Lewis C Cantley

Lewis C Cantley

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Lewis C Cantley

Lewis C Cantley

Publications by authors named "Lewis C Cantley"

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98Publications

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Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.

Biochemistry 2018 Nov 12;57(47):6604-6614. Epub 2018 Nov 12.

Department of Molecular and Integrative Physiology, Department of Internal Medicine, Division of Gastroenterology, and Rogel Cancer Center , University of Michigan , Ann Arbor , Michigan 48109 , United States.

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http://pubs.acs.org/doi/10.1021/acs.biochem.8b00914
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http://dx.doi.org/10.1021/acs.biochem.8b00914DOI Listing
November 2018

Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer.

N Engl J Med 2018 11;379(21):2052-2062

From the Meyer Cancer Center (M.D.G., B.D.H., L.C.C.) and the Division of Endocrinology (M.D.G.), Department of Medicine, Weill Cornell Medicine, New York.

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http://www.nejm.org/doi/10.1056/NEJMra1704560
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http://dx.doi.org/10.1056/NEJMra1704560DOI Listing
November 2018

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells.

Cell 2018 Nov;175(6):1546-1560.e17

Department of Medicine, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.09.041DOI Listing
November 2018

Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant.

J Allergy Clin Immunol 2018 Oct 16. Epub 2018 Oct 16.

Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183144
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http://dx.doi.org/10.1016/j.jaci.2018.10.005DOI Listing
October 2018

Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.

Bioorg Med Chem Lett 2018 Sep 27;28(16):2675-2678. Epub 2018 Apr 27.

California Institute for Biomedical Research, 11119 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.04.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119644PMC
September 2018

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment.

Cell 2018 Sep;174(6):1347-1360

Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2018.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136429PMC
September 2018

A Glycolysis Outsider Steps into the Cancer Spotlight.

Cell Metab 2018 Jul;28(1):3-4

Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.017DOI Listing
July 2018

Cancer metabolism gets physical.

Sci Transl Med 2018 May;10(442)

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaq1011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990021PMC
May 2018

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Cell 2017 Dec 16;171(7):1545-1558.e18. Epub 2017 Nov 16.

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pharmacology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.10.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920692PMC
December 2017

The PI3K Pathway in Human Disease.

Cell 2017 Aug;170(4):605-635

Oncology R&D Group, Pfizer Worldwide Research and Development, 10646/CB4 Science Center Drive, San Diego, CA 92121, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173086
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http://dx.doi.org/10.1016/j.cell.2017.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726441PMC
August 2017

Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer.

J Cancer Res Clin Oncol 2017 Jul 28;143(7):1255-1262. Epub 2017 Feb 28.

Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.

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http://dx.doi.org/10.1007/s00432-017-2358-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486569PMC
July 2017

PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α.

Proc Natl Acad Sci U S A 2017 07 19;114(27):7095-7100. Epub 2017 Jun 19.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1704706114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502636PMC
July 2017

Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma.

J Invest Dermatol 2017 05 28;137(5):1135-1143. Epub 2017 Jan 28.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392423PMC
May 2017

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition.

Cancer Discov 2017 04 2;7(4):380-390. Epub 2017 Mar 2.

Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562025PMC
April 2017

Membrane Lipids Speak to Histones.

Mol Cell 2017 Apr;66(2):163-164

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.04.001DOI Listing
April 2017

Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer.

Recent Results Cancer Res 2016;207:39-72

Department of Medicine, the Cancer Center, Weill Cornell Medical College, The Belfer Research Building, 413 East 69th Street, Floor 13 Room BB-1362, New York, NY, 10021, USA.

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http://dx.doi.org/10.1007/978-3-319-42118-6_3DOI Listing
March 2017

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation.

Mol Cell 2017 Mar;65(6):999-1013.e7

Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK; Division of Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426642PMC
March 2017

α-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH).

J Med Chem 2017 02 27;60(4):1591-1597. Epub 2017 Jan 27.

Medicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain , 73 avenue Mounier, B-1200 Brussels, Belgium.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603230PMC
February 2017

Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.

Cell Death Differ 2017 02 4;24(2):238-250. Epub 2016 Nov 4.

Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/cdd.2016.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299707PMC
February 2017

Obesity and Cancer Mechanisms: Cancer Metabolism.

J Clin Oncol 2016 12 7;34(35):4277-4283. Epub 2016 Nov 7.

All authors: Meyer Cancer Center, Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.67.9712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562429PMC
December 2016

Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley.

Authors:
Lewis C Cantley

Dis Model Mech 2016 09 4;9(9):911-6. Epub 2016 Aug 4.

Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047696PMC
http://dx.doi.org/10.1242/dmm.026856DOI Listing
September 2016

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.

Proc Natl Acad Sci U S A 2016 08 15;113(35):9810-5. Epub 2016 Aug 15.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1606862113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024598PMC
August 2016

Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.

Proc Natl Acad Sci U S A 2016 07 16;113(27):7596-601. Epub 2016 Jun 16.

Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065; Department of Medicine, Weill Cornell Medical College, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1600934113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941458PMC
July 2016

Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.

Proc Natl Acad Sci U S A 2016 07 8;113(30):E4338-47. Epub 2016 Jul 8.

Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1522223113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968752PMC
July 2016

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.

Mol Cell Oncol 2016 Jul 30;3(4):e1164280. Epub 2016 Mar 30.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1080/23723556.2016.1164280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972100PMC
July 2016

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer.

Nat Cell Biol 2016 05 18;18(5):572-8. Epub 2016 Apr 18.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncb3341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848114PMC
May 2016

Computational prediction of protein-protein interactions.

Methods Mol Biol 2015 ;1278:57-75

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-2425-7_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4435844PMC
December 2015

Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy.

Cell Signal 2015 Dec 9;27(12):2389-400. Epub 2015 Sep 9.

Department of Biochemistry, Yonsei University, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2015.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847727PMC
December 2015

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.

Nat Struct Mol Biol 2015 Dec 9;22(12):983-90. Epub 2015 Nov 9.

Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.3117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824005PMC
December 2015

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Cancer Discov 2015 Nov 20;5(11):1194-209. Epub 2015 Aug 20.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631654PMC
November 2015

Cancer's Fuel Choice: New Flavors for a Picky Eater.

Mol Cell 2015 Nov;60(4):514-23

Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676726PMC
November 2015

Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.

Biochim Biophys Acta 2015 Oct 11;1852(10 Pt A):2056-65. Epub 2015 Jul 11.

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2015.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862866PMC
October 2015

Regulation of mTORC1 by PI3K signaling.

Trends Cell Biol 2015 Sep 6;25(9):545-55. Epub 2015 Jul 6.

Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2015.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734635PMC
September 2015

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer.

Nat Med 2015 May 13;21(5):457-66. Epub 2015 Apr 13.

1] Division of Translational Therapeutics, Department of Medicine, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Medicine, BIDMC, Harvard Medical School, Boston, Massachusetts, USA.. [3] Cancer Research Institute, Beth Israel Deaconess Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425616PMC
May 2015

Acetate fuels the cancer engine.

Cell 2014 Dec;159(7):1492-4

Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York City, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.12.009DOI Listing
December 2014

Signal transduction: From the atomic age to the post-genomic era.

Cold Spring Harb Perspect Biol 2014 Oct 30;6(12):a022913. Epub 2014 Oct 30.

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724.

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http://dx.doi.org/10.1101/cshperspect.a022913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292159PMC
October 2014

Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis.

Cell 2014 Sep;158(6):1309-1323

Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02114, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197056PMC
September 2014

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.

Cancer Discov 2014 Aug 27;4(8):896-904. Epub 2014 May 27.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School; Department of Medicine; Divisions of

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http://dx.doi.org/10.1158/2159-8290.CD-13-0230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125493PMC
August 2014

BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K.

Cell Metab 2014 Jul 15;20(1):73-84. Epub 2014 May 15.

Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079724PMC
July 2014

BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity.

Mol Cell 2014 Apr 20;54(1):193-202. Epub 2014 Mar 20.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004185PMC
April 2014

Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.

J Clin Oncol 2014 Apr 24;32(12):1202-9. Epub 2014 Mar 24.

Ingrid A. Mayer, Vandana G. Abramson, Justin M. Balko, María Gabriela Kuba, Melinda E. Sanders, and Carlos L. Arteaga, Vanderbilt University, Nashville, TN; Steven J. Isakoff, Massachusetts General Hospital, Boston, MA; Andres Forero, University of Alabama, Birmingham, AL; Jeffrey T. Yap, Huntsman Cancer Institute, Salt Lake City, UT; Annick D. Van den Abbeele and Eric Winer, Dana-Farber Cancer Institute, Boston, MA; Yisheng Li, MD Anderson Cancer Center, Houston, TX; and Lewis C. Cantley, Weill Cornell Medical College, New York, NY.

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http://jco.ascopubs.org/content/early/2014/03/18/JCO.2013.54
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.54.0518
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http://dx.doi.org/10.1200/JCO.2013.54.0518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986383PMC
April 2014

Idelalisib--a PI3Kδ inhibitor for B-cell cancers.

N Engl J Med 2014 Mar;370(11):1061-2

From the Department of Molecular Biology and Biochemistry and Institute for Immunology, University of California, Irvine (D.A.F.); and Weill Cornell Medical College, New York (L.C.C.).

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http://dx.doi.org/10.1056/NEJMe1400055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088325PMC
March 2014

Targeting metabolic scavenging in pancreatic cancer.

Clin Cancer Res 2014 Jan 28;20(1):6-8. Epub 2013 Oct 28.

Authors' Affiliation: Department of Medicine, Weill Cornell Medical College, New York City, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930347PMC
January 2014

A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition.

Cancer Res 2014 Jan 9;74(1):15-23. Epub 2013 Dec 9.

Authors' Affiliations: Department of Cancer Biology; Division of Women's Cancers, Department of Medical Oncology, Dana-Farber Cancer Institute; Departments of Biological Chemistry and Molecular Pharmacology and Systems Biology; Rodent Histopathology Core, DF/HCC, Harvard Medical School; Department of Surgery, Brigham and Women's Hospital; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston; Novartis Institutes for Biomedical Research, Cambridge, Massacheusetts; Department of System Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and Novartis Institutes for Biomedical Research, Oncology Disease Area, Novartis Pharma AG, Basel, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982380PMC
January 2014

What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway.

Cancer Discov 2013 Dec 21;3(12):1345-54. Epub 2013 Nov 21.

1Division of Hematology-Oncology, University of California Irvine Medical Center, Orange, California; 2Division of Signal Transduction, Beth Israel Deaconess Medical Center; 3Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; and 4Department of Medicine, Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864542PMC
December 2013

Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma.

Proc Natl Acad Sci U S A 2013 Nov 21;110(45):18226-31. Epub 2013 Oct 21.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.

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http://dx.doi.org/10.1073/pnas.1317577110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831456PMC
November 2013

Lin28 enhances tissue repair by reprogramming cellular metabolism.

Cell 2013 Nov;155(4):778-92

Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA; Manton Center for Orphan Disease Research, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA; Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2013.09.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917449PMC
November 2013

Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Cell 2013 Nov;155(4):844-57

Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.cell.2013.09.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070383PMC
November 2013

FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.

EMBO J 2013 Oct 6;32(19):2589-602. Epub 2013 Sep 6.

Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, NY, USA.

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http://dx.doi.org/10.1038/emboj.2013.186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791369PMC
October 2013

Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.

Mol Cell 2013 Oct 3;52(2):161-72. Epub 2013 Oct 3.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA; Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA; Department of Dermatology, Columbia University Medical Center, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.molcel.2013.08.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892895PMC
October 2013

Metabolic syndrome: F stands for fructose and fat.

Nature 2013 Oct;502(7470):181-2

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http://dx.doi.org/10.1038/502181aDOI Listing
October 2013

Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism.

Stem Cells 2013 Aug;31(8):1563-73

Stem Cell Transplantation Program, Stem Cell Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Stem Cell Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/stem.1423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775935PMC
August 2013

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling.

Cell 2013 Jul 3;154(2):311-324. Epub 2013 Jul 3.

Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215.

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http://dx.doi.org/10.1016/j.cell.2013.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767157PMC
July 2013

Stem cell metabolism in tissue development and aging.

Development 2013 Jun;140(12):2535-47

Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1242/dev.091777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666381PMC
June 2013

Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.

Sci Signal 2013 May 28;6(277):ra40. Epub 2013 May 28.

Hematology-Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.2003936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735445PMC
May 2013

Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar.

Authors:
Lewis C Cantley

BMC Biol 2013 Jan 31;12. Epub 2013 Jan 31.

Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1186/1741-7007-12-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909335PMC
January 2013