Levi Garraway

Levi Garraway

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Levi Garraway

Levi Garraway

Publications by authors named "Levi Garraway"

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Synthetic lethality as an engine for cancer drug target discovery.

Nat Rev Drug Discov 2020 Jan 11;19(1):23-38. Epub 2019 Nov 11.

Tango Therapeutics, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41573-019-0046-zDOI Listing
January 2020

6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels.

Cell Chem Biol 2019 Sep 13;26(9):1306-1314.e5. Epub 2019 Jun 13.

Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754299PMC
September 2019

A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma.

Cancer Res 2019 05 28;79(9):2352-2366. Epub 2019 Feb 28.

Cancer Program, The Broad Institute of M.I.T. and Harvard, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2711DOI Listing
May 2019

A Convergence-Based Framework for Cancer Drug Resistance.

Cancer Cell 2018 05;33(5):801-815

Eli Lilly and Company, Indianapolis, IN 46225, USA.

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http://dx.doi.org/10.1016/j.ccell.2018.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957297PMC
May 2018

Inherited DNA-Repair Defects in Colorectal Cancer.

Am J Hum Genet 2018 03 22;102(3):401-414. Epub 2018 Feb 22.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985280PMC
March 2018

Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Cancer Discov 2018 02 3;8(2):196-215. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809290PMC
February 2018

Defining a Cancer Dependency Map.

Cell 2017 Jul;170(3):564-576.e16

Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667678PMC
July 2017

Remember why we work on cancer.

Authors:
Levi Garraway

Nature 2017 03;543(7647):613-615

Eli Lilly in Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1038/543613aDOI Listing
March 2017

Believe the miracles: of biomedical science and human suffering.

Authors:
Levi A Garraway

J Clin Invest 2016 12 1;126(12):4716-4722. Epub 2016 Dec 1.

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http://dx.doi.org/10.1172/JCI90893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127662PMC
December 2016

Bidirectional cross talk between patient-derived melanoma and cancer-associated fibroblasts promotes invasion and proliferation.

Pigment Cell Melanoma Res 2016 11 22;29(6):656-668. Epub 2016 Sep 22.

Division of Surgical Oncology, Department of Surgery, Brigham and Womens Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1111/pcmr.12513DOI Listing
November 2016

Distinct genetic profiles of extracranial and intracranial acral melanoma metastases.

J Cutan Pathol 2016 Oct 29;43(10):884-91. Epub 2016 Jun 29.

Division of Surgical Oncology, Department of Surgery, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/cup.12746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347374PMC
October 2016

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Cancer Discov 2016 08 3;6(8):914-29. Epub 2016 Jun 3.

Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972686PMC
August 2016

Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

N Engl J Med 2016 Aug 6;375(5):443-53. Epub 2016 Jul 6.

From the University of Washington (C.C.P., M. Beightol, C.M., B.N., H.H.C., B.M., T.W., S. Casadei, P.S.N.) and Fred Hutchinson Cancer Research Center (N.D.S., R.G., P.S.N.) - both in Seattle; the Institute of Cancer Research and Royal Marsden Hospital, London (J.M., S. Carreira, R.E., J.B.); Memorial Sloan Kettering Cancer Center (M.F.W., W.A., M. Berger, L.Z., A.Z., J. Vijai, H.I.S., C.S., N.S., P.W.K., D.S., M.R., K.O.), Weill Cornell Medical College (H.B., O.E., M.A.R.), and the Prostate Cancer Clinical Trials Consortium (J. Vinson, J.F.) - all in New York; the University of Michigan, Ann Arbor (D.R., R.L., M.H., A.C.); Howard Hughes Medical Institute, Chevy Chase, MD (A.C., C.S.); and Dana-Farber Cancer Institute, Boston (A.G., L.G., M.-E.T., S.A., G.C.H., E.M.V.A.).

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http://dx.doi.org/10.1056/NEJMoa1603144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986616PMC
August 2016

gkmSVM: an R package for gapped-kmer SVM.

Bioinformatics 2016 07 19;32(14):2205-7. Epub 2016 Apr 19.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btw203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937197PMC
July 2016

Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies.

Dis Model Mech 2016 07 11;9(7):811-20. Epub 2016 May 11.

Stem Cell Program and Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA Howard Hughes Medical Institute, Boston, MA 02115, USA Harvard Medical School, Boston, MA 02138, USA

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http://dmm.biologists.org/lookup/doi/10.1242/dmm.024166
Publisher Site
http://dx.doi.org/10.1242/dmm.024166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958307PMC
July 2016

TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer.

Cancer Cell 2016 06 26;29(6):846-858. Epub 2016 May 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124371PMC
June 2016

Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors.

Clin Cancer Res 2016 05 2;22(9):2183-9. Epub 2015 Dec 2.

Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854770PMC
May 2016

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.

Cell Rep 2016 Apr 14;15(4):857-865. Epub 2016 Apr 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.03.075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850357PMC
April 2016

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.

Proc Natl Acad Sci U S A 2016 Mar 16;113(9):E1296-305. Epub 2016 Feb 16.

Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030; Institute for Applied Cancer Science (IACS), The University of Texas MD Anderson Cancer Center, Houston, TX 77030;

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http://dx.doi.org/10.1073/pnas.1513801113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780599PMC
March 2016

Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors.

Mol Cancer Ther 2015 Dec 8;14(12):2700-11. Epub 2015 Sep 8.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. The Broad Institute, Cambridge, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0136-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674359PMC
December 2015

Fusobacterium nucleatum and T Cells in Colorectal Carcinoma.

JAMA Oncol 2015 Aug;1(5):653-61

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts3Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts5Department of Pathology, Brigham and Women's Hospital.

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http://dx.doi.org/10.1001/jamaoncol.2015.1377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537376PMC
August 2015

Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.

Proc Natl Acad Sci U S A 2015 May 20;112(18):5708-13. Epub 2015 Apr 20.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1505979112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426412PMC
May 2015

Integrative clinical genomics of advanced prostate cancer.

Cell 2015 May;161(5):1215-1228

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Urology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484602PMC
May 2015

ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors.

Cancer Res 2014 Dec 15;74(23):7079-89. Epub 2014 Oct 15.

Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300142PMC
December 2014

RNF43 is frequently mutated in colorectal and endometrial cancers.

Nat Genet 2014 Dec 26;46(12):1264-6. Epub 2014 Oct 26.

1] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [3] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283570PMC
December 2014

Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.

Cancer Cell 2014 Dec;26(6):813-825

Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology/Oncology, Children's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.10.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302418PMC
December 2014

Genetic modifiers of EGFR dependence in non-small cell lung cancer.

Proc Natl Acad Sci U S A 2014 Dec 15;111(52):18661-6. Epub 2014 Dec 15.

Broad Institute of Harvard and MIT, Cambridge, MA 02142; Departments of Pathology and Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115; and

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http://dx.doi.org/10.1073/pnas.1412228112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284598PMC
December 2014