Lesley Mathews Griner

Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis.

Cancer Res 2020 06 27;80(12):2689-2702. Epub 2020 Apr 27.

Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

June 2020

Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors.

Authors:

Sukhbir Kaur Anthony L Schwartz David G Jordan David R Soto-Pantoja Bethany Kuo Abdel G Elkahloun Lesley Mathews Griner Craig J Thomas Marc Ferrer Anish Thomas Sai-Wen Tang Vinodh N Rajapakse Yves Pommier David D Roberts

Front Oncol 2019 1;9:994. Epub 2019 Oct 1.

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

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October 2019

Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype.

Authors:

Yansong Bian Yaroslav Teper Lesley A Mathews Griner Taylor J Aiken Vivek Shukla Rajarshi Guha Paul Shinn Hong-Wu Xin Holger Pflicke Astin S Powers Dandan Li Jian-Kang Jiang Paresma Patel Steven A Rogers Jeffrey Aubé Marc Ferrer Craig J Thomas Udo Rudloff

Mol Cancer Ther 2019 11 8;18(11):2097-2110. Epub 2019 Aug 8.

Rare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

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November 2019

Design and Discovery of -(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.

J Med Chem 2020 03 16;63(5):2013-2027. Epub 2019 May 16.

Oncology, Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

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March 2020

Sunitinib promotes myogenic regeneration and mitigates disease progression in the mdx mouse model of Duchenne muscular dystrophy.

Authors:

Tatiana M Fontelonga Brennan Jordan Andreia M Nunes Pamela Barraza-Flores Nicholas Bolden Ryan D Wuebbles Lesley Mathews Griner Xin Hu Marc Ferrer Juan Marugan Noel Southall Dean J Burkin

Hum Mol Genet 2019 07;28(13):2120-2132

Department of Pharmacology, University of Nevada, Reno School of Medicine, , Reno, NV, USA.

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July 2019

Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy.

Authors:

Kelli M Wilson Lesley A Mathews-Griner Tara Williamson Rajarshi Guha Lu Chen Paul Shinn Crystal McKnight Sam Michael Carleen Klumpp-Thomas Zev A Binder Marc Ferrer Gary L Gallia Craig J Thomas Gregory J Riggins

SLAS Technol 2019 02 5;24(1):28-40. Epub 2018 Oct 5.

1 Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore MD, USA.

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February 2019

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening.

Authors:

Lesley Mathews Griner Kalyani Gampa Toan Do Huyen Nguyen David Farley Christopher J Hogan Douglas S Auld Serena J Silver

J Vis Exp 2018 09 5(139). Epub 2018 Sep 5.

Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research.

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September 2018

Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy.

Authors:

Yismeilin R Feliz-Mosquea Ashley A Christensen Adam S Wilson Brian Westwood Jasmina Varagic Giselle C Meléndez Anthony L Schwartz Qing-Rong Chen Lesley Mathews Griner Rajarshi Guha Craig J Thomas Marc Ferrer Maria J Merino Katherine L Cook David D Roberts David R Soto-Pantoja

Breast Cancer Res Treat 2018 Nov 28;172(1):69-82. Epub 2018 Jul 28.

Department of Surgery, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.

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November 2018

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

Sci Transl Med 2018 05;10(441)

Department of Cell and Molecular Biology, Northwestern University, Chicago, IL 60611, USA.

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May 2018

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.

Cancer Res 2018 03 17;78(6):1537-1548. Epub 2018 Jan 17.

Oncology, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.

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March 2018

Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

J Med Chem 2017 06 8;60(12):4869-4881. Epub 2017 Jun 8.

Global Discovery Chemistry, Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.

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June 2017

SU9516 Increases α7β1 Integrin and Ameliorates Disease Progression in the mdx Mouse Model of Duchenne Muscular Dystrophy.

Mol Ther 2017 06 5;25(6):1395-1407. Epub 2017 Apr 5.

Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA. Electronic address:

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June 2017

Large-scale pharmacological profiling of 3D tumor models of cancer cells.

Authors:

Lesley A Mathews Griner Xiaohu Zhang Rajarshi Guha Crystal McKnight Ian S Goldlust Madhu Lal-Nag Kelli Wilson Sam Michael Steve Titus Paul Shinn Craig J Thomas Marc Ferrer

Cell Death Dis 2016 12 1;7(12):e2492. Epub 2016 Dec 1.

National Center for Advancing Translational Sciences, Division of Pre-Clinical Innovation, National Institutes of Health, Bethesda, MD, USA.

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December 2016

Chemical Screens Identify Drugs that Enhance or Mitigate Cellular Responses to Antibody-Toxin Fusion Proteins.

Authors:

Antonella Antignani Lesley Mathews Griner Rajarshi Guha Nathan Simon Matteo Pasetto Jonathan Keller Manjie Huang Evan Angelus Ira Pastan Marc Ferrer David J FitzGerald Craig J Thomas

PLoS One 2016 24;11(8):e0161415. Epub 2016 Aug 24.

Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, 20850, United States of America.

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July 2017

Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus.

Authors:

Rupkatha Mukhopadhyay Sujayita Roy Rajkumar Venkatadri Yu-Pin Su Wenjuan Ye Elena Barnaeva Lesley Mathews Griner Noel Southall Xin Hu Amy Q Wang Xin Xu Andrés E Dulcey Juan J Marugan Marc Ferrer Ravit Arav-Boger

PLoS Pathog 2016 06 23;12(6):e1005717. Epub 2016 Jun 23.

Department of Pediatrics, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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June 2016