Li-Huei Tsai

Li-Huei Tsai

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Li-Huei Tsai

Li-Huei Tsai

Publications by authors named "Li-Huei Tsai"

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The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology.

J Exp Med 2019 Aug 17;216(8):1891-1903. Epub 2019 Jun 17.

Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH

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http://dx.doi.org/10.1084/jem.20182238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683996PMC
August 2019

Modeling Alzheimer's disease with iPSC-derived brain cells.

Mol Psychiatry 2019 Aug 7. Epub 2019 Aug 7.

Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41380-019-0468-3DOI Listing
August 2019

Single-cell transcriptomic analysis of Alzheimer's disease.

Nature 2019 Jun 1;570(7761):332-337. Epub 2019 May 1.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1195-2DOI Listing
June 2019

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection.

Neuron 2019 Jun 7;102(5):929-943.e8. Epub 2019 May 7.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2019.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697125PMC
June 2019

The complexity of neuroinflammation at single-cell resolution.

Nat Rev Neurol 2019 May;15(5):249-250

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41582-019-0165-5DOI Listing
May 2019

Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition.

Cell 2019 Apr 14;177(2):256-271.e22. Epub 2019 Mar 14.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.02.014DOI Listing
April 2019

Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease.

Cell Stem Cell 2019 Mar;24(3):347-349

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.02.003DOI Listing
March 2019

S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy.

Transl Psychiatry 2019 01 29;9(1):44. Epub 2019 Jan 29.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

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http://dx.doi.org/10.1038/s41398-019-0388-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351542PMC
January 2019

Examining the Role of HDACs in DNA Double-Strand Break Repair in Neurons.

Methods Mol Biol 2019 ;1983:225-234

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-9434-2_13DOI Listing
January 2019

Elimination of senescent cells prevents neurodegeneration in mice.

Nature 2018 10;562(7728):503-504

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http://dx.doi.org/10.1038/d41586-018-06677-7DOI Listing
October 2018

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory.

ACS Chem Neurosci 2018 09 22;9(9):2262-2273. Epub 2018 Jun 22.

Chemical Neurobiology Laboratory, Center for Genomic Medicine , Massachusetts General Hospital , 185 Cambridge Street , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/acschemneuro.8b00116DOI Listing
September 2018

Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load.

Nat Protoc 2018 08;13(8):1850-1868

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41596-018-0021-xDOI Listing
August 2018

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

Neuron 2018 06 31;98(6):1141-1154.e7. Epub 2018 May 31.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023751PMC
June 2018

A Developmental Switch in Microglial HDAC Function.

Immunity 2018 03;48(3):476-478

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.03.010DOI Listing
March 2018

Glutamate Receptors in Alzheimer's Disease: Mechanisms and Therapies.

Neural Plast 2016 16;2016:8256196. Epub 2016 May 16.

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia.

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http://dx.doi.org/10.1155/2016/8256196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884857PMC
February 2018

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution.

Cell Rep 2017 Oct;21(2):366-380

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642107PMC
October 2017

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes.

PLoS One 2016 13;11(9):e0161969. Epub 2016 Sep 13.

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161969PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021368PMC
August 2017

The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons.

Cell Rep 2017 08;20(6):1319-1334

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.044DOI Listing
August 2017

Molecular biology: Local metabolites linked to memory.

Nature 2017 06 31;546(7658):361-362. Epub 2017 May 31.

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.

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http://dx.doi.org/10.1038/nature22498DOI Listing
June 2017

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.

Cell 2017 Jun;169(6):1029-1041.e16

Media Lab, MIT, Cambridge, MA 02139, USA; McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard University and MIT, Cambridge, MA 02142, USA; Department of Biological Engineering, MIT, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Center for Neurobiological Engineering, MIT, Cambridge, MA 02139, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173058
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http://dx.doi.org/10.1016/j.cell.2017.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520675PMC
June 2017

In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory.

Curr Opin Neurobiol 2017 04 23;43:48-55. Epub 2016 Dec 23.

Picower Institute for Learning and Memory, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 46, Room 4235A, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.conb.2016.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447486PMC
April 2017

MethyLock: DNA Demethylation Is the Epigenetic Key to Axon Regeneration.

Neuron 2017 Apr;94(2):221-223

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Room 4235A, Building 46, 77 Massachusetts Avenue, Cambridge, MA, USA 02139; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Room 4235A, Building 46, 77 Massachusetts Avenue, Cambridge, MA, USA 02139. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.04.006DOI Listing
April 2017

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

Nat Neurosci 2016 11 18;19(11):1497-1505. Epub 2016 Jul 18.

The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5083138PMC
http://dx.doi.org/10.1038/nn.4347DOI Listing
November 2016

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling.

Nat Neurosci 2016 11 3;19(11):1477-1488. Epub 2016 Oct 3.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts USA.

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http://dx.doi.org/10.1038/nn.4400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386887PMC
November 2016

The road to restoring neural circuits for the treatment of Alzheimer's disease.

Nature 2016 11;539(7628):187-196

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature20412DOI Listing
November 2016

The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System.

J Neurosci 2016 11;36(45):11427-11434

Picower Institute for Learning and Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

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http://www.jneurosci.org/content/jneuro/36/45/11427.full.pdf
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http://dx.doi.org/10.1523/JNEUROSCI.2492-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125210PMC
November 2016

Cortical neurons gradually attain a post-mitotic state.

Cell Res 2016 09 21;26(9):1033-47. Epub 2016 Jun 21.

Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 46, Room 4235A, Cambridge, MA 02139, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034108PMC
http://dx.doi.org/10.1038/cr.2016.76DOI Listing
September 2016

The hippocampus grows up.

Nat Neurosci 2016 08;19(9):1190-1

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA, and.

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http://dx.doi.org/10.1038/nn.4368DOI Listing
August 2016

Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology.

Cereb Cortex 2016 07 17;26(7):2937-51. Epub 2015 Jun 17.

Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1093/cercor/bhv032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898661PMC
July 2016

Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells.

Mol Cell Neurosci 2016 06 4;73:13-31. Epub 2015 Dec 4.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA, USA.

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http://dx.doi.org/10.1016/j.mcn.2015.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930170PMC
June 2016

How MicroRNAs Are Involved in Splitting the Mind.

JAMA Psychiatry 2016 Apr;73(4):409-10

Institute of Science and Technology Austria, Klosterneuburg, Austria.

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http://dx.doi.org/10.1001/jamapsychiatry.2015.3144DOI Listing
April 2016

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.

Proc Natl Acad Sci U S A 2016 Apr 24;113(15):4152-7. Epub 2016 Mar 24.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139

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http://dx.doi.org/10.1073/pnas.1521318113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839463PMC
April 2016

Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.

Bioorg Med Chem Lett 2016 Feb 11;26(4):1265-1271. Epub 2016 Jan 11.

Chemical Neurobiology Laboratory, Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1016/j.bmcl.2016.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753070PMC
February 2016

JAKMIP1: Translating the Message for Social Behavior.

Neuron 2015 Dec;88(6):1070-1072

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.12.003DOI Listing
December 2015

The schizophrenia risk gene product miR-137 alters presynaptic plasticity.

Nat Neurosci 2015 Jul 25;18(7):1008-16. Epub 2015 May 25.

1] Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA. [2] Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts, USA. [3] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.4023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506960PMC
July 2015

Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway.

Proc Natl Acad Sci U S A 2015 Jun 20;112(23):7291-6. Epub 2015 May 20.

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 and

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http://dx.doi.org/10.1073/pnas.1415845112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466741PMC
June 2015

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes.

Cell 2015 Jun 4;161(7):1592-605. Epub 2015 Jun 4.

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; The Broad Institute of Harvard and MIT, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886855PMC
June 2015

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

Genes Dev 2015 Mar;29(5):501-12

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA; Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts 02115, USA;

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http://dx.doi.org/10.1101/gad.258483.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358403PMC
March 2015

Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment.

J Neurosci 2015 Feb;35(6):2372-83

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Broad Institute, Cambridge, Massachusetts 02142, and

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http://dx.doi.org/10.1523/JNEUROSCI.0969-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323522PMC
February 2015

Integrative analysis of 111 reference human epigenomes.

Nature 2015 Feb;518(7539):317-30

1] Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, Massachusetts 02139, USA. [2] The Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nature14248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530010PMC
February 2015

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease.

Nature 2015 Feb;518(7539):365-9

1] Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA [2] Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature14252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530583PMC
February 2015

HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex.

Neuroepigenetics 2015 Jan;1:34-40

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.

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http://dx.doi.org/10.1016/j.nepig.2014.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331030PMC
January 2015

Histone deacetylases in memory and cognition.

Sci Signal 2014 Dec 9;7(355):re12. Epub 2014 Dec 9.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1126/scisignal.aaa0069DOI Listing
December 2014

Chromatin regulation of DNA damage repair and genome integrity in the central nervous system.

J Mol Biol 2014 Oct 14;426(20):3376-88. Epub 2014 Aug 14.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2014.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560486PMC
October 2014

On the resilience of remote traumatic memories against exposure therapy-mediated attenuation.

EMBO Rep 2014 Aug 15;15(8):853-61. Epub 2014 Jul 15.

Brain Mind Institute, School of Life Sciences Ecole Polytechnique Fédérale Lausanne (EPFL), Lausanne, Switzerland

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http://dx.doi.org/10.15252/embr.201438913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197042PMC
August 2014

Early remodeling of the neocortex upon episodic memory encoding.

Proc Natl Acad Sci U S A 2014 Aug 28;111(32):11852-7. Epub 2014 Jul 28.

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142; and

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http://dx.doi.org/10.1073/pnas.1408378111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136596PMC
August 2014

Neuronal differentiation: 5-HT6R can do it alone.

Nat Chem Biol 2014 Jul;10(7):488-9

Picower Institute for Learning and Memory and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1557DOI Listing
July 2014

Human induced pluripotent stem cells: now open to discovery.

Cell Stem Cell 2014 Jul;15(1):4-6

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.06.014DOI Listing
July 2014

DNA damage and its links to neurodegeneration.

Neuron 2014 Jul;83(2):266-282

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564444PMC
July 2014

Epigenetic modifications in the nervous system and their impact upon cognitive impairments.

Neuropharmacology 2014 May 1;80:70-82. Epub 2014 Feb 1.

Picower Institute for Learning and Memory, Howard Hughes Medical Institute, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.01.043DOI Listing
May 2014

Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment.

Cell 2014 Apr;157(2):486-498

The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.01.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327772PMC
April 2014

Alzheimer's disease: A protective factor for the ageing brain.

Nature 2014 Mar 19;507(7493):439-40. Epub 2014 Mar 19.

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nature13214DOI Listing
March 2014

Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.

Cell 2014 Jan;156(1-2):261-76

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2013.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986862PMC
January 2014

Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment.

Neurobiol Learn Mem 2013 Oct 11;105:54-62. Epub 2013 Jul 11.

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, United States.

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http://dx.doi.org/10.1016/j.nlm.2013.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775577PMC
October 2013

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.

Nat Neurosci 2013 Oct 15;16(10):1383-91. Epub 2013 Sep 15.

1] Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. [2] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA. [3].

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http://dx.doi.org/10.1038/nn.3514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564396PMC
October 2013

The Top3β way to untangle RNA.

Nat Neurosci 2013 Sep;16(9):1163-4

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http://dx.doi.org/10.1038/nn.3506DOI Listing
September 2013

Tet1 is critical for neuronal activity-regulated gene expression and memory extinction.

Neuron 2013 Sep;79(6):1109-1122

The Picower Institute for Learning and Memory, 77 Massachusetts Avenue, Cambridge, MA, 02139.

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http://dx.doi.org/10.1016/j.neuron.2013.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543319PMC
September 2013

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.

Nat Neurosci 2013 Aug 14;16(8):1008-15. Epub 2013 Jul 14.

Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.3460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758134PMC
August 2013

The potential of HDAC inhibitors as cognitive enhancers.

Annu Rev Pharmacol Toxicol 2013 ;53:311-30

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1146/annurev-pharmtox-011112-140216DOI Listing
July 2013

Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models.

J Biol Chem 2013 Jul 4;288(30):22042-56. Epub 2013 Jun 4.

Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, California 93106, USA.

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http://dx.doi.org/10.1074/jbc.M112.436402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724657PMC
July 2013

A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration.

J Neurosci 2013 May;33(21):8951-60

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5657-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775567PMC
May 2013

Histone acetylation: molecular mnemonics on the chromatin.

Nat Rev Neurosci 2013 Feb 17;14(2):97-111. Epub 2013 Jan 17.

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/nrn3427DOI Listing
February 2013

A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors.

J Biomol Screen 2012 Oct 24;17(9):1252-63. Epub 2012 Aug 24.

Center for Human Genetic Research, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1177/1087057112456876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903585PMC
October 2012

Cognitive function in health and disease: the role of epigenetic mechanisms.

Neurodegener Dis 2012 1;10(1-4):191-4. Epub 2012 Feb 1.

Picower Institute for Learning and Memory, Cambridge, Mass, USA.

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http://dx.doi.org/10.1159/000334602DOI Listing
August 2012

MicroRNAs in learning, memory, and neurological diseases.

Learn Mem 2012 Aug 16;19(9):359-68. Epub 2012 Aug 16.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1101/lm.026492.112DOI Listing
August 2012

Regulation of N-type voltage-gated calcium channels and presynaptic function by cyclin-dependent kinase 5.

Neuron 2012 Aug;75(4):675-87

The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.neuron.2012.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428598PMC
August 2012

DNA methylation in cognition comes of age.

Nat Neurosci 2012 Jul 26;15(8):1061-2. Epub 2012 Jul 26.

Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.3169DOI Listing
July 2012

Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

J Gerontol A Biol Sci Med Sci 2012 Jun 20;67(7):741-6. Epub 2012 Apr 20.

Neuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, USA.

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http://dx.doi.org/10.1093/gerona/gls110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009730PMC
June 2012

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

Nat Neurosci 2012 Jun 10;15(7):1022-31. Epub 2012 Jun 10.

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nn.3141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017029PMC
June 2012

Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice.

Conf Proc IEEE Eng Med Biol Soc 2011 ;2011:7529-32

Department of Brain and Cognitive Science Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1109/IEMBS.2011.6091856DOI Listing
May 2012

Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.

PLoS One 2011 30;6(9):e25735. Epub 2011 Sep 30.

Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025735PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184170PMC
March 2012

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts.

Cell Stem Cell 2011 Nov 20;9(5):413-9. Epub 2011 Oct 20.

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.stem.2011.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210333PMC
November 2011

Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1).

J Neurosci 2011 Nov;31(44):15751-6

Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.3588-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248793PMC
November 2011

Axon selection: From a polarized cytoplasm to a migrating neuron.

Commun Integr Biol 2011 May 1;4(3):304-7. Epub 2011 May 1.

Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory; Massachusetts Institute of Technology; Cambridge, MA USA.

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http://dx.doi.org/10.4161/cib.4.3.14781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3187892PMC
May 2011