Leticia G Leon

Leticia G Leon

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Leticia G Leon

Leticia G Leon

Publications by authors named "Leticia G Leon"

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Lung transcriptional unresponsiveness and loss of early influenza virus control in infected neonates is prevented by intranasal Lactobacillus rhamnosus GG.

PLoS Pathog 2019 Oct 11;15(10):e1008072. Epub 2019 Oct 11.

Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1008072DOI Listing
October 2019

Stem cell factor supports migration in canine mesenchymal stem cells.

Vet Res Commun 2018 Mar 3;42(1):29-38. Epub 2018 Jan 3.

Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040, Madrid, Spain.

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http://dx.doi.org/10.1007/s11259-017-9705-xDOI Listing
March 2018

Double Trouble: A Case Series on Concomitant Genetic Aberrations in NSCLC.

Clin Lung Cancer 2018 01 6;19(1):35-41. Epub 2017 Jul 6.

Center for Oncological Research, University of Antwerp, Antwerp, Belgium; Phase I - Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital, Antwerp, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2017.06.010DOI Listing
January 2018

Molecular bases of anorexia nervosa, bulimia nervosa and binge eating disorder: shedding light on the darkness.

J Neurogenet 2017 12 1;31(4):266-287. Epub 2017 Aug 1.

a Centre for Biomedical Research of the Canary Islands , Institute of Biomedical Technologies, University of La Laguna , Tenerife , Spain.

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http://dx.doi.org/10.1080/01677063.2017.1353092DOI Listing
December 2017

On the pharmacogenetics of non-small cell lung cancer treatment.

Expert Opin Drug Metab Toxicol 2016 17;12(3):307-17. Epub 2016 Feb 17.

c Department of Medical Oncology , VU University Medical Center , Amsterdam , The Netherlands.

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http://dx.doi.org/10.1517/17425255.2016.1141894DOI Listing
October 2016

The MEK1/2 Inhibitor Pimasertib Enhances Gemcitabine Efficacy-Letter.

Clin Cancer Res 2016 05;22(10):2594

Cancer Pharmacology Lab, AIRC Start-UP Unit, University of Pisa, Pisa, Italy. Department of Medical Oncology, VU University Medical Center Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-0259DOI Listing
May 2016

Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells.

Curr Drug Targets 2014 ;15(14):1331-40

Center for Biomedical Research of the Canary Islands, Instituto de Tecnologias Biomedicas, University of La Laguna, Campus de la Salud s/n, 38071 La Laguna, Tenerife, Spain.

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http://dx.doi.org/10.2174/1389450116666141205160924DOI Listing
August 2015

Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids.

Molecules 2015 Jul 30;20(8):13854-63. Epub 2015 Jul 30.

Instituto Universitario de Bio-Orgánica Antonio González (CIBICAN), Universidad de La Laguna, Av. Astrofísico Francisco Sánchez 2, La Laguna 38206, Spain.

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http://dx.doi.org/10.3390/molecules200813854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332398PMC
July 2015

Antiproliferative evaluation of N-sulfonyl-2-alkyl-six membered azacycles. A QSAR study.

Med Chem 2014 ;10(6):571-9

Instituto de Productos Naturales y Agrobiologia, CSIC, C/Astrofisico Francisco Sanchez 3, 38206 La Laguna, Spain.

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April 2015

Antiproliferative and quinone reductase-inducing activities of withanolides derivatives.

Eur J Med Chem 2014 Jul 20;82:68-81. Epub 2014 May 20.

Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2014.05.045DOI Listing
July 2014

FireDB: a compendium of biological and pharmacologically relevant ligands.

Nucleic Acids Res 2014 Jan 15;42(Database issue):D267-72. Epub 2013 Nov 15.

Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre, Madrid, 28029, Spain and Spanish National Bioinformatics Institute (INB-ISCIII).

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkt1127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965074PMC
January 2014

Derivatives of grindelic acid: from a non-active natural diterpene to synthetic antitumor derivatives.

Eur J Med Chem 2013 Sep 18;67:28-38. Epub 2013 Jun 18.

INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina.

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http://dx.doi.org/10.1016/j.ejmech.2013.06.013DOI Listing
September 2013

Polymorphisms to predict outcome to the tyrosine kinase inhibitors gefitinib, erlotinib, sorafenib and sunitinib.

Curr Top Med Chem 2012 ;12(15):1649-59

Dept. of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.2174/156802612803531333DOI Listing
April 2013

Antiproliferative activity of epi-cercosporin in human solid tumor cell lines.

Nat Prod Commun 2013 Feb;8(2):187-9

Laboratorio de Alta Tecnología de Xalapa, Universidad Veracruzana, Calle Médicos, 5, Col. Unidad del Bosque, 91010 Xalapa, Veracruz, México.

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February 2013

In vitro synergistic interaction between DTA0100 and radiation in human cancer cell lines.

Anticancer Agents Med Chem 2012 Oct;12(8):988-93

BioLab, Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, C/ Astrofisico Francisco Sanchez 2, 38206 La Laguna, Spain.

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October 2012

Cytotoxic bioactivity of some phenylpropanoic acid derivatives.

Nat Prod Commun 2012 Oct;7(10):1341-6

INTEQUI-CONICET, Facultad de Quimica, Bioquimica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera -5700 San Luis, Argentina.

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October 2012

β-Lapachone analogs with enhanced antiproliferative activity.

Eur J Med Chem 2012 Jul 19;53:264-74. Epub 2012 Apr 19.

BioLab, Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1016/j.ejmech.2012.04.008DOI Listing
July 2012

Heterometallic platinum(II) compounds with β-aminoethylferrocenes: synthesis, electrochemical behaviour and anticancer activity.

Dalton Trans 2012 Jan 25;41(2):432-41. Epub 2011 Oct 25.

Departamento de Química Inorgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 29049, Madrid, Spain.

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http://dx.doi.org/10.1039/c1dt11358eDOI Listing
January 2012

DNA copy number profiles correlate with outcome in colorectal cancer patients treated with fluoropyrimidine/antifolate-based regimens.

Curr Drug Metab 2011 Dec;12(10):956-65

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam - CCA 1.52, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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December 2011

Association between DNA-repair polymorphisms and survival in pancreatic cancer patients treated with combination chemotherapy.

Pharmacogenomics 2011 Dec 25;12(12):1641-52. Epub 2011 Oct 25.

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.2217/pgs.11.109DOI Listing
December 2011

A modular approach to trim cellular targets in anticancer drug discovery.

Bioorg Med Chem Lett 2011 Nov 22;21(22):6641-5. Epub 2011 Sep 22.

BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1016/j.bmcl.2011.09.069DOI Listing
November 2011

Antiproliferative activity of dmoPTA-Ru(II) complexes against human solid tumor cells.

Bioorg Med Chem Lett 2011 Aug 12;21(15):4568-71. Epub 2011 Jun 12.

BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, La Laguna, Spain.

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http://dx.doi.org/10.1016/j.bmcl.2011.05.116DOI Listing
August 2011

Antiproliferative effects of novel aliphatic acetogenin analogs against aggressive solid tumor cell lines.

In Vivo 2011 Mar-Apr;25(2):203-7

BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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July 2011

Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer.

Front Biosci (Landmark Ed) 2011 Jan 1;16:116-30. Epub 2011 Jan 1.

Department Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.2741/3679DOI Listing
January 2011

Mitotic arrest induced by a novel family of DNA topoisomerase II inhibitors.

J Med Chem 2010 May;53(9):3835-9

BioLab, Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, C/Astrofisico Francisco Sanchez 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1021/jm100155yDOI Listing
May 2010

Enhancement of antiproliferative activity by molecular simplification of catalpol.

Bioorg Med Chem 2010 Apr 1;18(7):2515-23. Epub 2010 Mar 1.

Instituto Universitario de Bio-Orgánica 'Antonio González' (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1016/j.bmc.2010.02.044DOI Listing
April 2010

Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.

Bioorg Med Chem 2010 Apr 23;18(7):2621-30. Epub 2010 Feb 23.

Departamento de Química Orgánica and UMYMFOR (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.

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http://dx.doi.org/10.1016/j.bmc.2010.02.032DOI Listing
April 2010

Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.

Bioorg Med Chem 2009 Sep 25;17(17):6251-6. Epub 2009 Jul 25.

Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1016/j.bmc.2009.07.053DOI Listing
September 2009

Synthesis and antiproliferative activity of 2,4-disubstituted 6-aryl-7H-pyrrolo[3,2-d]pyrimidin-7-one 5-oxides.

Bioorg Med Chem 2009 Jul 6;17(14):4955-60. Epub 2009 Jun 6.

Department of Organic Chemistry, Faculty of Chemistry, Vilnius University, Naugarduko 24, Vilnius LT-03225, Lithuania.

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http://dx.doi.org/10.1016/j.bmc.2009.05.078DOI Listing
July 2009

beta'-Hydroxy-alpha,beta-unsaturated ketones: A new pharmacophore for the design of anticancer drugs. Part 2.

ChemMedChem 2008 Nov;3(11):1740-7

Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Universidad de la Laguna, C/ Astrofísico Francisco Sánchez, 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1002/cmdc.200800212DOI Listing
November 2008

Gamma-lactones alpha,beta- and beta,gamma-fused to carbocycles as novel antiproliferative drugs.

Bioorg Med Chem Lett 2008 Oct 29;18(19):5171-3. Epub 2008 Aug 29.

Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1016/j.bmcl.2008.08.098DOI Listing
October 2008

Antiproliferative activity of 4-chloro-5,6-dihydro-2H-pyrans. Part 2: Enhancement of drug cytotoxicity.

Bioorg Med Chem Lett 2007 Jun 19;17(11):3087-90. Epub 2007 Mar 19.

Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1016/j.bmcl.2007.03.045DOI Listing
June 2007

Antiproliferative activity of 2-alkyl-4-halopiperidines and 2-alkyl-4-halo-1,2,5,6-tetrahydropyridines in solid tumor cell lines.

Bioorg Med Chem Lett 2007 May 7;17(10):2681-4. Epub 2007 Mar 7.

Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0700304
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http://dx.doi.org/10.1016/j.bmcl.2007.03.010DOI Listing
May 2007

Novel antiproliferative analogs of the Taq DNA polymerase inhibitor catalpol.

Bioorg Med Chem Lett 2007 Mar 3;17(5):1332-5. Epub 2006 Dec 3.

Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1016/j.bmcl.2006.11.086DOI Listing
March 2007

Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans. Part 2: Effect of side chain homologation.

Bioorg Med Chem Lett 2007 Feb 27;17(3):780-3. Epub 2006 Oct 27.

Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0601250
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http://dx.doi.org/10.1016/j.bmcl.2006.10.066DOI Listing
February 2007

Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans.

Bioorg Med Chem Lett 2006 Dec 6;16(23):6135-8. Epub 2006 Sep 6.

Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0600993
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http://dx.doi.org/10.1016/j.bmcl.2006.08.094DOI Listing
December 2006

Abietane diterpenoids from Salvia pachyphylla and S. clevelandii with cytotoxic activity against human cancer cell lines.

J Nat Prod 2006 Dec;69(12):1803-5

Facultad de Ciencias Químicas e Ingeniería, Universidad Autónoma de Baja California, Calzada Tecnológico 14418, Mesa de Otay, C.P. 22390 Tijuana, Baja California, Mexico.

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http://dx.doi.org/10.1021/np060279iDOI Listing
December 2006

One-pot synthesis and SAR study of cis-2,6-dialkyl-4-chloro-tetrahydropyrans.

Bioorg Med Chem Lett 2006 Jun 5;16(12):3135-8. Epub 2006 Apr 5.

Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, C/ Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.

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http://dx.doi.org/10.1016/j.bmcl.2006.03.064DOI Listing
June 2006

Molecular simplification in bioactive molecules: formal synthesis of (+)-muconin.

J Org Chem 2006 Mar;71(6):2339-45

Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, Astrofísico Astrofísico Francisco Sanchez 2, 38206 La Laguna, Tenerife, Islas Canarias, Spain.

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http://dx.doi.org/10.1021/jo0524674DOI Listing
March 2006

In vitro generation of mature neutrophils from canine Lin- bone marrow cells.

Vet Immunol Immunopathol 2005 Aug;107(1-2):41-50

Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain.

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http://dx.doi.org/10.1016/j.vetimm.2005.03.014DOI Listing
August 2005