Lex H T Van der Ploeg

Lex H T Van der Ploeg

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Lex H T Van der Ploeg

Lex H T Van der Ploeg

Publications by authors named "Lex H T Van der Ploeg"

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Magel2-null mice are hyper-responsive to setmelanotide, a melanocortin 4 receptor agonist.

Br J Pharmacol 2016 09 27;173(17):2614-21. Epub 2016 Jul 27.

Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1111/bph.13540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978157PMC
September 2016

Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists.

Mol Endocrinol 2015 Nov 29;29(11):1619-33. Epub 2015 Sep 29.

Department of Biochemistry and Molecular Biology (B.M.M., K.A.C., K.W., G.B.), University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199; and Rhythm Pharmaceuticals, Inc (L.H.T.V.D.P.), Boston, Massachusetts 02116.

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http://dx.doi.org/10.1210/me.2015-1071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627605PMC
November 2015

The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor.

Front Nutr 2014 12;1:31. Epub 2015 Jan 12.

Institute for Diabetes and Obesity (IDO) and Helmholtz Diabetes Center, Helmholtz Center Munich, German Research Center for Environmental Health (GmbH) , Neuherberg , Germany ; Division of Metabolic Diseases, Department of Medicine, Technische Universität München , Munich , Germany.

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http://dx.doi.org/10.3389/fnut.2014.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428373PMC
May 2015

RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals.

J Clin Endocrinol Metab 2015 Apr 12;100(4):1639-45. Epub 2015 Feb 12.

Diabetes, Endocrinology, and Obesity Branch (K.Y.C., R.M., B.S.A., K.P.M., P.S., R.J.B., X.Z., M.R., T.L.P., M.L.R., M.C.S.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892; Department of Molecular Physiology and Biophysics (R.D.C., B.L.P.), Vanderbilt University School of Medicine, Nashville, Tennessee 37232; and Rhythm Pharmaceuticals (K.M.G., L.H.T.V.d.P.), Boston, Massachusetts 02116.

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http://rhythmpharmaceutical.com/pdfs/Chen%202015%20JCEM.pdf
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http://press.endocrine.org/doi/10.1210/jc.2014-4024
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http://dx.doi.org/10.1210/jc.2014-4024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399297PMC
April 2015

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice.

EMBO Mol Med 2015 Mar;7(3):288-98

Institute for Diabetes and Obesity & Helmholtz Diabetes Center, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), Neuherberg, Germany Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany

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http://dx.doi.org/10.15252/emmm.201404508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364946PMC
March 2015

4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

Bioorg Med Chem Lett 2006 Oct 17;16(20):5275-9. Epub 2006 Aug 17.

Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.08.008DOI Listing
October 2006

Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands.

Bioorg Med Chem Lett 2006 Mar 20;16(5):1130-3. Epub 2005 Dec 20.

Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0501531
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http://dx.doi.org/10.1016/j.bmcl.2005.11.095DOI Listing
March 2006

Novel aspects of accumulation dynamics and A beta composition in transgenic models of AD.

Neurobiol Aging 2004 Oct;25(9):1175-85

Department of Molecular and Cellular Neuroscience, Merck Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2003.12.009DOI Listing
October 2004

The role of tryptophan 1072 in human PDE3B inhibitor binding.

Biochem Biophys Res Commun 2003 Aug;307(4):1045-50

Department of Metabolic Disorders, Merck Research Laboratories, P.O. Box 2000, Mailstop: RY80M-213, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s0006-291x(03)01299-3DOI Listing
August 2003

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats.

Eur J Pharmacol 2003 Aug;475(1-3):37-47

Department of Pharmacology, Merck Research Laboratories, PO Box 2000, Building RY80Y-150, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s0014-2999(03)02146-0DOI Listing
August 2003

Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats.

Brain Res 2003 Jul;977(2):221-30

Department of Obesity and Metabolic Research, Merck Research Laboratories, P.O. Box 2000, R80M-213, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s0006-8993(03)02683-0DOI Listing
July 2003

Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula.

Eur J Pharmacol 2002 Nov;454(1):71-9

Department of Pharmacology, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/s0014-2999(02)02479-2DOI Listing
November 2002

Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).

Biochemistry 2002 Jul;41(28):8954-60

Department of Obesity and Metabolic Research, Merck Research Laboratories, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1021/bi0202777DOI Listing
July 2002