Leslie M Thompson

Leslie M Thompson

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Leslie M Thompson

Leslie M Thompson

Publications by authors named "Leslie M Thompson"

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IKKβ slows Huntington's disease progression in R6/1 mice.

Proc Natl Acad Sci U S A 2019 May 14;116(22):10952-10961. Epub 2019 May 14.

Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697;

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http://dx.doi.org/10.1073/pnas.1814246116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561205PMC
May 2019

Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites.

Hum Mol Genet 2019 Feb 15. Epub 2019 Feb 15.

Division of Neurobiology, Departments of Psychiatry, Neurology, Pharmacology, and Neuroscience, Johns Hopkins University School of Medicine, 600 North Wolfe Street, CMSC 8-121, Baltimore, Maryland 21287 USA.

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http://dx.doi.org/10.1093/hmg/ddy430DOI Listing
February 2019

Therapeutic effects of stem cells in rodent models of Huntington's disease: Review and electrophysiological findings.

CNS Neurosci Ther 2018 04 6;24(4):329-342. Epub 2018 Mar 6.

Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/cns.12839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489814PMC
April 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species.

J Vis Exp 2018 02 27(132). Epub 2018 Feb 27.

Department of Psychiatry and Human Behavior, University of California Irvine; UCI MIND, University of California Irvine; Department of Neurobiology and Behavior, University of California Irvine;

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http://dx.doi.org/10.3791/57082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931423PMC
February 2018

The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.

Neurobiol Dis 2018 Jan 3;109(Pt A):127-136. Epub 2017 Oct 3.

Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Program, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973538PMC
January 2018

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Authors:
Alexandra B Keenan Sherry L Jenkins Kathleen M Jagodnik Simon Koplev Edward He Denis Torre Zichen Wang Anders B Dohlman Moshe C Silverstein Alexander Lachmann Maxim V Kuleshov Avi Ma'ayan Vasileios Stathias Raymond Terryn Daniel Cooper Michele Forlin Amar Koleti Dusica Vidovic Caty Chung Stephan C Schürer Jouzas Vasiliauskas Marcin Pilarczyk Behrouz Shamsaei Mehdi Fazel Yan Ren Wen Niu Nicholas A Clark Shana White Naim Mahi Lixia Zhang Michal Kouril John F Reichard Siva Sivaganesan Mario Medvedovic Jaroslaw Meller Rick J Koch Marc R Birtwistle Ravi Iyengar Eric A Sobie Evren U Azeloglu Julia Kaye Jeannette Osterloh Kelly Haston Jaslin Kalra Steve Finkbiener Jonathan Li Pamela Milani Miriam Adam Renan Escalante-Chong Karen Sachs Alex Lenail Divya Ramamoorthy Ernest Fraenkel Gavin Daigle Uzma Hussain Alyssa Coye Jeffrey Rothstein Dhruv Sareen Loren Ornelas Maria Banuelos Berhan Mandefro Ritchie Ho Clive N Svendsen Ryan G Lim Jennifer Stocksdale Malcolm S Casale Terri G Thompson Jie Wu Leslie M Thompson Victoria Dardov Vidya Venkatraman Andrea Matlock Jennifer E Van Eyk Jacob D Jaffe Malvina Papanastasiou Aravind Subramanian Todd R Golub Sean D Erickson Mohammad Fallahi-Sichani Marc Hafner Nathanael S Gray Jia-Ren Lin Caitlin E Mills Jeremy L Muhlich Mario Niepel Caroline E Shamu Elizabeth H Williams David Wrobel Peter K Sorger Laura M Heiser Joe W Gray James E Korkola Gordon B Mills Mark LaBarge Heidi S Feiler Mark A Dane Elmar Bucher Michel Nederlof Damir Sudar Sean Gross David F Kilburn Rebecca Smith Kaylyn Devlin Ron Margolis Leslie Derr Albert Lee Ajay Pillai

Cell Syst 2018 01 29;6(1):13-24. Epub 2017 Nov 29.

NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cels.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799026PMC
January 2018

Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice.

Stem Cell Reports 2018 01 7;10(1):58-72. Epub 2017 Dec 7.

Institute for Memory Impairment and Neurological Disorders, University of California, Irvine, 3400 Biological Sciences III, Irvine, CA 92697-4545, USA; Department of Neurobiology & Behavior, University of California, Irvine, 3400 Biological Sciences III, Irvine, CA 92697-4545, USA; Department of Psychiatry & Human Behavior, University of California, Irvine, 3400 Biological Sciences III, Irvine, CA 92697-4545, USA; Sue and Bill Gross Stem Cell Center, University of California, Irvine, Gross Hall, Room 3219, 845 Health Sciences Road, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768890PMC
January 2018

Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.

Cell Rep 2017 05;19(7):1365-1377

Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA; UCI MIND, University of California, Irvine, Irvine, CA 92697, USA; Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA 92697, USA; Sue and Bill Gross Stem Cell Center, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646270PMC
May 2017

Mutant Huntingtin Disrupts the Nuclear Pore Complex.

Neuron 2017 Apr;94(1):93-107.e6

Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595097PMC
April 2017

Introducing the "Clinical Trials Corner".

J Huntingtons Dis 2017 ;6(3):167

University of California, Irvine, CA, USA.

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http://dx.doi.org/10.3233/JHD-179003DOI Listing
January 2017

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.

Proc Natl Acad Sci U S A 2016 09 6;113(38):E5655-64. Epub 2016 Sep 6.

Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035849PMC
http://dx.doi.org/10.1073/pnas.1603020113DOI Listing
September 2016

Journal of Huntington's Disease.

J Huntingtons Dis 2012 ;1(1)

University of California, Irvine, CA, USA.

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http://dx.doi.org/10.3233/JHD-2012-120001DOI Listing
May 2016

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In Vivo.

Neuron 2016 05 14;90(3):507-20. Epub 2016 Apr 14.

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA; Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942306PMC
May 2016

Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.

Neuron 2015 Jan 31;85(2):303-15. Epub 2014 Dec 31.

The Center for Cell and Molecular Therapy, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; The Department of Pathology & Laboratory Medicine, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://www.cell.com/cms/attachment/2041269710/2055112257/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S089662731401100
Publisher Site
http://dx.doi.org/10.1016/j.neuron.2014.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355620PMC
January 2015

We are pleased to introduce this next volume of the Journal of Huntington's Disease. Introduction.

J Huntingtons Dis 2013 ;2(1)

University of California, Irvine, CA, USA.

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http://dx.doi.org/10.3233/JHD-130003DOI Listing
September 2014

Targeting H3K4 trimethylation in Huntington disease.

Proc Natl Acad Sci U S A 2013 Aug 19;110(32):E3027-36. Epub 2013 Jul 19.

Department of Psychiatry and Human Behavior and UCI Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1073/pnas.1311323110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740882PMC
August 2013

Therapeutic application of histone deacetylase inhibitors for central nervous system disorders.

Nat Rev Drug Discov 2008 Oct;7(10):854-68

Harvard Medical School, Massachusetts General Hospital, Mass General Institute for Neurodegenerative Disease, Charlestown, Massachusetts 02129-4404, USA.

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http://dx.doi.org/10.1038/nrd2681DOI Listing
October 2008

Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies.

Proc Natl Acad Sci U S A 2005 Aug 1;102(32):11563-8. Epub 2005 Aug 1.

Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA.

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http://dx.doi.org/10.1073/pnas.0505321102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1183604PMC
August 2005

Fly models of Huntington's disease.

Hum Mol Genet 2003 Oct 12;12 Spec No 2:R187-93. Epub 2003 Aug 12.

Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-2300, USA.

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http://dx.doi.org/10.1093/hmg/ddg271DOI Listing
October 2003

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.

Proc Natl Acad Sci U S A 2003 Feb 7;100(4):2041-6. Epub 2003 Feb 7.

Medical and Molecular Genetics, Guy's, King's and St. Thomas' School of Medicine, King's College London, Eighth Floor Guy's Tower, Guy's Hospital, London SE1 9RT, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0437870100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149955PMC
February 2003

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.

Nat Genet 2002 Apr 25;30(4):367-76. Epub 2002 Mar 25.

Department of Biology, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://www.nature.com/articles/ng864
Publisher Site
http://dx.doi.org/10.1038/ng864DOI Listing
April 2002

Arfaptin 2 regulates the aggregation of mutant huntingtin protein.

Nat Cell Biol 2002 Mar;4(3):240-5

Division of Tumor Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncb761DOI Listing
March 2002