Leonora Balaj

Leonora Balaj

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Leonora Balaj

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Navigating the Landscape of Tumor Extracellular Vesicle Heterogeneity.

Int J Mol Sci 2019 Mar 18;20(6). Epub 2019 Mar 18.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.3390/ijms20061349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471355PMC
March 2019

Overview of Protocols for Studying Extracellular RNA and Extracellular Vesicles.

Methods Mol Biol 2018 ;1740:17-21

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-7652-2_2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472704PMC
January 2019

Isolation of Extracellular RNA from Serum/Plasma.

Methods Mol Biol 2018 ;1740:43-57

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX, USA.

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http://dx.doi.org/10.1007/978-1-4939-7652-2_5DOI Listing
January 2019

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018

Multiplexed Profiling of Single Extracellular Vesicles.

ACS Nano 2018 01 4;12(1):494-503. Epub 2018 Jan 4.

Center for Systems Biology, Massachusetts General Hospital , 185 Cambridge St, CPZN 5206, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acsnano.7b07060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898240PMC
January 2018

Liquid biopsy for brain tumors.

Expert Rev Mol Diagn 2017 10 6;17(10):943-947. Epub 2017 Sep 6.

a Department of Neurosurgery , Massachusetts General Hospital , Boston , MA , USA.

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http://dx.doi.org/10.1080/14737159.2017.1374854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856481PMC
October 2017

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells.

Nat Commun 2017 10 26;8(1):1145. Epub 2017 Oct 26.

Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, HMS Initiative for RNA Medicine, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-017-01196-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658400PMC
October 2017

Extracellular Mitochondria in Cerebrospinal Fluid and Neurological Recovery After Subarachnoid Hemorrhage.

Stroke 2017 08 29;48(8):2231-2237. Epub 2017 Jun 29.

From the Neuroprotection Research Laboratories, Departments of Radiology and Neurology (S.H.-Y.C., J.L., E.E., M.N., E.H.L., K.H.) and Clinical Proteomics Research Center, Department of Neurology (M.N., E.H.L.), Massachusetts General Hospital and Harvard Medical School, Boston; Departments of Critical Care Medicine, Neurology, and Neurosurgery, University of Pittsburgh, PA (S.H.-Y.C.); Department of Neurology, Brigham and Women's Hospital, Boston, MA (S.H.-Y.C.); Cerebrovascular Research Center, Xuanwu Hospital, Capital Medical University, Beijing, China (J.L., X.J.); and Department of Neurology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston (L.B.).

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http://dx.doi.org/10.1161/STROKEAHA.117.017758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526718PMC
August 2017

Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson's Disease, Glioma, and Schwannoma.

Cell Mol Neurobiol 2016 Apr 26;36(3):417-27. Epub 2016 Mar 26.

Department of Neurology and Center for Molecular Imaging Research, Department of Radiology, Massachusetts General Hospital and NeuroDiscovery Center, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s10571-015-0309-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860146PMC
April 2016

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study.

Bioscience 2015 Aug 26;65(8):783-797. Epub 2015 Jun 26.

Mikołaj P. Zaborowski ( ; ), Leonora Balaj ( ), Xandra O. Breakefield ( ), and Charles P. Lai ( ) are affiliated with the Department of Neurology at Massachusetts General Hospital, in Charlestown, and with the Harvard NeuroDiscovery Center at Harvard Medical School, in Boston, Massachusetts. XOB is also affiliated with the Department of Radiology at Massachusetts General Hospital, in Charlestown, and MPZ is also affiliated with the Department of Gynecology, Obstetrics, and Gynecologic Oncology at the Poznan University of Medical Sciences, in Poland.

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http://dx.doi.org/10.1093/biosci/biv084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776721PMC
August 2015

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.

Nat Commun 2015 May 11;6:6999. Epub 2015 May 11.

1] Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, Massachusetts 02114, USA [2] Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA [3] Department of Radiology, Massachusetts General Hospital, Fruit St, Boston, Massachusetts 02114, USA [4] Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms7999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430127PMC
May 2015

Heparin affinity purification of extracellular vesicles.

Sci Rep 2015 May 19;5:10266. Epub 2015 May 19.

Department of Neurology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1038/srep10266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437317PMC
May 2015

Extracellular RNA mediates and marks cancer progression.

Semin Cancer Biol 2014 Oct 28;28:14-23. Epub 2014 Apr 28.

Departments of Neurology and Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2014.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162815PMC
October 2014

Glioma diagnostics and biomarkers: an ongoing challenge in the field of medicine and science.

Expert Rev Mol Diagn 2014 May;14(4):439-52

Department of Neurology and Program in Neuroscience, Massachusetts General Hospital and Harvard Medical School, Suite 340, 175 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1586/14737159.2014.905202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451266PMC
May 2014

Heparin blocks transfer of extracellular vesicles between donor and recipient cells.

J Neurooncol 2013 Dec 4;115(3):343-51. Epub 2013 Sep 4.

Department of Neurology and Program in Neuroscience, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1007/s11060-013-1235-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856724PMC
December 2013

BEAMing and Droplet Digital PCR Analysis of Mutant IDH1 mRNA in Glioma Patient Serum and Cerebrospinal Fluid Extracellular Vesicles.

Mol Ther Nucleic Acids 2013 Jul 23;2:e109. Epub 2013 Jul 23.

1] Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA [2] Department of Radiology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA [3] Program, Harvard-MIT Division of Health, Science, and Technology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/mtna.2013.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732870PMC
July 2013

Impact of biofluid viscosity on size and sedimentation efficiency of the isolated microvesicles.

Front Physiol 2012 28;3:162. Epub 2012 May 28.

Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School Boston, MA, USA.

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http://dx.doi.org/10.3389/fphys.2012.00162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362089PMC
October 2012

Alternative methods for characterization of extracellular vesicles.

Front Physiol 2012 7;3:354. Epub 2012 Sep 7.

Harvard Catalyst Laboratory for Innovative Translational Technologies, Harvard Medical School Boston, MA, USA.

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http://dx.doi.org/10.3389/fphys.2012.00354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435888PMC
October 2012

Extracellular vesicles and their convergence with viral pathways.

Adv Virol 2012 25;2012:767694. Epub 2012 Jul 25.

Departments of Neurology and Radiology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1155/2012/767694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410301PMC
August 2012

Microvesicle-associated AAV vector as a novel gene delivery system.

Mol Ther 2012 May 7;20(5):960-71. Epub 2012 Feb 7.

Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/mt.2011.303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345986PMC
May 2012

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls.

BMC Cancer 2012 Jan 17;12:22. Epub 2012 Jan 17.

Department of Neurology, Neurosurgery and Radiology, Massachusetts General Hospital and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-12-22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329625PMC
January 2012

Blood platelets contain tumor-derived RNA biomarkers.

Blood 2011 Sep 10;118(13):3680-3. Epub 2011 Aug 10.

Neuro-oncology Research Group, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2011-03-344408DOI Listing
September 2011

Brain tumor microvesicles: insights into intercellular communication in the nervous system.

Cell Mol Neurobiol 2011 Aug 8;31(6):949-59. Epub 2011 May 8.

Department of Neurology, Boston, MA, USA.

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http://dx.doi.org/10.1007/s10571-011-9697-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702172PMC
August 2011

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences.

Nat Commun 2011 Feb 1;2:180. Epub 2011 Feb 1.

Department of Neurology, Harvard Medical School, Boston, MA 02129, USA.

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http://dx.doi.org/10.1038/ncomms1180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040683PMC
February 2011

Microfluidic isolation and transcriptome analysis of serum microvesicles.

Lab Chip 2010 Feb 8;10(4):505-11. Epub 2009 Dec 8.

BioMEMS Resource Center, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/b916199fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136803PMC
February 2010