Leslie Cope

Leslie Cope

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Leslie Cope

Leslie Cope

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High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer.

Breast Cancer Res Treat 2020 Jan 17;179(1):25-35. Epub 2019 Sep 17.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.1007/s10549-019-05419-1DOI Listing
January 2020

DNA methylation genome-wide analysis in remnant and primary gastric cancers.

Gastric Cancer 2019 11 12;22(6):1109-1120. Epub 2019 Mar 12.

Department of Surgery, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 600N. Wolfe Street, Blalock 240, Baltimore, MD, 21287, USA.

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http://link.springer.com/10.1007/s10120-019-00949-5
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http://dx.doi.org/10.1007/s10120-019-00949-5DOI Listing
November 2019

Measuring DNA Copy Number Variation Using High-Density Methylation Microarrays.

J Comput Biol 2019 Apr 21;26(4):295-304. Epub 2019 Feb 21.

5 Department of Oncology Bioinformatics, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1089/cmb.2018.0143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479247PMC
April 2019

Young age at diagnosis is associated with worse prognosis in the Luminal A breast cancer subtype: a retrospective institutional cohort study.

Breast Cancer Res Treat 2018 Dec 17;172(3):689-702. Epub 2018 Sep 17.

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1007/s10549-018-4950-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786966PMC
December 2018

Do End-of-Rotation and End-of-Shift Assessments Inform Clinical Competency Committees' (CCC) Decisions?

West J Emerg Med 2018 Jan 13;19(1):121-127. Epub 2017 Dec 13.

Johns Hopkins University Department of Emergency Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.5811/westjem.2017.10.35290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785178PMC
January 2018

Comparison of 20% sulfur hexafluoride with air for intraocular tamponade in Descemet membrane endothelial keratoplasty (DMEK).

Arq Bras Oftalmol 2016 Sep-Oct;79(5):299-302

Wilmer Eye Institute, Johns Hopkins Medical Institutions, Baltimore, MD, United States.

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http://dx.doi.org/10.5935/0004-2749.20160086DOI Listing
July 2017

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche.

Nat Commun 2017 04 28;8:15008. Epub 2017 Apr 28.

Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Research Building, Room 1025, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1038/ncomms15008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414379PMC
April 2017

Monitoring of Serum DNA Methylation as an Early Independent Marker of Response and Survival in Metastatic Breast Cancer: TBCRC 005 Prospective Biomarker Study.

J Clin Oncol 2017 Mar 21;35(7):751-758. Epub 2016 Nov 21.

Kala Visvanathan, Johns Hopkins University School of Medicine and Bloomberg School of Public Health; MaryJo S. Fackler, Zhe Zhang, Zoila A. Lopez-Bujanda, Stacie C. Jeter, Lori J. Sokoll, Leslie M. Cope, Christopher B. Umbricht, David M. Euhus, Saraswati Sukumar, and Antonio C. Wolff, Johns Hopkins University School of Medicine, Baltimore, MD; Elizabeth Garrett-Mayer, Medical University of South Carolina, Charleston, SC; Andres Forero, University of Alabama at Birmingham, Birmingham, AL; Anna M. Storniolo, Indiana University, Bloomington, IN; Rita Nanda, University of Chicago, Chicago, IL; Nancy U. Lin, Dana-Farber Cancer Institute, Boston, MA; Lisa A. Carey, University of North Carolina, Chapel Hill, NC; and James N. Ingle, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1200/JCO.2015.66.2080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455421PMC
March 2017

Fecal Metabolome in Hmga1 Transgenic Mice with Polyposis: Evidence for Potential Screen for Early Detection of Precursor Lesions in Colorectal Cancer.

J Proteome Res 2016 12 4;15(12):4176-4187. Epub 2016 Nov 4.

Department of Chemistry, ‡School of Molecular Biosciences, and §Institute of Biological Chemistry, Washington State University , Pullman, Washington 99164, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00035DOI Listing
December 2016

Optimizing the Use of Gene Expression Profiling in Early-Stage Breast Cancer.

J Clin Oncol 2016 12 31;34(36):4390-4397. Epub 2016 Oct 31.

Hyun-seok Kim, Christopher B. Umbricht, Peter B. Illei, Ashley Cimino-Mathews, Soonweng Cho, Nivedita Chowdhury, Maria Cristina Figueroa-Magalhaes, Catherine Pesce, Stacie C. Jeter, Deborah K. Armstrong, Roisin M. Connolly, John H. Fetting, Ben Ho Park, Vered Stearns, Antonio C. Wolff, and Leslie Cope, The Johns Hopkins University School of Medicine; Kala Visvanathan, The Johns Hopkins University Bloomberg School of Public Health, Baltimore; Charles Mylander, Martin Rosman, and Lorraine Tafra, Anne Arundel Medical Center, Annapolis, MD; Bradley M. Turner, David G. Hicks, University of Rochester Medical Center, Rochester, NY; Robert S. Miller, American Society of Clinical Oncology, Alexandria, VA; and Tyler A. Jensen and Dylan V. Miller, Intermountain Healthcare, Salt Lake City, UT.

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http://ascopubs.org/doi/10.1200/JCO.2016.67.7195
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http://dx.doi.org/10.1200/JCO.2016.67.7195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455310PMC
December 2016

Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors.

Proc Natl Acad Sci U S A 2016 11 11;113(48):E7769-E7777. Epub 2016 Nov 11.

Department of Oncology, The Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287;

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http://dx.doi.org/10.1073/pnas.1607836113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137776PMC
November 2016

The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors.

Gynecol Oncol 2016 06 8;141(3):580-587. Epub 2016 Apr 8.

Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Pathobiology Graduate Program, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Institute for Cellular Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2016.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770984PMC
June 2016

Functions of Peptidoglycan Recognition Proteins (Pglyrps) at the Ocular Surface: Bacterial Keratitis in Gene-Targeted Mice Deficient in Pglyrp-2, -3 and -4.

PLoS One 2015 2;10(9):e0137129. Epub 2015 Sep 2.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137129PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558058PMC
May 2016

Do breast cancer cell lines provide a relevant model of the patient tumor methylome?

PLoS One 2014 26;9(8):e105545. Epub 2014 Aug 26.

Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105545PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144876PMC
May 2015

Risk factors for eye bank preparation failure of Descemet membrane endothelial keratoplasty tissue.

Am J Ophthalmol 2015 May 30;159(5):829-34.e2. Epub 2015 Jan 30.

Cornea and Anterior Segment Service, Wilmer Eye Institute, Johns Hopkins Medical School, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.ajo.2015.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856026PMC
May 2015

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy.

EMBO Mol Med 2015 May;7(5):648-69

Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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http://dx.doi.org/10.15252/emmm.201404368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492822PMC
May 2015

AGA: Interactive pipeline for reproducible genomics analyses.

F1000Res 2015 28;4:28. Epub 2015 Jan 28.

Department of Oncology Biostatistics & Bioinformatics, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

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http://dx.doi.org/10.12688/f1000research.6030.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617321PMC
January 2015

Functional p38 MAPK identified by biomarker profiling of pancreatic cancer restrains growth through JNK inhibition and correlates with improved survival.

Clin Cancer Res 2014 Dec 24;20(23):6200-11. Epub 2014 Jun 24.

Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland. Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland. Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-13-2823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866510PMC
December 2014

Rapamycin rescues ABT-737 efficacy in small cell lung cancer.

Cancer Res 2014 May 10;74(10):2846-56. Epub 2014 Mar 10.

Authors' Affiliations: Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine; Departments of Oncology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; and Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York

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http://cancerres.aacrjournals.org/content/early/2014/03/12/0
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-3460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510983PMC
May 2014

Novel methylated biomarkers and a robust assay to detect circulating tumor DNA in metastatic breast cancer.

Cancer Res 2014 Apr;74(8):2160-70

Authors' Affiliations: Departments of Oncology, Surgery, and Surgical Pathology, Johns Hopkins University School of Medicine; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore Maryland; Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York; Departments of Oncology and Surgery, Mayo Clinic, Rochester, Minnesota; Department of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327879PMC
April 2014

Modular network construction using eQTL data: an analysis of computational costs and benefits.

Front Genet 2014 26;5:40. Epub 2014 Feb 26.

Dana-Farber Cancer Institute and Harvard School of Public Health Boston, MA, USA.

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http://dx.doi.org/10.3389/fgene.2014.00040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935177PMC
March 2014

Methylation of the claudin 1 promoter is associated with loss of expression in estrogen receptor positive breast cancer.

PLoS One 2013 3;8(7):e68630. Epub 2013 Jul 3.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068630PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701071PMC
February 2014

Integrative correlation: Properties and relation to canonical correlations.

J Multivar Anal 2014 Jan;123:270-280

Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, United States ; Department of Biostatistics, Harvard School of Public Health, United States.

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http://dx.doi.org/10.1016/j.jmva.2013.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447241PMC
January 2014

HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells.

PLoS One 2013 2;8(5):e63419. Epub 2013 May 2.

Hematology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063419PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642138PMC
December 2013

High level of chromosomal aberration in ovarian cancer genome correlates with poor clinical outcome.

Gynecol Oncol 2013 Mar 28;128(3):500-5. Epub 2012 Nov 28.

The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.ygyno.2012.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364416PMC
March 2013

DNA copy number variations characterize benign and malignant thyroid tumors.

J Clin Endocrinol Metab 2013 Mar 23;98(3):E558-66. Epub 2013 Jan 23.

Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1210/jc.2012-3113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590464PMC
March 2013

Exploring massive, genome scale datasets with the GenometriCorr package.

PLoS Comput Biol 2012 May 31;8(5):e1002529. Epub 2012 May 31.

Department of Oncology, Division of Biostatistics and Bioinformatics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1002529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364938PMC
May 2012

Modeling liquid association.

Biometrics 2011 Mar;67(1):133-41

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1111/j.1541-0420.2010.01440.xDOI Listing
March 2011

Subnormal cytokine profile in the tear fluid of keratoconus patients.

PLoS One 2011 Jan 27;6(1):e16437. Epub 2011 Jan 27.

Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016437PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029330PMC
January 2011

Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis.

Am J Obstet Gynecol 2010 Dec 20;203(6):584.e1-22. Epub 2010 Oct 20.

Division of Gynecologic Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.ajog.2010.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993872PMC
December 2010

The ordering of expression among a few genes can provide simple cancer biomarkers and signal BRCA1 mutations.

BMC Bioinformatics 2009 Aug 20;10:256. Epub 2009 Aug 20.

Department of Applied Mathematics and Statistics, The Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1186/1471-2105-10-256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745389PMC
August 2009

Identifying differential correlation in gene/pathway combinations.

BMC Bioinformatics 2008 Nov 18;9:488. Epub 2008 Nov 18.

National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/1471-2105-9-488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613418PMC
November 2008

Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays.

J Proteome Res 2008 Sep 13;7(9):3900-10. Epub 2008 Aug 13.

McKusick-Nathans Institute of Genetic Medicine and the Departments of Biological Chemistry, Pathology and Oncology, Johns Hopkins University, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1021/pr800198wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646669PMC
September 2008

A novel 6C assay uncovers Polycomb-mediated higher order chromatin conformations.

Genome Res 2008 Jul 23;18(7):1171-9. Epub 2008 May 23.

Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA.

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http://dx.doi.org/10.1101/gr.073452.107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493406PMC
July 2008

Cross-study validation and combined analysis of gene expression microarray data.

Biostatistics 2008 Apr 14;9(2):333-54. Epub 2007 Sep 14.

Division of Biostatistics, The Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.

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http://dx.doi.org/10.1093/biostatistics/kxm033DOI Listing
April 2008

Statistical methods for identifying differentially expressed gene combinations.

Methods Mol Biol 2007 ;408:171-91

Johns Hopkins University, Baltimore, MD, USA.

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http://dx.doi.org/10.1007/978-1-59745-547-3_10DOI Listing
April 2008

Gene expression profiles associated with advanced pancreatic cancer.

Int J Clin Exp Pathol 2008 Jan 1;1(1):32-43. Epub 2008 Jan 1.

Departments of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2480531PMC
January 2008

Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis.

Inflamm Bowel Dis 2007 Jul;13(7):807-21

Department of Medicine (Gastroenterology Division), Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1002/ibd.20110DOI Listing
July 2007

Pre-processing Agilent microarray data.

BMC Bioinformatics 2007 May 1;8:142. Epub 2007 May 1.

Johns Hopkins University School of Medicine, Oncology Biostatistics, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1186/1471-2105-8-142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876252PMC
May 2007