Leroy F Liu

Leroy F Liu

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Leroy F Liu

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Thyroid hormone-induced expression of inflammatory cytokines interfere with resveratrol-induced anti-proliferation of oral cancer cells.

Food Chem Toxicol 2019 Oct 20;132:110693. Epub 2019 Jul 20.

Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei, 11031, Taiwan; Taipei Cancer Center, Taipei Medical University, Taipei, 11031, Taiwan.

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http://dx.doi.org/10.1016/j.fct.2019.110693DOI Listing
October 2019

Nano-Diamino-Tetrac (NDAT) Enhances Resveratrol-Induced Antiproliferation by Action on the RRM2 Pathway in Colorectal Cancers.

Horm Cancer 2018 10 20;9(5):349-360. Epub 2018 Jul 20.

PhD Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.

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http://dx.doi.org/10.1007/s12672-018-0334-9DOI Listing
October 2018

Tetrac downregulates β-catenin and HMGA2 to promote the effect of resveratrol in colon cancer.

Endocr Relat Cancer 2018 03 18;25(3):279-293. Epub 2017 Dec 18.

Pharmaceutical Research InstituteAlbany College of Pharmacy and Health Sciences, Albany, New York, USA.

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http://dx.doi.org/10.1530/ERC-17-0450DOI Listing
March 2018

Therapeutic applications of resveratrol and its derivatives on periodontitis.

Ann N Y Acad Sci 2017 09 30;1403(1):101-108. Epub 2017 Aug 30.

Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan.

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http://dx.doi.org/10.1111/nyas.13433DOI Listing
September 2017

Erratum: "Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma".

Am J Chin Med 2017 ;45(5):1125

§ Center for Comparative Respiratory Biology and Medicine, Internal Medicine, College of Medicine, University of California at Davis, Davis, California 95616, USA.

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http://dx.doi.org/10.1142/S0192415X17920033DOI Listing
January 2017

Polygonum multiflorum Decreases Airway Allergic Symptoms in a Murine Model of Asthma.

Am J Chin Med 2016 ;44(1):133-47

§ Center for Comparative Respiratory Biology and Medicine, Internal Medicine, College of Medicine, University of California at Davis, Davis, California 95616, USA.

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http://dx.doi.org/10.1142/S0192415X16500099DOI Listing
December 2016

The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status.

Steroids 2016 07 12;111:63-70. Epub 2016 Mar 12.

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, USA; Albany Medical College, Albany, NY, USA.

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http://dx.doi.org/10.1016/j.steroids.2016.03.006DOI Listing
July 2016

A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit.

PLoS One 2014 8;9(12):e111529. Epub 2014 Dec 8.

Institute of Biochemistry and Molecular Biology, National Yang-Ming University, Taipei, Taiwan; Department of Biochemistry, Medical College, Taipei Medical University, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111529PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259298PMC
August 2015

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro.

Oncotarget 2014 Dec;5(24):12891-907

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York, USA. Albany Medical College, Albany, New York, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350334PMC
http://dx.doi.org/10.18632/oncotarget.2632DOI Listing
December 2014

Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells.

Biol Open 2014 Feb 15;3(2):172-84. Epub 2014 Feb 15.

Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1242/bio.20146767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3925320PMC
February 2014

Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock.

Mol Cell Biol 2013 Oct 12;33(20):4008-16. Epub 2013 Aug 12.

Department of Pharmacology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA.

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http://dx.doi.org/10.1128/MCB.00403-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811683PMC
October 2013

Macrocyclic biphenyl tetraoxazoles: synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity.

Bioorg Med Chem 2013 Aug 30;21(15):4511-20. Epub 2013 May 30.

Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers - The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmc.2013.05.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949619PMC
August 2013

Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis.

J Biol Chem 2013 Mar 22;288(10):7182-92. Epub 2013 Jan 22.

Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.M112.415471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591627PMC
March 2013

A novel synthetic bipartite carrier protein for developing glycotope-based vaccines.

Vaccine 2012 Dec 22;30(52):7573-81. Epub 2012 Oct 22.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.vaccine.2012.10.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513549PMC
December 2012

Identification of the molecular basis of doxorubicin-induced cardiotoxicity.

Nat Med 2012 Nov 28;18(11):1639-42. Epub 2012 Oct 28.

Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/nm.2919DOI Listing
November 2012

Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity.

PLoS One 2012 3;7(4):e34250. Epub 2012 Apr 3.

Molecular and Cell Biology Program, Graduate Institute of Life Sciences, National Defense Medical Center, Academia Sinica, Taipei, Taiwan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034250PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317942PMC
August 2012

Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cells.

PLoS One 2012 1;7(3):e32542. Epub 2012 Mar 1.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032542PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291570PMC
July 2012

ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells.

Exp Biol Med (Maywood) 2012 Jan 20;237(1):38-49. Epub 2011 Dec 20.

Department of Biochemistry and Molecular Biology, LSU Health Sciences Center-School of Medicine, 1901 Perdido Street, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1258/ebm.2011.011236DOI Listing
January 2012

Interferon-β signaling contributes to Ras transformation.

PLoS One 2011 29;6(8):e24291. Epub 2011 Aug 29.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0024291PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3163666PMC
December 2011

Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.

J Biol Chem 2011 Sep 1;286(38):33591-600. Epub 2011 Aug 1.

Department of Pharmacology and the Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.M111.258137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190902PMC
September 2011

Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia.

Biochem Biophys Res Commun 2010 Aug 16;399(1):66-71. Epub 2010 Jul 16.

Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1001345
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http://dx.doi.org/10.1016/j.bbrc.2010.07.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376163PMC
August 2010

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity.

Bioorg Med Chem Lett 2010 May 30;20(10):3150-4. Epub 2010 Mar 30.

Department of Medicinal Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X1000427
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http://dx.doi.org/10.1016/j.bmcl.2010.03.086DOI Listing
May 2010

Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks.

J Biol Chem 2009 Oct 6;284(41):28084-92. Epub 2009 Aug 6.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635, USA.

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http://dx.doi.org/10.1074/jbc.M109.030601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788859PMC
October 2009

A G-quadruplex stabilizer induces M-phase cell cycle arrest.

J Biol Chem 2009 Aug 16;284(34):22535-43. Epub 2009 Jun 16.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635, USA.

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http://dx.doi.org/10.1074/jbc.M109.020230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755660PMC
August 2009

Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.

Eur J Med Chem 2009 Apr 11;44(4):1471-6. Epub 2008 Oct 11.

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.ejmech.2008.09.048DOI Listing
April 2009

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents.

Bioorg Med Chem 2009 Apr 20;17(7):2877-85. Epub 2009 Feb 20.

Department of Medicinal Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmc.2009.02.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752343PMC
April 2009

TOR regulates cell death induced by telomere dysfunction in budding yeast.

PLoS One 2008 24;3(10):e3520. Epub 2008 Oct 24.

Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003520PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567032PMC
January 2009

Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.

Bioorg Med Chem 2008 Oct 5;16(20):9295-301. Epub 2008 Sep 5.

Department of Pharmaceutical Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752341PMC
October 2008

11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents.

Bioorg Med Chem 2008 Sep 7;16(18):8598-606. Epub 2008 Aug 7.

Department of Pharmaceutical Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733853PMC
September 2008

Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31).

Bioorg Med Chem 2008 Aug 26;16(16):7824-31. Epub 2008 Jun 26.

Department of Pharmaceutical Chemistry, Rutgers, Ernest Mario School of Pharmacy, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.06.046DOI Listing
August 2008

Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency.

Bioorg Med Chem Lett 2008 Jul 15;18(13):3802-4. Epub 2008 May 15.

Department of Pharmaceutical Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518403PMC
July 2008

A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes.

J Biol Chem 2008 Jul 30;283(30):21074-83. Epub 2008 May 30.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1074/jbc.M803493200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475699PMC
July 2008

Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.

Bioorg Med Chem Lett 2008 Jun 6;18(12):3570-2. Epub 2008 May 6.

Department of Pharmaceutical Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.05.005DOI Listing
June 2008

ISG15 as a novel tumor biomarker for drug sensitivity.

Mol Cancer Ther 2008 Jun;7(6):1430-9

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-2345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561335PMC
June 2008

Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation.

PLoS One 2008 Apr 23;3(4):e2009. Epub 2008 Apr 23.

Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002009PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329593PMC
April 2008

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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http://www.dwalab.ca/common/pdf/cdd200944a.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654259PMC
http://dx.doi.org/10.4161/auto.5338DOI Listing
February 2008

Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane.

Cancer Res 2007 Sep;67(18):8839-46

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854-5635, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1649DOI Listing
September 2007

The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains.

Autophagy 2007 Jul-Aug;3(4):337-46. Epub 2007 Jul 9.

Pharmacology Department and the Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.4161/auto.4127DOI Listing
August 2007

Protection of DNA ends by telomeric 3' G-tail sequences.

J Biol Chem 2007 Jun 4;282(26):18786-92. Epub 2007 May 4.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.M702171200DOI Listing
June 2007

Role of DNA topoisomerase IIbeta in neurite outgrowth.

Brain Res 2007 Jun 19;1154:50-60. Epub 2007 Apr 19.

Department of Biology, MEC-CUNY, 1150 Carroll Street, Brooklyn, NY 11225, USA.

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http://dx.doi.org/10.1016/j.brainres.2007.04.029DOI Listing
June 2007

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

Proc Natl Acad Sci U S A 2007 Jun 19;104(26):11014-9. Epub 2007 Jun 19.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0704002104
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http://dx.doi.org/10.1073/pnas.0704002104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904155PMC
June 2007

Autophagy regulates ageing in C. elegans.

Autophagy 2007 Mar-Apr;3(2):93-5. Epub 2007 Mar 30.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.4161/auto.3636DOI Listing
April 2007

Targeting mammalian target of rapamycin (mTOR) for health and diseases.

Drug Discov Today 2007 Feb 15;12(3-4):112-24. Epub 2006 Dec 15.

Department of Pharmacology and Cancer Institute of New Jersey (CINJ) Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854 USA.

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http://dx.doi.org/10.1016/j.drudis.2006.12.008DOI Listing
February 2007

G-quadruplexes induce apoptosis in tumor cells.

Cancer Res 2006 Dec;66(24):11808-16

Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1225DOI Listing
December 2006

Role of topoisomerase IIbeta in the expression of developmentally regulated genes.

Mol Cell Biol 2006 Nov 21;26(21):7929-41. Epub 2006 Aug 21.

Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00617-06
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http://dx.doi.org/10.1128/MCB.00617-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636731PMC
November 2006

A protease pathway for the repair of topoisomerase II-DNA covalent complexes.

J Biol Chem 2006 Nov 13;281(47):35997-6003. Epub 2006 Sep 13.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.M604149200DOI Listing
November 2006

Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment-related acute myelogenous leukemia.

Cancer Res 2006 Sep;66(18):8975-9

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1724DOI Listing
September 2006

Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity.

J Med Chem 2006 Jun;49(12):3710-8

Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.

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http://dx.doi.org/10.1021/jm060197rDOI Listing
June 2006

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.

Bioorg Med Chem 2006 May 18;14(9):3131-43. Epub 2006 Jan 18.

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.12.028DOI Listing
May 2006

Assembly of a polymeric chain of SUMO1 on human topoisomerase I in vitro.

J Biol Chem 2006 Mar 20;281(12):8264-74. Epub 2006 Jan 20.

Institute of Biochemistry and Molecular Biology, School of Life Science, National Yang Ming University, Taipei 112, Taiwan.

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http://dx.doi.org/10.1074/jbc.M510364200DOI Listing
March 2006

Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway.

Cancer Res 2006 Jan;66(2):921-8

Department of Pharmacology, University of Medicine and Dentistry of New Jersey/Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1123DOI Listing
January 2006

Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.

Bioorg Med Chem 2005 Dec 8;13(24):6782-94. Epub 2005 Sep 8.

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.07.033DOI Listing
December 2005

Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity.

Bioorg Med Chem 2005 Jun;13(12):3993-4006

Laboratory of Bioorganic Chemistry, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.

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http://dx.doi.org/10.1016/j.bmc.2005.03.057DOI Listing
June 2005

5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.

J Med Chem 2005 Feb;48(3):792-804

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, New Jersey 08854-8020, USA.

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http://dx.doi.org/10.1021/jm049447zDOI Listing
February 2005

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.

Bioorg Med Chem Lett 2004 Nov;14(22):5585-9

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmcl.2004.08.070DOI Listing
November 2004

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

J Biol Chem 2004 Aug 9;279(35):36440-4. Epub 2004 Jul 9.

Department of Pharmacology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.1074/jbc.C400300200DOI Listing
August 2004

Nuclear translocation of cytochrome c during apoptosis.

J Biol Chem 2004 Jun 8;279(24):24911-4. Epub 2004 Apr 8.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.C400051200DOI Listing
June 2004

Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death.

J Biol Chem 2004 Apr 19;279(15):14587-94. Epub 2003 Dec 19.

Department of Pharmacology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.M311370200DOI Listing
April 2004

11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.

Bioorg Med Chem 2004 Feb;12(4):795-806

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/j.bmc.2003.10.061DOI Listing
February 2004

Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.

Cancer Res 2003 Dec;63(23):8400-7

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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December 2003

Isodiospyrin as a novel human DNA topoisomerase I inhibitor.

Biochem Pharmacol 2003 Nov;66(10):1981-91

Institute of Biochemistry, School of Life Science, National Yang Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.bcp.2003.07.003DOI Listing
November 2003

DNA damage-mediated apoptosis induced by selenium compounds.

J Biol Chem 2003 Aug 24;278(32):29532-7. Epub 2003 May 24.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1074/jbc.M301877200DOI Listing
August 2003

8,9-methylenedioxybenzo[i]phenanthridines: topoisomerase I-targeting activity and cytotoxicity.

Bioorg Med Chem 2003 Aug;11(17):3795-805

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/s0968-0896(03)00394-8DOI Listing
August 2003

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.

Bioorg Med Chem 2003 May;11(9):2061-73

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/s0968-0896(03)00051-8DOI Listing
May 2003

Single-stranded DNA induces ataxia telangiectasia mutant (ATM)/p53-dependent DNA damage and apoptotic signals.

J Biol Chem 2003 Apr 21;278(14):12475-81. Epub 2003 Jan 21.

Department of Pharmacology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M212915200
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http://dx.doi.org/10.1074/jbc.M212915200DOI Listing
April 2003

Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast.

J Biol Chem 2003 Apr 3;278(17):15136-41. Epub 2003 Feb 3.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M212808200
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http://dx.doi.org/10.1074/jbc.M212808200DOI Listing
April 2003

Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents.

Bioorg Med Chem 2003 Apr;11(7):1475-91

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/s0968-0896(02)00604-1DOI Listing
April 2003

Transcription-dependent degradation of topoisomerase I-DNA covalent complexes.

Mol Cell Biol 2003 Apr;23(7):2341-50

Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150741PMC
http://dx.doi.org/10.1128/mcb.23.7.2341-2350.2003DOI Listing
April 2003

Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents.

Bioorg Med Chem 2003 Apr;11(8):1809-20

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1016/s0968-0896(03)00053-1DOI Listing
April 2003

Acidic pH induces topoisomerase II-mediated DNA damage.

Proc Natl Acad Sci U S A 2003 Apr 11;100(9):5205-10. Epub 2003 Apr 11.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854-5635, USA.

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http://dx.doi.org/10.1073/pnas.0935978100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154323PMC
April 2003

The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway.

Proc Natl Acad Sci U S A 2003 Mar 10;100(6):3239-44. Epub 2003 Mar 10.

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854-5635, USA.

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http://dx.doi.org/10.1073/pnas.0736401100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC152276PMC
March 2003

2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents.

Bioorg Med Chem 2003 Feb;11(4):521-8

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, NJ 08854-8020, Piscataway, USA.

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http://dx.doi.org/10.1016/s0968-0896(02)00530-8DOI Listing
February 2003

Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.

Bioorg Med Chem Lett 2002 Nov;12(22):3333-6

Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, USA.

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http://dx.doi.org/10.1016/s0960-894x(02)00737-0DOI Listing
November 2002