Leslie M Shaw

Leslie M Shaw

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Leslie M Shaw

Leslie M Shaw

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Method comparison study of the Elecsys® β-Amyloid (1-42) CSF assay versus comparator assays and LC-MS/MS.

Clin Biochem 2019 Oct 23;72:7-14. Epub 2019 May 23.

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Göteborgsvägen 31, 431 80 Mölndal, Sweden; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Wallinsgatan 6, 431 41 Mölndal, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2019.05.006DOI Listing
October 2019

Elecsys Total-Tau and Phospho-Tau (181P) CSF assays: Analytical performance of the novel, fully automated immunoassays for quantification of tau proteins in human cerebrospinal fluid.

Clin Biochem 2019 Oct 23;72:30-38. Epub 2019 May 23.

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Göteborgsvägen 31, 431 80 Mölndal, Sweden; Institute of Neuroscience and Physiology, Dept. of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Wallinsgatan 6, 431 41 Mölndal, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2019.05.005DOI Listing
October 2019

Insulin Receptor Substrate-1 (IRS-1) and IRS-2 expression levels are associated with prognosis in non-small cell lung cancer (NSCLC).

PLoS One 2019 8;14(8):e0220567. Epub 2019 Aug 8.

Department of Molecular, Cell & Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220567PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687170PMC
August 2019

Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration.

Alzheimers Dement 2019 Jul 1. Epub 2019 Jul 1.

Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco CA, USA.

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http://dx.doi.org/10.1016/j.jalz.2019.04.007DOI Listing
July 2019

Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer's disease.

Alzheimers Dement 2019 May 4;15(5):655-665. Epub 2019 Mar 4.

Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511459PMC
May 2019

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.

Alzheimers Dement 2019 May 11. Epub 2019 May 11.

Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15525260193004
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http://dx.doi.org/10.1016/j.jalz.2019.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842665PMC
May 2019

Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau).

Acta Neuropathol Commun 2019 03 4;7(1):34. Epub 2019 Mar 4.

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, 3600 Spruce St. 3 Maloney, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s40478-019-0687-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399892PMC
March 2019

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.

Alzheimers Dement 2019 Feb 15;15(2):232-244. Epub 2018 Oct 15.

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA; Duke Institute of Brain Sciences, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454538PMC
February 2019

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Alzheimers Dement 2019 01 12;15(1):55-64. Epub 2018 Oct 12.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333489PMC
January 2019

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement 2019 01 13;15(1):106-152. Epub 2018 Oct 13.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2018.08.005DOI Listing
January 2019

APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points.

J Alzheimers Dis 2019 ;69(3):783-793

Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.3233/JAD-181282DOI Listing
January 2019

The impact of preanalytical variables on measuring cerebrospinal fluid biomarkers for Alzheimer's disease diagnosis: A review.

Alzheimers Dement 2018 10 23;14(10):1313-1333. Epub 2018 Jun 23.

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2018.05.008DOI Listing
October 2018

Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.

Alzheimers Dement 2018 09 23;14(9):1159-1170. Epub 2018 Jul 23.

Boston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131058PMC
September 2018

Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.

Alzheimers Dement 2018 08 28;14(8):1052-1062. Epub 2018 Mar 28.

Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA; Department of Pathology, Peking University Health Science Centre and Third Hospital, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097943PMC
August 2018

The technical reliability and biotemporal stability of cerebrospinal fluid biomarkers for profiling multiple pathophysiologies in Alzheimer's disease.

PLoS One 2018 5;13(3):e0193707. Epub 2018 Mar 5.

MGH Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193707PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837100PMC
July 2018

Identification of a Novel Invasion-Promoting Region in Insulin Receptor Substrate 2.

Mol Cell Biol 2018 07 28;38(14). Epub 2018 Jun 28.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA

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http://dx.doi.org/10.1128/MCB.00590-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024166PMC
July 2018

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

World J Biol Psychiatry 2018 06 27;19(4):244-328. Epub 2017 Oct 27.

a Department of Psychiatry and Psychotherapy , Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany.

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http://dx.doi.org/10.1080/15622975.2017.1375556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916324PMC
June 2018

Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.

J Neurochem 2018 06 10;145(6):489-503. Epub 2018 Jun 10.

Center for Neurodegenerative Disease Research and Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1111/jnc.14330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030437PMC
June 2018

Plasma Tau Association with Brain Atrophy in Mild Cognitive Impairment and Alzheimer's Disease.

J Alzheimers Dis 2017 ;58(4):1245-1254

Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.3233/JAD-161114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523909PMC
May 2018

Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease.

Neurobiol Aging 2018 03 21;63:75-87. Epub 2017 Nov 21.

Penn Frontotemporal Degeneration Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801003PMC
March 2018

CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders.

Neurology 2018 03 21;90(12):e1038-e1046. Epub 2018 Feb 21.

From Penn Frontotemporal Degeneration Center (D.J.I., N.N., C.T.M., M.G.), Alzheimer's Disease Core Center (D.A.W., J.Q.T.), Department of Neurology (D.J.I., D.C., R.S.A., C.T.M., D.A.W., D.W., A.C.-P., M.S., A.S., H.I.H., M.G.), Penn Morris K. Udall Parkinson's Disease Research Center of Excellence (D.J.I., R.S.A., C.T.M., D.W., A.C.-P., J.E.D., M.G., J.Q.T.), Center for Neurodegenerative Disease Research (L.M.S., J.Q.T.), Translational Neuropathology Research Laboratory (E.B.L.), Department of Pathology and Laboratory Medicine (E.B.L., L.M.S., J.Q.T.), and Department of Biostatistics and Epidemiology Perelman School of Medicine (S.X.X.), University of Pennsylvania; and Parkinson's Disease Research, Education and Clinical Center (D.W., J.E.D.), Michael J. Crescenz VA Medical Center, Philadelphia, PA.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000005166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874449PMC
March 2018

APOE, thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease.

Mov Disord 2018 02 23;33(2):289-297. Epub 2017 Nov 23.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.27204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809205PMC
February 2018

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Neurology 2018 01 13;90(2):74-82. Epub 2017 Dec 13.

From Muhammad Ali Parkinson Center (R.R.W.), Barrow Neurological Institute, Phoenix, AZ; Department of Neurology (F.K., G.K.W., W.P., K.S., N.S.), Medical University Innsbruck, Austria; National Institute of Neurological Disorders and Stroke (W.R.G., W.J.K.), NIH, Bethesda, MD; Department of Neurology (P.A.L.), Mayo Clinic, Rochester, MN; Brain and Mind Centre (G.H.), Sydney Medical School, the University of Sydney; UNSW Medicine & Neuroscience Research Australia (G.H.), Sydney; Queen Square Brain Bank (J.H.), UCL Institute of Neurology (N.P.Q.), London, UK; UPS, INSERM, and CHU de Toulouse (O.R.), University de Toulouse; Centre de Référence Maladie Rare contre l'AMS (O.R.), Centre d'Investigation Clinique CIC1436, Départments de Pharmacologie Clinique et de Neurosciences, NeuroToul/COEN Center of Excellence in Neurodegeneration, Toulouse, France; Department of Pathology & Laboratory Medicine (L.M.S.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Center for Neurosciences (D.E.), The Feinstein Institute for Medical Research, Manhasset, NY; The Multiple System Atrophy (MSA) Coalition, Inc. (P. B., J.B., P.F., L.K., C.L., C.R., S.S.), Charlotte, NC; Cleveland Clinic Lou Ruvo Center for Brain Health (J.L.C.), Las Vegas, NV; Medical Affairs (V.A.), Teva Pharmaceuticals, Frazer, PA; Department of Neurology (G.B.), David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California at Los Angeles; Institute of Neurology (D.J.B.), University of Newcastle upon Tyne, UK; Van Andel Research Institute (P. Brundin), Center for Neurodegenerative Science, Grand Rapids, MI; Center for Neurological Restoration (H.F.), Cleveland Clinic, OH; Defeat MSA (P.F.); MSA Shoe Charity (P.F., C.R.), Saint Clair Shores, MI; Department of Neurology (R.F.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Neurodegenerative Diseases (T.G.), Hertie Institute of Clinical Brain Research, University of Tübingen; German Center for Neurodegenerative Diseases (DZNE) (T.G.), Tübingen, Germany; Lundbeck LLC (A.H.), Deerfield, IL; German Center for Neurodegenerative Diseases (DZNE) (G.U.H.), Munich; Department of Neurology (G.U.H.), Technical University of Munich, Germany; Neurogenomics Division (M.J.H.), The Translational Genomics Research Institute, Phoenix, AZ; Dandrite & Department of Biomedicine (P.H.J.), Aarhus University, Denmark; Quanterix (A.J.), Lexington, MA; Department of Neurology (U.J.K.), Columbia University Medical Center; Department of Neurology (H.K.), New York University School of Medicine, New York; Whitehead Institute for Biomedical Research (V.K.), Cambridge; Ann Romney Center for Neurologic Disease (V.K.), Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston; Harvard Stem Cell Institute (V.K.), Cambridge, MA; Department of Neurology (T.K.), University of Bonn; German Center for Neurodegenerative Diseases (DZNE) (T.K.), Bonn, Germany; Brain and Mind Centre (W.S.K.), Sydney Medical School, University of Sydney, Australia; Department of Neurology (P.L.), Henry Ford Hospital; Department of Neurology (P.L.), Wayne State University School of Medicine, Detroit, MI; Division of Neurosciences (E.M.), National Institute on Aging/NIH, Bethesda, MD; Centre de Référence Maladie Rare AMS (W.M.), Hôpital Pellegrin, CHU de Bordeaux; Université de Bordeaux (W.M.), Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux; Paris Saclay Institute of Neuroscience (R.M.), CNRS, Gif-sur-Yvette, France; Genentech Inc. (S.O.), South San Francisco; Cedars-Sinai Medical Center (S.P.), Los Angeles, CA; Department of Neurology (D.R.), Vanderbilt University Medical Center, Nashville, TN; MSA NJ (C.R.), Howell, NJ; Prothena Biosciences (D.S.), South San Francisco, CA; Division of Neurology (M.S.), Department of Medicine, The Ottawa Hospital, Canada; Department of Neurology (J.D.S.), Massachusetts General Hospital, Harvard Medical School, Boston, MA; Cure MSA Foundation (L.S.), Fremont, CA; Avid Radiopharmaceuticals (A.S.), Philadelphia, PA; Department of Neurological Sciences (G.T.S.), Rush University Medical Center, Chicago, IL; Department of Neurology (S.T.), Graduate School of Medicine, Tokyo University, Tokyo, Japan; and University of Washington (J.Z.), Seattle. W.R.G. is currently affiliated with Janssen Research and Development, Titusville, NJ.

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http://dx.doi.org/10.1212/WNL.0000000000004798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772155PMC
January 2018

Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease.

Neurobiol Aging 2017 Dec 18;60:92-103. Epub 2017 Aug 18.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774672PMC
December 2017

Development, validation and application of a new fornix template for studies of aging and preclinical Alzheimer's disease.

Neuroimage Clin 2017 25;13:106-115. Epub 2016 Nov 25.

Department of Neuroscience, University of Kentucky, Lexington, KY, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1016/j.nicl.2016.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137184PMC
November 2017

Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls.

Neurology 2017 Nov 13;89(19):1959-1969. Epub 2017 Oct 13.

From the Department of Neurology (B.M.), University Medical Center, Göttingen; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; Department of Biostatistics (C.J.C.-G., C.S.C.), College of Public Health, University of Iowa, Iowa City; BioLegend Inc. (P.T.), San Diego, CA; Department of Pathology & Laboratory Medicine (L.M.S., J.Q.T.), Center for Neurodegenerative Disease Research, Institute on Aging (L.M.S. , J.Q.T.), and Morris K. Udall Center of Excellence for Parkinson's Disease Research (J.Q.T.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Molecular Genetics Section (A.S.), Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD; The Michael J. Fox Foundation for Parkinson's Research (M.F.), New York, NY; Institute for Neurodegenerative Disorders (K.M.), New Haven, CT; and Department of Neurosciences (D.G.), University of California, San Diego.

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http://dx.doi.org/10.1212/WNL.0000000000004609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679418PMC
November 2017

Clinically silent Alzheimer's and vascular pathologies influence brain networks supporting executive function in healthy older adults.

Neurobiol Aging 2017 10 24;58:102-111. Epub 2017 Jun 24.

Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, USA; Department of Neurology, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581730PMC
October 2017

Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration.

Ann Neurol 2017 Aug 19;82(2):247-258. Epub 2017 Aug 19.

Frontotemporal Degeneration Center, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://dx.doi.org/10.1002/ana.24996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776747PMC
August 2017

RUNX1 and breast cancer.

Oncotarget 2017 Jun;8(23):36934-36935

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.

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http://dx.doi.org/10.18632/oncotarget.17249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514882PMC
June 2017

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement.

Alzheimers Dement 2017 May 5;13(5):561-571. Epub 2016 Dec 5.

Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536850PMC
May 2017

Differential involvement of the microtubule cytoskeleton in insulin receptor substrate 1 (IRS-1) and IRS-2 signaling to AKT determines the response to microtubule disruption in breast carcinoma cells.

J Biol Chem 2017 05 20;292(19):7806-7816. Epub 2017 Mar 20.

From the Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605

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http://dx.doi.org/10.1074/jbc.M117.785832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427262PMC
May 2017

CSF Aβ - an excellent but complicated Alzheimer's biomarker - a route to standardisation.

Clin Chim Acta 2017 Apr 20;467:27-33. Epub 2016 May 20.

Inst. of Neuroscience and Physiology Dept. of Psychiatry and Neurochemistry The Sahlgrenska Academy at University of Gothenburg Mölndal, Sweden; Clinical Neurochemistry LaboratorySahlgrenska University Hospital, MölndalSE-431 80 Mölndal Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.05.014DOI Listing
April 2017

Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.

Alzheimers Dement 2017 Apr 22;13(4):e1-e85. Epub 2017 Mar 22.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1016/j.jalz.2016.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818723PMC
April 2017

Alzheimer disease: CSF biomarkers for Alzheimer disease - approaching consensus.

Nat Rev Neurol 2017 03 3;13(3):131-132. Epub 2017 Feb 3.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrneurol.2017.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912691PMC
March 2017

Cocaine Detection in Peritoneal Dialysis Fluid.

Am J Kidney Dis 2017 01 15;69(1):161. Epub 2016 Oct 15.

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2016.07.036DOI Listing
January 2017

Evaluation of Cerebrospinal Fluid Assay Variability in Alzheimer's Disease.

J Alzheimers Dis 2016 ;51(2):463-70

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.3233/JAD-151045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930357PMC
December 2016

Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease.

Neurobiol Dis 2016 Oct 31;94:10-7. Epub 2016 May 31.

Neurobiology Unit, Institut d'Investigacions Biomèdiques de Barcelona, Consejo Superior de Investigaciones Científicas (CSIC), Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2016.05.019DOI Listing
October 2016

Plasma tau in Alzheimer disease.

Neurology 2016 Oct 30;87(17):1827-1835. Epub 2016 Sep 30.

From the Clinical Memory Research Unit (N.M., S.J., P.S.I., E.S., S.P., O.H.), Department of Clinical Sciences, Malmö, Lund University; Department of Neurology (N.M., E.S., O.H., S.P.), Skåne University Hospital, Lund; Clinical Neurochemistry Laboratory (H.Z., U.A., K.B.), Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Canpus, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; Janssen R&D (D.B.), Titusville, NJ; Diagnostics and Life Sciences (C.A.T.H.), GE Global Research, Niskayuna, NY; Quanterix Corporation (A.J., D.H., L.S.), Lexington, MA; Department of Pathology and Laboratory Medicine (L.M.S., J.Q.T.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Veterans Affairs Medical Center; and Department of Radiology and Biomedical Imaging (M.W.W.), University of California, San Francisco.

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http://dx.doi.org/10.1212/WNL.0000000000003246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089525PMC
October 2016

Active Cigarette Smoking in Cognitively-Normal Elders and Probable Alzheimer's Disease is Associated with Elevated Cerebrospinal Fluid Oxidative Stress Biomarkers.

J Alzheimers Dis 2016 07;54(1):99-107

Department of Pathology & Laboratory Medicine and Center for Neurodegenerative Diseases Research, Perelman School of Medicine University of Pennsylvania, PA, USA.

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http://dx.doi.org/10.3233/JAD-160413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127393PMC
July 2016

Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers.

Mov Disord 2016 06 4;31(6):906-14. Epub 2016 Apr 4.

Parkinson's Disease and Movement Disorders Unit, Neurology Service, Institut de Neurociències Hospital Clínic, University of Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1002/mds.26591DOI Listing
June 2016

Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging.

Ann Clin Transl Neurol 2016 05 13;3(5):399-403. Epub 2016 Apr 13.

Department of Medicine UCSF Medical Center and the Jewish Home of San Francisco San Francisco California.

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http://dx.doi.org/10.1002/acn3.309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863753PMC
May 2016

Round robin test on quantification of amyloid-β 1-42 in cerebrospinal fluid by mass spectrometry.

Alzheimers Dement 2016 Jan 21;12(1):55-9. Epub 2015 Jul 21.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Salgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2015.06.1890DOI Listing
January 2016

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression.

JAMA Neurol 2016 Jan;73(1):60-7

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1001/jamaneurol.2015.3037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624219PMC
January 2016

An autophagy-independent function for Beclin 1 in cancer.

Mol Cell Oncol 2016 Jan 14;3(1). Epub 2015 Apr 14.

Department of Molecular, Cell & Cancer Biology, University of Massachusetts Medical School Worcester, MA 01605.

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https://www.tandfonline.com/doi/full/10.1080/23723556.2015.1
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http://dx.doi.org/10.1080/23723556.2015.1030539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792009PMC
January 2016

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern.

Alzheimers Dement 2015 Dec 7;11(12):1417-1429. Epub 2015 May 7.

Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637003PMC
December 2015

Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding.

Neurol Genet 2015 Oct 15;1(3):e22. Epub 2015 Oct 15.

University of California Berkeley (A.L.), Berkeley; Oakland University William Beaumont School of Medicine (K.S.H.), Rochester, MI; Department of Neurology (K.S.H., N.G., A.E.B., E.T., G.C., L.G.A.), David Geffen School of Medicine at UCLA, Los Angeles, CA; Drexel University College of Medicine (L.M.R.), Philadelphia, PA; Northwestern University Feinberg School of Medicine (J.E.), Chicago, IL; Veterans Affairs Greater Los Angeles Healthcare System (E.T., G.C.), Los Angeles, CA; School of Nursing (K.G.), UCLA, Los Angeles, CA; Department of Radiology and Imaging Sciences, Center for Neuroimaging (A.J.S., L.G.A.), Department of Neurology (L.G.A.), and Department of Medical and Molecular Genetics (L.G.A.), School of Medicine, Indiana University, Indianapolis; Department of Pathology and Laboratory Medicine (L.M.S., J.Q.T.), University of Pennsylvania School of Medicine, Philadelphia; Department of Public Health and Neuroscience (W.J.J.), UC Berkeley, CA; and Department of Veterans' Affairs Medical Center (M.W.W.), San Francisco, CA.

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http://dx.doi.org/10.1212/NXG.0000000000000022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809461PMC
October 2015

Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.

Neurobiol Dis 2015 Aug 15;80:29-41. Epub 2015 May 15.

Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.05.004DOI Listing
August 2015

Memory, executive, and multidomain subtle cognitive impairment: clinical and biomarker findings.

Neurology 2015 Jul 17;85(2):144-53. Epub 2015 Jun 17.

From the Department of Pathology & Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research (J.B.T., M.B., L.M.S., J.Q.T.), and Department of Psychiatry (S.E.A.), University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Banner Alzheimer's Institute (K.C., E.M.R.), Phoenix, AZ; Center for Biomedical Image Computing and Analytics (M.R., C.D.), Philadelphia, PA; Mayo Clinic College of Medicine (C.R.J.), Rochester, MN; and Center for Imaging of Neurodegenerative Diseases (M.W.W.), Department of Radiology, San Francisco VA Medical Center/University of California San Francisco.

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http://www.neurology.org/content/85/2/144.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000173
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http://dx.doi.org/10.1212/WNL.0000000000001738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515043PMC
July 2015

The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans.

Alzheimers Dement 2015 Jul;11(7):772-91

Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Neurodegenerative Disease Research, Institute on Aging, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127404PMC
July 2015

CSF beta-amyloid 1-42 - what are we measuring in Alzheimer's disease?

Ann Clin Transl Neurol 2015 Feb 19;2(2):131-9. Epub 2014 Dec 19.

Department of Neurology, Emory University Atlanta, Georgia ; Center for Neurodegenerative Diseases, Emory University Atlanta, Georgia ; Alzheimer's Disease Research Center, Emory University Atlanta, Georgia.

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http://dx.doi.org/10.1002/acn3.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338954PMC
February 2015

Role of cerebrospinal fluid biomarkers in clinical trials for Alzheimer's disease modifying therapies.

Korean J Physiol Pharmacol 2014 Dec 30;18(6):447-56. Epub 2014 Dec 30.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. ; Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.4196/kjpp.2014.18.6.447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296032PMC
December 2014