Lewis C Cantley

Lewis C Cantley

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Lewis C Cantley

Lewis C Cantley

Publications by authors named "Lewis C Cantley"

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98Publications

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Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.

Bioorg Med Chem Lett 2018 Sep 27;28(16):2675-2678. Epub 2018 Apr 27.

California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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September 2018

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment.

Cell 2018 Sep;174(6):1347-1360

Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.

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September 2018

A Glycolysis Outsider Steps into the Cancer Spotlight.

Cell Metab 2018 Jul;28(1):3-4

Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address:

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July 2018

Cancer metabolism gets physical.

Sci Transl Med 2018 May;10(442)

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.

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May 2018

Fenofibrate prevents skeletal muscle loss in mice with lung cancer.

Proc Natl Acad Sci U S A 2018 01 8;115(4):E743-E752. Epub 2018 Jan 8.

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021;

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January 2018

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Cell 2017 Dec 16;171(7):1545-1558.e18. Epub 2017 Nov 16.

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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December 2017

The PI3K Pathway in Human Disease.

Cell 2017 Aug;170(4):605-635

Oncology R&D Group, Pfizer Worldwide Research and Development, 10646/CB4 Science Center Drive, San Diego, CA 92121, USA.

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August 2017

Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer.

J Cancer Res Clin Oncol 2017 Jul 28;143(7):1255-1262. Epub 2017 Feb 28.

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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July 2017

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.

Proc Natl Acad Sci U S A 2017 07 19;114(27):7095-7100. Epub 2017 Jun 19.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115;

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July 2017

Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma.

J Invest Dermatol 2017 05 28;137(5):1135-1143. Epub 2017 Jan 28.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.

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May 2017

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.

Cancer Discov 2017 04 2;7(4):380-390. Epub 2017 Mar 2.

Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

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April 2017

Membrane Lipids Speak to Histones.

Mol Cell 2017 Apr;66(2):163-164

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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April 2017

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.

Recent Results Cancer Res 2016;207:39-72

Department of Medicine, the Cancer Center, Weill Cornell Medical College, The Belfer Research Building, 413 East 69th Street, Floor 13 Room BB-1362, New York, NY, 10021, USA.

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March 2017

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.

Mol Cell 2017 Mar;65(6):999-1013.e7

Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK. Electronic address:

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March 2017

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).

J Med Chem 2017 Feb 27;60(4):1591-1597. Epub 2017 Jan 27.

Medicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain , 73 avenue Mounier, B-1200 Brussels, Belgium.

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February 2017

Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.

Cell Death Differ 2017 02 4;24(2):238-250. Epub 2016 Nov 4.

Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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February 2017

Obesity and Cancer Mechanisms: Cancer Metabolism.

J Clin Oncol 2016 Dec 7;34(35):4277-4283. Epub 2016 Nov 7.

All authors: Meyer Cancer Center, Weill Cornell Medical College, New York, NY.

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December 2016

Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley.

Authors:
Lewis C Cantley

Dis Model Mech 2016 09 4;9(9):911-6. Epub 2016 Aug 4.

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA

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September 2016

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.

Proc Natl Acad Sci U S A 2016 08 15;113(35):9810-5. Epub 2016 Aug 15.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

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August 2016

Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.

Proc Natl Acad Sci U S A 2016 07 16;113(27):7596-601. Epub 2016 Jun 16.

Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;

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July 2016

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Proc Natl Acad Sci U S A 2016 07 8;113(30):E4338-47. Epub 2016 Jul 8.

Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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July 2016

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.

Mol Cell Oncol 2016 Jul 30;3(4):e1164280. Epub 2016 Mar 30.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.

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July 2016

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Nat Cell Biol 2016 05 18;18(5):572-8. Epub 2016 Apr 18.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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May 2016

Computational prediction of protein-protein interactions.

Methods Mol Biol 2015 ;1278:57-75

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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December 2015

Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.

Cell Signal 2015 Dec 9;27(12):2389-400. Epub 2015 Sep 9.

Department of Biochemistry, Yonsei University, Seoul, Republic of Korea. Electronic address:

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December 2015

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.

Nat Struct Mol Biol 2015 Dec 9;22(12):983-90. Epub 2015 Nov 9.

Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

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December 2015

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Cancer Discov 2015 Nov 20;5(11):1194-209. Epub 2015 Aug 20.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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November 2015

Cancer's Fuel Choice: New Flavors for a Picky Eater.

Mol Cell 2015 Nov;60(4):514-23

Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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November 2015

PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients.

Mol Oncol 2015 Oct 16;9(8):1694-703. Epub 2015 May 16.

Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.

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October 2015

Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.

Biochim Biophys Acta 2015 Oct 11;1852(10 Pt A):2056-65. Epub 2015 Jul 11.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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October 2015

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone.

Cancer Metab 2015 12;3:12. Epub 2015 Oct 12.

Department of Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Drive, Dallas, 75390-8807 TX USA ; Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX USA.

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October 2015

Regulation of mTORC1 by PI3K signaling.

Trends Cell Biol 2015 Sep 6;25(9):545-55. Epub 2015 Jul 6.

Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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September 2015

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.

Nat Med 2015 May 13;21(5):457-66. Epub 2015 Apr 13.

1] Division of Translational Therapeutics, Department of Medicine, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Medicine, BIDMC, Harvard Medical School, Boston, Massachusetts, USA.. [3] Cancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.

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May 2015

Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain.

Cancer Res 2015 Feb 15;75(3):554-65. Epub 2014 Dec 15.

Department of Biochemistry and Biology, College of Natural Science and Mathematics, University of Houston, Houston, Texas.

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February 2015

Acetate fuels the cancer engine.

Cell 2014 Dec;159(7):1492-4

Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address:

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December 2014

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

Nature 2014 Oct 10;514(7524):628-32. Epub 2014 Aug 10.

1] Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA [2] Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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October 2014

Signal transduction: From the atomic age to the post-genomic era.

Cold Spring Harb Perspect Biol 2014 Oct 30;6(12):a022913. Epub 2014 Oct 30.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.

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October 2014

Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.

Cell 2014 Sep;158(6):1309-1323

Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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September 2014

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

Cancer Discov 2014 Aug 27;4(8):896-904. Epub 2014 May 27.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School; Department of Medicine; Divisions of

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August 2014

BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K.

Cell Metab 2014 Jul 15;20(1):73-84. Epub 2014 May 15.

Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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July 2014

A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis.

J Biol Chem 2014 May 14;289(19):13010-25. Epub 2014 Mar 14.

From the Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115.

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May 2014

BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity.

Mol Cell 2014 Apr 20;54(1):193-202. Epub 2014 Mar 20.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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April 2014

Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.

J Clin Oncol 2014 Apr 24;32(12):1202-9. Epub 2014 Mar 24.

Ingrid A. Mayer, Vandana G. Abramson, Justin M. Balko, María Gabriela Kuba, Melinda E. Sanders, and Carlos L. Arteaga, Vanderbilt University, Nashville, TN; Steven J. Isakoff, Massachusetts General Hospital, Boston, MA; Andres Forero, University of Alabama, Birmingham, AL; Jeffrey T. Yap, Huntsman Cancer Institute, Salt Lake City, UT; Annick D. Van den Abbeele and Eric Winer, Dana-Farber Cancer Institute, Boston, MA; Yisheng Li, MD Anderson Cancer Center, Houston, TX; and Lewis C. Cantley, Weill Cornell Medical College, New York, NY.

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April 2014

Idelalisib--a PI3Kδ inhibitor for B-cell cancers.

N Engl J Med 2014 Mar;370(11):1061-2

From the Department of Molecular Biology and Biochemistry and Institute for Immunology, University of California, Irvine (D.A.F.); and Weill Cornell Medical College, New York (L.C.C.).

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March 2014

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.

Cell 2014 Feb;156(4):771-85

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address:

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February 2014

Targeting metabolic scavenging in pancreatic cancer.

Clin Cancer Res 2014 Jan 28;20(1):6-8. Epub 2013 Oct 28.

Authors' Affiliation: Department of Medicine, Weill Cornell Medical College, New York City, New York.

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January 2014

A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.

Cancer Res 2014 Jan 9;74(1):15-23. Epub 2013 Dec 9.

Authors' Affiliations: Department of Cancer Biology; Division of Women's Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of Biological Chemistry and Molecular Pharmacology and Systems Biology; Rodent Histopathology Core, DF/HCC, Harvard Medical School; Department of Surgery, Brigham and Women's Hospital; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston; Novartis Institutes for Biomedical Research, Cambridge, Massacheusetts; Department of System Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and Novartis Institutes for Biomedical Research, Oncology Disease Area, Novartis Pharma AG, Basel, Switzerland.

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January 2014

What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway.

Cancer Discov 2013 Dec 21;3(12):1345-54. Epub 2013 Nov 21.

1Division of Hematology-Oncology, University of California Irvine Medical Center, Orange, California; 2Division of Signal Transduction, Beth Israel Deaconess Medical Center; 3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 4Department of Medicine, Weill Cornell Medical College, New York, New York.

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December 2013

Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):18226-31. Epub 2013 Oct 21.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.

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November 2013

Lin28 enhances tissue repair by reprogramming cellular metabolism.

Cell 2013 Nov;155(4):778-92

Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA; Manton Center for Orphan Disease Research, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA; Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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November 2013

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Cell 2013 Nov;155(4):844-57

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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November 2013

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.

EMBO J 2013 Oct 6;32(19):2589-602. Epub 2013 Sep 6.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, USA.

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October 2013

Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.

Mol Cell 2013 Oct 3;52(2):161-72. Epub 2013 Oct 3.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA; Department of Dermatology, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.

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October 2013

Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.

Stem Cells 2013 Aug;31(8):1563-73

Stem Cell Transplantation Program, Stem Cell Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Stem Cell Institute, Boston, Massachusetts, USA.

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August 2013

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

Cell 2013 Jul 3;154(2):311-324. Epub 2013 Jul 3.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215.

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July 2013

Heterogeneity of tumor-induced gene expression changes in the human metabolic network.

Nat Biotechnol 2013 Jun 21;31(6):522-9. Epub 2013 Apr 21.

Center for Computational Biology and Bioinformatics and Initiative in Systems Biology, Columbia University, New York, New York, USA.

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June 2013

Stem cell metabolism in tissue development and aging.

Development 2013 Jun;140(12):2535-47

Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.

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June 2013

Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.

Sci Signal 2013 May 28;6(277):ra40. Epub 2013 May 28.

Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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May 2013

Cancer metabolism: fatty acid oxidation in the limelight.

Nat Rev Cancer 2013 04 28;13(4):227-32. Epub 2013 Feb 28.

CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.

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April 2013

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Nature 2013 Apr 27;496(7443):101-5. Epub 2013 Mar 27.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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April 2013

Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.

Proc Natl Acad Sci U S A 2013 Apr 15;110(18):7193-8. Epub 2013 Apr 15.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

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April 2013

Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar.

Authors:
Lewis C Cantley

BMC Biol 2013 Jan 31;12. Epub 2013 Jan 31.

Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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January 2013