Leyre Brizuela

Leyre Brizuela

UNVERIFIED PROFILE

Are you Leyre Brizuela?   Register this Author

Register author
Leyre Brizuela

Leyre Brizuela

Publications by authors named "Leyre Brizuela"

Are you Leyre Brizuela?   Register this Author

22Publications

373Reads

30Profile Views

Phospholipase D: A new mediator during high phosphate-induced vascular calcification associated with chronic kidney disease.

J Cell Physiol 2019 Apr 12;234(4):4825-4839. Epub 2018 Sep 12.

University of Lyon, Université Claude Bernard Lyon 1 (UCBL), CNRS UMR 5246, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Lyon, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.27281DOI Listing
April 2019

Design, synthesis and biological evaluation of inhibitors of cathepsin K on dedifferentiated chondrocytes.

Bioorg Med Chem 2019 Mar 2;27(6):1034-1042. Epub 2019 Feb 2.

Univ. Lyon, Univ. Claude Bernard Lyon 1, CNRS UMR 5246, ICBMS, F-69622 Lyon, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2019.02.003DOI Listing
March 2019

Osteoblast-derived sphingosine 1-phosphate to induce proliferation and confer resistance to therapeutics to bone metastasis-derived prostate cancer cells.

Mol Oncol 2014 Oct 13;8(7):1181-95. Epub 2014 Apr 13.

CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France; Université de Toulouse, UPS, IPBS, Toulouse, France; Equipe Labellisée Ligue contre le Cancer, France. Electronic address:

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1016/j.molonc.2014.04.001
Publisher Site
http://dx.doi.org/10.1016/j.molonc.2014.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528572PMC
October 2014

Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1.

Bioorg Med Chem 2014 Sep 27;22(17):4955-60. Epub 2014 Jun 27.

Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507 & FR3038, ENSICAEN, Normandie Université, Université de Caen Basse-Normandie, 6 Bd du Maréchal Juin, Caen 14050, France. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09680896140048
Publisher Site
http://dx.doi.org/10.1016/j.bmc.2014.06.038DOI Listing
September 2014

Hypoxia, therapeutic resistance, and sphingosine 1-phosphate.

Adv Cancer Res 2013 ;117:117-41

CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France; Université de Toulouse, Toulouse, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-394274-6.00005-4DOI Listing
June 2013

Biochemical methods for quantifying sphingolipids: ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate.

Methods Mol Biol 2012 ;874:1-20

Institut de Pharmacologie et de Biologie Structurale, CNRS, Toulouse, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-800-9_1DOI Listing
November 2012

First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.

Mol Cancer Ther 2012 Sep 10;11(9):1841-51. Epub 2012 Jul 10.

CNRS, Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, UPS, IPBS Toulouse Cedex 4, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-12-0227DOI Listing
September 2012

Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.

Prog Lipid Res 2010 Oct 1;49(4):316-34. Epub 2010 Mar 1.

Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Bilbao, Spain.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01637827100001
Publisher Site
http://dx.doi.org/10.1016/j.plipres.2010.02.004DOI Listing
October 2010

The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer.

FASEB J 2010 Oct 3;24(10):3882-94. Epub 2010 Jun 3.

Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.10-160838DOI Listing
October 2010

Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting.

Curr Mol Pharmacol 2010 Jun;3(2):53-65

CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, F-31000 France.

View Article

Download full-text PDF

Source
June 2010

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.

Mol Cancer Ther 2009 Apr;8(4):809-20

INSERM U858, I2MR, IFR31, CNRS, Institut de Pharmacologie et de Biologie Structurale, UMR5089, Service d'Anatomie-Pathologique, Rangueil Hospital, Toulouse, France.

View Article

Download full-text PDF

Source
http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-08
Publisher Site
http://dx.doi.org/10.1158/1535-7163.MCT-08-1096DOI Listing
April 2009

Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells.

Cancer Res 2008 Oct;68(20):8635-42

Centre National de la Recherche Scientifique, Sphingolipids and Cancer Research Laboratory, Institut de Pharmacologie et de Biologie Structurale, UMR5089, Université Toulouse III Paul Sabatier, Toulouse, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-08-0917DOI Listing
October 2008

Sphingosine-1-phosphate stimulates aldosterone secretion through a mechanism involving the PI3K/PKB and MEK/ERK 1/2 pathways.

J Lipid Res 2007 Oct 3;48(10):2264-74. Epub 2007 Jul 3.

Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, 48080, Bilbao, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M700291-JLR200DOI Listing
October 2007

Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide.

Mol Pharmacol 2007 Aug 23;72(2):341-9. Epub 2007 May 23.

Institut National de la Santé et de la Recherche Médicale U466, Toulouse, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.106.033738DOI Listing
August 2007

Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion.

J Lipid Res 2006 Jun 22;47(6):1238-49. Epub 2006 Mar 22.

Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, 48080 Bilbao, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1194/jlr.M500510-JLR200DOI Listing
June 2006

Angiotensin II-stimulated cortisol secretion is mediated by phospholipase D.

Mol Cell Endocrinol 2004 Jul;222(1-2):9-20

Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country, P.O. Box 644, 48080 Bilbao, Spain.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S030372070400213
Publisher Site
http://dx.doi.org/10.1016/j.mce.2004.05.006DOI Listing
July 2004

Sphingosine-1-phosphate stimulates cortisol secretion.

FEBS Lett 2003 Jan;535(1-3):101-5

Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of the Basque Country, P.O. Box 644, 48080 Bilbao, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0014-5793(02)03882-6DOI Listing
January 2003