Leonardo Ferreira, PhD - UCSF

Leonardo Ferreira

PhD

UCSF

San Francisco, California | United States

Main Specialties: Allergy & Immunology, Biology

Additional Specialties: Immune tolerance

ORCID logohttps://orcid.org/0000-0003-2491-9866


Top Author

Leonardo Ferreira, PhD - UCSF

Leonardo Ferreira

PhD

Introduction

Leonardo M.R. Ferreira, Ph.D. is a molecular immunologist and human genome engineer in the laboratories of Dr. Qizhi Tang (Department of Surgery) and Dr. Jeffrey Bluestone (Diabetes Center) at UCSF.

Dr. Ferreira has a B.Sc. in biochemistry from the University of Coimbra, Portugal, and received a Ph.D. in biochemistry from Harvard University in 2016. During his doctoral studies, under the supervision of Dr. Jack Strominger and Dr. Chad Cowan at Harvard's Department of Stem Cell and Regenerative Biology, he focused on studying immune tolerance using pregnancy as a model, as well as on developing new tools to edit the genome of primary human T cells.

Currently, Dr. Ferreira is working to develop the next generation of chimeric antigen receptors for regulatory T cell therapy, aiming to establish tolerance in the contexts of autoimmune disease and transplant rejection.

Primary Affiliation: UCSF - San Francisco, California , United States

Specialties:

Additional Specialties:

Research Interests:


View Leonardo Ferreira’s Resume / CV

Education

Jul 2011 - May 2016
Harvard University
Ph.D.
Biochemistry
May 2013
Harvard University
A.M.
Biology
Jun 2011
University of Coimbra
B.Sc.
Biochemistry

Experience

Feb 2020
AAI-Thermo Fisher Trainee Achievement Award
Jan 2019
Jeffrey G. Klein Family Diabetes Fellowship
Nov 2018
Keystone Symposia Future of Science Fund Scholarship
May 2018
AAI Trainee Poster Award
Jun 2017
FOCIS FCE Best Poster Award
May 2015
AAI Travel Award

Publications

43Publications

1284Reads

27Profile Views

244PubMed Central Citations

Plasma-based COVID-19 treatments in low- and middle-income nations pose a high risk of an HIV epidemic.

NPJ Vaccines 2020 6;5:58. Epub 2020 Jul 6.

Clubes de Ciencia Bolivia Foundation, Santa Cruz de la Sierra, Bolivia.

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http://dx.doi.org/10.1038/s41541-020-0209-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338534PMC
July 2020

Intermediary metabolism: An intricate network at the crossroads of cell fate and function.

Biochim Biophys Acta Mol Basis Dis 2020 Jun 26;1866(10):165887. Epub 2020 Jun 26.

Molecular Physical Chemistry Research Unit (QFM-UC), Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO) and Department of Life Sciences, University of Coimbra, 3000-456 Coimbra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2020.165887DOI Listing
June 2020
4.882 Impact Factor

GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.

Cell 2019 11;179(6):1276-1288.e14

Department of Medicine, Division of Cardiology, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, Boston, MA 02215, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.10.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889877PMC
November 2019
32.242 Impact Factor

Scientists as non-state actors of public diplomacy.

Nat Hum Behav 2019 11;3(11):1129-1130

Clubes de Ciencia Bolivia Foundation, Santa Cruz de la Sierra, Bolivia.

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http://dx.doi.org/10.1038/s41562-019-0716-1DOI Listing
November 2019
5 Reads

Next-generation regulatory T cell therapy.

Nat Rev Drug Discov 2019 10 20;18(10):749-769. Epub 2019 Sep 20.

Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.

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http://www.nature.com/articles/s41573-019-0041-4
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http://dx.doi.org/10.1038/s41573-019-0041-4DOI Listing
October 2019
392 Reads
41.908 Impact Factor

Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress.

Int J Mol Sci 2019 Oct 3;20(19). Epub 2019 Oct 3.

Department of Life Sciences, Molecular Physical Chemistry Research Unit and Center of Investigation in Environment, Genetics and Oncobiology (CIMAGO), University of Coimbra, 3000-456 Coimbra, Portugal.

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https://www.mdpi.com/1422-0067/20/19/4901
Publisher Site
http://dx.doi.org/10.3390/ijms20194901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801751PMC
October 2019
7 Reads
2.862 Impact Factor

Developing Brains, Developing Nations: Can Scientists Be Effective Non-state Diplomats?

Frontiers in Education

Foreign education efforts by institutions of developed nations often meet resistance abroad, when the need for national sovereignty stands in opposition to collaborative opportunities with outside states. Strict isolationist policies can not only impact diplomatic ties, but also prevent the transfer of technologies, knowledge, and innovation that ultimately drive economic strength. Developing nations are particularly vulnerable to stagnation—both economic and scientific—when divorced from the march of global progress. We believe there is a balance to be struck whereby advances can be shared to mutual benefit on all sides while respecting local contexts, and science education may serve as an effective vehicle for such cross-border connection.

http://dx.doi.org/10.3389/feduc.2019.00095

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September 2019
9 Reads

Scientists as non-state actors of public diplomacy

Nature Human Behaviour

Establishing trust between distant nations requires a level of openness that fosters mutual understandings at individual and population scales. This is especially true in countries separated by degrees of economic development, where feelings of distrust felt by a less developed nation may cast perceptions of imperialistic intents upon the activities of more industrialized nations. Furthermore, between countries that do not enjoy advanced diplomatic relationships, there may appear to be no clear path to realizing cross-border connections in a top-down manner. We present here the argument that, under conditions of suboptimal diplomatic ties between developed and developing governments, there is an opportunity for non-state actors to fill the void and foster nationwide trust. The vehicle, in our case? Science education.

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August 2019
16 Reads

Effective participatory science education in a diverse Latin American population

Palgrave Communications

Particular challenges exist for science education in the developing world, where limited resources require curricula designed to balance state-of-the-art knowledge with practical and political considerations in region-specific contexts. Project-based biology teaching is especially difficult to execute due to high infrastructural costs and limited teacher training. Here, we report the results of implementing short, challenging, and low-cost biology courses to high school and college students in Bolivia, designed and taught in collaboration between scientists from developed nations and local science instructors. We find our approach to be effective at transmitting advanced topics in disease modeling, microscopy, genome engineering, neuroscience, microbiology, and regenerative biology. We find that student learning through this approach was not significantly affected by their background, education level, socioeconomic status, or initial interest in the course. Moreover, participants reported a heightened interest in pursuing scientific careers after course completion. These results demonstrate efficacy of participatory learning in a developing nation, and suggest that similar techniques could drive scientific engagement in other developing economies.

http://dx.doi.org/10.1057/s41599-019-0275-0

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June 2019
14 Reads

Generation of hypoimmunogenic human pluripotent stem cells.

Proc Natl Acad Sci U S A 2019 05 30;116(21):10441-10446. Epub 2019 Apr 30.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1902566116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535035PMC
May 2019
222 Reads
9.809 Impact Factor

Hexavalent chromium, a lung carcinogen, confers resistance to thermal stress and interferes with heat shock protein expression in human bronchial epithelial cells.

Biometals 2018 08 16;31(4):477-487. Epub 2018 Mar 16.

Molecular Physical Chemistry Research Unit and Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.

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http://dx.doi.org/10.1007/s10534-018-0093-7DOI Listing
August 2018
142 Reads
2.503 Impact Factor

NLRP2 is a suppressor of NF-ƙB signaling and HLA-C expression in human trophoblasts†,‡.

Tilburgs T, Meissner TB, Ferreira LMR, Mulder A, Musunuru K, Ye J, Strominger JL, Biology of reproduction, 2017, vol. 96, no. 4, pp. 831-842, 2017

http://europepmc.org/abstract/med/28340094

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May 2017
22 Reads

HLA-G: At the Interface of Maternal-Fetal Tolerance.

Ferreira LM, Meissner TB, Tilburgs T, Strominger JL, Trends in immunology, 2017, vol. 38, no. 4, pp. 272-286, 2017

http://europepmc.org/abstract/med/28279591

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May 2017
27 Reads

Generating Antigen-Specific Regulatory T Cells in the Fast Lane.

Ferreira LM, Tang Q, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017, vol. 17, no. 4, pp. 851-853, 2017

http://europepmc.org/abstract/med/28102024

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May 2017
40 Reads

NLRP2 is a suppressor of NF-ƙB signaling and HLA-C expression in human trophoblasts†,‡.

Biol Reprod 2017 Apr;96(4):831-842

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1093/biolre/iox009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803763PMC
April 2017
238 Reads
3.320 Impact Factor

HLA-G: At the Interface of Maternal-Fetal Tolerance.

Trends Immunol 2017 04 6;38(4):272-286. Epub 2017 Mar 6.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine mucosa without being rejected by the maternal immune system. Several mechanisms were initially proposed by Peter Medawar half a century ago to explain this apparent violation of the laws of transplantation. Then, three decades ago, an unusual human leukocyte antigen (HLA) molecule was identified: HLA-G. Uniquely expressed in EVT, HLA-G has since become the center of the present understanding of fetus-induced immune tolerance. Despite slow progress in the field, the last few years have seen an explosion in our knowledge of HLA-G biology. Here, we critically review new insights into the mechanisms controlling the expression and function of HLA-G at the maternal-fetal interface, and discuss their relevance for fetal tolerance.



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http://dx.doi.org/10.1016/j.it.2017.01.009DOI Listing
April 2017
62 Reads
28 Citations
14.188 Impact Factor

A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface.

Proc Natl Acad Sci U S A 2016 May 13;113(19):5364-9. Epub 2016 Apr 13.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138;

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http://dx.doi.org/10.1073/pnas.1602886113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868469PMC
May 2016
49 Reads
10 Citations
9.810 Impact Factor

Genome editing for human gene therapy.

Methods Enzymol 2014 ;546:273-95

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA; Harvard Stem Cell Institute, Sherman Fairchild Biochemistry, Cambridge, Massachusetts, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801185-0.00013-1DOI Listing
July 2015
52 Reads
4 Citations
2.090 Impact Factor

Genome Editing for Human Gene Therapy

The Use of CRISPR/Cas9, ZFNs, and TALENs in Generating Site-Specific Genome Alterations

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2014
27 Reads

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9.

Cell Stem Cell 2014 Nov 6;15(5):643-52. Epub 2014 Nov 6.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Broad Institute, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269831PMC
November 2014
31 Reads
105 Citations

Gammadelta T cells: innately adaptive immune cells?

Int Rev Immunol 2013 Jun 25;32(3):223-48. Epub 2013 Apr 25.

Department of Molecular and Cellular Biology and Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.3109/08830185.2013.783831DOI Listing
June 2013
14 Reads
16 Citations
4.103 Impact Factor

How induced pluripotent stem cells are redefining personalized medicine.

Gene 2013 May 5;520(1):1-6. Epub 2013 Mar 5.

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, United States.

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http://dx.doi.org/10.1016/j.gene.2013.02.037DOI Listing
May 2013
30 Reads
9 Citations
2.140 Impact Factor

Gammadelta T Cells: Innately Adaptive Immune Cells?

International Reviews of Immunology

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May 2013
25 Reads

Changing cell identity to create true personalized medicine

Mostajo-Radji, Mohammed A., & M.R. Ferreira, Leonardo. (2012). Cambiando la Identidad celular para crear una verdadera medicina personalizada. Gaceta Médica Boliviana, 35(2), 76-79. Recuperado en 20 de enero de 2019, de http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1012-296620120002000

Gad Med Bol

The 2012 Nobel Prize in Physiology or Medicine was awarded to Sir John Gurdon and Shinya Yamanaka for their breakthroughs in cellular reprogramming. These discoveries not only changed our view of the process of cell fate determination, but also hold the potential to revolutionize medicine. By providing a brief historical context and a succinct summary of the current methodologies, we present the major advances in basic research, as well as their potential applications to the clinic. This review aims to provide a concise overview of the current state of the field and its implications for therapy.

http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1012-29662012000200007

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2012
14 Reads

Changlng cell identity to create true personalized medicine

Mostajo-Radji, Mohammed A., & M.R. Ferreira, Leonardo. (2012). Cambiando la Identidad celular para crear una verdadera medicina personalizada. Gaceta Médica Boliviana, 35(2), 76-79. Recuperado en 20 de enero de 2019, de http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1012-296620120002000

Gad Med Bol

The 2012 Nobel Prize in Physiology or Medicine was awarded to Sir John Gurdon and Shinya Yamanaka for their breakthroughs in cellular reprogramming. These discoveries not only changed our view of the process of cell fate determination, but also hold the potential to revolutionize medicine. By providing a brief historical context and a succinct summary of the current methodologies, we present the major advances in basic research, as well as their potential applications to the clinic. This review aims to provide a concise overview of the current state of the field and its implications for therapy.

http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1012-29662012000200007

View Article
2012
25 Reads

Neural regeneration: lessons from regenerating and non-regenerating systems.

Mol Neurobiol 2012 Oct 21;46(2):227-41. Epub 2012 Jun 21.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1007/s12035-012-8290-9DOI Listing
October 2012
24 Reads
4 Citations
5.140 Impact Factor

Cancer metabolism: The Warburg effect today

Experimental and Molecular Pathology

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2010
25 Reads

Cancer metabolism: the Warburg effect today.

Exp Mol Pathol 2010 Dec 8;89(3):372-80. Epub 2010 Sep 8.

Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, Rua dos Estudos, 3001-401 Coimbra, Portugal.

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http://dx.doi.org/10.1016/j.yexmp.2010.08.006DOI Listing
December 2010
16 Reads
68 Citations
2.710 Impact Factor

Top co-authors

Torsten B Meissner
Torsten B Meissner

Dana-Farber Cancer Institute

6
Chad A Cowan
Chad A Cowan

Harvard University

5
Jack L Strominger
Jack L Strominger

Harvard University

4
Ana M Urbano
Ana M Urbano

Environmental Services Laboratory of Malaga

3
Mohammed A Mostajo-Radji
Mohammed A Mostajo-Radji

University of Rochester

3
Tamara Tilburgs
Tamara Tilburgs

Leiden University Medical Center

3
Teresa Cunha-Oliveira
Teresa Cunha-Oliveira

University of Coimbra

2
Pankaj K Mandal
Pankaj K Mandal

Boston Children's Hospital

2
Yulei Xia
Yulei Xia

Institute for Nutritional Sciences

2