Leslie Baier

Leslie Baier

UNVERIFIED PROFILE

Are you Leslie Baier?   Register this Author

Register author
Leslie Baier

Leslie Baier

Publications by authors named "Leslie Baier"

Are you Leslie Baier?   Register this Author

92Publications

2833Reads

22Profile Views

Atg7 Knockdown Reduces Chemerin Secretion in Murine Adipocytes.

J Clin Endocrinol Metab 2019 Nov;104(11):5715-5728

Medical Department III, Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-01980DOI Listing
November 2019

Identification and functional validation of genetic variants in potential miRNA target sites of established BMI genes.

Int J Obes (Lond) 2019 Nov 19. Epub 2019 Nov 19.

Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41366-019-0488-8DOI Listing
November 2019

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.

Authors:
Jonathan P Bradfield Suzanne Vogelezang Janine F Felix Alessandra Chesi Øyvind Helgeland Momoko Horikoshi Ville Karhunen Estelle Lowry Diana L Cousminer Tarunveer S Ahluwalia Elisabeth Thiering Eileen Tai-Hui Boh Mohammad H Zafarmand Natalia Vilor-Tejedor Carol A Wang Raimo Joro Zhanghua Chen William J Gauderman Niina Pitkänen Esteban J Parra Lindsay Fernandez-Rhodes Akram Alyass Claire Monnereau John A Curtin Christian T Have Shana E McCormack Mette Hollensted Christine Frithioff-Bøjsøe Adan Valladares-Salgado Jesus Peralta-Romero Yik-Ying Teo Marie Standl Jaakko T Leinonen Jens-Christian Holm Triinu Peters Jesus Vioque Martine Vrijheid Angela Simpson Adnan Custovic Marc Vaudel Mickaël Canouil Virpi Lindi Mustafa Atalay Mika Kähönen Olli T Raitakari Barbera D C van Schaik Robert I Berkowitz Shelley A Cole V Saroja Voruganti Yujie Wang Heather M Highland Anthony G Comuzzie Nancy F Butte Anne E Justice Sheila Gahagan Estela Blanco Terho Lehtimäki Timo A Lakka Johannes Hebebrand Amélie Bonnefond Niels Grarup Philippe Froguel Leo-Pekka Lyytikäinen Miguel Cruz Sayuko Kobes Robert L Hanson Babette S Zemel Anke Hinney Koon K Teo David Meyre Kari E North Frank D Gilliland Hans Bisgaard Mariona Bustamante Klaus Bonnelykke Craig E Pennell Fernando Rivadeneira André G Uitterlinden Leslie J Baier Tanja G M Vrijkotte Joachim Heinrich Thorkild I A Sørensen Seang-Mei Saw Oluf Pedersen Torben Hansen Johan Eriksson Elisabeth Widén Mark I McCarthy Pål R Njølstad Christine Power Elina Hyppönen Sylvain Sebert Christopher D Brown Marjo-Riitta Järvelin Nicholas J Timpson Stefan Johansson Hakon Hakonarson Vincent W V Jaddoe

Hum Mol Genet 2019 Oct;28(19):3327-3338

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddz161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859434PMC
October 2019

Birthweight and early-onset type 2 diabetes in American Indians: differential effects in adolescents and young adults and additive effects of genotype, BMI and maternal diabetes.

Diabetologia 2019 09 20;62(9):1628-1637. Epub 2019 May 20.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, 1550 East Indian School Road, Phoenix, AZ, 85014, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-019-4899-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679754PMC
September 2019

Association of CREBRF variants with obesity and diabetes in Pacific Islanders from Guam and Saipan.

Diabetologia 2019 09 6;62(9):1647-1652. Epub 2019 Jul 6.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E. Indian School Road, Phoenix, AZ, 85014, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-019-4932-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721609PMC
September 2019

Assessing the Role of 98 Established Loci for BMI in American Indians.

Obesity (Silver Spring) 2019 May 18;27(5):845-854. Epub 2019 Mar 18.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/oby.22433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478540PMC
May 2019

Using Luciferase Reporter Assays to Identify Functional Variants at Disease-Associated Loci.

Methods Mol Biol 2018 ;1706:303-319

Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 N 5th Street, Phoenix, AZ, 85004, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/978-1-4939-7471-9_17
Publisher Site
http://dx.doi.org/10.1007/978-1-4939-7471-9_17DOI Listing
October 2018

Complex Genetics of Type 2 Diabetes and Effect Size: What have We Learned from Isolated Populations?

Rev Diabet Stud 2015 Fall-Winter;12(3-4):299-319. Epub 2016 Feb 10.

Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1900/RDS.2015.12.299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5275756PMC
July 2018

Identification and functional analysis of a novel G310D variant in the insulin-like growth factor 1 receptor (IGF1R) gene associated with type 2 diabetes in American Indians.

Diabetes Metab Res Rev 2018 05 25;34(4):e2994. Epub 2018 Mar 25.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/dmrr.2994DOI Listing
May 2018

Functional and association analysis of an Amerindian-derived population-specific p.(Thr280Met) variant in RBPJL, a component of the PTF1 complex.

Eur J Hum Genet 2018 02 4;26(2):238-246. Epub 2018 Jan 4.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445N 5th Street, Phoenix, AZ, 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41431-017-0062-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839029PMC
February 2018

Identity-by-Descent Mapping Identifies Major Locus for Serum Triglycerides in Amerindians Largely Explained by an Founder Mutation.

Circ Cardiovasc Genet 2017 Dec;10(6)

From the Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, AZ (W.-C.H., A.K.N., S.K., P.C., A.M., W.C.K., L.J.B., R.L.H.); South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, San Antonio (H.H.H.G.); Departments of Medicine and Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore (T.I.P.); and Illumina Inc, San Diego, CA (A.M.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.117.001809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736502PMC
December 2017

A Loss-of-Function Splice Acceptor Variant in Is Protective for Type 2 Diabetes.

Diabetes 2017 11 24;66(11):2903-2914. Epub 2017 Aug 24.

Broad Metabolism Program and Program in Medical and Population Genetics, Broad Institute, Cambridge, MA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db17-0187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652606PMC
November 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783PMC
November 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-017-00031-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526PMC
July 2017

Assessing variation across 8 established East Asian loci for type 2 diabetes mellitus in American Indians: Suggestive evidence for new sex-specific diabetes signals in GLIS3 and ZFAND3.

Diabetes Metab Res Rev 2017 05 28;33(4). Epub 2016 Dec 28.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/dmrr.2869
Publisher Site
http://dx.doi.org/10.1002/dmrr.2869DOI Listing
May 2017

Differential methylation of genes in individuals exposed to maternal diabetes in utero.

Diabetologia 2017 04 26;60(4):645-655. Epub 2017 Jan 26.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 1550 E. Indian School Rd, Phoenix, AZ, 85014, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-016-4203-1DOI Listing
April 2017

Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.

Diabetologia 2016 Mar 15;59(3):481-91. Epub 2015 Dec 15.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 North 5th Street, Phoenix, AZ, 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-015-3835-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744100PMC
March 2016

Assessing FOXO1A as a potential susceptibility locus for type 2 diabetes and obesity in American Indians.

Obesity (Silver Spring) 2015 Oct 4;23(10):1960-5. Epub 2015 Sep 4.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes Of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/oby.21236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586407PMC
October 2015

The effect of differing patterns of childhood body mass index gain on adult physiology in American Indians.

Obesity (Silver Spring) 2015 Sep;23(9):1872-80

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/oby.21162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552081PMC
September 2015

Role of Established Type 2 Diabetes-Susceptibility Genetic Variants in a High Prevalence American Indian Population.

Diabetes 2015 Jul 9;64(7):2646-57. Epub 2015 Feb 9.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db14-1715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477349PMC
July 2015

Assessing accuracy of genotype imputation in American Indians.

PLoS One 2014 11;9(7):e102544. Epub 2014 Jul 11.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102544PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094523PMC
March 2015

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.

Hum Genet 2014 Nov 8;133(11):1431-41. Epub 2014 Aug 8.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 445 North 5th street, Phoenix, AZ, 85004, USA,

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00439-014-1477-6
Publisher Site
http://dx.doi.org/10.1007/s00439-014-1477-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185108PMC
November 2014

Variants associated with type 2 diabetes identified by the transethnic meta-analysis study: assessment in American Indians and evidence for a new signal in LPP.

Diabetologia 2014 Nov 12;57(11):2334-8. Epub 2014 Aug 12.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 North 5th Street, Phoenix, AZ, 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-014-3351-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180905PMC
November 2014

Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.

Diabetologia 2014 Jul 13;57(7):1382-90. Epub 2014 Apr 13.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, 445 North 5th street, Phoenix, AZ, 85004, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00125-014-3234-8
Publisher Site
http://dx.doi.org/10.1007/s00125-014-3234-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052004PMC
July 2014

Potential epigenetic dysregulation of genes associated with MODY and type 2 diabetes in humans exposed to a diabetic intrauterine environment: an analysis of genome-wide DNA methylation.

Metabolism 2014 May 21;63(5):654-60. Epub 2014 Jan 21.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 East Indian School Road, Phoenix, AZ, 85014. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00260495140002
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995826PMC
http://dx.doi.org/10.1016/j.metabol.2014.01.007DOI Listing
May 2014

Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes.

Obesity (Silver Spring) 2014 Apr 5;22(4):984-8. Epub 2013 Dec 5.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/oby.20647
Publisher Site
http://dx.doi.org/10.1002/oby.20647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968243PMC
April 2014

MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation.

Hum Mol Genet 2013 Nov 3;22(21):4438-49. Epub 2013 Jul 3.

Diabetes Molecular Genetics Section and Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Phoenix, AZ 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddt291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792696PMC
November 2013

NGSPE: A pipeline for end-to-end analysis of DNA sequencing data and comparison between different platforms.

Comput Biol Med 2013 Sep 13;43(9):1171-6. Epub 2013 Jun 13.

Diabetes Molecular Genetics Section, PECRB, NIDDK, National Institutes of Health, Phoenix, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiomed.2013.05.025DOI Listing
September 2013

Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes.

Hum Genet 2013 Jun 7;132(6):697-707. Epub 2013 Mar 7.

Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00439-013-1278-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654185PMC
June 2013

Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.

Obesity (Silver Spring) 2013 Jan;21(1):193-202

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/oby.20243
Publisher Site
http://dx.doi.org/10.1002/oby.20243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666094PMC
January 2013

Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians.

Obesity (Silver Spring) 2012 Dec 22;20(12):2426-30. Epub 2012 Jun 22.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health Phoenix, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/oby.2012.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479320PMC
December 2012

Greater impact of melanocortin-4 receptor deficiency on rates of growth and risk of type 2 diabetes during childhood compared with adulthood in Pima Indians.

Diabetes 2012 Jan 21;61(1):250-7. Epub 2011 Nov 21.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db11-0708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237672PMC
January 2012

Association analyses of variants in the DIO2 gene with early-onset type 2 diabetes mellitus in Pima Indians.

Thyroid 2012 Jan 5;22(1):80-7. Epub 2011 Dec 5.

Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/thy.2010.0455
Publisher Site
http://dx.doi.org/10.1089/thy.2010.0455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247704PMC
January 2012

A genome-wide association study of BMI in American Indians.

Obesity (Silver Spring) 2011 Oct 23;19(10):2102-6. Epub 2011 Jun 23.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1038/oby.2011.178
Publisher Site
http://dx.doi.org/10.1038/oby.2011.178DOI Listing
October 2011

Bimodal distribution of RNA expression levels in human skeletal muscle tissue.

BMC Genomics 2011 Feb 7;12:98. Epub 2011 Feb 7.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 1550 E, Indian School Rd, Phoenix, AZ 85014, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-12-98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044673PMC
February 2011

Evaluation of A2BP1 as an obesity gene.

Diabetes 2010 Nov 19;59(11):2837-45. Epub 2010 Aug 19.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db09-1604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963542PMC
November 2010

Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish.

Diabetes 2010 Aug 3;59(8):2080-5. Epub 2010 Jun 3.

Diabetes Molecular Genetics Section and, Diabetes Epidemiology, the National Institute of Diabetes and Digestive andKidney Disease, the National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db09-1593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911048PMC
August 2010

Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians.

Diabetes 2010 May 25;59(5):1276-82. Epub 2010 Feb 25.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/content/early/2010/03/0
Web Search
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-17
Publisher Site
http://dx.doi.org/10.2337/db09-1700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857909PMC
May 2010

Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.

Diabetes 2009 Jul 28;58(7):1682-9. Epub 2009 Apr 28.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, Phoenix, AZ, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db09-0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699863PMC
July 2009

Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.

Diabetes 2009 Feb 13;58(2):478-88. Epub 2008 Nov 13.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db08-0877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628623PMC
February 2009

Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant.

Diabetes 2008 Dec 3;57(12):3267-72. Epub 2008 Oct 3.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, Phoenix, AZ, USA.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db08-05
Publisher Site
http://dx.doi.org/10.2337/db08-0577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584132PMC
December 2008

PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.

Diabetes 2008 Nov 22;57(11):3156-60. Epub 2008 Jul 22.

Department of Health and HumanServices, Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and KidneyDiseases, National Institutes of Health, Phoenix, Arizona, USA.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/content/early/2008/07/2
Web Search
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db07-18
Publisher Site
http://dx.doi.org/10.2337/db07-1800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570415PMC
November 2008

Association analysis of Krüppel-like factor 11 variants with type 2 diabetes in Pima Indians.

J Clin Endocrinol Metab 2008 Sep 1;93(9):3644-9. Epub 2008 Jul 1.

Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Phoenix, Arizona 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2008-0546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729234PMC
September 2008

Variants in the Ca V 2.3 (alpha 1E) subunit of voltage-activated Ca2+ channels are associated with insulin resistance and type 2 diabetes in Pima Indians.

Diabetes 2007 Dec 24;56(12):3089-94. Epub 2007 Aug 24.

Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 455 North 5th St., Phoenix, AZ 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db07-0587DOI Listing
December 2007

A search for variants associated with young-onset type 2 diabetes in American Indians in a 100K genotyping array.

Diabetes 2007 Dec 10;56(12):3045-52. Epub 2007 Sep 10.

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 550 E. Indian School Rd., Phoenix, AZ 85014, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db07-0462DOI Listing
December 2007

TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima Indians: analysis of 3,501 individuals.

Diabetes 2007 Dec 1;56(12):3082-8. Epub 2007 Oct 1.

Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, NIH, 445 North 5th St., Phoenix, AZ 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db07-0621DOI Listing
December 2007

Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians.

Diabetes 2007 May 7;56(5):1454-9. Epub 2007 Feb 7.

Diabetes Molecular Genetics Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85004, USA.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/content/56/5/1454.full.
Web Search
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db06-06
Publisher Site
http://dx.doi.org/10.2337/db06-0640DOI Listing
May 2007

Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits.

Diabetes 2007 Mar;56(3):856-62

Division of Endocrinology 111J-1/LR, Department of Medicine, University of Arkansas for Medical Sciences, John L. McClellan Memorial Veterans Hospital, 4700 W. 7th Street, Little Rock, AR 72205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db06-1305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672156PMC
March 2007

CHRM3 gene variation is associated with decreased acute insulin secretion and increased risk for early-onset type 2 diabetes in Pima Indians.

Diabetes 2006 Dec;55(12):3625-9

Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 N. 5th St., Suite 210, Phoenix, AZ 85004, USA.

View Article

Download full-text PDF

Source
http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db06-03
Publisher Site
http://dx.doi.org/10.2337/db06-0379DOI Listing
December 2006

A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo.

Diabetes 2006 May;55(5):1497-503

Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 North 5th Street, Phoenix, AZ 85004, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db05-1331DOI Listing
May 2006

Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.

Diabetes 2005 Oct;54(10):3035-9

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85016, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1351112PMC
http://dx.doi.org/10.2337/diabetes.54.10.3035DOI Listing
October 2005

Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men.

Diabetes 2005 May;54(5):1598-602

Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 North 16th St., Phoenix, AZ 85016, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350723PMC
http://dx.doi.org/10.2337/diabetes.54.5.1598DOI Listing
May 2005

Melanocortin 4 receptor gene variation is associated with severe obesity in Pima Indians.

Diabetes 2004 Oct;53(10):2696-9

Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, 4212 N. 16th St., Phoenix, AZ 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.53.10.2696DOI Listing
October 2004

A novel missense substitution (Val1483Ile) in the fatty acid synthase gene (FAS) is associated with percentage of body fat and substrate oxidation rates in nondiabetic Pima Indians.

Diabetes 2004 Jul;53(7):1915-9

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.53.7.1915DOI Listing
July 2004

Genetic studies of the etiology of type 2 diabetes in Pima Indians: hunting for pieces to a complicated puzzle.

Diabetes 2004 May;53(5):1181-6

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N. 16th Street, Phoenix, AZ 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.53.5.1181DOI Listing
May 2004

The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians.

Diabetes 2003 Dec;52(12):3005-9

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.52.12.3005DOI Listing
December 2003

A functional variant in the peroxisome proliferator-activated receptor gamma2 promoter is associated with predictors of obesity and type 2 diabetes in Pima Indians.

Diabetes 2003 Jul;52(7):1864-71

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.52.7.1864DOI Listing
July 2003

Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity.

Diabetes 2003 Jun;52(6):1544-50

Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N. 16th Street, Room 5-41, Phoenix, AZ 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.52.6.1544DOI Listing
June 2003

Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism.

Biochemistry 2003 Jun;42(24):7339-47

Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118-2526, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0273617DOI Listing
June 2003

Genetic variation in the human winged helix/forkhead transcription factor gene FOXC2 in Pima Indians.

Diabetes 2003 May;52(5):1292-5

Department of Health and Human Services, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases/NIH, 4212 N. 16th Street, Phoenix, AZ 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.52.5.1292DOI Listing
May 2003

A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians.

Diabetes 2003 Mar;52(3):895-8

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease/NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.52.3.895DOI Listing
March 2003

The insulin gene variable number tandem repeat class I/III polymorphism is in linkage disequilibrium with birth weight but not Type 2 diabetes in the Pima population.

Diabetes 2003 Jan;52(1):187-93

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.52.1.187DOI Listing
January 2003

Gene for susceptibility to diabetic nephropathy in type 2 diabetes maps to 18q22.3-23.

Kidney Int 2002 Dec;62(6):2176-83

5th Medical Department (Nephrology/Endocrinology/Rheumatology), and Eye Clinic, University Hospital Mannheim ofthe University of Heidelberg, Mannheim, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1523-1755.2002.00663.xDOI Listing
December 2002

Identification of susceptibility genes for complex metabolic diseases.

Ann N Y Acad Sci 2002 Jun;967:1-6

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2002.tb04257.xDOI Listing
June 2002

Positional cloning of an obesity/diabetes susceptibility gene(s) on chromosome 11 in Pima Indians.

Ann N Y Acad Sci 2002 Jun;967:258-64

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Arizona 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1749-6632.2002.tb04281.xDOI Listing
June 2002

Polymorphisms in the oxygen-regulated protein 150 gene (ORP150) are associated with insulin resistance in Pima Indians.

Diabetes 2002 May;51(5):1618-21

Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Phoenix, Arizona 85016, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/diabetes.51.5.1618DOI Listing
May 2002