Lewis Roberts

Lewis Roberts

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Hepatology 2020 Jan 4. Epub 2020 Jan 4.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, MN.

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http://dx.doi.org/10.1002/hep.31097DOI Listing
January 2020

Reply to letter.

Hepatology 2020 Jan 4. Epub 2020 Jan 4.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, MN.

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http://dx.doi.org/10.1002/hep.31098DOI Listing
January 2020

Current Status of the GALAD and BALAD Biomarker Models for Hepatocellular Carcinoma.

Authors:
Lewis R Roberts

Gastroenterol Hepatol (N Y) 2019 Dec;15(12):672-675

Professor of Medicine Division of Gastroenterology and Hepatology Mayo Clinic Rochester, Minnesota.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935027PMC
December 2019

Epidemiology of Liver Cancer in Africa: Current and Future Trends.

Semin Liver Dis 2019 Nov 14. Epub 2019 Nov 14.

Department of Internal Medicine, University of Jos, Jos, Plateau, Nigeria.

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http://dx.doi.org/10.1055/s-0039-3399566DOI Listing
November 2019

A global view of hepatocellular carcinoma: trends, risk, prevention and management.

Nat Rev Gastroenterol Hepatol 2019 10 22;16(10):589-604. Epub 2019 Aug 22.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

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http://dx.doi.org/10.1038/s41575-019-0186-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813818PMC
October 2019

DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma.

Clin Epigenetics 2019 Oct 21;11(1):145. Epub 2019 Oct 21.

Center for Global Oncology, Institute for Global Health, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL, 60611-4402, USA.

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http://dx.doi.org/10.1186/s13148-019-0733-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802191PMC
October 2019

Single-Dose Neoadjuvant AKT Pathway Inhibitor Reduces Growth of Hepatocellular Carcinoma after Laser Thermal Ablation in Small-Animal Model.

Radiology 2019 09 23;292(3):752-759. Epub 2019 Jul 23.

From the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, 200 First St SW, Rochester, MN 55905.

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http://dx.doi.org/10.1148/radiol.2019190115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736176PMC
September 2019

Neoadjuvant vs. adjuvant chemotherapy for cholangiocarcinoma: A propensity score matched analysis.

Eur J Surg Oncol 2019 Aug 21;45(8):1432-1438. Epub 2019 Mar 21.

Department of Oncology, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejso.2019.03.023DOI Listing
August 2019

Gallbladder cancer: epidemiology and genetic risk associations.

Chin Clin Oncol 2019 Aug;8(4):31

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.21037/cco.2019.08.13DOI Listing
August 2019

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice.

Gastroenterology 2019 07 13;157(1):210-226.e12. Epub 2019 Mar 13.

Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193355
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http://dx.doi.org/10.1053/j.gastro.2019.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800187PMC
July 2019

Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular-clinical analysis and potential targeted approach.

Hepatol Int 2019 Jul 18;13(4):490-500. Epub 2019 Jun 18.

Department of Surgery, Dongsan Medical Center, School of Medicine, Keimyung University, 56 Dalseong-ro, Jung-gu, Daegu, 700-712, Republic of Korea.

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http://dx.doi.org/10.1007/s12072-019-09954-3DOI Listing
July 2019

TLX3 repressed SNAI1-induced epithelial-mesenchymal transition by directly constraining STAT3 phosphorylation and functionally sensitized 5-FU chemotherapy in hepatocellular carcinoma.

Int J Biol Sci 2019 5;15(8):1696-1711. Epub 2019 Jun 5.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

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http://dx.doi.org/10.7150/ijbs.33844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643223PMC
June 2019

Genetic features associated with F-FDG uptake in intrahepatic cholangiocarcinoma.

Ann Surg Treat Res 2019 Apr 28;96(4):153-161. Epub 2019 Mar 28.

Department of Nuclear Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.

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http://dx.doi.org/10.4174/astr.2019.96.4.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444048PMC
April 2019

Targeting sphingosine kinase 2 suppresses cell growth and synergizes with BCL2/BCL-XL inhibitors through NOXA-mediated MCL1 degradation in cholangiocarcinoma.

Am J Cancer Res 2019 1;9(3):546-561. Epub 2019 Mar 1.

Department of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University Nanjing 210008, Jiangsu, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448062PMC
March 2019

The incidence rates and survival of gallbladder cancer in the USA.

Eur J Cancer Prev 2019 01;28(1):1-9

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1097/CEJ.0000000000000402DOI Listing
January 2019

Preclinical In Vitro and In Vivo Evidence of an Antitumor Effect of CX-4945, a Casein Kinase II Inhibitor, in Cholangiocarcinoma.

Transl Oncol 2019 Jan 11;12(1):143-153. Epub 2018 Oct 11.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187100PMC
January 2019

Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy.

Gastroenterology 2019 01 4;156(2):492-509. Epub 2018 Nov 4.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte De Recherche 1162, Génomique Fonctionnelle des Tumeurs Solides, Université Paris Descartes, Université Paris Diderot, Université Paris 13, Labex Immuno-Oncology, Paris, France; Hôpital Europeen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183521
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http://dx.doi.org/10.1053/j.gastro.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340723PMC
January 2019

Barriers in Hepatitis C Treatment in Somali Patients in the Direct Acting Antiviral Therapy Era.

J Natl Med Assoc 2018 Dec 10;110(6):556-559. Epub 2018 Mar 10.

Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, Minneapolis, MN, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00279684173031
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http://dx.doi.org/10.1016/j.jnma.2018.02.002DOI Listing
December 2018

Gastrointestinal and Extra-Intestinal Manifestations of IgG4-Related Disease.

Gastroenterology 2018 10 12;155(4):990-1003.e1. Epub 2018 Sep 12.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.06.082DOI Listing
October 2018

A model predicting short-term mortality in patients with advanced liver cirrhosis and concomitant infection.

Medicine (Baltimore) 2018 Oct;97(41):e12758

Department of Hepatology and Gastroenterology, Tianjin Third Central Hospital Affiliated to Tianjin Medical University, Tianjin Key Laboratory of Artificial Cells, Tianjin, China.

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http://Insights.ovid.com/crossref?an=00005792-201810120-0006
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http://dx.doi.org/10.1097/MD.0000000000012758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203558PMC
October 2018

Heat Stress and Hepatic Laser Thermal Ablation Induce Hepatocellular Carcinoma Growth: Role of PI3K/mTOR/AKT Signaling.

Radiology 2018 09 8;288(3):730-738. Epub 2018 May 8.

From the Department of Radiology (D.E.J., S.M.T., K.A.B., B.E.K., J.L.A., M.R.C., D.A.W.) and Division of Gastroenterology and Hepatology (L.R.R.), Mayo Clinic School of Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Health Sciences Research, Mayo Clinic School of Medicine, Jacksonville, Fla (R.E.C.).

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http://dx.doi.org/10.1148/radiol.2018172944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122226PMC
September 2018

Venous invasion by hepatic tumors: imaging appearance and implications for management.

Abdom Radiol (NY) 2018 08;43(8):1947-1967

Department of Radiology, Mayo Clinic School of Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1007/s00261-017-1298-xDOI Listing
August 2018

DNA Methylation of Telomere-Related Genes and Cancer Risk.

Cancer Prev Res (Phila) 2018 08 12;11(8):511-522. Epub 2018 Jun 12.

Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center and Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1158/1940-6207.CAPR-17-0413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800137PMC
August 2018

Impact of surveillance for hepatocellular carcinoma on survival in patients with compensated cirrhosis.

Hepatology 2018 07 9;68(1):78-88. Epub 2018 May 9.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA.

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http://dx.doi.org/10.1002/hep.29594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897179PMC
July 2018

HGT-ID: an efficient and sensitive workflow to detect human-viral insertion sites using next-generation sequencing data.

BMC Bioinformatics 2018 07 17;19(1):271. Epub 2018 Jul 17.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1186/s12859-018-2260-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050683PMC
July 2018

An Enlarging Metastatic Calcified Liver Lesion of an Occult Melanoma.

Case Rep Oncol 2018 May-Aug;11(2):388-391. Epub 2018 Jun 18.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1159/000489555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047565PMC
June 2018

More advanced disease and worse survival in cryptogenic compared to viral hepatocellular carcinoma.

Liver Int 2018 05 3;38(5):895-902. Epub 2017 Nov 3.

Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, CA, USA.

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http://dx.doi.org/10.1111/liv.13613DOI Listing
May 2018

Qualitative exploration of the effect of a television soap opera storyline on women with experience of postpartum psychosis.

BJPsych Open 2018 Mar 19;4(2):75-82. Epub 2018 Mar 19.

University of Birmingham Institute of Cardiovascular Sciences, City Hospital, Birmingham, UK.

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http://dx.doi.org/10.1192/bjo.2018.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020274PMC
March 2018

AASLD guidelines for the treatment of hepatocellular carcinoma.

Hepatology 2018 01;67(1):358-380

Digestive and Liver Diseases Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX.

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http://dx.doi.org/10.1002/hep.29086DOI Listing
January 2018

Imaging for the diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis.

Hepatology 2018 01 29;67(1):401-421. Epub 2017 Nov 29.

Evidence-Based Practice Center, Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic College of Medicine and Science, Rochester, MN.

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http://doi.wiley.com/10.1002/hep.29487
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http://dx.doi.org/10.1002/hep.29487DOI Listing
January 2018

Recent Trends in the Epidemiology of Hepatocellular Carcinoma in Olmsted County, Minnesota: A US Population-based Study.

J Clin Gastroenterol 2017 Sep;51(8):742-748

*Division of Gastroenterology and Hepatology †Division of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, MN.

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http://dx.doi.org/10.1097/MCG.0000000000000810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552490PMC
September 2017

Identification of fucosylated Fetuin-A as a potential biomarker for cholangiocarcinoma.

Proteomics Clin Appl 2017 09 10;11(9-10). Epub 2017 Jul 10.

Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, SC, USA.

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http://dx.doi.org/10.1002/prca.201600141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014737PMC
September 2017

Clinical, Biochemical, and Histopathology Features of Patients With Glycogenic Hepatopathy.

Clin Gastroenterol Hepatol 2017 Jun 30;15(6):927-933. Epub 2016 Dec 30.

Division of Endocrinology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2016.11.038DOI Listing
June 2017

Early age at diagnosis of hepatocellular carcinoma in sub-Saharan Africa - Authors' reply.

Lancet Gastroenterol Hepatol 2017 06;2(6):394

Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/S2468-1253(17)30107-3DOI Listing
June 2017

Should AFP (or any biomarkers) be used for HCC surveillance?

Curr Hepatol Rep 2017 Jun 28;16(2):137-145. Epub 2017 Apr 28.

Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, MN.

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http://dx.doi.org/10.1007/s11901-017-0349-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659201PMC
June 2017

Hepatocellular Carcinoma Is the Most Common Indication for Liver Transplantation and Placement on the Waitlist in the United States.

Clin Gastroenterol Hepatol 2017 May 21;15(5):767-775.e3. Epub 2016 Dec 21.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2016.11.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401787PMC
May 2017

Increased Prevalence of Metabolic Risk Factors in Asian Americans With Hepatocellular Carcinoma.

J Clin Gastroenterol 2017 Apr;51(4):384-390

*Department of Medicine §School of Medicine †Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA ‡Washington University in St. Louis, St. Louis, MO ∥Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1097/MCG.0000000000000689DOI Listing
April 2017

MR elastography of hepatocellular carcinoma: Correlation of tumor stiffness with histopathology features-Preliminary findings.

Magn Reson Imaging 2017 Apr 11;37:41-45. Epub 2016 Nov 11.

Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mri.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5587120PMC
April 2017

Reply.

Hepatology 2017 04 29;65(4):1422-1423. Epub 2016 Dec 29.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN.

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http://dx.doi.org/10.1002/hep.28922DOI Listing
April 2017

Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer.

Epigenetics 2017 03 6;12(3):215-225. Epub 2017 Jan 6.

a Department of Molecular Pharmacology and Experimental Therapeutics , Mayo Clinic , Rochester , MN , USA.

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http://dx.doi.org/10.1080/15592294.2016.1277297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406211PMC
March 2017

Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression.

Sci Rep 2017 03 6;7:43864. Epub 2017 Mar 6.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, 213003, China.

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http://dx.doi.org/10.1038/srep43864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338333PMC
March 2017

Factors Influencing Surveillance for Hepatocellular Carcinoma in Patients with Liver Cirrhosis.

Liver Cancer 2017 Feb 17;6(2):126-136. Epub 2016 Dec 17.

Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, Minn., USA.

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http://dx.doi.org/10.1159/000450833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340216PMC
February 2017

Impact of country of birth on age at the time of diagnosis of hepatocellular carcinoma in the United States.

Cancer 2017 Jan 29;123(1):81-89. Epub 2016 Aug 29.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.

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http://dx.doi.org/10.1002/cncr.30246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161593PMC
January 2017

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver.

Epigenetics 2017 01 18;12(1):55-69. Epub 2016 Nov 18.

a Department of Molecular Pharmacology and Experimental Therapeutics , Mayo Clinic , Rochester , MN , USA.

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http://dx.doi.org/10.1080/15592294.2016.1261239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270632PMC
January 2017

Reply.

Hepatology 2016 12 18;64(6):2258-2259. Epub 2016 Oct 18.

Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1002/hep.28807DOI Listing
December 2016

Antepartum voiding symptoms following prior tension-free vaginal tape (TVT) operation: A case report.

J Obstet Gynaecol 2016 Nov 14;36(8):1002-1003. Epub 2016 Sep 14.

b Department of Urogynaecology , King's College Hospital , London , UK.

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http://dx.doi.org/10.1080/01443615.2016.1217512DOI Listing
November 2016

Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151.

Int J Oncol 2016 Nov 2;49(5):2037-2045. Epub 2016 Sep 2.

College of Pharmacy, Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.3892/ijo.2016.3677DOI Listing
November 2016

Diabetes Mellitus Heightens the Risk of Hepatocellular Carcinoma Except in Patients With Hepatitis C Cirrhosis.

Am J Gastroenterol 2016 11 16;111(11):1573-1580. Epub 2016 Aug 16.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Palo Alto, California, USA.

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http://dx.doi.org/10.1038/ajg.2016.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040826PMC
November 2016

Direct acting antiviral therapy and tumor recurrence after liver transplantation for hepatitis C-associated hepatocellular carcinoma.

J Hepatol 2016 10 5;65(4):859-860. Epub 2016 Jul 5.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, MN, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2016.06.023DOI Listing
October 2016

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.

Cancer Cell 2016 10;30(4):595-609

Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081228PMC
http://dx.doi.org/10.1016/j.ccell.2016.09.004DOI Listing
October 2016

Biliary tract cancers: epidemiology, molecular pathogenesis and genetic risk associations.

Chin Clin Oncol 2016 Oct;5(5):61

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA; Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.21037/cco.2016.10.09DOI Listing
October 2016

Statins and metformin for chemoprevention of hepatocellular carcinoma.

Clin Liver Dis (Hoboken) 2016 Aug 29;8(2):48-52. Epub 2016 Aug 29.

Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine Rochester MN.

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http://dx.doi.org/10.1002/cld.568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490194PMC
August 2016

Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advances.

F1000Res 2016 12;5. Epub 2016 May 12.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://dx.doi.org/10.12688/f1000research.6946.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870992PMC
May 2016

Biomarkers for Hepatocellular Carcinoma.

Authors:
Lewis R Roberts

Gastroenterol Hepatol (N Y) 2016 Apr;12(4):252-5

Professor of Medicine Department of Gastroenterology and Hepatology Mayo Clinic Rochester, Minnesota.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872856PMC
April 2016