Lewis A Chodosh

Lewis A Chodosh

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Lewis A Chodosh

Lewis A Chodosh

Publications by authors named "Lewis A Chodosh"

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Chronic expression of wild-type Ret receptor in the mammary gland induces luminal tumors that are sensitive to Ret inhibition.

Oncogene 2018 07 26;37(29):4046-4054. Epub 2018 Apr 26.

Friedrich Miescher Institute for Biomedical Research (FMI), Maulbeerstrasse 66, CH-4058, Basel, Switzerland.

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http://dx.doi.org/10.1038/s41388-018-0235-yDOI Listing
July 2018

WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis.

Dev Cell 2017 11 2;43(4):436-448.e6. Epub 2017 Nov 2.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698144PMC
November 2017

A novel approach for next-generation sequencing of circulating tumor cells.

Mol Genet Genomic Med 2016 Jul 28;4(4):395-406. Epub 2016 Feb 28.

Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania; Abramson Cancer CenterUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania.

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http://dx.doi.org/10.1002/mgg3.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947859PMC
July 2016

"Braking" the Cycle of Resistance in Endocrine Therapy for Breast Cancer.

Clin Cancer Res 2015 Nov 22;21(22):4999-5001. Epub 2015 Jul 22.

2-PREVENT Breast Cancer Translational Center of Excellence, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. The Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-1146DOI Listing
November 2015

Tissue phosphoproteomics with PolyMAC identifies potential therapeutic targets in a transgenic mouse model of HER2 positive breast cancer.

Electrophoresis 2014 Dec 12;35(24):3463-9. Epub 2014 Jun 12.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://doi.wiley.com/10.1002/elps.201400022
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http://dx.doi.org/10.1002/elps.201400022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193948PMC
December 2014

Oncogene pathway activation in mammary tumors dictates FDG-PET uptake.

Cancer Res 2014 Dec 19;74(24):7583-98. Epub 2014 Sep 19.

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342047PMC
December 2014

Ceramide kinase promotes tumor cell survival and mammary tumor recurrence.

Cancer Res 2014 Nov 27;74(21):6352-63. Epub 2014 Aug 27.

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285436PMC
November 2014

Tetracycline-regulated mouse models of cancer.

Cold Spring Harb Protoc 2014 Oct 1;2014(10):pdb.top069823. Epub 2014 Oct 1.

Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104.

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http://dx.doi.org/10.1101/pdb.top069823DOI Listing
October 2014

SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.

Cancer Discov 2014 Jul 30;4(7):790-803. Epub 2014 Apr 30.

Authors' Affiliations: Departments of Cancer Biology and Medicine; and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

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http://dx.doi.org/10.1158/2159-8290.CD-13-0548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121738PMC
July 2014

The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia.

Haematologica 2013 Jun 24;98(6):918-27. Epub 2013 Jan 24.

Abramson Family Cancer Research Institute, Department of Cancer Biology, Abramson Cancer Center, the University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.3324/haematol.2012.074195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669449PMC
June 2013

Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten.

Proc Natl Acad Sci U S A 2013 Apr 21;110(15):6103-8. Epub 2013 Mar 21.

Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1073/pnas.1217415110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625285PMC
April 2013

PUMA and BIM are required for oncogene inactivation-induced apoptosis.

Sci Signal 2013 Mar 26;6(268):ra20. Epub 2013 Mar 26.

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1126/scisignal.2003483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753585PMC
March 2013

P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.

Breast Cancer Res 2010 22;12(5):R73. Epub 2010 Sep 22.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, South Bend, 46617, USA.

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http://dx.doi.org/10.1186/bcr2643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096962PMC
February 2013

Breast cancer biology and therapy: From patients to mouse models.

Authors:
Lewis A Chodosh

Phys Med 2006 ;21 Suppl 1

University of Pennsylvania, Philadelphia, Pennsylvania (USA).

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http://linkinghub.elsevier.com/retrieve/pii/S112017970680012
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http://dx.doi.org/10.1016/S1120-1797(06)80012-8DOI Listing
October 2012

Breast cancer: current state and future promise.

Authors:
Lewis A Chodosh

Breast Cancer Res 2011 1;13(6):113. Epub 2011 Nov 1.

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http://dx.doi.org/10.1186/bcr3045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326550PMC
June 2012

Preparation and characterization of L-[5-11C]-glutamine for metabolic imaging of tumors.

J Nucl Med 2012 Jan 15;53(1):98-105. Epub 2011 Dec 15.

Departments of Radiology and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.2967/jnumed.111.093831DOI Listing
January 2012

PET imaging of glutaminolysis in tumors by 18F-(2S,4R)4-fluoroglutamine.

J Nucl Med 2011 Dec 15;52(12):1947-55. Epub 2011 Nov 15.

Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.2967/jnumed.111.093815DOI Listing
December 2011

Hunk is required for HER2/neu-induced mammary tumorigenesis.

J Clin Invest 2011 Mar;121(3):866-79

Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1172/JCI42928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049391PMC
March 2011

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression.

J Clin Invest 2011 Mar;121(3):1064-74

Department of Medicine, Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614, USA.

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http://www.jci.org/articles/view/44540
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http://dx.doi.org/10.1172/JCI44540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049398PMC
March 2011

HIF-2alpha deletion promotes Kras-driven lung tumor development.

Proc Natl Acad Sci U S A 2010 Aug 21;107(32):14182-7. Epub 2010 Jul 21.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1001296107
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http://dx.doi.org/10.1073/pnas.1001296107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922515PMC
August 2010

ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.

Mol Cell Biol 2009 Sep 13;29(18):4935-48. Epub 2009 Jul 13.

UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1128/MCB.01705-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738276PMC
September 2009

The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis.

Proc Natl Acad Sci U S A 2009 Sep 28;106(37):15855-60. Epub 2009 Aug 28.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1073/pnas.0906993106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734880PMC
September 2009

Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition.

J Clin Invest 2009 Sep 24;119(9):2663-77. Epub 2009 Aug 24.

Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

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http://dx.doi.org/10.1172/JCI37691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735909PMC
September 2009

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

Cell Stem Cell 2009 Sep;5(3):279-89

Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.stem.2009.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939833PMC
September 2009

Abnormal mammary gland development in MMTV-CBLC transgenic mouse.

In Vivo 2009 Mar-Apr;23(2):225-8

Marseille Cancer Research Center, UMR891 Inserm, 27 Bd. Leï Roure, 13009 Marseille, France.

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July 2009

Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo.

Genome Biol 2008 18;9(12):R180. Epub 2008 Dec 18.

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Blvd, BRB II/III 616, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1186/gb-2008-9-12-r180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646284PMC
March 2009

Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss.

J Clin Invest 2008 Jan;118(1):51-63

Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.

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http://dx.doi.org/10.1172/JCI33320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2104482PMC
January 2008

Deciphering the molecular basis of breast cancer metastasis with mouse models.

Rev Endocr Metab Disord 2007 Sep;8(3):199-213

Department of Cancer Biology, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 612 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA.

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http://link.springer.com/10.1007/s11154-007-9041-5
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http://dx.doi.org/10.1007/s11154-007-9041-5DOI Listing
September 2007

c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1.

Mol Cell Biol 2007 Jul 7;27(14):5135-46. Epub 2007 May 7.

Dartmouth Medical School, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.02282-06
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http://dx.doi.org/10.1128/MCB.02282-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951955PMC
July 2007

Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

Nat Cell Biol 2007 May 22;9(5):493-505. Epub 2007 Apr 22.

Department of Cancer Biology, The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1038/ncb1567DOI Listing
May 2007

Isoform-specific ras activation and oncogene dependence during MYC- and Wnt-induced mammary tumorigenesis.

Mol Cell Biol 2006 Nov 14;26(21):8109-21. Epub 2006 Aug 14.

Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1128/MCB.00404-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636749PMC
November 2006

mILC-ing the mouse mammary gland: A model for invasive lobular carcinoma.

Cancer Cell 2006 Nov;10(5):347-9

Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2006.10.016DOI Listing
November 2006

The AP-1 transcription factor regulates postnatal mammary gland development.

Dev Biol 2006 Jul 4;295(2):589-603. Epub 2006 Apr 4.

Breast Center, Baylor College of Medicine, MS600, 1 Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.03.042DOI Listing
July 2006

Computational expression deconvolution in a complex mammalian organ.

BMC Bioinformatics 2006 Jul 3;7:328. Epub 2006 Jul 3.

Departments of Cancer Biology, Medicine, and Cell & Developmental Biology, and the Abramson Family Cancer Research Institute, University of Pennsylvania, 612 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1186/1471-2105-7-328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1559723PMC
July 2006

P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.

Mol Endocrinol 2006 Jun 9;20(6):1391-405. Epub 2006 Feb 9.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1210/me.2005-0426DOI Listing
June 2006

Induction of neuregulin signaling in mouse schwann cells in vivo mimics responses to denervation.

J Neurosci 2006 Jun;26(25):6873-84

Section of Neurobiology and Institute for Neuroscience, University of Texas, Austin, Texas 78712, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.1086-06.2006DOI Listing
June 2006

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.

Mol Cell Biol 2006 May;26(9):3514-26

Howard Hughes Medical Institute and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1128/MCB.26.9.3514-3526.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1447431PMC
May 2006

Analysis of cell migration using whole-genome expression profiling of migratory cells in the Drosophila ovary.

Dev Cell 2006 Apr;10(4):483-95

Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1016/j.devcel.2006.02.003DOI Listing
April 2006

In vivo imaging of the mammary gland: the shape of things to come.

J Mammary Gland Biol Neoplasia 2006 Apr;11(2):101-2

The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1007/s10911-006-9016-2DOI Listing
April 2006

Genomic analysis of early murine mammary gland development using novel probe-level algorithms.

Genome Biol 2005 1;6(2):R20. Epub 2005 Feb 1.

Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1186/gb-2005-6-2-r20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC551540PMC
March 2006

Defective neuromuscular synaptogenesis in mice expressing constitutively active ErbB2 in skeletal muscle fibers.

Mol Cell Neurosci 2006 Feb 8;31(2):334-45. Epub 2005 Nov 8.

Section of Neurobiology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712-0248, USA.

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http://dx.doi.org/10.1016/j.mcn.2005.10.004DOI Listing
February 2006

The serine/threonine kinase, Krct, affects endbud morphogenesis during murine mammary gland development.

Transgenic Res 2005 Dec;14(6):919-40

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 19104-6160, USA.

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http://link.springer.com/10.1007/s11248-005-1806-6
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http://dx.doi.org/10.1007/s11248-005-1806-6DOI Listing
December 2005

Dynamics of DNA repair suggested by the subcellular localization of Brca1 and Brca2 proteins.

J Cell Biochem 2005 Sep;96(1):47-55

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.

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http://doi.wiley.com/10.1002/jcb.20517
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http://dx.doi.org/10.1002/jcb.20517DOI Listing
September 2005

The transcriptional repressor Snail promotes mammary tumor recurrence.

Cancer Cell 2005 Sep;8(3):197-209

Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2005.07.009DOI Listing
September 2005

Evolving views of involution.

Breast Cancer Res 2004 10;6(2):89-92. Epub 2004 Feb 10.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Pennsylvania, USA.

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http://dx.doi.org/10.1186/bcr765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC400663PMC
July 2005

Large-scale transcriptional profiling of murine mammary development.

Breast Dis 2004 ;19:47-57

Department of Cancer Biology, University of Pennsylvania School of Medicine Philadelphia, PA 19104-6160, USA.

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March 2005

Developmental stage determines the effects of MYC in the mammary epithelium.

Development 2005 Mar 2;132(5):1147-60. Epub 2005 Feb 2.

Departments of Cancer Biology, Cell and Developmental Biology, Medicine, and The Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1242/dev.01655DOI Listing
March 2005

Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ.

Cancer Res 2005 Feb;65(3):681-5

Lombardi Comprehensive Cancer Center, Departments of Oncology and Pathology, Georgetown University, 3970 Reservoir Road, Washington, DC 20057, USA.

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February 2005

Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors.

Cancer Res 2004 Dec;64(24):9002-11

Department of Cancer Biology, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2111DOI Listing
December 2004

Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation.

Cancer Cell 2004 Dec;6(6):577-86

Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.ccr.2004.10.013DOI Listing
December 2004

Global regulation of erythroid gene expression by transcription factor GATA-1.

Blood 2004 Nov 5;104(10):3136-47. Epub 2004 Aug 5.

The Children's Hospital of Philadelphia, Division of Hematology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1182/blood-2004-04-1603DOI Listing
November 2004

Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1.

Mol Cell Biol 2004 Nov;24(21):9498-507

Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 10/9N105, 10 Center Dr., Bethesda, MD 20892, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.24.21.9498-9507.2004
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http://dx.doi.org/10.1128/MCB.24.21.9498-9507.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC522227PMC
November 2004

Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS.

Cell Cycle 2004 Nov 8;3(11):1451-6. Epub 2004 Nov 8.

Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

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http://dx.doi.org/10.4161/cc.3.11.1211DOI Listing
November 2004

Deregulated expression of LRBA facilitates cancer cell growth.

Oncogene 2004 May;23(23):4089-97

Immunology Programs and Department of Interdisciplinary Oncology, H Lee Moffitt Comprehensive Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL 33612, USA.

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http://dx.doi.org/10.1038/sj.onc.1207567DOI Listing
May 2004

A lysosomal tetraspanin associated with retinal degeneration identified via a genome-wide screen.

EMBO J 2004 Feb 12;23(4):811-22. Epub 2004 Feb 12.

Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1038/sj.emboj.7600112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC381016PMC
February 2004

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.

Mol Cell Biol 2003 Dec;23(24):9361-74

Abramson Family Cancer Research Institute. Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309606PMC
http://dx.doi.org/10.1128/mcb.23.24.9361-9374.2003DOI Listing
December 2003

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor.

Genes Dev 2003 Aug 17;17(15):1841-54. Epub 2003 Jul 17.

Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1105003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC196230PMC
August 2003

GATA-1-mediated proliferation arrest during erythroid maturation.

Mol Cell Biol 2003 Jul;23(14):5031-42

Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC162202PMC
http://dx.doi.org/10.1128/mcb.23.14.5031-5042.2003DOI Listing
July 2003

Gene expression profile of human cells irradiated in G1 and G2 phases of cell cycle.

Cancer Lett 2003 Jun;195(2):221-33

Department of Microbiology and Molecular Genetics, University of Vermont, 226 Stafford Hall, Burlington 05401, USA.

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June 2003

Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis.

Genes Dev 2003 Feb;17(4):488-501

Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1101/gad.1051603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC195997PMC
February 2003

Genomic scale profiling of autoimmune inflammation in the central nervous system: the nervous response to inflammation.

J Neuroimmunol 2002 Dec;133(1-2):95-107

Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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December 2002

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis.

Cancer Cell 2002 Dec;2(6):451-61

Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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December 2002

Persistent parity-induced changes in growth factors, TGF-beta3, and differentiation in the rodent mammary gland.

Mol Endocrinol 2002 Sep;16(9):2034-51

Departments of Cancer Biology, of Cell and Developmental Biology, and of Medicine, and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1210/me.2002-0073DOI Listing
September 2002

Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction.

Nat Immunol 2002 Jul 10;3(7):652-8. Epub 2002 Jun 10.

Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA.

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http://dx.doi.org/10.1038/ni807DOI Listing
July 2002

The reciprocal dance between cancer and development.

Authors:
Lewis A Chodosh

N Engl J Med 2002 Jul;347(2):134-6

University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://www.nejm.org/doi/abs/10.1056/NEJMcibr020712
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http://dx.doi.org/10.1056/NEJMcibr020712DOI Listing
July 2002

Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors.

Proc Natl Acad Sci U S A 2002 Jul 12;99(15):9830-5. Epub 2002 Jul 12.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.152571899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125032PMC
July 2002

Functional microarray analysis of mammary organogenesis reveals a developmental role in adaptive thermogenesis.

Mol Endocrinol 2002 Jun;16(6):1185-203

Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1210/mend.16.6.0865DOI Listing
June 2002

A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology.

FASEB J 2002 Mar;16(3):283-92

Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA.

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http://dx.doi.org/10.1096/fj.01-0551comDOI Listing
March 2002

Gene expression profiling of HeLa cells in G1 or G2 phases.

Oncogene 2002 Mar;21(12):1934-42

Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, PA 19104, USA.

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http://dx.doi.org/10.1038/sj.onc.1205264DOI Listing
March 2002