital, Denver, Colorado, USA.

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http://dx.doi.org/10.1002/pbc.20803DOI Listing
April 2007

Dynamic and modern: bringing the ethics of phase I trials up to date.

J Clin Oncol 2006 Nov;24(32):5178-9; author reply 5179-80

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http://ascopubs.org/doi/10.1200/JCO.2006.09.1207
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http://dx.doi.org/10.1200/JCO.2006.09.1207DOI Listing
November 2006

Gefitinib is effective against juvenile pilocytic astrocytoma in vitro.

Pediatr Blood Cancer 2006 Sep;47(3):293-8

University of Colorado at Denver and Health Sciences Center (UCDHSC) and The Children's Hospital, Denver, Colorado.

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http://dx.doi.org/10.1002/pbc.20619DOI Listing
September 2006

Cord blood transplant in childhood ALL.

Pediatr Blood Cancer 2005 Dec;45(7):964-70

The Children's Hospital, Denver, Colorado, USA.

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http://dx.doi.org/10.1002/pbc.20414DOI Listing
December 2005

Long-term survival after intralesional resection and multi-modal therapy of thoracic spine osteosarcoma.

Med Pediatr Oncol 2003 Jun;40(6):400-2

Section of Pediatric Hematology/Oncology, University of Colorado Health Sciences Center, Colorado, USA.

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http://dx.doi.org/10.1002/mpo.10255DOI Listing
June 2003

Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro.

Blood 2002 Jul;100(2):458-66

Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1182/blood-2001-12-0321DOI Listing
July 2002