Publications by authors named "Li Jin"

4,410 Publications

  • Page 1 of 1

Refractive Index and Temperature Sensing Performance of Microfiber Modified by UV Glue Distributed Nanoparticles.

Polymers (Basel) 2022 Jun 15;14(12). Epub 2022 Jun 15.

Shaanxi Engineering Research Center of Controllable Neutron Source, School of Electronic Information, Xijing University, Xi'an 710123, China.

Dielectric materials with high refractive index have been widely studied to develop novel photonic devices for modulating optical signals. In this paper, the microfibers were modified by silicon nanoparticles (NPs) and silver NPs mixed in UV glue with ultra-low refractive index, respectively, whose corresponding optical and sensing properties have been studied and compared. The influence from either the morphological parameters of microfiber or the concentration of NPs on the refractive index sensing performance of microfiber has been investigated. The refractive index sensitivities for the microfiber tapers elaborated with silver NPs and silicon NPs were experimentally demonstrated to be 1382.3 nm/RIU and 1769.7 nm/RIU, respectively. Furthermore, the proposed microfiber was encapsulated in one cut of capillary to develop a miniature temperature probe, whose sensitivity was determined as 2.08 nm/°C, ranging from 28 °C to 43 °C.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/polym14122425DOI Listing
June 2022

Maternal High-Fat Diet Aggravates Allergic Asthma in Offspring via Modulating CD4 T-Cell Differentiation.

Nutrients 2022 Jun 16;14(12). Epub 2022 Jun 16.

Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai 200011, China.

Maternal improper nutrition has been reported to trigger respiratory disorders in offspring. Here, we characterized the effects of high-fat environment in the fetal period on mice and human cord blood CD4 T-lymphocytes, and investigated their roles in susceptibility to asthma. Mice born to mothers that consumed a high-fat diet (HFD) throughout the gestation period were sensitized by ovalbumin to establish an experimental asthma model. To further extrapolate to humans, we collected cord blood from neonates of hypercholesterolemic (HC) mothers ( = 18) and control mothers ( = 20). In mice, aggravated airway hyperresponsiveness and inflammation revealed that maternal high-fat diet could lead to exacerbated allergic asthma in adult offspring. It was partially due to augmented activation and proliferation of CD4 T-cells, where upregulated mRNA levels may be potentially involved. Notably, naïve HFD CD4 T-cells had enhanced T2-based immune response both in vivo and in vitro, resulting from DNA hypomethylation of the promoter region. Moreover, in human, T2 cytokines transcripts were enhanced in CD4 T-cells of the HC group, which was associated with an increased risk of developing allergic diseases at 3 years old. Together, our study indicated that early life improper nutrition-triggered epigenetic changes in T-cells may contribute to long-lasting alterations in allergic diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu14122508DOI Listing
June 2022

A Highly Efficient Bismuth Nitrate/Keto-ABNO Catalyst System for Aerobic Oxidation of Alcohols to Carbonyl Compounds under Mild Conditions.

Molecules 2022 Jun 9;27(12). Epub 2022 Jun 9.

National & Local Joint Engineering Research Center for Mineral Salt Deep Utilization, Huaiyin Institute of Technology, Huaian 223003, China.

An efficient and practical catalytic system for the oxidation of alcohols to aldehydes/ketones using catalytic amounts of Bi(NO) and Keto-ABNO (9-azabicyclo [3.3.1]nonan-3-one -oxyl) with air as the environmentally benign oxidant was developed. Various primary and secondary alcohols were smoothly oxidized to the corresponding products under mild conditions, and satisfactory yields were achieved. Moreover, this methodology avoids the use of a ligand and base. The gram-scale reaction was demonstrated for the oxidation of 1-phenyl ethanol, and the product of acetophenone was obtained at an isolated yield of about 94%.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules27123727DOI Listing
June 2022

Effect of Sulfur Content in Sulfate-Rich Copper Tailings on the Properties of MgO-Activated Slag Materials.

Materials (Basel) 2022 Jun 20;15(12). Epub 2022 Jun 20.

School of Civil Engineering and Architecture, Anhui University of Science and Technology, Huainan 232001, China.

The high-value utilization of sulfate-rich tailings (SRCTs) can accelerate their mass consumption, so the many problems caused by the massive accumulation of SRCTs can be alleviated, such as environmental pollution, land occupation, security risk, etc. This study proposes using SRCTs to replace fine natural aggregates in MgO-activated slag materials (MASMs) and investigate the influence of the sulfur content in SRCTs on the properties of MASMs. The experimental results showed that the 28 d compressive strength of MASM mortars was increased by up to 83% using SRCT composites. Two major mechanisms were discovered: additional hydration product formation and pore structure refinement. The results of XRD suggested that incorporating SRCT composite into MASMs increased the production of expansive sulfate-containing hydration products, such as ettringite, gypsum, and hydroxyl-Afm. The results of element mapping showed that the oxidation of pyrite in SRCTs could release sulfates into the surrounding area and participate in the hydration of MASM, indicating that SRCTs can work as an auxiliary activator for MASMs. Furthermore, the addition of SRCT significantly refined the pore structure of MASMs, leading to the reduction in porosity by up to 37.77%. These findings confirm a synergistic effect on activating the slag between SRCTs and MgO, promoting the mass utilization of SRCTs. As a result, the additional expansive hydration products contribute to the enhanced compressive strength and refined pore structure.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma15124340DOI Listing
June 2022

Study on Toughening and Temperature Sensitivity of Polyurethane Cement (PUC).

Materials (Basel) 2022 Jun 18;15(12). Epub 2022 Jun 18.

School of Civil Engineering, Shandong University, Jinan 250061, China.

Polyurethane cement (PUC) is now commonly used in the reinforcement of old bridges, which exhibit various issues such as poor toughness, temperature-sensitive mechanical properties, and brittle failure. These problems can lead to the failure of the reinforcement effect of the PUC on old bridges in certain operating environments, leading to the collapse of such reinforced bridges. In order to alleviate these shortcomings, in this study, the toughness of PUC is improved by adding polyvinyl alcohol (PVA) fiber, carbon fiber, and steel fiber. In addition, we study the change law of the flexural strength of PUC between -40 °C and +40 °C. The control parameters evaluated are fiber type, fiber volume ratio, and temperature. A series of flexural tests and scanning electron microscope (SEM) test results show that the flexural strength first increases and then decreases with the increase in the volume-doping ratio of the three fibers. The optimum volume-mixing ratios of polyvinyl alcohol (PVA) fiber, carbon fiber, and steel fiber are 0.3%, 0.04% and 1%, respectively. Excessive addition of fiber will affect the operability and will adversely affect the mechanical properties. The flexural strength of both fiber-reinforced and control samples decreases with increasing temperature. Using the flexural test results, a two-factor (fiber content, temperature) BP neural network flexural strength prediction model is established. It is verified that the model is effective and accurate, and the experimental value and the predicted value are in good agreement.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma15124318DOI Listing
June 2022

Nonlinear Modeling Study of Aerodynamic Characteristics of an X38-like Vehicle at Strong Viscous Interaction Regions.

Entropy (Basel) 2022 Jun 17;24(6). Epub 2022 Jun 17.

Computational Aerodynamics Institute, China Aerodynamics Research and Development Center, Mianyang 621000, China.

Strong viscous interaction and multiple flow regimes exist when vehicles fly at high altitude and high Mach number conditions. The Navier-Stokes(NS) solver is no longer applicable in the above situation. Instead, the direct simulation Monte Carlo (DSMC) method or Boltzmann model equation solvers are usually needed. However, they are computationally more expensive than the NS solver. Therefore, it is of great engineering value to establish the aerodynamic prediction model of vehicles at high altitude and high Mach number conditions. In this paper, the hypersonic aerodynamic characteristics of an X38-like vehicle in typical conditions from 70 km to 110 km are simulated using the unified gas kinetic scheme (UGKS), which is applicable for all flow regimes. The contributions of pressure and viscous stress on the force coefficients are analyzed. The viscous interaction parameters, Mach number, and angle of attack are used as independent variables, and the difference between the force coefficients calculated by UGKS and the Euler solver is used as a dependent variable to establish a nonlinear viscous interaction model between them in the range of 70-110 km. The evaluation of the model is completed using the correlation coefficient and the relative orthogonal distance. The conventional viscous interaction effect and rarefied effect are both taken into account in the model. The model can be used to quickly obtain the hypersonic aerodynamic characteristics of X38-like vehicle in a wide range, which is meaningful for engineering design.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/e24060836DOI Listing
June 2022

CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity.

Signal Transduct Target Ther 2022 Jun 24;7(1):190. Epub 2022 Jun 24.

State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences & Human Phenome Institute, Fudan University, Shanghai, 200438, China.

Long-term use of antipsychotics is a common cause of myocardial injury and even sudden cardiac deaths that often lead to drug withdrawn or discontinuation. Mechanisms underlying antipsychotics cardiotoxicity remain largely unknown. Herein we performed RNA sequencing and found that NLRP3 inflammasome-mediated pyroptosis contributed predominantly to multiple antipsychotics cardiotoxicity. Pyroptosis-based small-molecule compound screen identified cannabinoid receptor 1 (CB1R) as an upstream regulator of the NLRP3 inflammasome. Mechanistically, antipsychotics competitively bond to the CB1R and led to CB1R translocation to the cytoplasm, where CB1R directly interacted with NLRP3 inflammasome via amino acid residues 177-209, rendering stabilization of the inflammasome. Knockout of Cb1r significantly alleviated antipsychotic-induced cardiomyocyte pyroptosis and cardiotoxicity. Multi-organ-based investigation revealed no additional toxicity of newer CB1R antagonists. In authentic human cases, the expression of CB1R and NLRP3 inflammasome positively correlated with antipsychotics-induced cardiotoxicity. These results suggest that CB1R is a potent regulator of the NLRP3 inflammsome-mediated pyroptosis and small-molecule inhibitors targeting the CB1R/NLRP3 signaling represent attractive approaches to rescue cardiac side effects of antipsychotics.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41392-022-01018-7DOI Listing
June 2022

Robust, Healable, Self-Locomotive Integrated Robots Enabled by Noncovalent Assembled Gradient Nanostructure.

Nano Lett 2022 Jun 22. Epub 2022 Jun 22.

State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China.

Integration, being lightweight, and intelligence are important orientations for the future advancement of soft robots. However, existing soft robots are generally hydrogels or silicone rubber, which are inherently mechanically inferior and easily damaged and difficult to integrate functions. Here, inspired by nacre, an elastomer actuator with sulfonated graphene-based gradient nanostructures is constructed via supramolecular multiscale assembly. The resulting nanocomposite possesses an ultrahigh toughness of 141.19 MJ/m and high room-temperature self-healing efficiency (89%). The proof-of-concept robot is demonstrated to emphasize its maximum swimming speed of 2.67 body length per second, whose speed is comparable to that of plankton, representing the outperformance of most artificial soft robots. Furthermore, the robot can stably absorb pollutants and recover its robustness and functionality even when damaged. This study breaks the mutual exclusivity of functional execution and fast locomotions, and we anticipate that our nanostructural design will offer an effective extended path to other integrated robots that required multifunction integration.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.nanolett.2c01375DOI Listing
June 2022

[Characterization of greenhouse gas emissions and stable isotopic composition of ammonia during industrial composting process].

Ying Yong Sheng Tai Xue Bao 2022 Jun;33(6):1451-1458

Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China.

Carbon dioxide (CO), nitrous oxide (NO), methane (CH) and ammonia (NH) emitted during the composting of livestock and poultry waste are important gaseous atmospheric pollutants. However, most previous studies on compost-related anthropogenic emissions of these gases were based on small reactor composting. Our understanding of their emissions during industrial composting remains extremely limited. In order to explore the influence of gas produced by industrial composting on regional environment, we monitored CO, CH, NO and NH emissions during industrial composting for 19 days and characterized the isotopic composition of emitted NH. On average, the emission rates of CO, CH, NO, and NH during the composting cycle were 86.8 g CO-C·d·m, 9.8 g CH-C·d·m, 3.7 mg NO-N·d·m and 736.6 mg NH-N·d·m, respectively. The contribution of CH to daily global warming potential (GWP) was the highest (65%), followed by CO, NH(indirect), and NO. Moreover, ammonia emitted from industrial compost had a mean δN value of -11.6‰±1.2‰ (range: -21.8‰--7.2‰). Overall, this study provided useful information for understanding greenhouse gas emission dynamics and characterizing atmospheric NH sources during composting process in livestock and poultry breeding areas.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.13287/j.1001-9332.202206.009DOI Listing
June 2022

Development of a novel signature derived from single cell RNA-sequencing for preoperative prediction of lymph node metastasis in head and neck squamous cell carcinoma.

Head Neck 2022 Jun 21. Epub 2022 Jun 21.

Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, Nanjing Medical University, Nanjing, China.

Background: Lymph node metastasis (LNM) is considered as an adverse prognostic indicator for cancer patients. Preoperative knowledge of LNM is valuable for pretreatment decision making. Here, we sought to develop and validate an LNM signature for preoperative prediction of LNM in patients with head and neck squamous cell carcinoma (HNSCC).

Methods: By studying single cell RNA-sequencing data (scRNA-seq), differentially expressed mRNA were selected and analyzed through univariate logistic regression and least absolute shrinkage and selection operator (LASSO) to identify an LNM signature. Multivariate logistic regression was utilized to establish an LNM nomogram incorporating LNM signature and T-classification.

Results: The LNM signature was significantly associated with lymph node status and prognosis. The LNM signature and LNM nomogram displayed a robust predictive effect.

Conclusion: Our study reveals that LNM signature is a powerful biomarker for preoperative prediction of LNM in patients with HNSCC, which may be effective to realize individualized outcome prediction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/hed.27126DOI Listing
June 2022

[Synthesis, characterization, and immunological activity of Rehmannia glutinosa seleno-polysaccharides].

Zhongguo Zhong Yao Za Zhi 2022 Jun;47(11):2938-2946

School of Traditional Chinese Pharmacy, China Pharmaceutical University Nanjing 211198, China.

The present study explored the optimum synthesis process of Rehmannia glutinosa seleno-polysaccharides with acetic acid as a catalyst, characterized the structure of R. glutinosa seleno-polysaccharides by Fourier transform infrared spectroscopy(FT-IR), scanning electron microscopy(SEM), thermogravimetry(TG), and atomic force microscopy(AFM), and preliminarily investigated the immunological activity of R. glutinosa seleno-polysaccharides. The results showed that the optimal conditions for the synthesis of R. glutinosa seleno-polysaccharides included m(acetic acid)∶m(R. glutinosa polysaccharides)=0.80, m(Na_2SeO_3)∶m(R. glutinosa polysaccharides)=1.25, reaction temperature of 80.0 ℃, and reaction time of 7.0 h. Under these conditions, the selenium content of R. glutinosa seleno-polysaccharides was 2.239 mg·g~(-1). The acetic acid catalysis method was milder than the nitric acid method, without affecting the structure of polysaccharides. The results of IR, SEM, TG, and AFM showed that R. glutinosa seleno-polysaccharides were properly prepared. The results of immunological activity showed that compared with the control group, R. glutinosa seleno-polysaccharides could significantly promote the phagocytic capacity of mouse monocyte macrophages and improve the spleen index and thymus index of mice. In the concentration range of 15-240 μg·mL~(-1), the proliferation of spleen lymphocytes of mice was strengthened, and the IL-2 and IFN-γ secretion by Th1 cytokines was promoted. This study can provide references for the further development and application of R. glutinosa polysaccharides.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.19540/j.cnki.cjcmm.20220224.304DOI Listing
June 2022

Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of China.

Front Med (Lausanne) 2022 31;9:816012. Epub 2022 May 31.

Department of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, China.

Objectives: To report the first series of testicular sex cord-stromal tumors (TSCSTs) with detailed clinicopathologic findings and long-term follow-up in the Chinese population.

Patients And Methods: From 2008 to 2018, 15 patients with TSCST were included in our study. The tumors were analyzed for epidemiological parameters, clinical characteristics, tumor markers, therapy, and follow-up data.

Results: The median age of the patients was 28 years (range, 13-80 years). Para-aortic lymph node metastases were detected in 2 patients after radiological evaluation. Orchiectomy was performed in all patients, and the median diameter of the tumor was 1.5 cm (range, 0.5-5.0 cm). Nine Leydig cell tumors (LCTs), 5 Sertoli cell tumors (SCTs), and 1 unclassified type were confirmed after pathologic evaluation. Thirteen patients (86.7%) were categorized as stage I, and 2 patients (13.3%) were categorized as stage II. The median clinical follow-up was 39.0 months (range, 5-97 months), which showed 10 alive patients, such as 1 patient with progression at 40 months after orchiectomy. The 3- and 5-year progression-free survivals were 100 and 90.0%, respectively.

Conclusion: Testicular sex cord-stromal tumor at stages I and II is a rare subtype with benign behavior and a favorable prognosis in the Chinese population. However, lymph node metastases may be the dominant risk factor for patients with TSCST.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2022.816012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197338PMC
May 2022

Erratum: Overexpression of TC2N is associated with poor prognosis in gastric cancer: Erratum.

J Cancer 2022 25;13(8):2413. Epub 2022 Apr 25.

Department of Gastrointestinal Surgery, the First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou 510080, China.

[This corrects the article DOI: 10.7150/jca.50653.].
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.7150/jca.73345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174853PMC
April 2022

Improved polar-code-based efficient post-processing algorithm for quantum key distribution.

Sci Rep 2022 Jun 16;12(1):10155. Epub 2022 Jun 16.

School of Computer Science and Technology, Harbin Institute of Technology, Shenzhen, Shenzhen, 518055, China.

Combined with one-time pad encryption scheme, quantum key distribution guarantees the unconditional security of communication in theory. However, error correction and privacy amplification in the post-processing phase of quantum key distribution result in high time delay, which limits the final secret key generation rate and the practicability of quantum key distribution systems. To alleviate this limitation, this paper proposes an efficient post-processing algorithm based on polar codes for quantum key distribution. In this algorithm, by analyzing the channel capacity of the main channel and the wiretap channel respectively under the Wyner's wiretap channel model, we design a codeword structure of polar codes, so that the error correction and privacy amplification could be completed synchronously in a single step. Through combining error correction and privacy amplification into one single step, this efficient post-processing algorithm reduces complexity of the system and lower the post-processing delay. Besides, the reliable and secure communicaiton conditions for this algorithm has been given in this paper. Simulation results show that this post-processing algorithm satisfies the reliable and secure communication conditions well.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-022-14145-6DOI Listing
June 2022

Cold-Adaptive Evolution at the Reproductive Stage in Geng/Japonica Subspecies Reveals the role of OsMAPK3 and OsLEA9.

Plant J 2022 Jun 15. Epub 2022 Jun 15.

State Key Laboratory of Agrobiotechnology/Beijing Key Laboratory of Crop Genetic Improvement, College of Agronomy and Biotechnology, China Agricultural University, Beijing, 100193, China.

Cold stress at the reproductive stage severely affects production and geographic distribution of rice. The Geng/japonica subpopulation gradually developed stronger cold adaptation than the Xian/indica subpopulation during the long-term domestication of cultivated rice. However, the evolutionary path and natural alleles underlying the cold adaptability of intra-Geng subspecies remain largely unknown. Here, we identified MITOGEN-ACTIVATED PROTEIN KINASE 3 (OsMAPK3) and LATE EMBRYOGENESIS ABUNDANT PROTEIN 9 (OsLEA9) as two important regulators for cold adaptation of Geng subspecies from a combination of transcriptome analysis and genome-wide association study. Transgenic validation showed that OsMAPK3 and OsLEA9 confer cold tolerance at the reproductive stage. Selection and evolution analysis suggested that the Geng version of OsMAPK3 (OsMAPK3 ) directly evolved from Chinese O. rufipogon III and was largely retained in high-latitude and high-altitude regions with low temperatures during domestication. Later, the functional nucleotide polymorphism (FNP-776) in the KMXBG & LJXHG version of OsLEA9 (OsLEA9 ) promoter originated from novel variation of intra-Geng was selected and predominantly retained in temperate Geng to improve the adaptation of Geng together with OsMAPK3 to colder climatic conditions in high-latitude areas. Breeding potential analysis suggested that pyramiding of OsMAPK3 and OsLEA9 enhanced the cold tolerance of Geng and promote the expansion of cultivated rice to colder regions. This study not only highlights the evolutionary path taken by the cold-adaptive differentiation of intra-Geng, but also provides new genetic resources for rice molecular breeding in low-temperature areas.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/tpj.15870DOI Listing
June 2022

Maturation of induced pluripotent stem cell-derived cardiomyocytes and its therapeutic effect on myocardial infarction in mouse.

Bioact Mater 2023 Feb 4;20:286-305. Epub 2022 Jun 4.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China.

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have an irreplaceable role in the treatment of myocardial infarction (MI), which can be injected into the transplanted area with new cardiomyocytes (Cardiomyocytes, CMs), and improve myocardial function. However, the immaturity of the structure and function of iPSC-CMs is the main bottleneck at present. Since collagen participates in the formation of extracellular matrix (ECM), we synthesized nano colloidal gelatin (Gel) with collagen as the main component, and confirmed that the biomaterial has good biocompatibility and is suitable for cellular in vitro growth. Subsequently, we combined the PI3K/AKT/mTOR pathway inhibitor BEZ-235 with Gel and found that the two combined increased the sarcomere length and action potential amplitude (APA) of iPSC-CMs, and improved the Ca processing ability, the maturation of mitochondrial morphological structure and metabolic function. Not only that, Gel can also prolong the retention rate of iPSC-CMs in the myocardium and increase the expression of Cx43 and angiogenesis in the transplanted area of mature iPSC-CMs, which also provides a reliable basis for the subsequent treatment of mature iPSC-CMs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bioactmat.2022.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167678PMC
February 2023

Pharmacokinetics and pharmacodynamic interaction of bergamottin with atorvastatin in rats.

Xenobiotica 2022 Jun 14:1-9. Epub 2022 Jun 14.

Department of Pharmacy, Huabei Petroleum Administration Bureau General Hospital, Cangzhou, Hebei 062552, China.

1. The pharmacokinetics and pharmacodynamic of concomitant administration of atorvastatin with bergamottin were investigated perspectives to reveal the potential herb-drug interaction between these two drugs.2. The hyperlipidemia-induced Wistar rats received atorvastatin with or without bergamottin (2.5 mg/kg). The concentration of atorvastatin in the rats' serum was determined using an established HPLC/MS/MS method. The pharmacokinetic parameters were calculated using DAS software. Lipid levels were determined.3. Bergamottin increases the C (from 48 ± 5 ng/mL to 89 ± 7 ng/mL), AUC ( from 176 ± 27 to 552 ± 131 h∗μg/L), and the elimination half-life of atorvastatin (t)of atorvastatin. Co-administration of atorvastatin with bergamottin decreased total cholesterol (by 14%), low-density lipoproteins-cholesterol (by 20%), and triglyceride (by 12%), but increased thigh-density lipoprotein-cholesterol, when compared with atorvastatin alone.4. Co-administration of bergamottin and atorvastatin alters both pharmacokinetics and pharmacodynamics of atorvastatin. This study provides pre-clinical information evidence that bergamottin could potentiate the therapeutic efficacy of atorvastatin or increase its accumulation and adverse effects.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/00498254.2022.2090301DOI Listing
June 2022

Engineered Stable Bioactive Per Se Amphiphilic Phosphorus Dendron Nanomicelles as a Highly Efficient Drug Delivery System To Take Down Breast Cancer In Vivo.

Biomacromolecules 2022 Jun 13. Epub 2022 Jun 13.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China.

Conventional small molecular chemical drugs always have challenging limitations in cancer therapy due to their high systemic toxicity and low therapeutic efficacy. Nanotechnology has been applied in drug delivery, bringing new promising potential to realize effective cancer treatment. In this context, we develop here a new nanomicellar drug delivery platform generated by amphiphilic phosphorus dendrons (1-C17G3.HCl), which could form micelles for effective encapsulation of a hydrophobic anticancer drug doxorubicin (DOX) with a high drug loading content (42.4%) and encapsulation efficiency (96.7%). Owing to the unique dendritic rigid structure and surface hydrophilic groups, large steady void space of micelles can be created for drug encapsulation. The created DOX-loaded micelles with a mean diameter of 26.3 nm have good colloidal stability. Strikingly, we show that the drug-free micelles possess good intrinsic anticancer activity and act collectively with DOX to take down breast cancer cells in vitro and the xenografted tumor model in vivo through upregulation of Bax, PTEN, and p53 proteins for enhanced cell apoptosis. Meanwhile, the resulting [email protected] micelles significantly abolish the toxicity relevant to the free drug. The findings of this study demonstrate a unique nanomicelle-based drug delivery system created with the self-assembling amphiphilic phosphorus dendrons that may be adapted for chemotherapy of different cancer types.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biomac.2c00197DOI Listing
June 2022

Genome sequencing reveals chromosome fusion and extensive expansion of genes related to secondary metabolism in Artemisia argyi.

Plant Biotechnol J 2022 Jun 11. Epub 2022 Jun 11.

College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China.

Artemisia argyi, as famous as Artemisia annua, is a medicinal plant with huge economic value in the genus of Artemisia and has been widely used in the world for about three thousand years. However, a lack of the reference genome severely hinders the understanding of genetic basis for the active ingredient synthesis of A. argyi. Here, we firstly report a complex chromosome-level genome assembly of A. argyi with a large size of 8.03 Gb, with features of high heterozygosity (2.36%), high repetitive sequences (73.59%) and a huge number of protein-coding genes (279,294 in total). The assembly reveals at least three rounds of whole-genome duplication (WGD) events, including a recent WGD event in the A. argyi genome, and a recent burst of transposable element, which may contribute to its large genome size. The genomic data and karyotype analyses confirmed that A. argyi is an allotetraploid with 34 chromosomes. Intragenome synteny analysis revealed the chromosomes fusion event occurred in the A. argyi genome, which elucidates the changes of basic chromosome numbers in Artemisia genus. Significant expansion of genes related to photosynthesis, DNA replication, stress responses and secondary metabolism were identified in A. argyi, explaining the extensive environmental adaptability and rapid growth characteristics. In addition, we analyzed genes involved in the biosynthesis pathways of flavonoids and terpenoids, and found that extensive gene amplification and tandem duplication contributed to the high contents of metabolites in A. argyi. Overall, the reference genome assembly provides scientific support for evolutionary biology, functional genomics and breeding in A. argyi and other Artemisia species.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/pbi.13870DOI Listing
June 2022

Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells.

Toxicol Appl Pharmacol 2022 Jun 7;449:116110. Epub 2022 Jun 7.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Institute of Lifeomics, Beijing 102206, China; Department of Biomedicine, School of Medicine, Guizhou University, Guiyang 550025, China; Hebei Province Key Lab of Research and Application on Microbial Diversity, College of Life Sciences, Hebei University, Baoding 071002, China; Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang 110122, China; Anhui Medical University, Hefei 230032, China; Academy of Military Medicines, Aceademy of Military Sciences, Beijing 100850, China. Electronic address:

Protein phosphorylation is the most common type of post-translational modification where serine, threonine or tyrosine are reversibly bound to the phosphate group of ATP in a reaction catalyzed by protein kinases. Phosphorylation plays an important role in regulation of cell homeostasis, including but not limited to signal perception and transduction, gene expression and function of proteins. Protein phosphorylation happens on a fast time scale and represents an energy-efficient way for the cell to adapt to exposure to chemical stressors. To understand the cascade of cellular signaling induced by exposure to chemicals, we have exposed HepG2 cells to three chemicals with different modes of action, namely, caffeine, coumarin, and quercetin in a concentration and time response manner. Significantly upregulated and downregulated phosphosites were screened to analyze the activation/deactivation of signaling pathways by protein kinases. In total, 69, 44 and 12 signaling pathways were found enriched in caffeine, coumarin and quercetin treated cells, respectively, of which 9 pathways were co-enriched with 11 jointly responded kinases. Among identified co-responded kinases, CDK1, MAPK1 and MAPK3 play important roles in cell cycle and insulin signaling pathways. Quantitative phosphoproteomics can sensitively distinguish the effects of different chemicals on cells, allowing the assessment of chemical safety through changes in substrates and metabolic pathways at the cellular level, which is important for the development of non-animal approaches for chemical safety assessment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.taap.2022.116110DOI Listing
June 2022

The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage.

Nutrients 2022 May 26;14(11). Epub 2022 May 26.

State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, and Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China.

The diet-induced obesity (DIO) mouse model has been widely used for obesity studies. The effects of storage conditions on the composition of nutrients in high-fat diets (HFDs) and their impact on metabolic homeostasis have not been systemically investigated. In the current study, we tested the effects of HFDs stored under different conditions and found that mice fed a HFD stored in the fridge (HFD) gained less weight than those fed HFDs stored in the freezer (HFD). Further analysis revealed that changes in the relative abundance of medium-chain triglyceride (MCT) in the HFD, which have much lower intestinal absorption rates, contributed to the body weight differences. In contrast, exacerbated liver damage and elevated levels of unfolded protein response (UPR) was observed in the mice fed by HFD. Depletion of the UPR-regulated gene alleviated liver damage via the inhibition of the integrated stress response (ISR). Our study, for the first time, provides evidence that HFD storage conditions can have a significant impact on both body weight changes and liver damage in the DIO model.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu14112222DOI Listing
May 2022

Long-Term High-Fat High-Fructose Diet Induces Type 2 Diabetes in Rats through Oxidative Stress.

Nutrients 2022 May 24;14(11). Epub 2022 May 24.

The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China.

Long-term consumption of a Western diet is a major cause of type 2 diabetes mellitus (T2DM). However, the effects of diet on pancreatic structure and function remain unclear. Rats fed a high-fat, high-fructose (HFHF) diet were compared with rats fed a normal diet for 3 and 18 months. Plasma biochemical parameters and inflammatory factors were used to reflect metabolic profile and inflammatory status. The rats developed metabolic disorders, and the size of the islets in the pancreas increased after 3 months of HFHF treatment but decreased and became irregular after 18 months. Fasting insulin, C-peptide, proinsulin, and intact proinsulin levels were significantly higher in the HFHF group than those in the age-matched controls. Plasmatic oxidative parameters and nucleic acid oxidation markers (8-oxo-Gsn and 8-oxo-dGsn) became elevated before inflammatory factors, suggesting that the HFHF diet increased the degree of oxidative stress before affecting inflammation. Single-cell RNA sequencing also verified that the transcriptional level of oxidoreductase changed differently in islet subpopulations with aging and long-term HFHF diet. We demonstrated that long-term HFHF diet and aging-associated structural and transcriptomic changes that underlie pancreatic islet functional decay is a possible underlying mechanism of T2DM, and our study could provide new insights to prevent the development of diet-induced T2DM.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu14112181DOI Listing
May 2022

Assembly and Photocatalytic Degradation Activity of Spherical ZnO/CdSe Heterostructures on Flexible Carbon Cloth Substrates.

Authors:
Xuan Chen Jin Li

Nanomaterials (Basel) 2022 Jun 1;12(11). Epub 2022 Jun 1.

Xinjiang Key Laboratory of Solid State Physics and Devices, Xinjiang University, Urumqi 830017, China.

With the increasing water pollution, traditional treatments cannot sufficiently remove pollutants, thereby prompting the development of photocatalysts. In this study, ZnO-carbon cloth (CC) and spherical ZnO/CdSe-CC heterostructures with different CdSe loadings were synthesized using an ultrasonic-hydrothermal method on flexible CC. Z20CdSe-CC (ZnO with 20 mg CdSe loaded on CC) exhibited the best visible-light-responsive photocatalytic performance, with approximately 83.5% methylene blue reduced in 180 min. In addition, the degradation efficiency of Z20CdSe-CC was maintained at 70.9% after three cycles in relation to that of the ZnO powder. The synergistic effect of CdSe and CC not only effectively widened the light absorption range of ZnO/CdSe-CC but also further promoted the effective transfer of carriers and realized an efficient photocatalytic degradation process. Therefore, the ZnO/CdSe-CC photocatalytic material with CC as the flexible substrate exhibited high photocatalytic activity and stability in environmental remediation. This provides a design idea for the development of an efficient and flexible photocatalytic material in line with the concept of green chemistry.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nano12111898DOI Listing
June 2022

A Two-Phase, Joint-Commuting Model for Primary and Secondary Schools Considering Parking Sharing.

Int J Environ Res Public Health 2022 May 25;19(11). Epub 2022 May 25.

College of Transportation, Jilin University, Changchun 130022, China.

In light of the traffic congestion and traffic environment problems around schools that are caused by students commuting by car, this paper explores an efficient and feasible student commuting travel plan. Based on the ideas of "public-private cooperation" and "parking sharing", combined with the characteristics of the family travel chain during the commuting period, a joint-commuting model of "private car and school bus" is creatively proposed. On the basis of considering the travel cost of parents and the operating cost of school bus, a two-phase commuting travel model for primary and secondary schools is proposed, and an algorithm is designed. The validity of the model is verified by an example and sensitivity analysis. The results show that the total time cost can be reduced by 23.33% when the private-car commuting mode is converted to the joint-commuting model. Among the results, we found that the driving time of a private car in the school commuting phase can be reduced by 23.36%, the dwell time can be reduced by 92.29%, and the driving time in the work and home phase can be reduced by 7.44%. Compared with the school-bus commuting mode, the school-bus time cost of joint commuting can be reduced by 54.88%. In addition, by analyzing the impact of various factors on the objective function and vehicle emissions, it can be seen that staggered commuting to school, regulating regional traffic volume, increasing parking spaces, and improving the utilization of parking spaces can effectively reduce the operating time cost of vehicles and exhaust emissions. The joint-commuting model proposed in this paper considers the balance between service level and resource consumption. While meeting the door-to-door travel needs of students, it can effectively reduce the travel costs of parents and school-bus operation costs, and it can alleviate traffic congestion around schools and reduce the impact on the environment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph19116435DOI Listing
May 2022

Hierarchical-Structured Pd Nanoclusters Catalysts -PdNCs/CoAl(O)/rGO- by the Captopril-Capped Pd Cluster Precursor Method for the Highly Efficient 4-Nitrophenol Reduction.

ACS Appl Mater Interfaces 2022 Jun 9;14(24):27775-27790. Epub 2022 Jun 9.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, P.O. Box 98, Beijing 100029, China.

Water-soluble captopril-capped atomically precise Pd nanoclusters (PdCapt NCs: 1.3 ± 0.5 nm) produced by a simple chemical reduction were supported on preprepared hybrid CoAl-layered double hydroxide/reduced graphene oxide (CoAl-LDH/rGO) by a pH-adjusted electrostatic adsorption strategy followed by proper calcinations, giving a series of novel catalysts -PdNCs/CoAl(O)/rGO- ( (Pd loading) = 0.09, 0.17, 0.43 wt % (ICP), = 230, 250, 280, 300, 320 °C). The characterization results show that the as-obtained catalysts possess the hierarchical nanosheet array morphology. Pd NCs with a size of ∼1.3 to 1.8 nm are highly distributed at the edge sites of the CoAl(O) nanosheets. All of the -PdNCs/CoAl(O)/rGO- catalysts show superior catalytic efficiency for the conversion of 4-nitrophenol to 4-aminophenol, particularly 0.17-PdNCs/CoAl(O)/rGO-300 possesses the highest performance with a turnover frequency (TOF) of 30 042 h, which is the highest among the reported Pd-based catalysts so far. The superior activity of 0.17-PdNCs/CoAl(O)/rGO-300 can be owing to ultrafine Pd NCs with a clean surface, the strongest PdNCs-Co-OH(LDH)-rGO three-phase synergy, and the much improved adsorption of the substrate via π-π stacking upon nanosheet array morphology. Meanwhile, 0.17-PdNCs/CoAl(O)/rGO-300 exhibits excellent catalytic activities for various nitroarenes and anionic azo dyes as well as good reusability with the complete reduction of 4-nitrophenol (4-NP) within 90 s after 10 successive runs. The present work provides not only a simple and convenient strategy for the synthesis of clean, efficient, and environmentally friendly supported metal nanocluster catalysts but also a new idea for the efficient catalytic degradation of environmental pollutants.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.2c01378DOI Listing
June 2022

Comparison of three different treatment methods for traumatic and Iatrogenic peripheral artery pseudoaneurysms.

Orthop Surg 2022 Jun 9. Epub 2022 Jun 9.

Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, China.

Objective: To compare the efficacy of open surgery (OS), endovascular interventions (EIs), and ultrasound-guided thrombin injection (UGTI) for the treatment of peripheral arterial pseudoaneurysms (PAs).

Methods: From January 1, 2001, to February 10, 2021, 38 patients diagnosed with traumatic and iatrogenic PAs treated with OS, EI, and UGTI were retrospectively analyzed. There were 18 females and 20 males, with an age of 56.47 ± 14.08 years (range,17-87 years). Anesthesia modality, operation duration, blood transfusion, duration of hospital stay, primary and secondary success rates, and complication rate were used to evaluate the surgical outcomes.

Results: There were 11 cases under regional anesthesia and 4 under general anesthesia in OS group, 9 under regional anesthesia and 1 under general anesthesia in EI group, and no regional or general anesthesia was required in UGTI group. There was no significant differences between any two groups (χ  = 39.80, p < 0.05). The blood tranfusion amount (units) were 3.6 ± 6.0, 0.8 ± 2.5, 0.0 ± 0.0 for OS, EI, and UGTI groups, respectively, with significant difference between OS and UGTI groups (F = 3.03, p < 0.05). The operation duration (minutes) of OS, EI, and UGTI groups were 80.0 ± 41.9, 56.0 ± 8.4, and 22.7 ± 5.3, respectively, with significant difference between any two groups (F = 15.69, p < 0.05). The duration of hospital stay (days) were 47.7 ± 39.0, 31.5 ± 17.6, and 16.3 ± 9.5, repectively, with significant difference between any two groups (F = 47.73, p < 0.05). The primary clinical success rates were 80% (12/15), 90% (9/10), and 92.3% (12/13) in OS,EI, and UGTI groups, respectively, with no significant difference between any two groups (χ  = 0.34, p > 0.05). The secondary clinical success rates were 100% for all three groups. The overall complication rates of OS, EI, and UGTI groups were 20% (3/15), 10% (1/10), and 7.7% (1/13), respectively, with no significant difference between any two groups (χ  = 1.00, p > 0.05). The infection rates were 13.3% (2/15), 10% (1/10), and 0% (0/13) in OS, EI, and UGTI groups respectively, with no significant difference between any two groups (χ  = 1.80, p > 0.05). The reintervention rates were 6.7% (1/15), 0% (0/10), 7.7% (1/13) in OS, EI, and UGTI groups, respectively, with no significant difference between two groups (χ  = 0.95, p > 0.05). Neuralgia was relieved in all patients.

Conclusions: OS, EI, and UGTI are efficacious and safe options for the treatment of appropriate patients with traumatic and iatrogenic PAs. UGTI would be considered as a first-line therapy for this condotion.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/os.13315DOI Listing
June 2022

Reproductive toxicity of InP/ZnS QDs in male rare minnow (Gobiocypris rarus).

Comp Biochem Physiol C Toxicol Pharmacol 2022 Jun 6;259:109392. Epub 2022 Jun 6.

Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Southwest University School of Life Sciences, Chongqing 400715, China. Electronic address:

InP/ZnS quantum dots (QDs) stand out among cadmium-free alternatives for higher exciton Bohr radius and strong quantum confined effect. In this study, the reproductive toxicity and mechanism of InP/ZnS QDs at different concentrations in male Chinese rare minnows (Gobiocypris rarus) were investigated. The results showed that QDs in 800 nmol/L concentration group could enter the testes after 1 d of exposure and caused changes in the structure of the testes, including the scattered distribution of seminal vesicles, reduction in germ cells and vacuolation in some areas of interstitial cells. The expression levels of androgen receptor (Ar) and doublesex and mab-3 related transcription factor 1 (Dmrt1) and the tight junction protein-related genes β-catenin and occludin were upregulated in rare minnows. The sperm quality and ATP content of parents in the 800 nmol/L treatment group were significantly decreased. Continuous detection of the development of F1 generation embryos showed that parental exposure to InP/ZnS QDs reduced the heart rate and spontaneous movement frequency of F1 generation embryos, and the fertilization rate of the F1 generation in the 800 nmol/L treatment group was significantly reduced. In general, the sperm quality and testicular structure of adult rare minnows were not significantly affected by concentrations below 400 nmol/L. High-concentration InP/ZnS QDs exposure can damage the integrity of the blood-testis barrier (BTB) and cause reproductive damage to the parents of rare minnows, which will continue to the next generation and affect their development.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cbpc.2022.109392DOI Listing
June 2022

12(S)-hydroxyeicosatetraenoic acid is significantly increased in diabetic kidney disease and associated with renal function decline.

Diabetes Metab Res Rev 2022 Jun 6:e3554. Epub 2022 Jun 6.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Aims: 12(S)-hydroxyeicosatetraenoic (12(S)-HETE), an alternate arachidonic acid metabolite, has been recently examined in metabolic disease. However, the role of 12(S)-HETE in diabetic kidney disease (DKD) remains unclear. We studied for the first time the relationship of serum 12(S)-HETE and DKD and renal function parameters in a Chinese population.

Materials And Methods: We recruited 275 subjects who were diagnosed with type 2 diabetes (T2DM) for more than 10 years, including 149 DKD patients and 126 T2DM patients without DKD. Serum 12(S)-HETE was measured using the enzyme-linked immunosorbent assay.

Results: Serum 12(S)-HETE was significantly higher in DKD patients than controls [384.69 (77.54, 1003.05) pg/ml and 17.77 (8.11, 75.13) pg/ml, respectively, p < 0.0001]. Compared to controls, 12(S)-HETE was significantly increased in both macroalbuminuria and microalbuminuria groups (p < 0.0001). Further, the macroalbuminuria group also had a higher serum 12(S)-HETE level compared to the microalbuminuria group (p = 0.0063). Moreover, serum 12(S)-HETE was positively correlated with the albuminuria level (r = 0.5833, p < 0.0001), serum creatinine (r = 0.2725, p < 0.0001), and was negatively associated with the estimated glomerular filtration rate (r = -0.2085, p = 0.0005). Further, receiver operating characteristic analysis (ROC) revealed that 12(S)-HETE had a good performance of distinguishing DKD from controls (AUC 0.828) with a sensitivity of 0.913 and a specificity of 0.711.

Conclusion: Our findings revealed that serum 12(S)-HETE significantly associated with DKD and disease severity, suggesting that serum 12(S)-HETE may be used as a potential biomarker for the early diagnosis of DKD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/dmrr.3554DOI Listing
June 2022

Landscape of Metabolic Fingerprinting for Diagnosis and Risk Stratification of Sepsis.

Front Immunol 2022 18;13:883628. Epub 2022 May 18.

Department of Emergency, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Background: Sepsis and septic shock, a subset of sepsis with higher risk stratification, are hallmarked by high mortality rates and necessitated early and accurate biomarkers.

Methods: Untargeted metabolomic analysis was performed to compare the metabolic features between the sepsis and control systemic inflammatory response syndrome (SIRS) groups in discovery cohort, and potential metabolic biomarkers were selected and quantified using multiple reaction monitoring based target metabolite detection method.

Results: Differentially expressed metabolites including 46 metabolites in positive electrospray ionization (ESI) ion mode, 22 metabolites in negative ESI ion mode, and 4 metabolites with dual mode between sepsis and SIRS were identified and revealed. Metabolites 5-Oxoproline, L-Kynurenine and Leukotriene D4 were selected based on least absolute shrinkage and selection operator regularization logistic regression and differential expressed between sepsis and septic shock group in the training and test cohorts. Respective risk scores for sepsis and septic shock based on a 3-metabolite fingerprint classifier were established to distinguish sepsis from SIRS, septic shock from sepsis. Significant relationship between developed sepsis risk scores, septic shock risk scores and Sequential (sepsis-related) Organ Failure Assessment (SOFA), procalcitonin (PCT) and lactic acid were observed.

Conclusions: Collectively, our findings demonstrated that the characteristics of plasma metabolites not only manifest phenotypic variation in sepsis onset and risk stratification of sepsis but also enable individualized treatment and improve current therapeutic strategies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2022.883628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159301PMC
June 2022
-->