Leonardo Ferreira, PhD - UCSF

Leonardo Ferreira

PhD

UCSF

San Francisco, California | United States

Main Specialties: Allergy & Immunology, Biology

Additional Specialties: Immune tolerance

ORCID logohttps://orcid.org/0000-0003-2491-9866


Top Author

Leonardo Ferreira, PhD - UCSF

Leonardo Ferreira

PhD

Introduction

Leonardo M.R. Ferreira, Ph.D. is a molecular immunologist and human genome engineer in the laboratories of Dr. Qizhi Tang (Department of Surgery) and Dr. Jeffrey Bluestone (Diabetes Center) at UCSF.

Dr. Ferreira has a B.Sc. in biochemistry from the University of Coimbra, Portugal, and received a Ph.D. in biochemistry from Harvard University in 2016. During his doctoral studies, under the supervision of Dr. Jack Strominger and Dr. Chad Cowan at Harvard's Department of Stem Cell and Regenerative Biology, he focused on studying immune tolerance using pregnancy as a model, as well as on developing new tools to edit the genome of primary human T cells.

Currently, Dr. Ferreira is working to develop the next generation of chimeric antigen receptors for regulatory T cell therapy, aiming to establish tolerance in the contexts of autoimmune disease and transplant rejection.

Primary Affiliation: UCSF - San Francisco, California , United States

Specialties:

Additional Specialties:

Research Interests:


View Leonardo Ferreira’s Resume / CV

Education

Jul 2011 - May 2016
Harvard University
Ph.D.
Department of Molecular and Cellular Biology
Sep 2008 - Jun 2011
University of Coimbra
B.Sc.
Department of Biochemistry

Experience

Nov 2018
Keystone Symposia Future of Science Fund Scholarship
May 2018
AAI Trainee Poster Award
Jun 2017
FOCIS FCE Best Poster Award
May 2015
AAI Travel Award

Publications

31Publications

207Reads

15Profile Views

244PubMed Central Citations

Generation of hypoimmunogenic human pluripotent stem cells.

Proc Natl Acad Sci U S A 2019 May 30;116(21):10441-10446. Epub 2019 Apr 30.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1902566116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535035PMC
May 2019
2 Reads
9.809 Impact Factor

Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells.

Biometals 2018 08 16;31(4):477-487. Epub 2018 Mar 16.

Molecular Physical Chemistry Research Unit and Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.

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http://dx.doi.org/10.1007/s10534-018-0093-7DOI Listing
August 2018
19 Reads
2.503 Impact Factor

NLRP2 is a suppressor of NF-ƙB signaling and HLA-C expression in human trophoblasts†,‡.

Tilburgs T, Meissner TB, Ferreira LMR, Mulder A, Musunuru K, Ye J, Strominger JL, Biology of reproduction, 2017, vol. 96, no. 4, pp. 831-842, 2017

http://europepmc.org/abstract/med/28340094

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May 2017
8 Reads

HLA-G: At the Interface of Maternal-Fetal Tolerance.

Ferreira LM, Meissner TB, Tilburgs T, Strominger JL, Trends in immunology, 2017, vol. 38, no. 4, pp. 272-286, 2017

http://europepmc.org/abstract/med/28279591

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May 2017
9 Reads

Generating Antigen-Specific Regulatory T Cells in the Fast Lane.

Ferreira LM, Tang Q, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017, vol. 17, no. 4, pp. 851-853, 2017

http://europepmc.org/abstract/med/28102024

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May 2017
11 Reads

HLA-G: At the Interface of Maternal-Fetal Tolerance.

Trends Immunol 2017 04 6;38(4):272-286. Epub 2017 Mar 6.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine mucosa without being rejected by the maternal immune system. Several mechanisms were initially proposed by Peter Medawar half a century ago to explain this apparent violation of the laws of transplantation. Then, three decades ago, an unusual human leukocyte antigen (HLA) molecule was identified: HLA-G. Uniquely expressed in EVT, HLA-G has since become the center of the present understanding of fetus-induced immune tolerance. Despite slow progress in the field, the last few years have seen an explosion in our knowledge of HLA-G biology. Here, we critically review new insights into the mechanisms controlling the expression and function of HLA-G at the maternal-fetal interface, and discuss their relevance for fetal tolerance.



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http://dx.doi.org/10.1016/j.it.2017.01.009DOI Listing
April 2017
20 Reads
28 Citations
14.188 Impact Factor

NLRP2 is a suppressor of NF-ƙB signaling and HLA-C expression in human trophoblasts†,‡.

Biol Reprod 2017 Apr;96(4):831-842

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1093/biolre/iox009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803763PMC
April 2017
24 Reads
3.320 Impact Factor

A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.

Proc Natl Acad Sci U S A 2016 May 13;113(19):5364-9. Epub 2016 Apr 13.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1602886113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868469PMC
May 2016
34 Reads
10 Citations
9.810 Impact Factor

Genome editing for human gene therapy.

Methods Enzymol 2014 ;546:273-95

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA; Harvard Stem Cell Institute, Sherman Fairchild Biochemistry, Cambridge, Massachusetts, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801185-0.00013-1DOI Listing
July 2015
37 Reads
4 Citations
2.090 Impact Factor

Genome Editing for Human Gene Therapy

The Use of CRISPR/Cas9, ZFNs, and TALENs in Generating Site-Specific Genome Alterations

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2014
6 Reads

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9.

Cell Stem Cell 2014 Nov 6;15(5):643-52. Epub 2014 Nov 6.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269831PMC
November 2014
23 Reads
105 Citations

Gammadelta T cells: innately adaptive immune cells?

Int Rev Immunol 2013 Jun 25;32(3):223-48. Epub 2013 Apr 25.

Department of Molecular and Cellular Biology and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.3109/08830185.2013.783831DOI Listing
June 2013
9 Reads
16 Citations
4.103 Impact Factor

How induced pluripotent stem cells are redefining personalized medicine.

Gene 2013 May 5;520(1):1-6. Epub 2013 Mar 5.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, United States.

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http://dx.doi.org/10.1016/j.gene.2013.02.037DOI Listing
May 2013
16 Reads
9 Citations
2.140 Impact Factor

Gammadelta T Cells: Innately Adaptive Immune Cells?

International Reviews of Immunology

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May 2013
7 Reads

Changlng cell identity to create true personalized medicine

Mostajo-Radji, Mohammed A., & M.R. Ferreira, Leonardo. (2012). Cambiando la Identidad celular para crear una verdadera medicina personalizada. Gaceta Médica Boliviana, 35(2), 76-79. Recuperado en 20 de enero de 2019, de http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1012-296620120002000

Gad Med Bol

The 2012 Nobel Prize in Physiology or Medicine was awarded to Sir John Gurdon and Shinya Yamanaka for their breakthroughs in cellular reprogramming. These discoveries not only changed our view of the process of cell fate determination, but also hold the potential to revolutionize medicine. By providing a brief historical context and a succinct summary of the current methodologies, we present the major advances in basic research, as well as their potential applications to the clinic. This review aims to provide a concise overview of the current state of the field and its implications for therapy.

http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1012-29662012000200007

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2012
3 Reads

Neural regeneration: lessons from regenerating and non-regenerating systems.

Mol Neurobiol 2012 Oct 21;46(2):227-41. Epub 2012 Jun 21.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1007/s12035-012-8290-9DOI Listing
October 2012
13 Reads
4 Citations
5.140 Impact Factor

Cancer metabolism: The Warburg effect today

Experimental and Molecular Pathology

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2010
8 Reads

Cancer metabolism: the Warburg effect today.

Exp Mol Pathol 2010 Dec 8;89(3):372-80. Epub 2010 Sep 8.

Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Rua dos Estudos, 3001-401 Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.yexmp.2010.08.006DOI Listing
December 2010
10 Reads
68 Citations
2.710 Impact Factor

Top co-authors

Torsten B Meissner
Torsten B Meissner

Dana-Farber Cancer Institute

6
Jack L Strominger
Jack L Strominger

Harvard University

4
Chad A Cowan
Chad A Cowan

Harvard University

4
Tamara Tilburgs
Tamara Tilburgs

Leiden University Medical Center

3
Kiran Musunuru
Kiran Musunuru

Massachusetts General Hospital

2
Pankaj K Mandal
Pankaj K Mandal

Boston Children's Hospital

2
Derrick J Rossi
Derrick J Rossi

Harvard Medical School

2
Vladimir Vrbanac
Vladimir Vrbanac

Massachusetts General Hospital

1
Brian S Garrison
Brian S Garrison

Harvard University

1
Christian L Boutwell
Christian L Boutwell

Ragon Institute of MGH

1